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In recent decades, responses to HIV/AIDS and other important and large-scale threats to health have often employed intensive "vertical" approaches to prevention, diagnosis and treatment of specific diseases. Despite substantial progress, much remains to be done to achieve and sustain ambitions set out in global projects that include the Sustainable Development Goals. As part of this framework, a transition is occurring to provision of integrated disease responses within the context of strengthened health systems in developing countries. In a Policy Forum, Jan Hontelez and co-authors discuss the use of different levels of evidence and diverse implementation strategies to inform HIV programme integration.

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