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Table of Contents

March 2018

In a Guest Editorial, Kazem Rahimi, Carolyn Lam, and Steven Steinhubl discuss PLOS Medicine's Special Issue on cardiovascular disease and multimorbidity. The demographic shift towards older populations across the globe and the relatively slower decline in morbidity compared with mortality from cardiovascular disease have resulted in increasing numbers of people with both cardiovascular disease and other chronic and disabling conditions. The authors call for interdisciplinary research and personalized cardiovascular care to better manage patients with cardiovascular disease and multimorbidity.

Image Credit: Geralt, Pixabay

Health in Action

Integrating HIV and hypertension management in low-resource settings: Lessons from Malawi

Pragna Patel, Colin Speight, Alice Maida, Fleetwood Loustalot, Denise Giles, Sam Phiri, Sundeep Gupta, Pratima Raghunathan

Research Articles

The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis

The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration, Amy L. Slogrove, Michael Schomaker, Mary-Ann Davies, Paige Williams, Suna Balkan, Jihane Ben-Farhat, Nancy Calles, Kulkanya Chokephaibulkit, Charlotte Duff, Tanoh François Eboua, Adeodata Kekitiinwa-Rukyalekere, Nicola Maxwell, Jorge Pinto, George Seage III, Chloe A. Teasdale, Sebastian Wanless, Josiane Warszawski, Kara Wools-Kaloustian, Marcel Yotebieng, Venessa Timmerman, Intira J. Collins, Ruth Goodall, Colette Smith, Kunjal Patel, Mary Paul, Diana Gibb, Rachel Vreeman, Elaine J. Abrams, Rohan Hazra, Russell Van Dyke, Linda-Gail Bekker, Lynne Mofenson, Marissa Vicari, Shaffiq Essajee, Martina Penazzato, Gabriel Anabwani, Edith Q. Mohapi, Peter N. Kazembe, Makhosazana Hlatshwayo, Mwita Lumumba, Tessa Goetghebuer, Claire Thorne, Luisa Galli, Annemarie van Rossum, Carlo Giaquinto, Magdalena Marczynska, Laura Marques, Filipa Prata, Luminita Ene, Liubov Okhonskaia, Pablo Rojo, Claudia Fortuny, Lars Naver, Christoph Rudin, Sophie Le Coeur, Alla Volokha, Vanessa Rouzier, Regina Succi, Annette Sohn, Azar Kariminia, Andrew Edmonds, Patricia Lelo, Samuel Ayaya, Patricia Ongwen, Laura F. Jefferys, Sam Phiri, Mwangelwa Mubiana-Mbewe, Shobna Sawry, Lorna Renner, Mariam Sylla, Mark J. Abzug, Myron Levin, James Oleske, Miriam Chernoff, Shirley Traite, Murli Purswani, Ellen G. Chadwick, Ali Judd, Valériane Leroy

Mortality, ethnicity, and country of birth on a national scale, 2001–2013: A retrospective cohort (Scottish Health and Ethnicity Linkage Study)

Raj S. Bhopal, Laurence Gruer, Genevieve Cezard, Anne Douglas, Markus F. C. Steiner, Andrew Millard, Duncan Buchanan, S. Vittal Katikireddi, Aziz Sheikh

Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort

Marlous Hall, Tatendashe B. Dondo, Andrew T. Yan, Mamas A. Mamas, Adam D. Timmis, John E. Deanfield, Tomas Jernberg, Harry Hemingway, Keith A. A. Fox, Chris P. Gale

Trajectories of functional decline in older adults with neuropsychiatric and cardiovascular multimorbidity: A Swedish cohort study

Davide L. Vetrano, Debora Rizzuto, Amaia Calderón-Larrañaga, Graziano Onder, Anna-Karin Welmer, Roberto Bernabei, Alessandra Marengoni, Laura Fratiglioni

Patterns and temporal trends of comorbidity among adult patients with incident cardiovascular disease in the UK between 2000 and 2014: A population-based cohort study

Jenny Tran, Robyn Norton, Nathalie Conrad, Fatemeh Rahimian, Dexter Canoy, Milad Nazarzadeh, Kazem Rahimi

The current and potential health benefits of the National Health Service Health Check cardiovascular disease prevention programme in England: A microsimulation study

Oliver T. Mytton, Christopher Jackson, Arno Steinacher, Anna Goodman, Claudia Langenberg, Simon Griffin, Nick Wareham, James Woodcock

Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study

Brant M. Wagener, Parker J. Hu, Joo-Yeun Oh, Cilina A. Evans, Jillian R. Richter, Jaideep Honavar, Angela P. Brandon, Judy Creighton, Shannon W. Stephens, Charity Morgan, Randal O. Dull, Marisa B. Marques, Jeffrey D. Kerby, Jean-Francois Pittet, Rakesh P. Patel

Related Articles

Physical activity levels in adults and older adults 3–4 years after pedometer-based walking interventions: Long-term follow-up of participants from two randomised controlled trials in UK primary care

Tess Harris, Sally M. Kerry, Elizabeth S. Limb, Cheryl Furness, Charlotte Wahlich, Christina R. Victor, Steve Iliffe, Peter H. Whincup, Michael Ussher, Ulf Ekelund, Julia Fox-Rushby, Judith Ibison, Stephen DeWilde, Cathy McKay, Derek G. Cook

Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study

Evan D. Muse, Nathan E. Wineinger, Emily G. Spencer, Melissa Peters, Riley Henderson, Yunyue Zhang, Paddy M. Barrett, Steven P. Rivera, Jay G. Wohlgemuth, James J. Devlin, Dov Shiffman, Eric J. Topol

Cerebral white matter disease and functional decline in older adults from the Northern Manhattan Study: A longitudinal cohort study

Mandip S. Dhamoon, Ying-Kuen Cheung, Yeseon Moon, Janet DeRosa, Ralph Sacco, Mitchell S. V. Elkind, Clinton B. Wright

Blood pressure-lowering treatment strategies based on cardiovascular risk versus blood pressure: A meta-analysis of individual participant data

Kunal N. Karmali, Donald M. Lloyd-Jones, Joep van der Leeuw, David C. Goff Jr., Salim Yusuf, Alberto Zanchetti, Paul Glasziou, Rodney Jackson, Mark Woodward, Anthony Rodgers, Bruce C. Neal, Eivind Berge, Koon Teo, Barry R. Davis, John Chalmers, Carl Pepine, Kazem Rahimi, Johan Sundström, on behalf of the Blood Pressure Lowering Treatment Trialists’ Collaboration

Related Articles

HIV treatment eligibility expansion and timely antiretroviral treatment initiation following enrollment in HIV care: A metaregression analysis of programmatic data from 22 countries

Olga Tymejczyk, Ellen Brazier, Constantin Yiannoutsos, Kara Wools-Kaloustian, Keri Althoff, Brenda Crabtree-Ramírez, Kinh Van Nguyen, Elizabeth Zaniewski, Francois Dabis, Jean d'Amour Sinayobye, Nanina Anderegg, Nathan Ford, Radhika Wikramanayake, Denis Nash, IeDEA Collaboration

Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques

Jérémie Guedj, Géraldine Piorkowski, Frédéric Jacquot, Vincent Madelain, Thi Huyen Tram Nguyen, Anne Rodallec, Stephan Gunther, Caroline Carbonnelle, France Mentré, Hervé Raoul, Xavier de Lamballerie

Comparative analysis of the association between 35 frailty scores and cardiovascular events, cancer, and total mortality in an elderly general population in England: An observational study

Gloria A. Aguayo, Michel T. Vaillant, Anne-Françoise Donneau, Anna Schritz, Saverio Stranges, Laurent Malisoux, Anna Chioti, Michèle Guillaume, Majon Muller, Daniel R. Witte

Transmission of HIV-1 drug resistance mutations within partner-pairs: A cross-sectional study of a primary HIV infection cohort

Joanne D. Stekler, Ross Milne, Rachel Payant, Ingrid Beck, Joshua Herbeck, Brandon Maust, Wenjie Deng, Kenneth Tapia, Sarah Holte, Janine Maenza, Claire E. Stevens, James I. Mullins, Ann C. Collier, Lisa M. Frenkel

Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: A longitudinal study based on a United Kingdom primary care database

Balachandran Kumarendran, Michael W. O’Reilly, Konstantinos N. Manolopoulos, Konstantinos A. Toulis, Krishna M. Gokhale, Alice J. Sitch, Chandrika N. Wijeyaratne, Arri Coomarasamy, Wiebke Arlt, Krishnarajah Nirantharakumar

Integration of postpartum healthcare services for HIV-infected women and their infants in South Africa: A randomised controlled trial

Landon Myer, Tamsin K. Phillips, Allison Zerbe, Kirsty Brittain, Maia Lesosky, Nei-Yuan Hsiao, Robert H. Remien, Claude A. Mellins, James A. McIntyre, Elaine J. Abrams