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Table of Contents

July 2021


Increasing manifestations of climate change have led to broad concern about direct and indirect implications for human health and wellbeing, now and in the future. In addition to observable impacts of more volatile weather patterns, including extreme heat and flooding, food insecurity and encroachment of infectious diseases into new regions are further examples of widespread threats that are challenging both to predict and to prepare for. In a Policy Forum, Robin Fears and co-authors discuss evidence-informed regional and global policy responses to health impacts of climate change, noting the importance of country climate adaptation plans and nationally determined contributions to global assessments.

Image Credit: Nicholas Doherty, Unsplash


Transdisciplinary research and clinical priorities for better health

Luigi Fontana, Alessio Fasano, Yap Seng Chong, Paolo Vineis, Walter C. Willett

Policy Forum

Evidence-informed policy for tackling adverse climate change effects on health: Linking regional and global assessments of science to catalyse action

Robin Fears, Khairul Annuar B. Abdullah, Claudia Canales-Holzeis, Deoraj Caussy, Andy Haines, Sherilee L. Harper, Jeremy N. McNeil, Johanna Mogwitz, Volker ter Meulen

Research Articles

Sales of antibiotics and hydroxychloroquine in India during the COVID-19 epidemic: An interrupted time series analysis

Giorgia Sulis, Brice Batomen, Anita Kotwani, Madhukar Pai, Sumanth Gandra

Evaluation of a package of risk-based pharmaceutical and lifestyle interventions in patients with hypertension and/or diabetes in rural China: A pragmatic cluster randomised controlled trial

Xiaolin Wei, Zhitong Zhang, Marc K. C. Chong, Joseph P. Hicks, Weiwei Gong, Guanyang Zou, Jieming Zhong, John D. Walley, Ross E. G. Upshur, Min Yu

Rotavirus vaccine efficacy up to 2 years of age and against diverse circulating rotavirus strains in Niger: Extended follow-up of a randomized controlled trial

Sheila Isanaka, Céline Langendorf, Monica Malone McNeal, Nicole Meyer, Brian Plikaytis, Souna Garba, Nathan Sayinzoga-Makombe, Issaka Soumana, Ousmane Guindo, Rockyiath Makarimi, Marie Francoise Scherrer, Eric Adehossi, Iza Ciglenecki, Rebecca F. Grais

SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants

Fiona Tea, Alberto Ospina Stella, Anupriya Aggarwal, David Ross Darley, Deepti Pilli, Daniele Vitale, Vera Merheb, Fiona X. Z. Lee, Philip Cunningham, Gregory J. Walker, Christina Fichter, David A. Brown, William D. Rawlinson, Sonia R. Isaacs, Vennila Mathivanan, Markus Hoffmann, Stefan Pöhlman, Ohan Mazigi, Daniel Christ, Dominic E. Dwyer, Rebecca J. Rockett, Vitali Sintchenko, Veronica C. Hoad, David O. Irving, Gregory J. Dore, Iain B. Gosbell, Anthony D. Kelleher, Gail V. Matthews, Fabienne Brilot, Stuart G. Turville

Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study

Shoya Iwanami, Keisuke Ejima, Kwang Su Kim, Koji Noshita, Yasuhisa Fujita, Taiga Miyazaki, Shigeru Kohno, Yoshitsugu Miyazaki, Shimpei Morimoto, Shinji Nakaoka, Yoshiki Koizumi, Yusuke Asai, Kazuyuki Aihara, Koichi Watashi, Robin N. Thompson, Kenji Shibuya, Katsuhito Fujiu, Alan S. Perelson, Shingo Iwami, Takaji Wakita

Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis

Sarah J. Stock, Margaret Horne, Merel Bruijn, Helen White, Kathleen A. Boyd, Robert Heggie, Lisa Wotherspoon, Lorna Aucott, Rachel K. Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L. David, Asma Khalil, Andrew Shennan, Gert-Jan van Baaren, Victoria Hodgetts-Morton, Tina Lavender, Ewoud Schuit, Susan Harper-Clarke, Ben W. Mol, Richard D. Riley, Jane E. Norman, John Norrie

Evaluating the use of the QUiPP app and its impact on the management of threatened preterm labour: A cluster randomised trial

Helena A. Watson, Naomi Carlisle, Paul T. Seed, Jenny Carter, Katy Kuhrt, Rachel M. Tribe, Andrew H. Shennan

Prediction of risk of prolonged post-concussion symptoms: Derivation and validation of the TRICORDRR (Toronto Rehabilitation Institute Concussion Outcome Determination and Rehab Recommendations) score

Laura Kathleen Langer, Seyed Mohammad Alavinia, David Wyndham Lawrence, Sarah Elizabeth Patricia Munce, Alice Kam, Alan Tam, Lesley Ruttan, Paul Comper, Mark Theodore Bayley

