Table of Contents

February 2015

The February Issue of PLOS Medicine includes two studies that relate intratumoral heterogeneity to clinical cancer outcomes. James Rocco and colleagues analyzed data from The Cancer Genome Atlas (TCGA) to show that tumor heterogeneity can serve as a prognostic indicator in head and neck squamous cell carcinoma (HNSCC), and James Brenton and colleagues found higher levels of tumor heterogeneity to be associated with decreased survival in serous ovarian cancer.

In a Guest Editorial, Andrew Beck of Harvard Medical School discusses how these two studies support the idea that molecular characterization of large sets of cancer samples can lead to improved personalized therapies for cancer.

Image Credit: Christian Schnettelker, Flickr

Policy Forum

The Movement of Multidrug-Resistant Tuberculosis across Borders in East Africa Needs a Regional and Global Solution

Kevin P. Cain, Nina Marano, Maureen Kamene, Joseph Sitienei, Subroto Mukherjee, Aleksandar Galev, John Burton, Orkhan Nasibov, Jackson Kioko, Kevin M. De Cock

Research Articles

Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis

Roland F. Schwarz, Charlotte K. Y. Ng, Susanna L. Cooke, Scott Newman, Jillian Temple, Anna M. Piskorz, Davina Gale, Karen Sayal, Muhammed Murtaza, Peter J. Baldwin, Nitzan Rosenfeld, Helena M. Earl, Evis Sala, Mercedes Jimenez-Linan, Christine A. Parkinson, Florian Markowetz, James D. Brenton

A Primary Care Nurse-Delivered Walking Intervention in Older Adults: PACE (Pedometer Accelerometer Consultation Evaluation)-Lift Cluster Randomised Controlled Trial

Tess Harris, Sally M. Kerry, Christina R. Victor, Ulf Ekelund, Alison Woodcock, Steve Iliffe, Peter H. Whincup, Carole Beighton, Michael Ussher, Elizabeth S. Limb, Lee David, Debbie Brewin, Fredrika Adams, Annabelle Rogers, Derek G. Cook

The Role of Abcb5 Alleles in Susceptibility to Haloperidol-Induced Toxicity in Mice and Humans

Ming Zheng, Haili Zhang, David L. Dill, J. David Clark, Susan Tu, Arielle L. Yablonovitch, Meng How Tan, Rui Zhang, Dan Rujescu, Manhong Wu, Lino Tessarollo, Wilfred Vieira, Michael M. Gottesman, Suhua Deng, Livia S. Eberlin, Richard N. Zare, Jean-Martin Billard, Jean-Pierre Gillet, Jin Billy Li, Gary Peltz