Table of Contents: June 2008

Pictured is a confocal image of live cells from a larval gland expressing a DsRED-tagged protein loaded into secretory granules and a GFP-tagged reporter protein localized to the nucleus. For the RED cargo to be synthesized and secreted, the tissue must be exposed to two different pulses of hormone. These steroid signals are also mediated by two distinct functional receptors, only one of which was previously characterized (see Costantino et al., doi:10.1371/journal.pgen.1000102).

Image Credit: Image generated by Benjamin F. B. Costantino and Daniel K. Bricker.

Research Articles

Genetic Identification of a Network of Factors that Functionally Interact with the Nucleosome Remodeling ATPase ISWI

Giosalba Burgio, Gaspare La Rocca, Anna Sala, Walter Arancio, Dario Di Gesù, Marianna Collesano, Adam S. Sperling, Jennifer A. Armstrong, Simon J. van Heeringen, Colin Logie, John W. Tamkun, Davide F. V. Corona

Genome-Wide Analysis Reveals a Complex Pattern of Genomic Imprinting in Mice

Jason B. Wolf, James M. Cheverud, Charles Roseman, Reinmar Hager

Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression

Peng-Chieh Chen, Mari Kuraguchi, John Velasquez, Yuxun Wang, Kan Yang, Robert Edwards, Dan Gillen, Winfried Edelmann, Raju Kucherlapati, Steven M. Lipkin

Regulation and Role of Arabidopsis CUL4-DDB1A-DDB2 in Maintaining Genome Integrity upon UV Stress

Jean Molinier, Esther Lechner, Eva Dumbliauskas, Pascal Genschik

SINE RNA Induces Severe Developmental Defects in Arabidopsis thaliana and Interacts with HYL1 (DRB1), a Key Member of the DCL1 Complex

Marie-Noëlle Pouch-Pélissier, Thierry Pélissier, Taline Elmayan, Hervé Vaucheret, Drasko Boko, Michael F. Jantsch, Jean-Marc Deragon

Evaluating Statistical Methods Using Plasmode Data Sets in the Age of Massive Public Databases: An Illustration Using False Discovery Rates

Gary L. Gadbury, Qinfang Xiang, Lin Yang, Stephen Barnes, Grier P. Page, David B. Allison

A Drastic Reduction in the Life Span of Cystatin C L68Q Carriers Due to Life-Style Changes during the Last Two Centuries

Astridur Palsdottir, Agnar Helgason, Snaebjorn Palsson, Hans Tomas Bjornsson, Birkir Thor Bragason, Solveig Gretarsdottir, Unnur Thorsteinsdottir, Elias Olafsson, Kari Stefansson

An Evolutionarily Conserved Sexual Signature in the Primate Brain

Björn Reinius, Peter Saetre, Jennifer A. Leonard, Ran Blekhman, Roxana Merino-Martinez, Yoav Gilad, Elena Jazin

Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis

Aimee K. Zaas, Guochun Liao, Jason W. Chien, Clarice Weinberg, David Shore, Steven S. Giles, Kieren A. Marr, Jonathan Usuka, Lauranell H. Burch, Lalith Perera, John R. Perfect, Gary Peltz, David A. Schwartz

A Novel Ecdysone Receptor Mediates Steroid-Regulated Developmental Events during the Mid-Third Instar of Drosophila

Benjamin F. B. Costantino, Daniel K. Bricker, Kelly Alexandre, Kate Shen, John R. Merriam, Christophe Antoniewski, Jenna L. Callender, Vincent C. Henrich, Asaf Presente, Andrew J. Andres

A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chromosome 9q33.2

Monica Chang, Charles M. Rowland, Veronica E. Garcia, Steven J. Schrodi, Joseph J. Catanese, Annette H. M. van der Helm-van Mil, Kristin G. Ardlie, Christopher I. Amos, Lindsey A. Criswell, Daniel L. Kastner, Peter K. Gregersen, Fina A. S. Kurreeman, Rene E. M. Toes, Tom W. J. Huizinga, Michael F. Seldin, Ann B. Begovich

Metabolic Actions of Estrogen Receptor Beta (ERβ) are Mediated by a Negative Cross-Talk with PPARγ

Anna Foryst-Ludwig, Markus Clemenz, Stephan Hohmann, Martin Hartge, Christiane Sprang, Nikolaj Frost, Maxim Krikov, Sanjay Bhanot, Rodrigo Barros, Andrea Morani, Jan-Åke Gustafsson, Thomas Unger, Ulrich Kintscher

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

Nicole Bennardo, Anita Cheng, Nick Huang, Jeremy M. Stark

Global Mapping of DNA Methylation in Mouse Promoters Reveals Epigenetic Reprogramming of Pluripotency Genes

Cassandra R. Farthing, Gabriella Ficz, Ray Kit Ng, Chun-Fung Chan, Simon Andrews, Wendy Dean, Myriam Hemberger, Wolf Reik

Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women

Guillaume Paré, Daniel I. Chasman, Mark Kellogg, Robert Y. L. Zee, Nader Rifai, Sunita Badola, Joseph P. Miletich, Paul M. Ridker