Table of Contents

June 2018

In this month's Editorial, Caitlin C. Murphy and Amit Singal recap population-level data on colorectal cancer incidence and mortality in the past 3 decades, documenting overall positive trends in screening, early detection of small cancers and premalignant lesions and better treatment options.

The authors then turn the focus on a different trend, seen since the 1990s, in younger patients (under the age of 50) in whom increased incidence rates have been observed continuously and discuss possible explanations, ranging from an increased number of cancers detected through screening to early-life exposure risks factors.

Image Credit: Stacey Geiger, US Air Force


Establishing a research agenda for early-onset colorectal cancer

Caitlin C. Murphy, Amit G. Singal

Research Articles

Estimating the real-world effects of expanding antiretroviral treatment eligibility: Evidence from a regression discontinuity analysis in Zambia

Aaloke Mody, Izukanji Sikazwe, Nancy L. Czaicki, Mwanza Wa Mwanza, Theodora Savory, Kombatende Sikombe, Laura K. Beres, Paul Somwe, Monika Roy, Jake M. Pry, Nancy Padian, Carolyn Bolton-Moore, Charles B. Holmes, Elvin H. Geng

A peer-support lifestyle intervention for preventing type 2 diabetes in India: A cluster-randomized controlled trial of the Kerala Diabetes Prevention Program

Kavumpurathu R. Thankappan, Thirunavukkarasu Sathish, Robyn J. Tapp, Jonathan E. Shaw, Mojtaba Lotfaliany, Rory Wolfe, Pilvikki Absetz, Elezebeth Mathews, Zahra Aziz, Emily D. Williams, Edwin B. Fisher, Paul Z. Zimmet, Ajay Mahal, Sajitha Balachandran, Fabrizio D'Esposito, Priyanka Sajeev, Emma Thomas, Brian Oldenburg

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

Frank Kloprogge, Lesley Workman, Steffen Borrmann, Mamadou Tékété, Gilbert Lefèvre, Kamal Hamed, Patrice Piola, Johan Ursing, Poul Erik Kofoed, Andreas Mårtensson, Billy Ngasala, Anders Björkman, Michael Ashton, Sofia Friberg Hietala, Francesca Aweeka, Sunil Parikh, Leah Mwai, Timothy M. E. Davis, Harin Karunajeewa, Sam Salman, Francesco Checchi, Carole Fogg, Paul N. Newton, Mayfong Mayxay, Philippe Deloron, Jean François Faucher, François Nosten, Elizabeth A. Ashley, Rose McGready, Michele van Vugt, Stephane Proux, Ric N. Price, Juntra Karbwang, Farkad Ezzet, Rajesh Bakshi, Kasia Stepniewska, Nicholas J. White, Philippe J. Guerin, Karen I. Barnes, Joel Tarning

Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial

Tracey L. Sletten, Michelle Magee, Jade M. Murray, Christopher J. Gordon, Nicole Lovato, David J. Kennaway, Stella M. Gwini, Delwyn J. Bartlett, Steven W. Lockley, Leon C. Lack, Ronald R. Grunstein, Shantha M. W. Rajaratnam, for the Delayed Sleep on Melatonin (DelSoM) Study Group

Geographic and sociodemographic variation of cardiovascular disease risk in India: A cross-sectional study of 797,540 adults

Pascal Geldsetzer, Jennifer Manne-Goehler, Michaela Theilmann, Justine I. Davies, Ashish Awasthi, Goodarz Danaei, Thomas A. Gaziano, Sebastian Vollmer, Lindsay M. Jaacks, Till Bärnighausen, Rifat Atun

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The association of lifetime alcohol use with mortality and cancer risk in older adults: A cohort study

Andrew T. Kunzmann, Helen G. Coleman, Wen-Yi Huang, Sonja I. Berndt

Single-dose oral ciprofloxacin prophylaxis as a response to a meningococcal meningitis epidemic in the African meningitis belt: A 3-arm, open-label, cluster-randomized trial

Matthew E. Coldiron, Bachir Assao, Anne-Laure Page, Matt D. T. Hitchings, Gabriel Alcoba, Iza Ciglenecki, Céline Langendorf, Christopher Mambula, Eric Adehossi, Fati Sidikou, Elhadji Ibrahim Tassiou, Victoire De Lastours, Rebecca F. Grais

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