Skip to main content
Table of Contents

May 2021


Despite advances in the prevention and treatment of HIV infection, the burden of new infections and disease remains high, especially in Africa. So as to meet agreed international targets, improvements are needed in population-wide HIV testing, provision of care and achieving viral suppression. Tailoring provision to local settings is particularly important to optimize retention in and effectiveness of care. In a Policy Forum, Peter Ehrenkranz and co-authors present a cyclical cascade of care for people with HIV infection, aiming to facilitate assessment of outcomes. This in turn should assist policymakers, health workers and others to identify and overcome barriers in care systems and reduce progression to advanced disease.

Image Credit: Kyla Marino, Flickr

Policy Forum

The revolving door of HIV care: Revising the service delivery cascade to achieve the UNAIDS 95-95-95 goals

Peter Ehrenkranz, Sydney Rosen, Andrew Boulle, Jeffrey W. Eaton, Nathan Ford, Matthew P. Fox, Anna Grimsrud, Brian D. Rice, Izukanji Sikazwe, Charles B. Holmes

Guidelines and Guidance

A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials

Jayne F. Tierney, David J. Fisher, Claire L. Vale, Sarah Burdett, Larysa H. Rydzewska, Ewelina Rogozińska, Peter J. Godolphin, Ian R. White, Mahesh K. B. Parmar

Research Articles

Sexual and reproductive health information and referrals for resettled refugee women: A survey of resettlement agencies in the United States

Tonya Katcher, Rebecca Thimmesch, Alison Spitz, Leena Kulkarni, Neelima Panth, Arlen Weiner, Michelle Woodford Martin

Tranexamic acid and bleeding in patients treated with non-vitamin K oral anticoagulants undergoing dental extraction: The EXTRACT-NOAC randomized clinical trial

Anna Ockerman, Isabel Miclotte, Maarten Vanhaverbeke, Thomas Vanassche, Ann Belmans, Jan Vanhove, Joeri Meyns, Nasser Nadjmi, Geert Van Hemelen, Patrick Winderickx, Reinhilde Jacobs, Constantinus Politis, Peter Verhamme

Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study

Jeanne Tie, Yuxuan Wang, Joshua Cohen, Lu Li, Wei Hong, Michael Christie, Hui Li Wong, Suzanne Kosmider, Rachel Wong, Benjamin Thomson, Julian Choi, Adrian Fox, Kathryn Field, Matthew Burge, Jenny Shannon, Dusan Kotasek, Niall C. Tebbutt, Christos Karapetis, Craig Underhill, Andrew Haydon, Joy Schaeffer, Janine Ptak, Cristian Tomasetti, Nicholas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Peter Gibbs

Financial incentives and deposit contracts to promote HIV retesting in Uganda: A randomized trial

Gabriel Chamie, Dalsone Kwarisiima, Alex Ndyabakira, Kara Marson, Carol S. Camlin, Diane V. Havlir, Moses R. Kamya, Harsha Thirumurthy

Components of clean delivery kits and newborn mortality in the Zambia Chlorhexidine Application Trial (ZamCAT): An observational study

Jason H. Park, Davidson H. Hamer, Reuben Mbewe, Nancy A. Scott, Julie M. Herlihy, Kojo Yeboah-Antwi, Katherine E. A. Semrau

Digital adherence technology for tuberculosis treatment supervision: A stepped-wedge cluster-randomized trial in Uganda

Adithya Cattamanchi, Rebecca Crowder, Alex Kityamuwesi, Noah Kiwanuka, Maureen Lamunu, Catherine Namale, Lynn Kunihira Tinka, Agnes Sanyu Nakate, Joseph Ggita, Patricia Turimumahoro, Diana Babirye, Denis Oyuku, Christopher Berger, Austin Tucker, Devika Patel, Amanda Sammann, Stavia Turyahabwe, David Dowdy, Achilles Katamba

Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis

Joshua Jeong, Emily E. Franchett, Clariana V. Ramos de Oliveira, Karima Rehmani, Aisha K. Yousafzai

Risk of miscarriage in women with chronic diseases in Norway: A registry linkage study

Maria C. Magnus, Nils-Halvdan Morken, Knut-Arne Wensaas, Allen J. Wilcox, Siri E. Håberg

Associations of treated and untreated human papillomavirus infection with preterm delivery and neonatal mortality: A Swedish population-based study

Johanna Wiik, Staffan Nilsson, Cecilia Kärrberg, Björn Strander, Bo Jacobsson, Verena Sengpiel

Cost-effectiveness evidence of mental health prevention and promotion interventions: A systematic review of economic evaluations

Long Khanh-Dao Le, Adrian Cuevas Esturas, Cathrine Mihalopoulos, Oxana Chiotelis, Jessica Bucholc, Mary Lou Chatterton, Lidia Engel

Effect of community-led delivery of HIV self-testing on HIV testing and antiretroviral therapy initiation in Malawi: A cluster-randomised trial

