September 2018

"Actin stabilization prevents PrPSc synaptotoxicity: In this report, the authors used a specialized neuronal culture system to dissect the cellular and molecular mechanisms by which prions damage synapses. Their results define a stepwise molecular pathway mediated by p38 MAPK that is responsible for prion synaptic toxicity. A key step in this pathway involves collapse of the actin cytoskeleton within dendritic spines, causing functional deficits in synaptic transmission. In this image, cultured hippocampal neurons were exposed to purified PrPSc for 24 hours in the presence of SiR-actin, a fluorogenic, cell-permeable peptide that stabilizes and labels F-actin in dendritic spines. SiR-actin prevents collapse of dendritic spines (bright green spots), which normally occurs after PrPSc treatment. See Figure 11 of Fang et al." David A. Harris et al.

Image Credit: Cheng Fang 2018

Pearls

Norovirus interactions with the commensal microbiota

Meagan E. Sullender, Megan T. Baldridge

PLOS Pathogens: published September 6, 2018 | https://doi.org/10.1371/journal.ppat.1007183

How fungi defend themselves against microbial competitors and animal predators

Markus Künzler

PLOS Pathogens: published September 6, 2018 | https://doi.org/10.1371/journal.ppat.1007184

It’s in the mix: Reassortment of segmented viral genomes

Anice C. Lowen

PLOS Pathogens: published September 13, 2018 | https://doi.org/10.1371/journal.ppat.1007200

Outbreaks of histoplasmosis: The spores set sail

George S. Deepe Jr.

PLOS Pathogens: published September 13, 2018 | https://doi.org/10.1371/journal.ppat.1007213

A viral trigger for celiac disease

Judy J. Brown, Bana Jabri, Terence S. Dermody

PLOS Pathogens: published September 20, 2018 | https://doi.org/10.1371/journal.ppat.1007181

Flu’s cues: Exploiting host post-translational modifications to direct the influenza virus replication cycle

Anthony R. Dawson, Andrew Mehle

PLOS Pathogens: published September 20, 2018 | https://doi.org/10.1371/journal.ppat.1007205

There was collusion: Microbes in inflammatory bowel disease

Serre-Yu Wong, Ken Cadwell

PLOS Pathogens: published September 20, 2018 | https://doi.org/10.1371/journal.ppat.1007215

Adenosine to inosine mRNA editing in fungi and how it may relate to fungal pathogenesis

Ines Teichert

PLOS Pathogens: published September 27, 2018 | https://doi.org/10.1371/journal.ppat.1007231

Five facts about Giardia lamblia

Lenka Cernikova, Carmen Faso, Adrian B. Hehl

PLOS Pathogens: published September 27, 2018 | https://doi.org/10.1371/journal.ppat.1007250

Research Articles

HLA-C downregulation by HIV-1 adapts to host HLA genotype

Nathaniel D. Bachtel, Gisele Umviligihozo, Suzanne Pickering, Talia M. Mota, Hua Liang, Gregory Q. Del Prete, Pramita Chatterjee, Guinevere Q. Lee, Rasmi Thomas, Mark A. Brockman, Stuart Neil, Mary Carrington, Bosco Bwana, David R. Bangsberg, Jeffrey N. Martin, Esper G. Kallas, Camila S. Donini, Natalia B. Cerqueira, Una T. O’Doherty, Beatrice H. Hahn, R. Brad Jones, Zabrina L. Brumme, Douglas F. Nixon, Richard Apps

PLOS Pathogens: published September 4, 2018 | https://doi.org/10.1371/journal.ppat.1007257

The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria

Olivia Benguettat, Rouba Jneid, Julie Soltys, Rihab Loudhaief, Alexandra Brun-Barale, Dani Osman, Armel Gallet

PLOS Pathogens: published September 4, 2018 | https://doi.org/10.1371/journal.ppat.1007279

Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness

Nnenna Nwogu, James R. Boyne, Samuel J. Dobson, Krzysztof Poterlowicz, G. Eric Blair, Andrew Macdonald, Jamel Mankouri, Adrian Whitehouse

PLOS Pathogens: published September 6, 2018 | https://doi.org/10.1371/journal.ppat.1007276

Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria

Ian J. Passmore, Marine P. M. Letertre, Mark D. Preston, Irene Bianconi, Mark A. Harrison, Fauzy Nasher, Harparkash Kaur, Huynh A. Hong, Simon D. Baines, Simon M. Cutting, Jonathan R. Swann, Brendan W. Wren, Lisa F. Dawson

PLOS Pathogens: published September 12, 2018 | https://doi.org/10.1371/journal.ppat.1007191

Antigenic evolution of viruses in host populations

Igor M. Rouzine, Ganna Rozhnova

PLOS Pathogens: published September 12, 2018 | https://doi.org/10.1371/journal.ppat.1007291

