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Table of Contents: May 2013

This montage shows a time-lapse of the C. elegans spermatheca, the site of sperm storage and fertilization, imaged with the genetically encoded calcium indicator GCaMP. Oocyte entry into the spermatheca stretches the spermathecal cells and initiates a series of calcium waves that sweep across the spermatheca and trigger myosin contractions, which propel the embryo into the uterus. In this image, the calcium oscillations are visible as brightening and dimming of the distal and proximal spermatheca. The authors show that FLN-1/filamin, a mechanically sensitive cytoskeletal protein, and PLC-1, a phospholipase, are key regulators of this process. See Kovacevic et al.

Image Credit: Dr. Erin Cram and Dr. Ismar Kovacevic

Research Articles

Using Extended Genealogy to Estimate Components of Heritability for 23 Quantitative and Dichotomous Traits

Noah Zaitlen, Peter Kraft, Nick Patterson, Bogdan Pasaniuc, Gaurav Bhatia, Samuela Pollack, Alkes L. Price

Strong Purifying Selection at Synonymous Sites in D. melanogaster

David S. Lawrie, Philipp W. Messer, Ruth Hershberg, Dmitri A. Petrov

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

Tatiane C. Nogueira, Flavia M. Paula, Olatz Villate, Maikel L. Colli, Rodrigo F. Moura, Daniel A. Cunha, Lorella Marselli, Piero Marchetti, Miriam Cnop, Cécile Julier, Decio L. Eizirik

Cell Polarity and Patterning by PIN Trafficking through Early Endosomal Compartments in Arabidopsis thaliana

Hirokazu Tanaka, Saeko Kitakura, Hana Rakusová, Tomohiro Uemura, Mugurel I. Feraru, Riet De Rycke, Stéphanie Robert, Tatsuo Kakimoto, Jiří Friml

DNA Binding of the Cell Cycle Transcriptional Regulator GcrA Depends on N6-Adenosine Methylation in Caulobacter crescentus and Other Alphaproteobacteria

Antonella Fioravanti, Coralie Fumeaux, Saswat S. Mohapatra, Coralie Bompard, Matteo Brilli, Antonio Frandi, Vincent Castric, Vincent Villeret, Patrick H. Viollier, Emanuele G. Biondi

CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point

Xavier Bisteau, Sabine Paternot, Bianca Colleoni, Karin Ecker, Katia Coulonval, Philippe De Groote, Wim Declercq, Ludger Hengst, Pierre P. Roger

Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration

Erik Corona, Rong Chen, Martin Sikora, Alexander A. Morgan, Chirag J. Patel, Aditya Ramesh, Carlos D. Bustamante, Atul J. Butte

RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2

Jafar Kiani, Valérie Grandjean, Reinhard Liebers, Francesca Tuorto, Hossein Ghanbarian, Frank Lyko, François Cuzin, Minoo Rassoulzadegan

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Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations

Gavin Band, Quang Si Le, Luke Jostins, Matti Pirinen, Katja Kivinen, Muminatou Jallow, Fatoumatta Sisay-Joof, Kalifa Bojang, Margaret Pinder, Giorgio Sirugo, David J. Conway, Vysaul Nyirongo, David Kachala, Malcolm Molyneux, Terrie Taylor, Carolyne Ndila, Norbert Peshu, Kevin Marsh, Thomas N. Williams, Daniel Alcock, Robert Andrews, Sarah Edkins, Emma Gray, Christina Hubbart, Anna Jeffreys, Kate Rowlands, Kathrin Schuldt, Taane G. Clark, Kerrin S. Small, Yik Ying Teo, Dominic P. Kwiatkowski, Kirk A. Rockett, Jeffrey C. Barrett, Chris C. A. Spencer, Malaria Genomic Epidemiological Network ¶

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Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression

Fu-Jung Lin, Li Shen, Chuan-Wei Jang, Pål Ø. Falnes, Yi Zhang

ttm-1 Encodes CDF Transporters That Excrete Zinc from Intestinal Cells of C. elegans and Act in a Parallel Negative Feedback Circuit That Promotes Homeostasis

