Table of Contents

October 2006

The cover image takes its theme from Dorothy Porter's article, which looks at the historical roots of social medicine and asks where it is heading. The article is part of a special collection of eleven magazine pieces and five original research papers examining social and cultural aspects of medicine and health and the socioeconomic determinants of disease.

Image Credit: Cover design by Natalie Davis, Public Library of Science, with images from the US Library of Congress (an image used by Dorothy Porter in her article) and Tavis Ford

The PLoS Medicine Debate


Five Myths about the HIV Epidemic in Asia

Peter Godwin, Nigel O'Farrell, Knut Fylkesnes, Sujaya Misra


Policy Forums

Priority Setting for Pandemic Influenza: An Analysis of National Preparedness Plans

Lori Uscher-Pines, Saad B Omer, Daniel J Barnett, Thomas A Burke, Ran D Balicer

Responding to AIDS, Tuberculosis, Malaria, and Emerging Infectious Diseases in Burma: Dilemmas of Policy and Practice

Chris Beyrer, Voravit Suwanvanichkij, Luke C Mullany, Adam K Richards, Nicole Franck, Aaron Samuels, Thomas J Lee

Research in Translation

HIV-1 Viral Load Assays for Resource-Limited Settings

Susan A Fiscus, Ben Cheng, Suzanne M Crowe, Lisa Demeter, Cheryl Jennings, Veronica Miller, Richard Respess, Wendy Stevens, and the Forum for Collaborative HIV Research Alternative Viral Load Assay Working Group

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Best Practice

Antidepressant Prevention of Postnatal Depression

Louise M Howard, Elizabeth Boath, Carol Henshaw

Research Articles

Indigenous Health and Socioeconomic Status in India

S. V Subramanian, George Davey Smith, Malavika Subramanyam

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Reinterpreting Ethnic Patterns among White and African American Men Who Inject Heroin: A Social Science of Medicine Approach

Philippe Bourgois, Alexis Martinez, Alex Kral, Brian R Edlin, Jeff Schonberg, Dan Ciccarone

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A Comparative Analysis of Influenza Vaccination Programs

Shweta Bansal, Babak Pourbohloul, Lauren Ancel Meyers

Tuberculosis Recurrence and Mortality after Successful Treatment: Impact of Drug Resistance

Helen Cox, Yared Kebede, Sholpan Allamuratova, Gabit Ismailov, Zamira Davletmuratova, Graham Byrnes, Christine Stone, Stefan Niemann, Sabine Rüsch-Gerdes, Lucie Blok, Daribay Doshetov

Cost-Effectiveness Study of Three Antimalarial Drug Combinations in Tanzania

Virginia Wiseman, Michelle Kim, Theonest K Mutabingwa, Christopher J. M Whitty

HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1

Marcus Altfeld, Elizabeth T Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N Johnston, Nicole Burgett, Martha E Swartz, Amy Yang, Galit Alter, Xu G Yu, Angela Meier, Juergen K Rockstroh, Todd M Allen, Heiko Jessen, Eric S Rosenberg, Mary Carrington, Bruce D Walker

Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

Anju Singh, Vikas Misra, Rajesh K Thimmulappa, Hannah Lee, Stephen Ames, Mohammad O Hoque, James G Herman, Stephen B Baylin, David Sidransky, Edward Gabrielson, Malcolm V Brock, Shyam Biswal

Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction

Michael N Weedon, Mark I McCarthy, Graham Hitman, Mark Walker, Christopher J Groves, Eleftheria Zeggini, N. William Rayner, Beverley Shields, Katharine R Owen, Andrew T Hattersley, Timothy M Frayling

Mortality in Pharmacologically Treated Older Adults with Diabetes: The Cardiovascular Health Study, 1989–2001

Richard A Kronmal, Joshua I Barzilay, Nicholas L Smith, Bruce M Psaty, Lewis H Kuller, Gregory L Burke, Curt Furberg

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Lentiviral Gene Transfer of Rpe65 Rescues Survival and Function of Cones in a Mouse Model of Leber Congenital Amaurosis

Alexis-Pierre Bemelmans, Corinne Kostic, Sylvain V Crippa, William W Hauswirth, Janis Lem, Francis L Munier, Mathias W Seeliger, Andreas Wenzel, Yvan Arsenijevic

Analysis of Gene Expression Using Gene Sets Discriminates Cancer Patients with and without Late Radiation Toxicity

J. Peter Svensson, Lukas J. A Stalpers, Rebecca E. E. Esveldt–van Lange, Nicolaas A. P Franken, Jaap Haveman, Binie Klein, Ingela Turesson, Harry Vrieling, Micheline Giphart-Gassler

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Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura

Cristina Granziera, Alexandre F. M DaSilva, Josh Snyder, David S Tuch, Nouchine Hadjikhani

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Dementia before Death in Ageing Societies— The Promise of Prevention and the Reality

Carol Brayne, Lu Gao, Michael Dewey, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Study Investigators

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Methods of Blinding in Reports of Randomized Controlled Trials Assessing Pharmacologic Treatments: A Systematic Review

Isabelle Boutron, Candice Estellat, Lydia Guittet, Agnes Dechartres, David L Sackett, Asbjørn Hróbjartsson, Philippe Ravaud

A Population-Based Study on Alcohol and High-Risk Sexual Behaviors in Botswana

Sheri D Weiser, Karen Leiter, Michele Heisler, Willi McFarland, Fiona Percy-de Korte, Sonya M DeMonner, Sheila Tlou, Nthabiseng Phaladze, Vincent Iacopino, David R Bangsberg

Time to Renal Disease and End-Stage Renal Disease in PROFILE: A Multiethnic Lupus Cohort

Graciela S Alarcón, Gerald McGwin Jr., Michelle Petri, Rosalind Ramsey-Goldman, Barri J Fessler, Luis M Vilá, Jeffrey C Edberg, John D Reveille, Robert P Kimberly, for the PROFILE Study Group

Atypical Haemolytic Uraemic Syndrome Associated with a Hybrid Complement Gene

Julian P Venables, Lisa Strain, Danny Routledge, David Bourn, Helen M Powell, Paul Warwicker, Martha L Diaz-Torres, Anne Sampson, Paul Mead, Michelle Webb, Yves Pirson, Michael S Jackson, Anne Hughes, Katrina M Wood, Judith A Goodship, Timothy H. J Goodship

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Correction: Routine HIV Testing in Botswana: A Population-Based Study on Attitudes, Practices, and Human Rights Concerns

Sheri D Weiser, Michele Heisler, Karen Leiter, Fiona Percy-de Korte, Sheila Tlou, Sonya DeMonner, Nthabiseng Phaladze, David R Bangsberg, Vincent Iacopino

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Correction: Frequency of Adverse Events after Vaccination with Different Vaccinia Strains

Mirjam Kretzschmar, Jacco Wallinga, Peter Teunis, Shuqin Xing, Rafael Mikolajczyk

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