CD4⁺T cells mediate protection against Zika associated severe disease in a mouse model of infection

Mariah Hassert, Kyle J. Wolf, Katherine E. Schwetye, Richard J. DiPaolo, James D. Brien, Amelia K. Pinto

PLOS Pathogens: published September 13, 2018 | https://doi.org/10.1371/journal.ppat.1007237

Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri

Wenxu Zhou, Anjan Debnath, Gareth Jennings, Hye Jee Hahn, Boden H. Vanderloop, Minu Chaudhuri, W. David Nes, Larissa M. Podust

PLOS Pathogens: published September 13, 2018 | https://doi.org/10.1371/journal.ppat.1007245

Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

Fengchao Lang, Zhiguo Sun, Yonggang Pei, Rajnish Kumar Singh, Hem Chandra Jha, Erle S. Robertson

PLOS Pathogens: published September 13, 2018 | https://doi.org/10.1371/journal.ppat.1007253

Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency

Sharon E. Hopcraft, Samantha G. Pattenden, Lindsey I. James, Stephen Frye, Dirk P. Dittmer, Blossom Damania

PLOS Pathogens: published September 13, 2018 | https://doi.org/10.1371/journal.ppat.1007267

The MAPK kinase BcMkk1 suppresses oxalic acid biosynthesis via impeding phosphorylation of BcRim15 by BcSch9 in Botrytis cinerea

Yanni Yin, Sisi Wu, Chaonan Chui, Tianling Ma, Huixian Jiang, Matthias Hahn, Zhonghua Ma

PLOS Pathogens: published September 13, 2018 | https://doi.org/10.1371/journal.ppat.1007285

Plant A20/AN1 protein serves as the important hub to mediate antiviral immunity

Li Chang, Ho-Hsiung Chang, Jui-Che Chang, Hsiang-Chia Lu, Tan-Tung Wang, Duen-Wei Hsu, Yuh Tzean, An-Po Cheng, Yi-Shu Chiu, Hsin-Hung Yeh

PLOS Pathogens: published September 13, 2018 | https://doi.org/10.1371/journal.ppat.1007288

Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection in patients with spontaneous viral clearance

Brad R. Rosenberg, Marion Depla, Catherine A. Freije, Denis Gaucher, Sabrina Mazouz, Maude Boisvert, Nathalie Bédard, Julie Bruneau, Charles M. Rice, Naglaa H. Shoukry

PLOS Pathogens: published September 17, 2018 | https://doi.org/10.1371/journal.ppat.1007290

Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation

Lidia Mingorance, Victoria Castro, Ginés Ávila-Pérez, Gema Calvo, María Josefa Rodriguez, José L. Carrascosa, Sofía Pérez-del-Pulgar, Xavier Forns, Pablo Gastaminza

PLOS Pathogens: published September 18, 2018 | https://doi.org/10.1371/journal.ppat.1007284

Circulating HLA-DR⁺CD4⁺ effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis

Asma Ahmed, Vasista Adiga, Soumya Nayak, J. Anto Jesuraj Uday Kumar, Chirag Dhar, Pravat Nalini Sahoo, Bharath K. Sundararaj, George D. Souza, Annapurna Vyakarnam

PLOS Pathogens: published September 19, 2018 | https://doi.org/10.1371/journal.ppat.1007289

Crystal structure of a soluble fragment of poliovirus 2C^ATPase

Hongxin Guan, Juan Tian, Chu Zhang, Bo Qin, Sheng Cui

PLOS Pathogens: published September 19, 2018 | https://doi.org/10.1371/journal.ppat.1007304

Manganese acquisition is essential for virulence of Enterococcus faecalis

Cristina Colomer-Winter, Ana L. Flores-Mireles, Shannon P. Baker, Kristi L. Frank, Aaron J. L. Lynch, Scott J. Hultgren, Todd Kitten, José A. Lemos

PLOS Pathogens: published September 20, 2018 | https://doi.org/10.1371/journal.ppat.1007102

Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice

Joseph H. Skalski, Jose J. Limon, Purnima Sharma, Matthew D. Gargus, Christopher Nguyen, Jie Tang, Ana Lucia Coelho, Cory M. Hogaboam, Timothy R. Crother, David M. Underhill

PLOS Pathogens: published September 20, 2018 | https://doi.org/10.1371/journal.ppat.1007260

Prions activate a p38 MAPK synaptotoxic signaling pathway

Cheng Fang, Bei Wu, Nhat T. T. Le, Thibaut Imberdis, Robert C. C. Mercer, David A. Harris

PLOS Pathogens: published September 20, 2018 | https://doi.org/10.1371/journal.ppat.1007283

Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis

Camille Cohen, Armelle Corpet, Simon Roubille, Mohamed Ali Maroui, Nolwenn Poccardi, Antoine Rousseau, Constance Kleijwegt, Olivier Binda, Pascale Texier, Nancy Sawtell, Marc Labetoulle, Patrick Lomonte

