More than 1 million people acquire a sexually transmitted infection (STI) each day. These infections, when not treated, take their toll in grievous outcomes—notably cancer deaths, infertility, and birth complications including stillbirth. Social stigma that limits care-seeking, causal pathogens with diverse characteristics, and commonly mild or nonexistent symptoms all contribute to the pernicious effects of STIs.
This month, PLOS Medicine features new research submitted in response to the Call for Papers for our Collection on "The Prevention, Diagnosis and Treatment of Sexually Transmitted Infections." This Collection research is varied in both topic and approach. Included studies address efficacy of an online STI testing service in the UK, prevalence of dual-strain HSV-2 infection, challenges facing health care providers managing STI care in Kenya, and market barriers to the global provision of an off-patent antibiotic used to prevent mother-to-child transmission of syphilis. Expert commentary on informed approaches to identifying the next STI, and future clinical significance of the vaginal microbiome, are featured as well. The Collection will continue in early 2018.
In the accompanying Editorial, Nicola Low of the University of Bern, Switzerland and Nathalie Broutet of the World Health Organization (WHO), Guest Editors for the Collection, highlight key advances from the month’s papers and discuss prominent challenges and priorities in the field.
Image Credit: eric molina/Flickr, NIAID/Flickr, kerryank/Pixabay
PLOS Medicine: published December 27, 2017 | https://doi.org/10.1371/journal.pmed.1002481
PLOS Medicine: published December 8, 2017 | https://doi.org/10.1371/journal.pmed.1002470
Re-emerging and newly recognized sexually transmitted infections: Can prior experiences shed light on future identification and control?
PLOS Medicine: published December 27, 2017 | https://doi.org/10.1371/journal.pmed.1002474
Bridging the quality chasm in maternal, newborn, and child healthcare in low- and middle-income countries
PLOS Medicine: published December 12, 2017 | https://doi.org/10.1371/journal.pmed.1002465
PLOS Medicine: published December 12, 2017 | https://doi.org/10.1371/journal.pmed.1002469
The vaginal microbiome and sexually transmitted infections are interlinked: Consequences for treatment and prevention
PLOS Medicine: published December 27, 2017 | https://doi.org/10.1371/journal.pmed.1002478
Effects of women’s groups practising participatory learning and action on preventive and care-seeking behaviours to reduce neonatal mortality: A meta-analysis of cluster-randomised trials
PLOS Medicine: published December 5, 2017 | https://doi.org/10.1371/journal.pmed.1002467
Psychosocial and socioeconomic determinants of cardiovascular mortality in Eastern Europe: A multicentre prospective cohort study
PLOS Medicine: published December 6, 2017 | https://doi.org/10.1371/journal.pmed.1002459
Association between infrastructure and observed quality of care in 4 healthcare services: A cross-sectional study of 4,300 facilities in 8 countries
PLOS Medicine: published December 12, 2017 | https://doi.org/10.1371/journal.pmed.1002464
Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study
PLOS Medicine: published December 12, 2017 | https://doi.org/10.1371/journal.pmed.1002468
Estimated clinical impact of the Xpert MTB/RIF Ultra cartridge for diagnosis of pulmonary tuberculosis: A modeling study
PLOS Medicine: published December 14, 2017 | https://doi.org/10.1371/journal.pmed.1002472
Cell salvage and donor blood transfusion during cesarean section: A pragmatic, multicentre randomised controlled trial (SALVO)
PLOS Medicine: published December 19, 2017 | https://doi.org/10.1371/journal.pmed.1002471
Shortages of benzathine penicillin for prevention of mother-to-child transmission of syphilis: An evaluation from multi-country surveys and stakeholder interviews
PLOS Medicine: published December 27, 2017 | https://doi.org/10.1371/journal.pmed.1002473
Dual-strain genital herpes simplex virus type 2 (HSV-2) infection in the US, Peru, and 8 countries in sub-Saharan Africa: A nested cross-sectional viral genotyping study
PLOS Medicine: published December 27, 2017 | https://doi.org/10.1371/journal.pmed.1002475
Internet-accessed sexually transmitted infection (e-STI) testing and results service: A randomised, single-blind, controlled trial
PLOS Medicine: published December 27, 2017 | https://doi.org/10.1371/journal.pmed.1002479
Healthcare provider perspectives on managing sexually transmitted infections in HIV care settings in Kenya: A qualitative thematic analysis
PLOS Medicine: published December 27, 2017 | https://doi.org/10.1371/journal.pmed.1002480