From pain to policy: Improving endometriosis awareness, diagnosis, and treatment

Alexandra Tosun, on behalf of the PLOS Medicine Staff Editors

PLOS Medicine: published March 2, 2026 | https://doi.org/10.1371/journal.pmed.1004981

From crisis response to country control: Restoring agency and sustainability in global health

Ebere Okereke

PLOS Medicine: published March 3, 2026 | https://doi.org/10.1371/journal.pmed.1004961

Clinical potential and challenges of spatially profiling tumor-infiltrating lymphocytes in early-stage breast cancer

David B. Page, Michael Simanonok, Douglas A. Hanes, Alan Su

PLOS Medicine: published March 10, 2026 | https://doi.org/10.1371/journal.pmed.1004979

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Gene-environment equivalence: The fundamental principle of Mendelian randomization

George Davey Smith, Gibran Hemani, Shah Ebrahim

PLOS Medicine: published March 13, 2026 | https://doi.org/10.1371/journal.pmed.1005013

Living to our full potential: Reassessing global sex inequalities in life expectancy

Ann M. Weber, Gary L. Darmstadt

PLOS Medicine: published March 17, 2026 | https://doi.org/10.1371/journal.pmed.1004987

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Reassessing BMI-based access to joint replacement surgery

Jonathan P. Evans, Joanna McLaughlin, Jonathan T. Evans

PLOS Medicine: published March 24, 2026 | https://doi.org/10.1371/journal.pmed.1005003

The future of medicine in a One Health world

John L. Gittleman

PLOS Medicine: published March 27, 2026 | https://doi.org/10.1371/journal.pmed.1005042

The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study

Richard A. Armstrong, Paul Yousefi, Ben Gibbison, Golam M. Khandaker, Tom R. Gaunt

PLOS Medicine: published March 2, 2026 | https://doi.org/10.1371/journal.pmed.1004963

Childhood cancer in Sweden during the COVID-19 pandemic: Temporal patterns in incidence and survival in a nationwide register-based cohort study

Christina-Evmorfia Kampitsi, Javier Louro, Hanna Mogensen, Friederike Erdmann, Kleopatra Georgantzi, Mats Heyman, Päivi Lähteenmäki, Anna Nilsson, Maria Feychting, Giorgio Tettamanti

PLOS Medicine: published March 5, 2026 | https://doi.org/10.1371/journal.pmed.1004934

SGLT2 inhibitors, GLP-1 RAs, and DPP4 inhibitors and the risk of hypomagnesemia in type 2 diabetes: A target trial emulation

Shih-Chieh Shao, Daniel Hsiang-Te Tsai, Albert Tzu-Ming Chuang, Kuan-Hung Liu, Edward Chia-Cheng Lai

PLOS Medicine: published March 6, 2026 | https://doi.org/10.1371/journal.pmed.1004968

Oral preexposure prophylaxis use and the risk of bacterial sexually transmitted infections and HIV among African women: A prospective observational cohort study

David Mukasa, John Kinuthia, Allison Meisner, Daniel Matemo, Torin Schaafsma, Jennifer Morton, Cynthia Wandera, Elvira Budiawan, Valarie Kemuto, Cherotich Irine, Stephen Odhiambo, Mercy Bii, Beatrice Oduor, Esther Achieng, Tessy Oyombra, Ugochinyere Vivian Ukah, Kenneth K. Mugwanya, for the FP Plus Project Team

PLOS Medicine: published March 9, 2026 | https://doi.org/10.1371/journal.pmed.1004962

The association between power outages and cardiovascular and respiratory hospitalizations among US Medicare beneficiaries in 2018: A case-crossover study

Heather McBrien, Daniel Mork, Vivian Do, Marianthi-Anna Kioumourtzoglou, Joan A. Casey

PLOS Medicine: published March 12, 2026 | https://doi.org/10.1371/journal.pmed.1004923

Quantify unmet medical need across the disease landscape – A large language model-based methodology

Elliott W. Sharp, Nicholas Fragola, Charlotte Blewitt, Matthew Goddeeris, Lee Lancashire, Charlie Hempstead, David C. Fajgenbaum

PLOS Medicine: published March 12, 2026 | https://doi.org/10.1371/journal.pmed.1004798

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Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study

Yulu Zheng, Jae Jeong Yang, Deepak K. Gupta, David M. Herrington, Bing Yu, Ngoc Quynh H. Nguyen, Rui Pinto, Ioanna Tzoulaki, Hui Cai, Qiuyin Cai, Loren Lipworth, Xiao-Ou Shu, Wei Zheng, Danxia Yu

PLOS Medicine: published March 17, 2026 | https://doi.org/10.1371/journal.pmed.1004750

Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study

Husam Abdel-Qadir, Hardil Anup Bhatt, Sarah Swayze, Michael Paterson, Dennis T. Ko, David N. Juurlink, Jeffrey C. Kwong

PLOS Medicine: published March 19, 2026 | https://doi.org/10.1371/journal.pmed.1004924

Estimating population immunity against serotype-two poliomyelitis from the inactivated polio vaccine in routine immunization across 112 countries: A modelling study

Elizabeth J. Gray, Laura V. Cooper, Alejandro Ramirez Gonzalez, Ondrej Mach, Nieves Derqui, Nicholas C. Grassly, Isobel M. Blake

