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June 2022

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Preprints are scientific papers that have been made available for general scrutiny prior to or alongside formal peer review and publication. Although preprinting has been a common mechanism for scientific critique and debate in some disciplines for many years, broader use and acceptance has been held back by concerns about the potential for loss of scientific priority and perceived risks of propagating misinformation. However, preprints hold great promise for accelerating scientific progress and discovery, and this potential has been realized during the COVID-19 pandemic for preprints in health and medical research. In an Editorial, Marcel LaFlamme and Raffaella Bosurgi discuss PLOS Medicine's evolving policy on preprint deposition.

Image Credit: Si Janko Ferlič, Unsplash

Editorial

Facilitating preprint sharing in the health sciences

Marcel LaFlamme, Raffaella Bosurgi

Policy Forum

Cancer systems epidemiology: Overcoming misconceptions and integrating systems approaches into cancer research

Patricia L. Mabry, Nicolaas P. Pronk, Christopher I. Amos, John S. Witte, Patrick T. Wedlock, Sarah M. Bartsch, Bruce Y. Lee

Research Articles

Exposure to road traffic noise and cognitive development in schoolchildren in Barcelona, Spain: A population-based cohort study

Maria Foraster, Mikel Esnaola, Mónica López-Vicente, Ioar Rivas, Mar Álvarez-Pedrerol, Cecilia Persavento, Nuria Sebastian-Galles, Jesus Pujol, Payam Dadvand, Jordi Sunyer

Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study

Alyaa M. Ajabnoor, Salwa S. Zghebi, Rosa Parisi, Darren M. Ashcroft, Martin K. Rutter, Tim Doran, Matthew J. Carr, Mamas A. Mamas, Evangelos Kontopantelis

Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial

Chris C. Parker, Nicholas D. James, Christopher D. Brawley, Noel W. Clarke, Adnan Ali, Claire L. Amos, Gerhardt Attard, Simon Chowdhury, Adrian Cook, William Cross, David P. Dearnaley, Hassan Douis, Duncan C. Gilbert, Clare Gilson, Silke Gillessen, Alex Hoyle, Rob J. Jones, Ruth E. Langley, Zafar I. Malik, Malcolm D. Mason, David Matheson, Robin Millman, Mary Rauchenberger, Hannah Rush, J Martin Russell, Hannah Sweeney, Amit Bahl, Alison Birtle, Lisa Capaldi, Omar Din, Daniel Ford, Joanna Gale, Ann Henry, Peter Hoskin, Mohammed Kagzi, Anna Lydon, Joe M. O’Sullivan, Sangeeta A. Paisey, Omi Parikh, Delia Pudney, Vijay Ramani, Peter Robson, Narayanan Nair Srihari, Jacob Tanguay, Mahesh K. B. Parmar, Matthew R. Sydes, for the STAMPEDE Trial Collaborative Group

Scaling up target regimens for tuberculosis preventive treatment in Brazil and South Africa: An analysis of costs and cost-effectiveness

Ntwali Placide Nsengiyumva, Jonathon R. Campbell, Olivia Oxlade, Juan F. Vesga, Christian Lienhardt, Anete Trajman, Dennis Falzon, Saskia Den Boon, Nimalan Arinaminpathy, Kevin Schwartzman

Integration of a multicomponent intervention for hypertension into primary healthcare services in Singapore—A cluster randomized controlled trial

Tazeen Hasan Jafar, Ngiap Chuan Tan, Rupesh Madhukar Shirore, John Carson Allen, Eric Andrew Finkelstein, Siew Wai Hwang, Agnes Ying Leng Koong, Peter Kirm Seng Moey, Gary Chun-Yun Kang, Chris Wan Teng Goh, Reena Chandhini Subramanian, Anandan Gerard Thiagarajah, Chandrika Ramakrishnan, Ching Wee Lim, Jianying Liu, for SingHypertension Study Group

Analysis of mortality metrics associated with a comprehensive range of disorders in Denmark, 2000 to 2018: A population-based cohort study

