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Table of Contents

July 2017

Traumatic injury has long been recognized as a neglected disease of extremely high burden. With this month's Special Issue, PLOS Medicine and guest editors Professor Karim Brohi and Dr. Martin Schreiber aim to highlight crucial research in this area. Studies in the collection focus on a broad range of topics – from epidemiologic and public health research into the risk factors for and causes of traumatic events that may help prevent avoidable injury, to new genetic methods giving insight into the body's response to trauma. In this month's Editorial, Drs. Brohi and Schreiber describe a new era in exploration of the biology of injury response and translation of new opportunities into clinical practice.

Image Credit: U.S. Navy Journalist 2nd Class Shane Tuck, Wikimedia Commons

Editorial

The new survivors and a new era for trauma research

Karim Brohi, Martin Schreiber

Essays

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines

Emilie Alirol, Teodora E. Wi, Manju Bala, Maria Luiza Bazzo, Xiang-Sheng Chen, Carolyn Deal, Jo-Anne R. Dillon, Ranmini Kularatne, Jutta Heim, Rob Hooft van Huijsduijnen, Edward W. Hook, Monica M. Lahra, David A. Lewis, Francis Ndowa, William M. Shafer, Liz Tayler, Kimberly Workowski, Magnus Unemo, Manica Balasegaram

Perspectives

Time for trauma immunology

Timothy R. Billiar, Yoram Vodovotz

Trauma care: Finding a better way

Hasan B. Alam

Health in Action

Leveraging peer-based support to facilitate HIV care in Kenya

Rakhi Karwa, Mercy Maina, Timothy Mercer, Benson Njuguna, Juddy Wachira, Celia Ngetich, Fatma Some, Beatrice Jakait, Regina K. Owino, Adrian Gardner, Sonak Pastakia

Policy Forum

Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action

Teodora Wi, Monica M. Lahra, Francis Ndowa, Manju Bala, Jo-Anne R. Dillon, Pilar Ramon-Pardo, Sergey R. Eremin, Gail Bolan, Magnus Unemo

Research Articles

Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

Alex Dyson, Felipe Dal-Pizzol, Giovanni Sabbatini, Anna B. Lach, Federica Galfo, Juliano dos Santos Cardoso, Bruna Pescador Mendonça, Iain Hargreaves, Bernardo Bollen Pinto, Daniel I. Bromage, John F. Martin, Kevin P. Moore, Martin Feelisch, Mervyn Singer

Long-term health status and trajectories of seriously injured patients: A population-based longitudinal study

Belinda J. Gabbe, Pam M. Simpson, Peter A. Cameron, Jennie Ponsford, Ronan A. Lyons, Alex Collie, Mark Fitzgerald, Rodney Judson, Warwick J. Teague, Sandra Braaf, Andrew Nunn, Shanthi Ameratunga, James E. Harrison

Community health promotion and medical provision for neonatal health—CHAMPION cluster randomised trial in Nagarkurnool district, Telangana (formerly Andhra Pradesh), India

Peter Boone, Alex Eble, Diana Elbourne, Chris Frost, Chitra Jayanty, Rashmi Lakshminarayana, Vera Mann, Rohini Mukherjee, Gilda Piaggio, Padmanabh Reddy

Timing of femoral shaft fracture fixation following major trauma: A retrospective cohort study of United States trauma centers

James P. Byrne, Avery B. Nathens, David Gomez, Daniel Pincus, Richard J. Jenkinson

Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale–29

Joel Raffel, Alison Wallace, Djordje Gveric, Richard Reynolds, Tim Friede, Richard Nicholas

Years of life lost due to traumatic brain injury in Europe: A cross-sectional analysis of 16 countries

Marek Majdan, Dominika Plancikova, Andrew Maas, Suzanne Polinder, Valery Feigin, Alice Theadom, Martin Rusnak, Alexandra Brazinova, Juanita Haagsma

Trends in traumatic brain injury mortality in China, 2006–2013: A population-based longitudinal study