PLOS Pathogens: published September 20, 2018 | https://doi.org/10.1371/journal.ppat.1007313

Proteome-wide analysis of CD8+ T cell responses to EBV reveals differences between primary and persistent infection

Calum Forrest, Andrew D. Hislop, Alan B. Rickinson, Jianmin Zuo

PLOS Pathogens: published September 24, 2018 | https://doi.org/10.1371/journal.ppat.1007110

The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

Daniela Niemeyer, Kirstin Mösbauer, Eva M. Klein, Andrea Sieberg, Robert C. Mettelman, Anna M. Mielech, Ronald Dijkman, Susan C. Baker, Christian Drosten, Marcel A. Müller

PLOS Pathogens: published September 24, 2018 | https://doi.org/10.1371/journal.ppat.1007296

NLRP6 negatively regulates pulmonary host defense in Gram-positive bacterial infection through modulating neutrophil recruitment and function

Laxman Ghimire, Sagar Paudel, Liliang Jin, Pankaj Baral, Shanshan Cai, Samithamby Jeyaseelan

PLOS Pathogens: published September 24, 2018 | https://doi.org/10.1371/journal.ppat.1007308

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

Daniela Begolo, Isabel M. Vincent, Federica Giordani, Ina Pöhner, Michael J. Witty, Timothy G. Rowan, Zakaria Bengaly, Kirsten Gillingwater, Yvonne Freund, Rebecca C. Wade, Michael P. Barrett, Christine Clayton

PLOS Pathogens: published September 25, 2018 | https://doi.org/10.1371/journal.ppat.1007315

Candida albicans Sfl1/Sfl2 regulatory network drives the formation of pathogenic microcolonies

Andrew D. McCall, Rohitashw Kumar, Mira Edgerton

PLOS Pathogens: published September 25, 2018 | https://doi.org/10.1371/journal.ppat.1007316

RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides

Haoyang Li, Bin Yin, Sheng Wang, Qihui Fu, Bang Xiao, Kai Lǚ, Jianguo He, Chaozheng Li

PLOS Pathogens: published September 26, 2018 | https://doi.org/10.1371/journal.ppat.1007109

Infection with flaviviruses requires BCLX_L for cell survival

Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa, Takashi Satoh, Sachiyo Yoshio, Ryosuke Suzuki, Masayuki Saijo, David C. S. Huang, Tatsuya Kanto, Shizuo Akira, Yoshiharu Matsuura

PLOS Pathogens: published September 27, 2018 | https://doi.org/10.1371/journal.ppat.1007299

Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1

May Kwang-Mei Wang, Tao Ren, Hu Liu, Sun-Young Lim, Kyungae Lee, Anna Honko, Huanying Zhou, Julie Dyall, Lisa Hensley, Ashley K. Gartin, James M. Cunningham

PLOS Pathogens: published September 28, 2018 | https://doi.org/10.1371/journal.ppat.1007322

Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus

Subramaniyam Ravichandran, Young-Eui Kim, Varun Bansal, Ambarnil Ghosh, Jeonghwan Hur, Vinod Kumar Subramani, Subhra Pradhan, Myoung Kyu Lee, Kyeong Kyu Kim, Jin-Hyun Ahn

PLOS Pathogens: published September 28, 2018 | https://doi.org/10.1371/journal.ppat.1007334

Corrections

Correction: miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence

Yingpu Yu, Troels K. H. Scheel, Joseph M. Luna, Hachung Chung, Eiko Nishiuchi, Margaret A. Scull, Natalia Echeverría, Inna Ricardo-Lax, Amit Kapoor, W. Ian Lipkin, Thomas J. Divers, Douglas F. Antczak, Bud C. Tennant, Charles M. Rice

PLOS Pathogens: published September 17, 2018 | https://doi.org/10.1371/journal.ppat.1007303

Correction: FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1

Jae-Hoon Kim, Min-Eun Park, Chamilani Nikapitiya, Tae-Hwan Kim, Md Bashir Uddin, Hyun-Cheol Lee, Eunhee Kim, Jin Yeul Ma, Jae U. Jung, Chul-Joong Kim, Jong-Soo Lee

PLOS Pathogens: published September 21, 2018 | https://doi.org/10.1371/journal.ppat.1007302

Correction: Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice

Nick D. Van Skike, Nana K. Minkah, Chad H. Hogan, Gary Wu, Peter T. Benziger, Darby G. Oldenburg, Mehmet Kara, Deborah M. Kim-Holzapfel, Douglas W. White, Scott A. Tibbetts, Jarrod B. French, Laurie T. Krug

PLOS Pathogens: published September 25, 2018 | https://doi.org/10.1371/journal.ppat.1007319

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Prions activate a p38 MAPK synaptotoxic signaling pathway

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