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Biofilms produce biofilm-specific antibiotics.
Biofilms protect member cells against antibiotics by enclosing them with biofilm matrix polymers. Bacillus subtilis biofilms produce the YIT toxin, which can spread within biofilms without being obstructed by biofilm matrix polymers and attack toxin-sensitive cells. The wild-type strain (left half) developed biofilm architectures on its colony surface whereas the YIT toxin-sensitive strain (right half) formed attenuated biofilm architectures. See Kobayashi, Ikemoto.
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Image Credit: Kazuo Kobayashi