PLOS Medicine: published March 19, 2026 | https://doi.org/10.1371/journal.pmed.1004952

The role of noninfectious comorbidities in the association between severe infections and risk of dementia in Finland: A nationwide registry study

Pyry N. Sipilä, Kaarina Korhonen, Joni V. Lindbohm, Mika Kivimäki, Pekka Martikainen

PLOS Medicine: published March 24, 2026 | https://doi.org/10.1371/journal.pmed.1004688

Transformer-based deep learning model for real-time prediction of intraoperative hypotension using dynamic time-series vital signs: A retrospective study

Shouqiang Zhu, Weihai Shi, Haichuan Qian, Xiaoqiang Tong, Rongliang Hu, Jinhua Bo, Xiaoping Gu

PLOS Medicine: published March 25, 2026 | https://doi.org/10.1371/journal.pmed.1005024

Evaluating the biomedical and behavioral drivers of HIV incidence decline in adolescent girls and young women in Uganda: A mathematical modeling study

Adam Akullian, Victor Ssempijja, Daniel Bridenbecker, Fred Nalugoda, Gertrude Nakigozi, John Santelli, Philip Kreniske, Larry W. Chang, Steven J. Reynolds, Robert Ssekubugu, Ronald H. Gray, Maria J. Wawer, Thomas C. Quinn, Ronald M. Galiwango, William J. M. Probert, Jeffrey W. Imai-Eaton, Oliver Ratmann, Christophe Fraser, Joseph Kagaayi, Godfrey Kigozi, Mary Kate Grabowski, David Serwadda

PLOS Medicine: published March 25, 2026 | https://doi.org/10.1371/journal.pmed.1004993

Early aspirin withdrawal versus dual antiplatelet therapy in high-risk patients after percutaneous coronary intervention: Meta-analysis of randomized trials

Eliano P. Navarese, Paul Gurbel, Udaya Tantry, Giuseppe Talanas, Klaudyna Grzelakowska, Julia Umińska, Young-Hoon Jeong, Kevin Bliden, Safi U. Khan, Jacek Kubica, Timothy D. Henry, Michael E. Farkouh, Dean J. Kereiakes

PLOS Medicine: published March 26, 2026 | https://doi.org/10.1371/journal.pmed.1004995

Policy stringency during the COVID-19 pandemic and healthcare services utilization in China: An interrupted time-series analysis

Hong Xiao, Guannan Bai, Fang Liu, Yuechong Cui, Joseph M. Unger

PLOS Medicine: published March 26, 2026 | https://doi.org/10.1371/journal.pmed.1004672

Pain and treatment outcomes after initiating methadone vs buprenorphine among medicare patients with opioid use disorder and comorbid chronic pain: A target trial emulation

Yu-Jung Jenny Wei, Almut G. Winterstein, Roger B. Fillingim, Stephan Schmidt, Siegfried Schmidt

PLOS Medicine: published March 26, 2026 | https://doi.org/10.1371/journal.pmed.1004846

Physical activity across mid-life and mortality outcomes in Australian women: A target trial emulation using a prospective cohort

Binh Nguyen, Katherine B. Owen, Mengyun Luo, Wendy Brown, Gregore I. Mielke, Philip J. Clare, Ding Ding

PLOS Medicine: published March 26, 2026 | https://doi.org/10.1371/journal.pmed.1004976

Effect of enhanced peer PrEP referral with HIV self-testing delivery among young Kenyan women: A randomized controlled trial of peer networks

Katrina F. Ortblad, Njeri Wairimu, Carlos Culquichicon, Irene Njeru, Rachel C. Malen, Adriana M. Reedy, Obinna Ekwunife, Maureen McGowan, Margaret Mwangi, Agata Muthoni, Dorcas Kiboi, Sarah Njoroge, Fei Gao, Jared M. Baeten, Kenneth Ngure

PLOS Medicine: published March 30, 2026 | https://doi.org/10.1371/journal.pmed.1005023

Machine learning assisted differentiation of low acuity patients at dispatch: The MADLAD randomized controlled trial

Douglas Nils Spangler, Simon Morelli, David Smekal, Lennart Edmark, Hans Blomberg

PLOS Medicine: published March 31, 2026 | https://doi.org/10.1371/journal.pmed.1004770

Impact of supermarket fruit and vegetable placement on store sales, customer purchasing, diet and household waste: A prospective matched-controlled cluster trial

Christina Vogel, Sarah Crozier, Preeti Dhuria, Joanne Lord, Graham Moon, Wendy Lawrence, Janet Cade, Kylie Ball, Cyrus Cooper, Janis Baird

PLOS Medicine: published March 31, 2026 | https://doi.org/10.1371/journal.pmed.1004575

Correction: How can middle-income countries successfully transition away from international health aid?

Osondu Ogbuoji, Ipchita Bharali, Justice Nonvignon, Gavin Yamey

PLOS Medicine: published March 23, 2026 | https://doi.org/10.1371/journal.pmed.1005018

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A responsible authorship culture is needed and it is a collective responsibility

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PLOS Medicine: published March 26, 2026 | https://doi.org/10.1371/journal.pmed.1005037