Submit Now

Your step-by-step guide to the submission form

Keep this page open for reference as you complete each task in the form. It has 6 major sections, which are outlined below. 

After you provide the required information, Editorial Manager will compile your files into a PDF to send to the journal.

6 major article submission steps in Editorial Manager submission form


Submit manuscript

Sign in to the submission system, and click Submit New Manuscript

Not sure if you’re ready? Check the submission requirements.

Unsure if your work is suitable for PLOS MedicineSubmit a presubmission inquiry for quick feedback.
Submission Steps

Article Type Selection

Select the appropriate article type. If you are submitting to the magazine section, follow the submission instructions for the matching magazine article type.

Attach Files

Upload the following submission files individually:

  • Cover letter
  • Manuscript (in DOC, DOCX, RTF, PDF), with each figure embedded after first mention in the text
  • Supporting information

Alternatively, you can submit all components in one PDF for initial assessment.

Upload LaTex manuscripts in PDF format. If the article is accepted for publication, the .tex files will be required.

For each file uploaded, choose the matching Item Type from the dropdown menu. Enter or edit the autofill description for each file in the Description field.

General Information

Add keywords to help expedite processing of your manuscript (optional). You will not have an opportunity to make changes, so make sure to add concise, accurate keywords now.

Review Preferences

Provide the names of recommended and opposed reviewers (optional). Give the reasons for your choice in each instance.

Additional Information

Required statements

Check the boxes to indicate your agreement with 5 required statements regarding PLOS Editorial and Publishing Policies: 

United States Government employee

Specify if any of the authors are employees of the US Government. If accepted, the article will use a CC0 license.

Financial disclosure

Describe the sources of funding that supported the work, if any, and indicate whether they played a role at any point in the research or publication process. To draft the statement, consult the submission guidelines and follow the in-system instructions.

This information will appear in the published article, if accepted. Make sure that it is detailed and accurate.

Competing interests statement

Declare any author affiliations or relationships that could be viewed as potential competing interests. To draft the statement, consult the competing interests policy and follow the in-system instructions.

This information will appear in the published article, if accepted. Make sure that it is detailed and accurate.

Ethics statement

If the study made use of human or animal subjects and/or tissue, you must provide an ethics statement. Make sure this information exactly matches the ethics statement included in the manuscript and that it fulfills our reporting requirements for human subjects research and animal research

We will evaluate your ethics statement to ensure that it meets our standards. Include as much information as possible.

Figure guidelines

Confirm that the figures comply with our image preparation guidelines, including those on image manipulation.

Copyrighted figures

If any of the images included in the submission fall under copyright or were adapted from images under copyright, provide the following additional details:

  • Image source
  • Permissions received from the copyright holder to publish under a CC BY license (CC0 for US Government employees)
  • Where the image appears in the manuscript and how it is used (e.g. visualized, reproduced)
  • For any adapted images, upload a copy of the original figure on the Attach Files screen

Dual publication

State whether any of the elements in the manuscript have been published or are under consideration for publication elsewhere. If yes, it is very important to provide full details in the event that the journal needs to consider copyright issues.

Calls for Papers and Collections

If you are submitting in response to a call for papers in a specific topic area, enter the title of the call in the space provided. Read more about current calls for papers on our website

Data availability statement

Answer the following questions to construct your Data Availability statement. This information will appear in the article, if accepted. 

  • Confirm whether all data reported in the manuscript are publicly available. PLOS requires that authors deposit all reported data and related metadata underlying the study findings in an appropriate public repository, unless already provided in the submission. See the data reporting guidelines.
  • Describe where the data can be found in full sentences. Use the in-system instructions to draft a suitable statement.
  • Check the boxes to specify if the data will be available in a repository upon acceptance or if you need journal assistance to make it available. Journal staff will follow up to help later on in the process.

Publication fees

Follow the in-system instructions to specify how payment will be handled if the manuscript is accepted for publication. If you have any questions, email the author billing department

Editors and reviewers have no access to payment information, therefore ability to pay does not influence the decision to publish.

Manuscript Data

Editorial Manager will extract details from the manuscript to gather the following information. Verify that they’re correct, and fill in any missing information:

  • Title
  • Abstract
  • Author list (see instructions below)
  • Funding information (optional)

Author list

Enter each author’s name, email address, institutional affiliation, and contributions. Make sure authors are listed in the same order as in the manuscript.

Do not list group authors here. Provide the names of group authors and consortia in the manuscript.

Corresponding author

The submitting author is automatically added to the author list and given the role of corresponding author in the submission system. You can designate different corresponding authors on the manuscript who will receive post-publication correspondence if the submission is accepted.

Change the corresponding author

To transfer the role to another author in the list, click the pencil icon next to the author name, and check This is the corresponding author.

Read more about designating corresponding authors and corresponding author responsibilities.

Send to PLOS

Once you supply all the requested information, click Build PDF for Approval on the final screen. The system will merge the submission files into a PDF for your review. Click Approve to send it to the journal. 

Congratulations! You’re done. You will receive a confirmation message with a manuscript number to track the submission’s progress.

Send it later...
If you’re not ready to send the file now, you can save it for later. To continue, sign into Editorial Manager and click  Submissions Waiting for Author’s Approval on the main menu.

Revised Manuscripts

Submitting a revision? Read the instructions for revised manuscripts.


Questions about the submission process? Email

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