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Table of Contents

April 2017

Implementation Science studies how treatments that have been found to work in controlled settings can reach their potential in real-world situations. The topic is of particular relevance to common conditions in resource-poor settings—in brief, to the most pressing issues in human health.

In this month's Editorial, PLOS Medicine editorial board members Elvin Geng (University of California, San Francisco, USA), David Peiris (The George Institute for Global Health, University of Sydney, Australia) and Margaret Kruk (Harvard T.H. Chan School of Public Health, Boston, USA) discuss the characteristics that lend relevance and reliability to an implementation study, and encourage the submission of high quality implementation research to PLOS Medicine.

Image Credit: The Noun Project, Duke Innovation Co-Lab, Wikimedia Commons

Editorial

Implementation science: Relevance in the real world without sacrificing rigor

Elvin H. Geng, David Peiris, Margaret E. Kruk

Essays

Talking sensibly about depression

Vikram Patel

A new cascade of HIV care for the era of “treat all”

Matthew P. Fox, Sydney Rosen

An open source pharma roadmap

Manica Balasegaram, Peter Kolb, John McKew, Jaykumar Menon, Piero Olliaro, Tomasz Sablinski, Zakir Thomas, Matthew H. Todd, Els Torreele, John Wilbanks

Policy Forums

Governing multisectoral action for health in low- and middle-income countries

Kumanan Rasanathan, Sara Bennett, Vincent Atkins, Robert Beschel, Gabriel Carrasquilla, Jodi Charles, Rajib Dasgupta, Kirk Emerson, Douglas Glandon, Churnrurtai Kanchanachitra, Pete Kingsley, Don Matheson, Rees Murithi Mbabu, Charles Mwansambo, Michael Myers, Jeremias Paul Jr., Thulisile Radebe, James Smith, Orielle Solar, Agnès Soucat, Aloysius Ssennyonjo, Matthias Wismar, Shehla Zaidi

Research Articles

Status and methodology of publicly available national HIV care continua and 90-90-90 targets: A systematic review

Reuben Granich, Somya Gupta, Irene Hall, John Aberle-Grasse, Shannon Hader, Jonathan Mermin

Demographic transition and the dynamics of measles in six provinces in China: A modeling study

Sheng Li, Chao Ma, Lixin Hao, Qiru Su, Zhijie An, Fubao Ma, Shuyun Xie, Aiqiang Xu, Yanyang Zhang, Zhengrong Ding, Hui Li, Lisa Cairns, Huaqing Wang, Huiming Luo, Ning Wang, Li Li, Matthew J. Ferrari

Risk prediction models for selection of lung cancer screening candidates: A retrospective validation study

Kevin ten Haaf, Jihyoun Jeon, Martin C. Tammemägi, Summer S. Han, Chung Yin Kong, Sylvia K. Plevritis, Eric J. Feuer, Harry J. de Koning, Ewout W. Steyerberg, Rafael Meza

The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care

Christian D. Mallen, Barbara I. Nicholl, Martyn Lewis, Bernadette Bartlam, Daniel Green, Sue Jowett, Jesse Kigozi, John Belcher, Kris Clarkson, Zoe Lingard, Christopher Pope, Carolyn A. Chew-Graham, Peter Croft, Elaine M. Hay, George Peat

Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults

Huaidong Du, Liming Li, Derrick Bennett, Yu Guo, Iain Turnbull, Ling Yang, Fiona Bragg, Zheng Bian, Yiping Chen, Junshi Chen, Iona Y. Millwood, Sam Sansome, Liangcai Ma, Ying Huang, Ningmei Zhang, Xiangyang Zheng, Qiang Sun, Timothy J. Key, Rory Collins, Richard Peto, Zhengming Chen, China Kadoorie Biobank study

Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial)

Kim S. Thomas, Lucy E. Bradshaw, Tracey H. Sach, Jonathan M. Batchelor, Sandra Lawton, Eleanor F. Harrison, Rachel H. Haines, Amina Ahmed, Hywel C. Williams, Taraneh Dean, Nigel P. Burrows, Ian Pollock, Joanne Llewellyn, Clare Crang, Jane D. Grundy, Juliet Guiness, Andrew Gribbin, Eleanor J. Mitchell, Fiona Cowdell, Sara J Brown, Alan A. Montgomery, UK Dermatology Clinical Trials Network’s CLOTHES Trial Team

Effectiveness of a live oral human rotavirus vaccine after programmatic introduction in Bangladesh: A cluster-randomized trial

K. Zaman, David A. Sack, Kathleen M. Neuzil, Mohammad Yunus, Lawrence H. Moulton, Jonathan D. Sugimoto, Jessica A. Fleming, Ilias Hossain, Shams El Arifeen, Tasnim Azim, Mustafizur Rahman, Kristen D. C. Lewis, Andrea J. Feller, Firdausi Qadri, M. Elizabeth Halloran, Alejandro Cravioto, John C. Victor

Changes in prices, sales, consumer spending, and beverage consumption one year after a tax on sugar-sweetened beverages in Berkeley, California, US: A before-and-after study

Lynn D. Silver, Shu Wen Ng, Suzanne Ryan-Ibarra, Lindsey Smith Taillie, Marta Induni, Donna R. Miles, Jennifer M. Poti, Barry M. Popkin

Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study

Ekkehard Schütz, Anna Fischer, Julia Beck, Markus Harden, Martina Koch, Tilo Wuensch, Martin Stockmann, Björn Nashan, Otto Kollmar, Johannes Matthaei, Philipp Kanzow, Philip D. Walson, Jürgen Brockmöller, Michael Oellerich

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

Charles C. White, Hyun-Sik Yang, Lei Yu, Lori B. Chibnik, Robert J. Dawe, Jingyun Yang, Hans-Ulrich Klein, Daniel Felsky, Alfredo Ramos-Miguel, Konstantinos Arfanakis, William G. Honer, Reisa A. Sperling, Julie A. Schneider, David A. Bennett, Philip L. De Jager