Spatial omics and AI for clinically actionable cancer biomarkers

Nic G. Reitsam

PLOS Medicine: published April 9, 2026 | https://doi.org/10.1371/journal.pmed.1005049

Supporting patients receiving oral systemic anti-cancer therapies

Amanda Drury, Matthew Fowler, Janice Richmond

PLOS Medicine: published April 1, 2026 | https://doi.org/10.1371/journal.pmed.1005022

Are ultra-processed foods too tasty? Toward a metabolic framework for diet and obesity

David S. Ludwig

PLOS Medicine: published April 3, 2026 | https://doi.org/10.1371/journal.pmed.1005025

Interpreting circulating microbiome-related metabolites in coronary heart disease

Zhonghan Sun, Mengkun Shi, Yan Zheng

PLOS Medicine: published April 15, 2026 | https://doi.org/10.1371/journal.pmed.1005056

Obesity and cancer: Methodological frontiers for mechanistic discoveries

Steven C. Moore, Patrick J. Ryan

PLOS Medicine: published April 24, 2026 | https://doi.org/10.1371/journal.pmed.1005081

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Optimizing dengue vaccination strategies

Annelies Wilder-Smith

PLOS Medicine: published April 27, 2026 | https://doi.org/10.1371/journal.pmed.1005068

The principles of Population-Level Approaches to Dementia Risk Reduction (PLADRR)

Sebastian Walsh, Susanne Röhr, Joaquin Mígeot, Yuliya Bodryzlova, Etuini Ma’u, Simone Salemme, Charles R. Marshall, Timothy Daly, Gary Cheung, Blossom C. M. Stephan, Raj Kalaria, Kenneth M. Langa, Naaheed Mukadam, Leslie Grasset, Sarah Cullum, Ishtar Govia, Nikki-Anne Wilson, Daniele Urso, Ruth Peters, Jingxuan Wang, Edo Richard, Giancarlo Logroscino, Stefano Giannoni-Luza, Nicola T. Lautenschlager, Josephine E. Prynn, Cleusa P. Ferri, Susan Yates, Frank J. Wolters, Lindsay Wallace, Carol Brayne, Kaarin J. Anstey

PLOS Medicine: published April 28, 2026 | https://doi.org/10.1371/journal.pmed.1005059

Impact of sugary drink taxes on beverage calories purchased in a national fast food restaurant chain: A quasi-experimental study

Pasquale E. Rummo, Juan A. Echenique, Erilia Wu, Tod Mijanovich, Sunita M. Desai, Marie A. Bragg, Beth C. Weitzman, Brian Elbel

PLOS Medicine: published April 2, 2026 | https://doi.org/10.1371/journal.pmed.1004642

Cost-effectiveness and benefit-cost analyses of promoting handwashing with soap: A systematic review

Ian Ross, David Bath, Joseph Wells, Robert Dreibelbis, Regina Ejemot-Nwadiaro, Joanna Esteves Mills, Giulia Greco, Catherine Pitt, Oliver Cumming

PLOS Medicine: published April 3, 2026 | https://doi.org/10.1371/journal.pmed.1004982

Physical frailty, genetic risk, mediating biomarkers, and risk of suicide attempt: A prospective cohort study

Wei Hu, Li-Jie Gao, Tian-Shu Liu, Ge Tian, Jia-Ning Wang, Yu-Bin Ma, Zi-Ang Zheng, Tong-Jie Feng, Xiao-Xin Niu, Yi-Ning Yan, Bao-Peng Liu, Cun-Xian Jia

PLOS Medicine: published April 6, 2026 | https://doi.org/10.1371/journal.pmed.1005045

Urban and rural prevalence of tuberculosis in low- and middle-income countries: A systematic review and meta-analysis

Seyed Alireza Mortazavi, Nicole A. Swartwood, Nanki Singh, Melike Hazal Can, Hening Cui, Do Kyung Ryuk, Katherine C. Horton, Nicolas A. Menzies, Peter MacPherson

PLOS Medicine: published April 6, 2026 | https://doi.org/10.1371/journal.pmed.1004779

Trade-offs in diagnostic algorithm, population coverage, and duration of community screening for tuberculosis: A modelling study

Katherine C. Horton, Alexandra S. Richards, Alvaro Schwalb, Rein M. G. J. Houben

PLOS Medicine: published April 6, 2026 | https://doi.org/10.1371/journal.pmed.1005040

Impact of abdominal obesity prevalence trends on dementia, cardiovascular disease, functional impairment, and mortality in older Chinese adults: A Markov scenario simulation, 2020–2050

Yujing Zhou, Minrui Zeng, Yuntao Chen, Piotr Bandosz, Eric Brunner, Jing Liao

PLOS Medicine: published April 7, 2026 | https://doi.org/10.1371/journal.pmed.1004970

The benefits of investments to combat HIV, tuberculosis, and malaria for primary healthcare from 2000 to 2023: An economic modeling analysis

Jiaying Stephanie Su, John Stover, Carel Pretorius, Peter Winskill, Sedona Sweeney, Timothy B. Hallett, Nicolas A. Menzies

PLOS Medicine: published April 8, 2026 | https://doi.org/10.1371/journal.pmed.1005036

