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Table of Contents

November 2013

During Drosophila cellularization, nuclei of the syncytial embryo are packaged into individual cells to generate an epithelial sheet. In this segmented confocal image, membrane furrows (green) divide nuclei (purple) into cells. Failed cellularization results in multinucleation (orange). We identified two new members of the Vinculin/α-Catenin Superfamily that work together to promote robust cellularization. Spt and Sry-α share redundant actin-regulating activity. Maternal Spt is sufficient for reliable cellularization at optimal conditions. However, both maternal Spt and zygotic Sry-α are required when conditions deviate from optimal. In this way, the maternal-to-zygotic transition ensures the robustness of cellularization via the actin cytoskeleton. See Zheng et al.

Image Credit: Liuliu Zheng, Leonardo A. Sepúlveda, and Anna Marie Sokac.

Research Articles

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females

Serge McGraw, Christopher C. Oakes, Josée Martel, M. Cecilia Cirio, Pauline de Zeeuw, Winifred Mak, Christoph Plass, Marisa S. Bartolomei, J. Richard Chaillet, Jacquetta M. Trasler

Parallel Evolution of Chordate Cis-Regulatory Code for Development

Laura Doglio, Debbie K. Goode, Maria C. Pelleri, Stefan Pauls, Flavia Frabetti, Sebastian M. Shimeld, Tanya Vavouri, Greg Elgar

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