Table of Contents: July 2018

A light microscope image of dissected Drosophila ovary where DNA (white) reveals perfectly round nurse and follicle cell nuclei of intact egg chambers in addition to bright-staining, condensed fragmented DNA from apoptotic nurse cells expressing activated caspases (red). The outline of egg surfaces is labelled by wheatgerm agglutinin (green). Predatory wasps inject their eggs into Drosophila larvae, but adult female flies can see the predator, or simply be informed by other flies exposed to wasps, and flies deprive this predator of larvae by triggering death of its own oocytes and halting egg production. See Kacsoh et al.

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Image Credit: Balint Z. Kacsoh, Geisel School of Medicine at Dartmouth

Research Articles

High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor

Tetsuji Yamashita, Fei Zheng, David Finkelstein, Zoe Kellard, Robert Carter, Celeste D. Rosencrance, Ken Sugino, John Easton, Charles Gawad, Jian Zuo

Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling

Olivia F. Duncan, Lucy Granat, Ramya Ranganathan, Vandana K. Singh, David Mazaud, Manolis Fanto, David Chambers, Clive G. Ballard, Joseph M. Bateman

The Lsm1-7/Pat1 complex binds to stress-activated mRNAs and modulates the response to hyperosmotic shock

Elena Garre, Vicent Pelechano, Manuel Sánchez del Pino, Paula Alepuz, Per Sunnerhagen

DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF

Rémy Bétous, Théo Goullet de Rugy, Alessandra Luiza Pelegrini, Sophie Queille, Jean-Pierre de Villartay, Jean-Sébastien Hoffmann

Ancestral polymorphisms explain the role of chromosomal inversions in speciation

Zachary L. Fuller, Christopher J. Leonard, Randee E. Young, Stephen W. Schaeffer, Nitin Phadnis

Relationships between estimated autozygosity and complex traits in the UK Biobank

Emma C. Johnson, Luke M. Evans, Matthew C. Keller

Small GTPase Rab7-mediated FgAtg9 trafficking is essential for autophagy-dependent development and pathogenicity in Fusarium graminearum

Huawei Zheng, Pengfei Miao, Xiaolian Lin, Lingping Li, Congxian Wu, Xiaomin Chen, Yakubu Saddeeq Abubakar, Justice Norvienyeku, Guangpu Li, Jie Zhou, Zonghua Wang, Wenhui Zheng

Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment

Laura Whitton, Galina Apostolova, Dietmar Rieder, Georg Dechant, Stephen Rea, Gary Donohoe, Derek W. Morris

Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci

Celja J. Uebel, Dorian C. Anderson, Lisa M. Mandarino, Kevin I. Manage, Stephan Aynaszyan, Carolyn M. Phillips

Evolutionary plasticity in the innate immune function of Akirin

Jolanta Polanowska, Jia-Xuan Chen, Julien Soulé, Shizue Omi, Jerome Belougne, Clara Taffoni, Nathalie Pujol, Matthias Selbach, Olivier Zugasti, Jonathan J. Ewbank

Binary addition in a living cell based on riboregulation

Arantxa Rosado, Teresa Cordero, Guillermo Rodrigo

Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis

Stephan A. Raiders, Michael D. Eastwood, Meghan Bacher, James R. Priess

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Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σV in response to lysozyme

Lincoln T. Lewerke, Paige J. Kies, Ute Müh, Craig D. Ellermeier

Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes

Yu Jiang, Sai Chen, Daniel McGuire, Fang Chen, Mengzhen Liu, William G. Iacono, John K. Hewitt, John E. Hokanson, Kenneth Krauter, Markku Laakso, Kevin W. Li, Sharon M. Lutz, Matthew McGue, Anita Pandit, Gregory J. M. Zajac, Michael Boehnke, Goncalo R. Abecasis, Scott I. Vrieze, Xiaowei Zhan, Bibo Jiang, Dajiang J. Liu

The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility

Robert K. Maeda, Jessica L. Sitnik, Yohan Frei, Elodie Prince, Dragan Gligorov, Mariana F. Wolfner, François Karch

Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster

Paola Cusumano, Alberto Biscontin, Federica Sandrelli, Gabriella M. Mazzotta, Claudia Tregnago, Cristiano De Pittà, Rodolfo Costa