Hyun Cheol Roh, Sara Collier, Krupa Deshmukh, James Guthrie, J. David Robertson, Kerry Kornfeld

Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway

Gang Li, Dorothée Diogo, Di Wu, Jim Spoonamore, Vlado Dancik, Lude Franke, Fina Kurreeman, Elizabeth J. Rossin, Grant Duclos, Cathy Hartland, Xuezhong Zhou, Kejie Li, Jun Liu, Philip L. De Jager, Katherine A. Siminovitch, Alexandra Zhernakova, Soumya Raychaudhuri, John Bowes, Steve Eyre, Leonid Padyukov, Peter K. Gregersen, Jane Worthington, Rheumatoid Arthritis Consortium International (RACI), Namrata Gupta, Paul A. Clemons, Eli Stahl, Nicola Tolliday, Robert M. Plenge

High-Resolution Transcriptome Maps Reveal Strain-Specific Regulatory Features of Multiple Campylobacter jejuni Isolates

Gaurav Dugar, Alexander Herbig, Konrad U. Förstner, Nadja Heidrich, Richard Reinhardt, Kay Nieselt, Cynthia M. Sharma

Congruence of Additive and Non-Additive Effects on Gene Expression Estimated from Pedigree and SNP Data

Joseph E. Powell, Anjali K. Henders, Allan F. McRae, Jinhee Kim, Gibran Hemani, Nicholas G. Martin, Emmanouil T. Dermitzakis, Greg Gibson, Grant W. Montgomery, Peter M. Visscher

HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages

Bruna Barneda-Zahonero, Lidia Román-González, Olga Collazo, Haleh Rafati, Abul B. M. M. K. Islam, Lars H. Bussmann, Alessandro di Tullio, Luisa De Andres, Thomas Graf, Núria López-Bigas, Tokameh Mahmoudi, Maribel Parra

ATM–Dependent MiR-335 Targets CtIP and Modulates the DNA Damage Response

Nathan T. Martin, Kotoka Nakamura, Robert Davies, Shareef A. Nahas, Christina Brown, Rashmi Tunuguntla, Richard A. Gatti, Hailiang Hu

The Secretory Pathway Calcium ATPase PMR-1/SPCA1 Has Essential Roles in Cell Migration during Caenorhabditis elegans Embryonic Development

Vida Praitis, Jeffrey Simske, Sarah Kniss, Rebecca Mandt, Leah Imlay, Charlotte Feddersen, Michael B. Miller, Juliet Mushi, Walter Liszewski, Rachel Weinstein, Adityarup Chakravorty, Dae-Gon Ha, Angela Schacht Farrell, Alexander Sullivan-Wilson, Tyson Stock

Clathrin and AP2 Are Required for Phagocytic Receptor-Mediated Apoptotic Cell Clearance in Caenorhabditis elegans

Didi Chen, Youli Jian, Xuezhao Liu, Yuanya Zhang, Jingjing Liang, Xiaying Qi, Hongwei Du, Wei Zou, Lianwan Chen, Yongping Chai, Guangshuo Ou, Long Miao, Yingchun Wang, Chonglin Yang

Duplication and Retention Biases of Essential and Non-Essential Genes Revealed by Systematic Knockdown Analyses

Shane Woods, Avril Coghlan, David Rivers, Tobias Warnecke, Sean J. Jeffries, Taejoon Kwon, Anthony Rogers, Laurence D. Hurst, Julie Ahringer

Genome-Wide Analysis in German Shepherd Dogs Reveals Association of a Locus on CFA 27 with Atopic Dermatitis

Katarina Tengvall, Marcin Kierczak, Kerstin Bergvall, Mia Olsson, Marcel Frankowiack, Fabiana H. G. Farias, Gerli Pielberg, Örjan Carlborg, Tosso Leeb, Göran Andersson, Lennart Hammarström, Åke Hedhammar, Kerstin Lindblad-Toh

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The Genomic Signature of Crop-Wild Introgression in Maize

Matthew B. Hufford, Pesach Lubinksy, Tanja Pyhäjärvi, Michael T. Devengenzo, Norman C. Ellstrand, Jeffrey Ross-Ibarra

