Cover
Addressing critical needs in the fight to end tuberculosis with innovative tools and strategies
The leading infectious cause of death worldwide, tuberculosis demands an urgent response that will realistically enable the disease's elimination. Despite increases in funding for TB prevention and care in recent years, progress towards TB elimination still lags behind WHO- and UN-endorsed targets, underscoring the need for novel approaches.
This month in PLOS Medicine we are proud to launch a Special Issue on New Tools and Strategies for Tuberculosis Diagnosis, Care, and Elimination, guest edited by Claudia Denkinger, Richard Chaisson, and Mark Hatherill. This Special Issue includes high-quality research focusing on novel biomarkers and diagnostic techniques, development of new treatments and vaccines, and testing of new strategies to find and treat tuberculosis and enhance adherence to therapy.
In this issue's Editorial, the Guest Editors highlight some of the research publishing in this special issue and how these studies focusing on discovery, clinical trials and implementation research collectively add to the prospects for reaching the EndTB targets of the WHO by 2035.
Image Credit: GDJ, Pixabay and NIAID, Flickr
Editorial
Addressing critical needs in the fight to end tuberculosis with innovative tools and strategies
PLOS Medicine: published April 30, 2019 | https://doi.org/10.1371/journal.pmed.1002795
Perspectives
Controlling latent TB tuberculosis infection in high-burden countries: A neglected strategy to end TB
PLOS Medicine: published April 23, 2019 | https://doi.org/10.1371/journal.pmed.1002787
Tuberculosis vaccines: Rising opportunities
PLOS Medicine: published April 23, 2019 | https://doi.org/10.1371/journal.pmed.1002791
Research Articles
Tuberculosis drugs’ distribution and emergence of resistance in patient’s lung lesions: A mechanistic model and tool for regimen and dose optimization
PLOS Medicine: published April 2, 2019 | https://doi.org/10.1371/journal.pmed.1002773
Risk score for predicting mortality including urine lipoarabinomannan detection in hospital inpatients with HIV-associated tuberculosis in sub-Saharan Africa: Derivation and external validation cohort study
PLOS Medicine: published April 5, 2019 | https://doi.org/10.1371/journal.pmed.1002776
Octreotide-LAR in later-stage autosomal dominant polycystic kidney disease (ALADIN 2): A randomized, double-blind, placebo-controlled, multicenter trial
PLOS Medicine: published April 5, 2019 | https://doi.org/10.1371/journal.pmed.1002777
Preferences for HIV testing services among men who have sex with men in the UK: A discrete choice experiment
PLOS Medicine: published April 11, 2019 | https://doi.org/10.1371/journal.pmed.1002779
Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis
PLOS Medicine: published April 12, 2019 | https://doi.org/10.1371/journal.pmed.1002771
Lipoarabinomannan in sputum to detect bacterial load and treatment response in patients with pulmonary tuberculosis: Analytic validation and evaluation in two cohorts
PLOS Medicine: published April 12, 2019 | https://doi.org/10.1371/journal.pmed.1002780
The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: A prospective population-level analysis
PLOS Medicine: published April 12, 2019 | https://doi.org/10.1371/journal.pmed.1002783
Screening for breech presentation using universal late-pregnancy ultrasonography: A prospective cohort study and cost effectiveness analysis
PLOS Medicine: published April 16, 2019 | https://doi.org/10.1371/journal.pmed.1002778
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
PLOS Medicine: published April 16, 2019 | https://doi.org/10.1371/journal.pmed.1002781
Related Articles
Socioeconomic position and use of healthcare in the last year of life: A systematic review and meta-analysis
PLOS Medicine: published April 23, 2019 | https://doi.org/10.1371/journal.pmed.1002782
Related Articles
Lay health supporters aided by mobile text messaging to improve adherence, symptoms, and functioning among people with schizophrenia in a resource-poor community in rural China (LEAN): A randomized controlled trial
PLOS Medicine: published April 23, 2019 | https://doi.org/10.1371/journal.pmed.1002785
Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures
PLOS Medicine: published April 23, 2019 | https://doi.org/10.1371/journal.pmed.1002786
Extended prophylaxis for venous thromboembolism after hospitalization for medical illness: A trial sequential and cumulative meta-analysis
PLOS Medicine: published April 29, 2019 | https://doi.org/10.1371/journal.pmed.1002797
Evaluation of a social protection policy on tuberculosis treatment outcomes: A prospective cohort study
PLOS Medicine: published April 30, 2019 | https://doi.org/10.1371/journal.pmed.1002788
Related Articles
Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies
PLOS Medicine: published April 30, 2019 | https://doi.org/10.1371/journal.pmed.1002789
Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial
PLOS Medicine: published April 30, 2019 | https://doi.org/10.1371/journal.pmed.1002790
Diagnostic value of the urine lipoarabinomannan assay in HIV-positive, ambulatory patients with CD4 below 200 cells/μl in 2 low-resource settings: A prospective observational study
PLOS Medicine: published April 30, 2019 | https://doi.org/10.1371/journal.pmed.1002792
Whole-genome and targeted sequencing of drug-resistant Mycobacterium tuberculosis on the iSeq100 and MiSeq: A performance, ease-of-use, and cost evaluation
PLOS Medicine: published April 30, 2019 | https://doi.org/10.1371/journal.pmed.1002794