Sequence features governing aggregation or degradation of prion-like proteins

Sean M. Cascarina, Kacy R. Paul, Satoshi Machihara, Eric D. Ross

Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development

Jérôme Mastio, Célestine Simand, Giovanni Cova, Philippe Kastner, Susan Chan, Peggy Kirstetter

Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth

Johanna M. Huusko, Minna K. Karjalainen, Britney E. Graham, Ge Zhang, Emily G. Farrow, Neil A. Miller, Bo Jacobsson, Haley R. Eidem, Jeffrey C. Murray, Bruce Bedell, Patrick Breheny, Noah W. Brown, Frans L. Bødker, Nadia K. Litterman, Pan-Pan Jiang, Laura Russell, David A. Hinds, Youna Hu, the 23andMe Research Team, Antonis Rokas, Kari Teramo, Kaare Christensen, Scott M. Williams, Mika Rämet, Stephen F. Kingsmore, Kelli K. Ryckman, Mikko Hallman, Louis J. Muglia

Related Articles

  1. Correction: Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth

Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability

Delphine Dardalhon-Cuménal, Jérôme Deraze, Camille A. Dupont, Valérie Ribeiro, Anne Coléno-Costes, Juliette Pouch, Stéphane Le Crom, Hélène Thomassin, Vincent Debat, Neel B. Randsholt, Frédérique Peronnet

Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex

Lucia Carolina Leal-Esteban, Benjamin Rothé, Simon Fortier, Manuela Isenschmid, Daniel B. Constam

Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus

Fabio Lino Gratani, Petra Horvatek, Tobias Geiger, Marina Borisova, Christoph Mayer, Iwan Grin, Samuel Wagner, Wieland Steinchen, Gert Bange, Ana Velic, Boris Maček, Christiane Wolz

No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice

Vivek Iyer, Katharina Boroviak, Mark Thomas, Brendan Doe, Laura Riva, Edward Ryder, David J. Adams

GROWTH-REGULATING FACTOR 9 negatively regulates arabidopsis leaf growth by controlling ORG3 and restricting cell proliferation in leaf primordia

Mohammad Amin Omidbakhshfard, Ushio Fujikura, Justyna Jadwiga Olas, Gang-Ping Xue, Salma Balazadeh, Bernd Mueller-Roeber

Discovery of a dual protease mechanism that promotes DNA damage checkpoint recovery

Peter E. Burby, Zackary W. Simmons, Jeremy W. Schroeder, Lyle A. Simmons

Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy

Caroline Choquet, Thi Hong Minh Nguyen, Pierre Sicard, Emeline Buttigieg, Thi Thom Tran, Frank Kober, Isabelle Varlet, Rachel Sturny, Mauro W. Costa, Richard P. Harvey, Catherine Nguyen, Pascal Rihet, Sylvain Richard, Monique Bernard, Robert G. Kelly, Nathalie Lalevée, Lucile Miquerol

Related Articles

  1. Correction: Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy

Genetic basis and evolution of rapid cycling in railway populations of tetraploid Arabidopsis arenosa

Pierre Baduel, Ben Hunter, Sarang Yeola, Kirsten Bomblies

mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development

Xuguang Nie, Jinxuan Zheng, Christopher L. Ricupero, Ling He, Kai Jiao, Jeremy J. Mao

rbpms2 functions in Balbiani body architecture and ovary fate

Odelya H. Kaufman, KathyAnn Lee, Manon Martin, Sophie Rothhämel, Florence L. Marlow

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  1. Correction: rbpms2 functions in Balbiani body architecture and ovary fate

Bases of antisense lncRNA-associated regulation of gene expression in fission yeast

Maxime Wery, Camille Gautier, Marc Descrimes, Mayuko Yoda, Valérie Migeot, Damien Hermand, Antonin Morillon

RES complex is associated with intron definition and required for zebrafish early embryogenesis

Juan Pablo Fernandez, Miguel Angel Moreno-Mateos, Andre Gohr, Liyun Miao, Shun Hang Chan, Manuel Irimia, Antonio J. Giraldez

Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms

Phu Van Nguyen, Otakar Hlaváček, Jana Maršíková, Libuše Váchová, Zdena Palková

RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics

Antoine Claessens, Lynne M. Harris, Slavica Stanojcic, Lia Chappell, Adam Stanton, Nada Kuk, Pamela Veneziano-Broccia, Yvon Sterkers, Julian C. Rayner, Catherine J. Merrick