Oleguer Plana-Ripoll, Julie W. Dreier, Natalie C. Momen, Anders Prior, Nanna Weye, Preben Bo Mortensen, Carsten B. Pedersen, Kim Moesgaard Iburg, Maria Klitgaard Christensen, Thomas Munk Laursen, Esben Agerbo, Marianne G. Pedersen, Jørgen Brandt, Lise Marie Frohn, Camilla Geels, Jesper H. Christensen, John J. McGrath

School racial segregation and long-term cardiovascular health among black adults in the US: A quasi-experimental study

Min Hee Kim, Gabriel L. Schwartz, Justin S. White, M. Maria Glymour, Sean F. Reardon, Kiarri N. Kershaw, Scarlett Lin Gomez, Daniel F. Collin, Pushkar Inamdar, Guangyi Wang, Rita Hamad

Safety evaluation of the single-dose Ad26.COV2.S vaccine among healthcare workers in the Sisonke study in South Africa: A phase 3b implementation trial

Simbarashe Takuva, Azwidhwi Takalani, Ishen Seocharan, Nonhlanhla Yende-Zuma, Tarylee Reddy, Imke Engelbrecht, Mark Faesen, Kentse Khuto, Carmen Whyte, Veronique Bailey, Valentina Trivella, Jonathan Peter, Jessica Opie, Vernon Louw, Pradeep Rowji, Barry Jacobson, Pamela Groenewald, Rob E. Dorrington, Ria Laubscher, Debbie Bradshaw, Harry Moultrie, Lara Fairall, Ian Sanne, Linda Gail-Bekker, Glenda Gray, Ameena Goga, Nigel Garrett, Sisonke study team

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Adverse events of special interest and mortality following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines in Hong Kong: A retrospective study

Carlos King Ho Wong, Kristy Tsz Kwan Lau, Xi Xiong, Ivan Chi Ho Au, Francisco Tsz Tsun Lai, Eric Yuk Fai Wan, Celine Sze Ling Chui, Xue Li, Esther Wai Yin Chan, Le Gao, Franco Wing Tak Cheng, Sydney Chi Wai Tang, Ian Chi Kei Wong

Related Articles

Evaluation of the Growth Assessment Protocol (GAP) for antenatal detection of small for gestational age: The DESiGN cluster randomised trial

Matias C. Vieira, Sophie Relph, Walter Muruet-Gutierrez, Maria Elstad, Bolaji Coker, Natalie Moitt, Louisa Delaney, Chivon Winsloe, Andrew Healey, Kirstie Coxon, Alessandro Alagna, Annette Briley, Mark Johnson, Louise M. Page, Donald Peebles, Andrew Shennan, Baskaran Thilaganathan, Neil Marlow, Lesley McCowan, Christoph Lees, Deborah A. Lawlor, Asma Khalil, Jane Sandall, Andrew Copas, Dharmintra Pasupathy, on behalf of the DESiGN Collaborative Group

Related Articles

Physiologically based cord clamping for infants ≥32+0 weeks gestation: A randomised clinical trial and reference percentiles for heart rate and oxygen saturation for infants ≥35+0 weeks gestation

Shiraz Badurdeen, Peter G. Davis, Stuart B. Hooper, Susan Donath, Georgia A. Santomartino, Alissa Heng, Diana Zannino, Monsurul Hoq, C. Omar F Kamlin, Stefan C. Kane, Anthony Woodward, Calum T. Roberts, Graeme R. Polglase, Douglas A. Blank, on behalf of the Baby Directed Umbilical Cord Clamping (BabyDUCC) collaborative group

Effects of a WHO-guided digital health intervention for depression in Syrian refugees in Lebanon: A randomized controlled trial

Pim Cuijpers, Eva Heim, Jinane Abi Ramia, Sebastian Burchert, Kenneth Carswell, Ilja Cornelisz, Christine Knaevelsrud, Philip Noun, Chris van Klaveren, Edith van’t Hof, Edwina Zoghbi, Mark van Ommeren, Rabih El Chammay