Association between early methadone dose titration and treatment discontinuation and opioid toxicity: A retrospective cohort study

Ria Garg, Jin Luo, Nikki Bozinoff, Beth Sproule, Tony Antoniou, Jennifer Wyman, Pamela Leece, Charlotte Munro, Jes Besharh, Tara Gomes

PLOS Medicine: published April 9, 2026 | https://doi.org/10.1371/journal.pmed.1004748

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and incidence of asthma and wheeze in childhood: A register-based cohort study in Ronneby, Sweden

Annelise J. Blomberg, Christel Nielsen, Beata Borgström Bolmsjö, Marie-Abèle Bind, Linda Hartman, Anna Saxne Jöud

PLOS Medicine: published April 9, 2026 | https://doi.org/10.1371/journal.pmed.1004659

Clostridioides difficile colonization amplification despite limited in-hospital transmission: A modeling study

Daniel De-la-Rosa-Martinez, Travis C. Porco, Ashley Hazel, Xinran Liu, Karim Khader, Seth Blumberg

PLOS Medicine: published April 13, 2026 | https://doi.org/10.1371/journal.pmed.1004712

Cost-effectiveness of esketamine versus alternative treatment strategies for treatment-resistant depression in Hong Kong: A multi-armed modeling study

Yifan Li, Vivien Kin Yi Chan, Mark Jit, Franco Wing Tak Cheng, Hei Hang Edmund Yiu, David Makram Bishai, Dawn Craig, Esther Wai Yin Chan, Sandra Sau Man Chan, Xue Li

PLOS Medicine: published April 16, 2026 | https://doi.org/10.1371/journal.pmed.1005047

Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis

Warittha Tieosapjaroen, Eloise Williams, Cheryl C. Johnson, Carlota Baptista Da Silva, Magdalena Barr-DiChiara, Michelle Rodolph, Heather Leigh Ingold, Heather-Marie A. Schmidt, Mateo Prochazka, Busi Msimanga, Celine Lastrucci, Hortensia Peralta, Lastone Chitembo, Precious Andifasi, Nandi Siegfried, Raphael J. Landovitz, Jason J. Ong

PLOS Medicine: published April 16, 2026 | https://doi.org/10.1371/journal.pmed.1005030

Association between gabapentinoid treatment, concurrent use with opioid or benzodiazepine and the risk of drug poisoning: A self-controlled case series study

Andrew S. C. Yuen, Boqing Chen, Adrienne Y. L. Chan, Joseph F. Hayes, David P. J. Osborn, Frank M. C. Besag, Wallis C. Y. Lau, Ian C. K. Wong, Li Wei, Kenneth K. C. Man

PLOS Medicine: published April 16, 2026 | https://doi.org/10.1371/journal.pmed.1005035

Quality of antenatal and delivery care and postnatal care use: A multi-country observational study of 400,000 births

Jan E. Cooper, Hwa-Young Lee, Katherine Wright, Prashant Jaryan, Margaret E. Kruk

PLOS Medicine: published April 21, 2026 | https://doi.org/10.1371/journal.pmed.1005055

Identification of lipid quantitative trait loci linked with cardiometabolic disease in Asian Indians and Europeans: A genome-wide association study and Mendelian randomization

Madhusmita Rout, Christopher E. Aston, Ravindranath Duggirala, Harald H. Goring, Oliver Fiehn, Dharambir K. Sanghera

PLOS Medicine: published April 23, 2026 | https://doi.org/10.1371/journal.pmed.1005039

Tobacco control policies on cancer prevention in the Eastern Mediterranean Region, 2025–2050: A modeling study

Saeed Nemati, Mojtaba Vand Rajabpour, Xiaoshuang Feng, Negar Taheri, Harriet Rumgay, Farrokh Heidari, Ebrahim Karimi, Sepideh Abdi, Mattias Johansson, Mahdi Sheikh

PLOS Medicine: published April 24, 2026 | https://doi.org/10.1371/journal.pmed.1005032

Subsequent primary cancer incidence among cancer survivors in the United States, 1975–2019: An age–period–cohort analysis

Hui G. Cheng, Livingstone Aduse-Poku, Chelsey McGill, Oxana Palesh, Susan Hong

PLOS Medicine: published April 28, 2026 | https://doi.org/10.1371/journal.pmed.1005034

Identifying novel prodromal symptoms of eclampsia: A two-country, case-control study

Roxanne Hastie, Farhatulain Ahmed, Parinaz Mehdipour, Bernard Yan, Susan P. Walker, Jacqui Visser, Anam Bashir, Lyle Gurrin, Anthea Lindquist, Jessica A. Atkinson, Catherine Cluver, Lina Bergman, Stephen Tong

PLOS Medicine: published April 28, 2026 | https://doi.org/10.1371/journal.pmed.1004994

Correction: Quantify unmet medical need across the disease landscape – A large language model-based methodology

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PLOS Medicine: published April 10, 2026 | https://doi.org/10.1371/journal.pmed.1005048

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Correction: Reassessing BMI-based access to joint replacement surgery

The PLOS Medicine Staff

PLOS Medicine: published April 29, 2026 | https://doi.org/10.1371/journal.pmed.1005076

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