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March 2007

The centerpiece of our cover design is a "forest plot" generated by a meta-analysis of data. Each short horizontal line represents outcome data from an individual study included in the analysis, with the central dot being the mean and the lines themselves being the confidence intervals around that mean.

The reporting of systematic reviews and meta-analyses comes under the magnifying glass in this month's issue of PLoS Medicine with our publication of a paper by David Moher and colleagues, who found great variations in the quality of the reporting of this type of research.

Image Credit: Cover design by Anthony Flores, Public Library of Science, based on an image supplied by David Moher


Think Globally Act Locally: The Case for Symphysiotomy

Douwe Arie Anne Verkuyl

Bone Quality: An Empty Term

Harri Sievänen, Pekka Kannus, Teppo L. N Järvinen

Policy Forums

How Should Treatment Decisions Be Made for Incapacitated Patients, and Why?

David I Shalowitz, Elizabeth Garrett-Mayer, David Wendler

Research in Translation

Why Is Long-Term Therapy Required to Cure Tuberculosis?

Lynn E Connolly, Paul H Edelstein, Lalita Ramakrishnan

Learning Forum

Research Articles

Evaluating Drug Prices, Availability, Affordability, and Price Components: Implications for Access to Drugs in Malaysia

Zaheer Ud Din Babar, Mohamed Izham Mohamed Ibrahim, Harpal Singh, Nadeem Irfan Bukahri, Andrew Creese

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Objectively Measured Physical Activity and Fat Mass in a Large Cohort of Children

Andy R Ness, Sam D Leary, Calum Mattocks, Steven N Blair, John J Reilly, Jonathan Wells, Sue Ingle, Kate Tilling, George Davey Smith, Chris Riddoch

Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

Anthony E Civitarese, Stacy Carling, Leonie K Heilbronn, Mathew H Hulver, Barbara Ukropcova, Walter A Deutsch, Steven R Smith, Eric Ravussin

Loperamide Therapy for Acute Diarrhea in Children: Systematic Review and Meta-Analysis

Su-Ting T Li, David C Grossman, Peter Cummings

X-Linked G6PD Deficiency Protects Hemizygous Males but Not Heterozygous Females against Severe Malaria

Aldiouma Guindo, Rick M Fairhurst, Ogobara K Doumbo, Thomas E Wellems, Dapa A Diallo

Dynamics of Polymorphism in a Malaria Vaccine Antigen at a Vaccine-Testing Site in Mali

Shannon L Takala, Drissa Coulibaly, Mahamadou A Thera, Alassane Dicko, David L Smith, Ando B Guindo, Abdoulaye K Kone, Karim Traore, Amed Ouattara, Abdoulaye A Djimde, Paul S Sehdev, Kirsten E Lyke, Dapa A Diallo, Ogobara K Doumbo, Christopher V Plowe

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Impact and Process Evaluation of Integrated Community and Clinic-Based HIV-1 Control: A Cluster-Randomised Trial in Eastern Zimbabwe

Simon Gregson, Saina Adamson, Spiwe Papaya, Jephias Mundondo, Constance A Nyamukapa, Peter R Mason, Geoffrey P Garnett, Stephen K Chandiwana, Geoff Foster, Roy M Anderson

HIV Patients Developing Primary CNS Lymphoma Lack EBV-Specific CD4+ T Cell Function Irrespective of Absolute CD4+ T Cell Counts

Olivier Gasser, Florian K Bihl, Marcel Wolbers, Elisabetta Loggi, Ingrid Steffen, Hans H Hirsch, Huldrych F Günthard, Bruce D Walker, Christian Brander, Manuel Battegay, Christoph Hess, for the Swiss HIV Cohort Study

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A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer

Haojie Li, Meir J Stampfer, J. Bruce W Hollis, Lorelei A Mucci, J. Michael Gaziano, David Hunter, Edward L Giovannucci, Jing Ma

Aberrant DNA Methylation of OLIG1, a Novel Prognostic Factor in Non-Small Cell Lung Cancer

Romulo M Brena, Carl Morrison, Sandya Liyanarachchi, David Jarjoura, Ramana V Davuluri, Gregory A Otterson, David Reisman, Selina Glaros, Laura J Rush, Christoph Plass

Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen

Philippe Bertheau, Elisabeth Turpin, David S Rickman, Marc Espié, Aurélien de Reyniès, Jean-Paul Feugeas, Louis-François Plassa, Hany Soliman, Mariana Varna, Anne de Roquancourt, Jacqueline Lehmann-Che, Yves Beuzard, Michel Marty, Jean-Louis Misset, Anne Janin, Hugues de Thé


Research Ethics Committees in Africa: Authors' Reply

Nancy E Kass, Adnan Ali Hyder, Ademola Ajuwon, John Appiah-Poku, Nicola Barsdorf, Dya Eldin Elsayed, Mantoa Mokhachane, Bavon Mupenda, Paul Ndebele, Godwin Ndossi, Bornwell Sikateyo, Godfrey Tangwa, Paulina Tindana

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