Peixia Cheng, Peng Yin, Peishan Ning, Lijun Wang, Xunjie Cheng, Yunning Liu, David C. Schwebel, Jiangmei Liu, Jinlei Qi, Guoqing Hu, Maigeng Zhou

Community and health system intervention to reduce disrespect and abuse during childbirth in Tanga Region, Tanzania: A comparative before-and-after study

Stephanie A. Kujawski, Lynn P. Freedman, Kate Ramsey, Godfrey Mbaruku, Selemani Mbuyita, Wema Moyo, Margaret E. Kruk

Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study

Claudia P. Cabrera, Joanna Manson, Joanna M. Shepherd, Hew D. Torrance, David Watson, M. Paula Longhi, Mimoza Hoti, Minal B. Patel, Michael O’Dwyer, Sussan Nourshargh, Daniel J. Pennington, Michael R. Barnes, Karim Brohi

Related Articles

Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study

Jon Hazeldine, David N. Naumann, Emma Toman, David Davies, Jonathan R. B. Bishop, Zhangjie Su, Peter Hampson, Robert J. Dinsdale, Nicholas Crombie, Niharika Arora Duggal, Paul Harrison, Antonio Belli, Janet M. Lord

Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: A case-crossover study

Mélanie Née, Marta Avalos, Audrey Luxcey, Benjamin Contrand, Louis-Rachid Salmi, Annie Fourrier-Réglat, Blandine Gadegbeku, Emmanuel Lagarde, Ludivine Orriols

Cerebrovascular pressure reactivity monitoring using wavelet analysis in traumatic brain injury patients: A retrospective study

Xiuyun Liu, Joseph Donnelly, Marek Czosnyka, Marcel J. H. Aries, Ken Brady, Danilo Cardim, Chiara Robba, Manuel Cabeleira, Dong-Joo Kim, Christina Haubrich, Peter J. Hutchinson, Peter Smielewski

Temporal profile of intracranial pressure and cerebrovascular reactivity in severe traumatic brain injury and association with fatal outcome: An observational study

Hadie Adams, Joseph Donnelly, Marek Czosnyka, Angelos G. Kolias, Adel Helmy, David K. Menon, Peter Smielewski, Peter J. Hutchinson

Ultrasound non-invasive measurement of intracranial pressure in neurointensive care: A prospective observational study

Chiara Robba, Danilo Cardim, Tamara Tajsic, Justine Pietersen, Michael Bulman, Joseph Donnelly, Andrea Lavinio, Arun Gupta, David K. Menon, Peter J. A. Hutchinson, Marek Czosnyka

Same-day HIV testing with initiation of antiretroviral therapy versus standard care for persons living with HIV: A randomized unblinded trial

Serena P. Koenig, Nancy Dorvil, Jessy G. Dévieux, Bethany L. Hedt-Gauthier, Cynthia Riviere, Mikerlyne Faustin, Kerlyne Lavoile, Christian Perodin, Alexandra Apollon, Limathe Duverger, Margaret L. McNairy, Kelly A. Hennessey, Ariadne Souroutzidis, Pierre-Yves Cremieux, Patrice Severe, Jean W. Pape

Related Articles

Community burden of undiagnosed HIV infection among adolescents in Zimbabwe following primary healthcare-based provider-initiated HIV testing and counselling: A cross-sectional survey

Victoria Simms, Ethel Dauya, Subathira Dakshina, Tsitsi Bandason, Grace McHugh, Shungu Munyati, Prosper Chonzi, Katharina Kranzer, Getrude Ncube, Collen Masimirembwa, Roslyn Thelingwani, Tsitsi Apollo, Richard Hayes, Helen A. Weiss, Rashida A. Ferrand

Related Articles

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model

Jing Xu, Jesse Guardado, Rosemary Hoffman, Hui Xu, Rami Namas, Yoram Vodovotz, Li Xu, Mostafa Ramadan, Joshua Brown, Heth R. Turnquist, Timothy R. Billiar