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February 2017

A 4-month-old Shetland sheepdog, Lorelei, displays facial skin lesions from dermatomyositis, a chronic inflammatory myopathy and vasculopathy affecting both people and dogs. Evans et al. identified three loci that contribute to pathogenesis in dogs and 9 allelic combinations that confer high or moderate probability of disease. Lorelei's genotype (AABbCC) is high-risk; 92% of dogs having this genotypic combination showed clinical signs of dermatomyositis. See Evans et al.

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Image Credit: Lex Gatineau

Review

The analysis of translation-related gene set boosts debates around origin and evolution of mimiviruses

Jônatas Santos Abrahão, Rodrigo Araújo, Philippe Colson, Bernard La Scola

Research Articles

Differential Sensitivity of Target Genes to Translational Repression by miR-17~92

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Condition-specific RNA editing in the coral symbiont Symbiodinium microadriaticum

Yi Jin Liew, Yong Li, Sebastian Baumgarten, Christian R. Voolstra, Manuel Aranda

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Li Deng, Lingmei Li, Shuo Zhang, Jianqiang Shen, Shaobo Li, Sifan Hu, Qiang Peng, Jinghua Xiao, Changyin Wu

Kinetics of large-scale chromosomal movement during asymmetric cell division in Escherichia coli

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A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B

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Raphaël Rousset, Fabrice Carballès, Nadège Parassol, Sébastien Schaub, Delphine Cérézo, Stéphane Noselli

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Meaghen Rollins, Sylvain Huard, Alan Morettin, Jennifer Takuski, Trang Thuy Pham, Morgan D. Fullerton, Jocelyn Côté, Kristin Baetz

The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin

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