Pitchaya P. Indravudh, Katherine Fielding, Moses K. Kumwenda, Rebecca Nzawa, Richard Chilongosi, Nicola Desmond, Rose Nyirenda, Melissa Neuman, Cheryl C. Johnson, Rachel Baggaley, Karin Hatzold, Fern Terris-Prestholt, Elizabeth L. Corbett

Adverse childhood experiences, adult depression, and suicidal ideation in rural Uganda: A cross-sectional, population-based study

Emily N. Satinsky, Bernard Kakuhikire, Charles Baguma, Justin D. Rasmussen, Scholastic Ashaba, Christine E. Cooper-Vince, Jessica M. Perkins, Allen Kiconco, Elizabeth B. Namara, David R. Bangsberg, Alexander C. Tsai

Outcomes and costs of publicly funded patient navigation interventions to enhance HIV care continuum outcomes in the United States: A before-and-after study

Starley B. Shade, Valerie B. Kirby, Sally Stephens, Lissa Moran, Edwin D. Charlebois, Jessica Xavier, Adan Cajina, Wayne T. Steward, Janet J. Myers

Assessment of the causal relevance of ECG parameters for risk of atrial fibrillation: A mendelian randomisation study

Parag Ravindra Gajendragadkar, Adam Von Ende, Maysson Ibrahim, Elsa Valdes-Marquez, Christian Fielder Camm, Federico Murgia, Alexander Stiby, Barbara Casadei, Jemma C. Hopewell

Effects of psychosocial support interventions on survival in inpatient and outpatient healthcare settings: A meta-analysis of 106 randomized controlled trials

Timothy B. Smith, Connor Workman, Caleb Andrews, Bonnie Barton, Matthew Cook, Ryan Layton, Alexandra Morrey, Devin Petersen, Julianne Holt-Lunstad

The sugar content of foods in the UK by category and company: A repeated cross-sectional study, 2015-2018

Lauren K. Bandy, Peter Scarborough, Richard A. Harrington, Mike Rayner, Susan A. Jebb

COVID-19 and excess mortality in the United States: A county-level analysis

Andrew C. Stokes, Dielle J. Lundberg, Irma T. Elo, Katherine Hempstead, Jacob Bor, Samuel H. Preston

Adherence at 2 years with distribution of essential medicines at no charge: The CLEAN Meds randomized clinical trial

Nav Persaud, Michael Bedard, Andrew Boozary, Richard H. Glazier, Tara Gomes, Stephen W. Hwang, Peter Juni, Michael R. Law, Muhammad Mamdani, Braden Manns, Danielle Martin, Steven G. Morgan, Paul Oh, Andrew D. Pinto, Baiju R. Shah, Frank Sullivan, Norman Umali, Kevin E. Thorpe, Karen Tu, Andreas Laupacis, for the Carefully seLected and Easily Accessible at No Charge Medications (CLEAN Meds) study team

SMS messaging to improve retention and viral suppression in prevention of mother-to-child HIV transmission (PMTCT) programs in Kenya: A 3-arm randomized clinical trial

John Kinuthia, Keshet Ronen, Jennifer A. Unger, Wenwen Jiang, Daniel Matemo, Trevor Perrier, Lusi Osborn, Bhavna H. Chohan, Alison L. Drake, Barbra A. Richardson, Grace John-Stewart

Taxed and untaxed beverage intake by South African young adults after a national sugar-sweetened beverage tax: A before-and-after study

Michael Essman, Lindsey Smith Taillie, Tamryn Frank, Shu Wen Ng, Barry M. Popkin, Elizabeth C. Swart

Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study

Steven Kho, Labibah Qotrunnada, Leo Leonardo, Benediktus Andries, Putu A. I. Wardani, Aurelie Fricot, Benoit Henry, David Hardy, Nur I. Margyaningsih, Dwi Apriyanti, Agatha M. Puspitasari, Pak Prayoga, Leily Trianty, Enny Kenangalem, Fabrice Chretien, Valentine Brousse, Innocent Safeukui, Hernando A. del Portillo, Carmen Fernandez-Becerra, Elamaran Meibalan, Matthias Marti, Ric N. Price, Tonia Woodberry, Papa A. Ndour, Bruce M. Russell, Tsin W. Yeo, Gabriela Minigo, Rintis Noviyanti, Jeanne R. Poespoprodjo, Nurjati C. Siregar, Pierre A. Buffet, Nicholas M. Anstey

Related Articles

Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

Vijay R. Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C. Delgado, Anup M. Oommen, Jackson A. Roberts, Dean F. Wong, Christos Davatzikos, Susan M. Resnick, Juan C. Troncoso, Olga Pletnikova, Richard O’Brien, Eelko Hak, Brenda N. Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A. Bennett, Shahinaz M. Gadalla, Madhav Thambisetty

Effects of community-based antiretroviral therapy initiation models on HIV treatment outcomes: A systematic review and meta-analysis

Ingrid Eshun-Wilson, Ajibola A. Awotiwon, Ashley Germann, Sophia A. Amankwaa, Nathan Ford, Sheree Schwartz, Stefan Baral, Elvin H. Geng