Despite advances in the prevention and treatment of HIV infection, the burden of new infections and disease remains high, especially in Africa. So as to meet agreed international targets, improvements are needed in population-wide HIV testing, provision of care and achieving viral suppression. Tailoring provision to local settings is particularly important to optimize retention in and effectiveness of care. In a Policy Forum, Peter Ehrenkranz and co-authors present a cyclical cascade of care for people with HIV infection, aiming to facilitate assessment of outcomes. This in turn should assist policymakers, health workers and others to identify and overcome barriers in care systems and reduce progression to advanced disease.
Image Credit: Kyla Marino, Flickr
Policy Forum
The revolving door of HIV care: Revising the service delivery cascade to achieve the UNAIDS 95-95-95 goals
PLOS Medicine: published May 24, 2021 | https://doi.org/10.1371/journal.pmed.1003651
Guidelines and Guidance
A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials
PLOS Medicine: published May 6, 2021 | https://doi.org/10.1371/journal.pmed.1003629
Research Articles
Sexual and reproductive health information and referrals for resettled refugee women: A survey of resettlement agencies in the United States
PLOS Medicine: published May 3, 2021 | https://doi.org/10.1371/journal.pmed.1003579
Tranexamic acid and bleeding in patients treated with non-vitamin K oral anticoagulants undergoing dental extraction: The EXTRACT-NOAC randomized clinical trial
PLOS Medicine: published May 3, 2021 | https://doi.org/10.1371/journal.pmed.1003601
Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study
PLOS Medicine: published May 3, 2021 | https://doi.org/10.1371/journal.pmed.1003620
Financial incentives and deposit contracts to promote HIV retesting in Uganda: A randomized trial
PLOS Medicine: published May 4, 2021 | https://doi.org/10.1371/journal.pmed.1003630
Components of clean delivery kits and newborn mortality in the Zambia Chlorhexidine Application Trial (ZamCAT): An observational study
PLOS Medicine: published May 5, 2021 | https://doi.org/10.1371/journal.pmed.1003610
Digital adherence technology for tuberculosis treatment supervision: A stepped-wedge cluster-randomized trial in Uganda
PLOS Medicine: published May 6, 2021 | https://doi.org/10.1371/journal.pmed.1003628
Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis
PLOS Medicine: published May 10, 2021 | https://doi.org/10.1371/journal.pmed.1003602
Risk of miscarriage in women with chronic diseases in Norway: A registry linkage study
PLOS Medicine: published May 10, 2021 | https://doi.org/10.1371/journal.pmed.1003603
Associations of treated and untreated human papillomavirus infection with preterm delivery and neonatal mortality: A Swedish population-based study
PLOS Medicine: published May 10, 2021 | https://doi.org/10.1371/journal.pmed.1003641
Cost-effectiveness evidence of mental health prevention and promotion interventions: A systematic review of economic evaluations
PLOS Medicine: published May 11, 2021 | https://doi.org/10.1371/journal.pmed.1003606
Effect of community-led delivery of HIV self-testing on HIV testing and antiretroviral therapy initiation in Malawi: A cluster-randomised trial
PLOS Medicine: published May 11, 2021 | https://doi.org/10.1371/journal.pmed.1003608
Adverse childhood experiences, adult depression, and suicidal ideation in rural Uganda: A cross-sectional, population-based study
PLOS Medicine: published May 12, 2021 | https://doi.org/10.1371/journal.pmed.1003642
Outcomes and costs of publicly funded patient navigation interventions to enhance HIV care continuum outcomes in the United States: A before-and-after study
PLOS Medicine: published May 13, 2021 | https://doi.org/10.1371/journal.pmed.1003418
Assessment of the causal relevance of ECG parameters for risk of atrial fibrillation: A mendelian randomisation study
PLOS Medicine: published May 13, 2021 | https://doi.org/10.1371/journal.pmed.1003572
Effects of psychosocial support interventions on survival in inpatient and outpatient healthcare settings: A meta-analysis of 106 randomized controlled trials
PLOS Medicine: published May 18, 2021 | https://doi.org/10.1371/journal.pmed.1003595
The sugar content of foods in the UK by category and company: A repeated cross-sectional study, 2015-2018
PLOS Medicine: published May 18, 2021 | https://doi.org/10.1371/journal.pmed.1003647
COVID-19 and excess mortality in the United States: A county-level analysis
PLOS Medicine: published May 20, 2021 | https://doi.org/10.1371/journal.pmed.1003571
Adherence at 2 years with distribution of essential medicines at no charge: The CLEAN Meds randomized clinical trial
PLOS Medicine: published May 21, 2021 | https://doi.org/10.1371/journal.pmed.1003590
California and federal school nutrition policies and obesity among children of Pacific Islander, American Indian/Alaska Native, and Filipino origins: Interrupted time series analysis
PLOS Medicine: published May 24, 2021 | https://doi.org/10.1371/journal.pmed.1003596
SMS messaging to improve retention and viral suppression in prevention of mother-to-child HIV transmission (PMTCT) programs in Kenya: A 3-arm randomized clinical trial
PLOS Medicine: published May 24, 2021 | https://doi.org/10.1371/journal.pmed.1003650
Taxed and untaxed beverage intake by South African young adults after a national sugar-sweetened beverage tax: A before-and-after study
PLOS Medicine: published May 25, 2021 | https://doi.org/10.1371/journal.pmed.1003574
Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study
PLOS Medicine: published May 26, 2021 | https://doi.org/10.1371/journal.pmed.1003567
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Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study
PLOS Medicine: published May 26, 2021 | https://doi.org/10.1371/journal.pmed.1003632
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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study
PLOS Medicine: published May 27, 2021 | https://doi.org/10.1371/journal.pmed.1003615