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Table of Contents

August 2006

The cover is based on a brain MRI scan of a child with obstructive sleep apnea, which most commonly occurs when children are very overweight. The related research article by Halbower et al. suggests that children with obstructive sleep apnea may also have changes in their brain metabolism, which could make them more likely to have learning difficulties.

Image Credit: Images taken from Halbower et al.

The PLoS Medicine Debate

Have Online International Medical Journals Made Local Journals Obsolete?

David Ofori-Adjei, Gerd Antes, Prathap Tharyan, Elizabeth Slade, Pritpal S Tamber


Health in Action

Evaluating Health Research Capacity Building: An Evidence-Based Tool

Imelda Bates, Alex Yaw Osei Akoto, Daniel Ansong, Patrick Karikari, George Bedu-Addo, Julia Critchley, Tsiri Agbenyega, Anthony Nsiah-Asare

Research in Translation

A Proposed Classification of the Immunological Diseases

Dennis McGonagle, Michael F McDermott

Learning Forum

A 26-Year-Old Man with Sternoclavicular Arthritis

Christian Gutierrez Ruiz, J. Jaime Miranda, Georgios Pappas

Case Report

Recurrent Hypoglycaemia in a Patient with Metastatic Pancreatic Carcinoma

Ronald C. W Ma, Raymond S. K Lo, Morris H. L Tai, Juliana C. N Chan, Chun Chung Chow, Jean L. F Woo

Research Articles

Travel-Related Venous Thrombosis: Results from a Large Population-Based Case Control Study (MEGA Study)

Suzanne C Cannegieter, Carine J. M Doggen, Hans C van Houwelingen, Frits R Rosendaal

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Creating and Validating an Algorithm to Measure AIDS Mortality in the Adult Population using Verbal Autopsy

Ben A Lopman, Ruanne V Barnabas, J. Ties Boerma, Godwin Chawira, Kezia Gaitskell, Tara Harrop, Peter Mason, Christl A Donnelly, Geoff P Garnett, Constance Nyamukapa, Simon Gregson

Core Verbal Autopsy Procedures with Comparative Validation Results from Two Countries

Philip W Setel, Chalapati Rao, Yusuf Hemed, David R Whiting, Gonghuan Yang, Daniel Chandramohan, K. G. M. M Alberti, Alan D Lopez

Conjunctival FOXP3 Expression in Trachoma: Do Regulatory T Cells Have a Role in Human Ocular Chlamydia trachomatis Infection?

Nkoyo Faal, Robin L Bailey, David Jeffries, Hassan Joof, Isatou Sarr, Mass Laye, David C. W Mabey, Martin J Holland

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Prospects for Advancing Tuberculosis Control Efforts through Novel Therapies

Joshua A Salomon, James O Lloyd-Smith, Wayne M Getz, Stephen Resch, María S Sánchez, Travis C Porco, Martien W Borgdorff

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Mycobacterium tuberculosis Induces Interleukin-32 Production through a Caspase- 1/IL-18/Interferon-γ-Dependent Mechanism

Mihai G Netea, Tania Azam, Eli C Lewis, Leo A. B Joosten, Maorong Wang, Dennis Langenberg, Xianzhong Meng, Edward D Chan, Do-Young Yoon, Tom Ottenhoff, Soo-Hyun Kim, Charles A Dinarello

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Determining Risk for Severe Leptospirosis by Molecular Analysis of Environmental Surface Waters for Pathogenic Leptospira

Christian A Ganoza, Michael A Matthias, Devon Collins-Richards, Kimberly C Brouwer, Calaveras B Cunningham, Eddy R Segura, Robert H Gilman, Eduardo Gotuzzo, Joseph M Vinetz

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Reduced Antibody Responses to Vaccinations in Children Exposed to Polychlorinated Biphenyls

Carsten Heilmann, Philippe Grandjean, Pál Weihe, Flemming Nielsen, Esben Budtz-Jørgensen

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Aberrant Receptor-Mediated Endocytosis of Schistosoma mansoni Glycoproteins on Host Lipoproteins

Hein Sprong, Monika Suchanek, Suzanne M van Dijk, Alexandra van Remoortere, Judith Klumperman, Diana Avram, Joke van der Linden, Jeanette H. W Leusen, Jaap J van Hellemond, Christoph Thiele

Abnormal Cortical Development after Premature Birth Shown by Altered Allometric Scaling of Brain Growth

Olga Kapellou, Serena J Counsell, Nigel Kennea, Leigh Dyet, Nadeem Saeed, Jaroslav Stark, Elia Maalouf, Philip Duggan, Morenike Ajayi-Obe, Jo Hajnal, Joanna M Allsop, James Boardman, Mary A Rutherford, Frances Cowan, A. David Edwards

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Childhood Obstructive Sleep Apnea Associates with Neuropsychological Deficits and Neuronal Brain Injury

Ann C Halbower, Mahaveer Degaonkar, Peter B Barker, Christopher J Earley, Carole L Marcus, Philip L Smith, M. Cristine Prahme, E. Mark Mahone

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Statins in the Treatment of Chronic Heart Failure: A Systematic Review

Pim van der Harst, Adriaan A Voors, Wiek H van Gilst, Michael Böhm, Dirk J van Veldhuisen

Inflammatory Cytokines as Risk Factors for a First Venous Thrombosis: A Prospective Population-Based Study

Sverre C Christiansen, Inger Anne Næss, Suzanne C Cannegieter, Jens Hammerstrøm, Frits R Rosendaal, Pieter H Reitsma

Metabolic Profiling of CSF: Evidence That Early Intervention May Impact on Disease Progression and Outcome in Schizophrenia

Elaine Holmes, Tsz M Tsang, Jeffrey T.-J Huang, F. Markus Leweke, Dagmar Koethe, Christoph W Gerth, Brit M Nolden, Sonja Gross, Daniela Schreiber, Jeremy K Nicholson, Sabine Bahn

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Correction: Streptococcal Toxic Shock Syndrome Caused by Streptococcus suis Serotype 2

Jiaqi Tang, Changjun Wang, Youjun Feng, Weizhong Yang, Huaidong Song, Zhihai Chen, Hongjie Yu, Xiuzhen Pan, Xiaojun Zhou, Huaru Wang, Bo Wu, Haili Wang, Huamei Zhao, Ying Lin, Jianhua Yue, Zhenqiang Wu, Xiaowei He, Feng Gao, Abdul Hamid Khan, Jian Wang, Guo-Ping Zhao, Yu Wang, Xiaoning Wang, Zhu Chen, George F Gao

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Correction: Manslaughter by Fake Artesunate in Asia—Will Africa Be Next?

Paul N Newton, Rose McGready, Facundo Fernandez, Michael D Green, Manuela Sunjio, Carinne Bruneton, Souly Phanouvong, Pascal Millet, Christopher J. M Whitty, Ambrose O Talisuna, Stephane Proux, Eva Maria Christophel, Grace Malenga, Pratap Singhasivanon, Kalifa Bojang, Harparkash Kaur, Kevin Palmer, Nicholas P. J Day, Brian M Greenwood, François Nosten, Nicholas J White

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