Table of Contents

March 2008

The image this month is a map of the Internet created by Matt Britt from data from the Opte Project. The closeup shows how nodes representing Internet addresses are connected (see the description in Wikimedia Commons).

The image relates to the theme of the editorial: network theory and how it is increasingly used to understand connections and relationships in health and medicine, whether at a cellular, population, or social level. In a paper on the dynamics of influenza transmission published this month (Mossong, et al. e74), network analysis helped the authors produce a mathematical model suggesting that 5- to 19-year-olds will suffer the highest burden of respiratory infection during any initial spread. Another paper (Lewis, et al. e50) using phylodynamics—a mix of genetics, epidemiology, and evolutionary biology—elucidated a transmission network that provides insights into HIV prevention.

Image Credit: Image by Matt Britt, using data from the Opte Project

The PLoS Medicine Debate

Policy Forums

Syndromic Surveillance: Adapting Innovations to Developing Settings

Jean-Paul Chretien, Howard S Burkom, Endang R Sedyaningsih, Ria P Larasati, Andres G Lescano, Carmen C Mundaca, David L Blazes, Cesar V Munayco, Jacqueline S Coberly, Raj J Ashar, Sheri H Lewis

Research in Translation

Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?

Moisés Selman, Annie Pardo, Naftali Kaminski

Research Articles

Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases

Joël Mossong, Niel Hens, Mark Jit, Philippe Beutels, Kari Auranen, Rafael Mikolajczyk, Marco Massari, Stefania Salmaso, Gianpaolo Scalia Tomba, Jacco Wallinga, Janneke Heijne, Malgorzata Sadkowska-Todys, Magdalena Rosinska, W. John Edmunds

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Chad K Heazlewood, Matthew C Cook, Rajaraman Eri, Gareth R Price, Sharyn B Tauro, Douglas Taupin, David J Thornton, Chin Wen Png, Tanya L Crockford, Richard J Cornall, Rachel Adams, Masato Kato, Keats A Nelms, Nancy A Hong, Timothy H. J Florin, Christopher C Goodnow, Michael A McGuckin

Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach

Lina Chen, George Davey Smith, Roger M Harbord, Sarah J Lewis

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

Kirsi H Pietiläinen, Jussi Naukkarinen, Aila Rissanen, Juha Saharinen, Pekka Ellonen, Heli Keränen, Anu Suomalainen, Alexandra Götz, Tapani Suortti, Hannele Yki-Järvinen, Matej Orešič, Jaakko Kaprio, Leena Peltonen

Exploring the Developmental Overnutrition Hypothesis Using Parental–Offspring Associations and FTO as an Instrumental Variable

Debbie A Lawlor, Nicholas J Timpson, Roger M Harbord, Sam Leary, Andy Ness, Mark I McCarthy, Timothy M Frayling, Andrew T Hattersley, George Davey Smith

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Magdalena Winiarska, Jacek Bil, Ewa Wilczek, Grzegorz M Wilczynski, Malgorzata Lekka, Patrick J Engelberts, Wendy J. M Mackus, Elzbieta Gorska, Lukasz Bojarski, Tomasz Stoklosa, Dominika Nowis, Zuzanna Kurzaj, Marcin Makowski, Eliza Glodkowska, Tadeusz Issat, Piotr Mrowka, Witold Lasek, Anna Dabrowska-Iwanicka, Grzegorz W Basak, Maria Wasik, Krzysztof Warzocha, Maciej Sinski, Zbigniew Gaciong, Marek Jakobisiak, Paul W. H. I Parren, Jakub Golab

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