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The use of gabapentinoids has substantially increased worldwide over the past decade. There are growing public health concerns about gabapentinoid-related poisoning, particularly among those also using opioids or benzodiazepines. In a self-controlled case series analysis, Andrew Yuen and colleagues assess whether there is an association between gabapentinoid use and drug poisoning, using data from the United Kingdom Clinical Practice Research Datalink (CPRD). Their findings suggest that use of gabapentinoids is associated with an increased risk of drug poisoning, particularly when opioids or benzodiazepines are also being used, and that closer clinical monitoring and reconsideration of concomitant treatment may be warranted.
Image Credit: Tara Winstead