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Liver X Receptors Protect from Development of Prostatic Intra-Epithelial Neoplasia in Mice

Aurélien J. C. Pommier, Julie Dufour, Georges Alves, Emilie Viennois, Hugues De Boussac, Amalia Trousson, David H. Volle, Françoise Caira, Pierre Val, Philippe Arnaud, Jean-Marc A. Lobaccaro, Silvère Baron

A Statistical Framework for Joint eQTL Analysis in Multiple Tissues

Timothée Flutre, Xiaoquan Wen, Jonathan Pritchard, Matthew Stephens

Loss of Expression and Promoter Methylation of SLIT2 Are Associated with Sessile Serrated Adenoma Formation

Andrew D. Beggs, Angela Jones, Neil Shepherd, Abed Arnaout, Caroline Finlayson, A. Muti Abulafi, Dion G. Morton, Glenn M. Matthews, Shirley V. Hodgson, Ian P. M. Tomlinson

Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile

Olga A. Soutourina, Marc Monot, Pierre Boudry, Laure Saujet, Christophe Pichon, Odile Sismeiro, Ekaterina Semenova, Konstantin Severinov, Chantal Le Bouguenec, Jean-Yves Coppée, Bruno Dupuy, Isabelle Martin-Verstraete

Chromosome Movements Promoted by the Mitochondrial Protein SPD-3 Are Required for Homology Search during Caenorhabditis elegans Meiosis

Leticia Labrador, Consuelo Barroso, James Lightfoot, Thomas Müller-Reichert, Stephane Flibotte, Jon Taylor, Donald G. Moerman, Anne M. Villeneuve, Enrique Martinez-Perez

The Specificity and Flexibility of L1 Reverse Transcription Priming at Imperfect T-Tracts

Clément Monot, Monika Kuciak, Sébastien Viollet, Ashfaq Ali Mir, Caroline Gabus, Jean-Luc Darlix, Gaël Cristofari

The Majority of Primate-Specific Regulatory Sequences Are Derived from Transposable Elements

Pierre-Étienne Jacques, Justin Jeyakani, Guillaume Bourque

Identification of Arabidopsis Meiotic Cyclins Reveals Functional Diversification among Plant Cyclin Genes

Petra Bulankova, Svetlana Akimcheva, Nicole Fellner, Karel Riha

EGL-13/SoxD Specifies Distinct O2 and CO2 Sensory Neuron Fates in Caenorhabditis elegans

Jakob Gramstrup Petersen, Teresa Rojo Romanos, Vaida Juozaityte, Alba Redo Riveiro, Ingrid Hums, Lisa Traunmüller, Manuel Zimmer, Roger Pocock

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Wnt Signaling Regulates the Lineage Differentiation Potential of Mouse Embryonic Stem Cells through Tcf3 Down-Regulation

Yaser Atlasi, Rubina Noori, Claudia Gaspar, Patrick Franken, Andrea Sacchetti, Haleh Rafati, Tokameh Mahmoudi, Charles Decraene, George A. Calin, Bradley J. Merrill, Riccardo Fodde

Neuropeptides Function in a Homeostatic Manner to Modulate Excitation-Inhibition Imbalance in C. elegans

Tamara M. Stawicki, Seika Takayanagi-Kiya, Keming Zhou, Yishi Jin

A Compendium of Nucleosome and Transcript Profiles Reveals Determinants of Chromatin Architecture and Transcription

Harm van Bakel, Kyle Tsui, Marinella Gebbia, Sanie Mnaimneh, Timothy R. Hughes, Corey Nislow

Female Bias in Rhox6 and 9 Regulation by the Histone Demethylase KDM6A

Joel B. Berletch, Xinxian Deng, Di Kim Nguyen, Christine M. Disteche

Chromosomal Organization and Segregation in Pseudomonas aeruginosa

Isabelle Vallet-Gely, Frédéric Boccard

Distinct Translational Control in CD4+ T Cell Subsets

Eva Bjur, Ola Larsson, Ekaterina Yurchenko, Lei Zheng, Valentina Gandin, Ivan Topisirovic, Shui Li, Carston R. Wagner, Nahum Sonenberg, Ciriaco A. Piccirillo