Table of Contents

May 2012

Mental health disorders are prevalent in all areas of the world, in every community and across all income levels. An estimated 13% of the total global burden of disease is attributable to mental health disorders, with almost three-quarters of this burden affecting people in the developing world. This makes mental health one of the most pressing challenges facing the global health community. In this month's editorial, the PLoS Medicine Editors, along with guest editors Vikram Patel, Rachel Jenkins, and Crick Lund, announce the launch of a new series on Global Mental Health Practice, and issue a call for case studies that can help broaden our understanding of global mental health interventions in “real-life” contexts. The first two papers in the series, commissioned for our Health in Action section, include an analysis by Simone Honikman and colleagues of the Perinatal Mental Health Project, which delivered mental health care to pregnant women in South Africa in a collaborative, step-wise manner, and a report by Peter Ventevogel and colleagues on their efforts to integrate brief, practice-oriented mental health training into the Afghanistan health care system. The Editors say, “A key motivation for this series is to emphasize the importance of ‘practice-based evidence,’ by placing value on the experiences and impact of interventions in real-world settings as evidence for implementation…The series addresses the need for greater awareness of global mental health in practice, and builds on PLoS Medicine's interest and leadership in global mental health.”

Image Credit: Marcie Casas (Marcie Casas at

Health in Action

The Midwives Service Scheme in Nigeria

Seye Abimbola, Ugo Okoli, Olalekan Olubajo, Mohammed J. Abdullahi, Muhammad A. Pate

Policy Forums

A Prescription for Improving Drug Formulary Decision Making

Gordon D. Schiff, William L. Galanter, Jay Duhig, Michael J. Koronkowski, Amy E. Lodolce, Pam Pontikes, John Busker, Daniel Touchette, Surrey Walton, Bruce L. Lambert

Criminal Justice Reform as HIV and TB Prevention in African Prisons

Katherine W. Todrys, Joseph J. Amon

Guidelines and Guidance

Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): Explanation and Elaboration

Douglas G. Altman, Lisa M. McShane, Willi Sauerbrei, Sheila E. Taube

Research Articles

Pregnancy and Infant Outcomes among HIV-Infected Women Taking Long-Term ART with and without Tenofovir in the DART Trial

Diana M. Gibb, Hilda Kizito, Elizabeth C. Russell, Ennie Chidziva, Eva Zalwango, Ruth Nalumenya, Moira Spyer, Dinah Tumukunde, Kusum Nathoo, Paula Munderi, Hope Kyomugisha, James Hakim, Heiner Grosskurth, Charles F. Gilks, A. Sarah Walker, Phillipa Musoke, on behalf of the DART trial team

Six-Year Follow-Up of Impact of Co-proxamol Withdrawal in England and Wales on Prescribing and Deaths: Time-Series Study

Keith Hawton, Helen Bergen, Sue Simkin, Claudia Wells, Navneet Kapur, David Gunnell

The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach

Børge G. Nordestgaard, Tom M. Palmer, Marianne Benn, Jeppe Zacho, Anne Tybjærg-Hansen, George Davey Smith, Nicholas J. Timpson

Reporting and Methods in Clinical Prediction Research: A Systematic Review

Walter Bouwmeester, Nicolaas P. A. Zuithoff, Susan Mallett, Mirjam I. Geerlings, Yvonne Vergouwe, Ewout W. Steyerberg, Douglas G. Altman, Karel G. M. Moons