Adipose tissue biomarkers and type 2 diabetes incidence in normoglycemic participants in the MESArthritis Ancillary Study: A cohort study

Farhad Pishgar, Mahsima Shabani, Thiago Quinaglia A. C. Silva, David A. Bluemke, Matthew Budoff, R Graham Barr, Matthew A. Allison, Alain G. Bertoni, Wendy S. Post, João A. C. Lima, Shadpour Demehri

Psychological distress, resettlement stress, and lower school engagement among Arabic-speaking refugee parents in Sydney, Australia: A cross-sectional cohort study

Jess R. Baker, Derrick Silove, Deserae Horswood, Afaf Al-Shammari, Mohammed Mohsin, Susan Rees, Valsamma Eapen

Changes in the calorie and nutrient content of purchased fast food meals after calorie menu labeling: A natural experiment

Joshua Petimar, Fang Zhang, Eric B. Rimm, Denise Simon, Lauren P. Cleveland, Steven L. Gortmaker, Sara N. Bleich, Michele Polacsek, Christina A. Roberto, Jason P. Block

Preventing microalbuminuria with benazepril, valsartan, and benazepril–valsartan combination therapy in diabetic patients with high-normal albuminuria: A prospective, randomized, open-label, blinded endpoint (PROBE) study

Piero Ruggenenti, Monica Cortinovis, Aneliya Parvanova, Matias Trillini, Ilian P. Iliev, Antonio C. Bossi, Antonio Belviso, Maria C. Aparicio, Roberto Trevisan, Stefano Rota, Annalisa Perna, Tobia Peracchi, Nadia Rubis, Davide Martinetti, Silvia Prandini, Flavio Gaspari, Fabiola Carrara, Salvatore De Cosmo, Giancarlo Tonolo, Ruggero Mangili, Giuseppe Remuzzi, on behalf of the VARIETY Study Organization

Mortality and concurrent use of opioids and hypnotics in older patients: A retrospective cohort study

Wayne A. Ray, Cecilia P. Chung, Katherine T. Murray, Beth A. Malow, James R. Daugherty, C. Michael Stein

Estimating the effect of moving meat-free products to the meat aisle on sales of meat and meat-free products: A non-randomised controlled intervention study in a large UK supermarket chain

Carmen Piernas, Brian Cook, Richard Stevens, Cristina Stewart, Jennifer Hollowell, Peter Scarborough, Susan A. Jebb

Obesity and revision surgery, mortality, and patient-reported outcomes after primary knee replacement surgery in the National Joint Registry: A UK cohort study

Jonathan Thomas Evans, Sofia Mouchti, Ashley William Blom, Jeremy Mark Wilkinson, Michael Richard Whitehouse, Andrew Beswick, Andrew Judge

Correlates of attendance at community engagement meetings held in advance of bio-behavioral research studies: A longitudinal, sociocentric social network study in rural Uganda

Bernard Kakuhikire, Emily N. Satinsky, Charles Baguma, Justin D. Rasmussen, Jessica M. Perkins, Patrick Gumisiriza, Mercy Juliet, Patience Ayebare, Rumbidzai C. Mushavi, Bridget F. O. Burns, Claire Q. Evans, Mark J. Siedner, David R. Bangsberg, Alexander C. Tsai

Telmisartan use and risk of dementia in type 2 diabetes patients with hypertension: A population-based cohort study

Chi-Hung Liu, Pi-Shan Sung, Yan-Rong Li, Wen-Kuan Huang, Tay-Wey Lee, Chin-Chang Huang, Tsong-Hai Lee, Tien-Hsing Chen, Yi-Chia Wei

Impact of assessment and intervention by a health and social care professional team in the emergency department on the quality, safety, and clinical effectiveness of care for older adults: A randomised controlled trial

Marica Cassarino, Katie Robinson, Dominic Trépel, Íde O’Shaughnessy, Eimear Smalle, Stephen White, Collette Devlin, Rosie Quinn, Fiona Boland, Marie E. Ward, Rosa McNamara, Fiona Steed, Margaret O’Connor, Andrew O’Regan, Gerard McCarthy, Damien Ryan, Rose Galvin

Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study

Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M. Mason, Stephen Burgess, Susanna C. Larsson

Long-term solid fuel use and risks of major eye diseases in China: A population-based cohort study of 486,532 adults

Ka Hung Chan, Mingshu Yan, Derrick A. Bennett, Yu Guo, Yiping Chen, Ling Yang, Jun Lv, Canqing Yu, Pei Pei, Yan Lu, Liming Li, Huaidong Du, Kin Bong Hubert Lam, Zhengming Chen, on behalf of the China Kadoorie Biobank Study group