A 4-month-old Shetland sheepdog, Lorelei, displays facial skin lesions from dermatomyositis, a chronic inflammatory myopathy and vasculopathy affecting both people and dogs. Evans et al. identified three loci that contribute to pathogenesis in dogs and 9 allelic combinations that confer high or moderate probability of disease. Lorelei's genotype (AABbCC) is high-risk; 92% of dogs having this genotypic combination showed clinical signs of dermatomyositis. See Evans et al.
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Perspectives
Epistasis Analysis Goes Genome-Wide
PLOS Genetics: published February 16, 2017 | https://doi.org/10.1371/journal.pgen.1006558
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Controlling caspase activity in life and death
PLOS Genetics: published February 16, 2017 | https://doi.org/10.1371/journal.pgen.1006545
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Review
The analysis of translation-related gene set boosts debates around origin and evolution of mimiviruses
PLOS Genetics: published February 16, 2017 | https://doi.org/10.1371/journal.pgen.1006532
Research Articles
Differential Sensitivity of Target Genes to Translational Repression by miR-17~92
PLOS Genetics: published February 27, 2017 | https://doi.org/10.1371/journal.pgen.1006623
Condition-specific RNA editing in the coral symbiont Symbiodinium microadriaticum
PLOS Genetics: published February 28, 2017 | https://doi.org/10.1371/journal.pgen.1006619
Suppressor of rid1 (SID1) shares common targets with RID1 on florigen genes to initiate floral transition in rice
PLOS Genetics: published February 24, 2017 | https://doi.org/10.1371/journal.pgen.1006642
Kinetics of large-scale chromosomal movement during asymmetric cell division in Escherichia coli
PLOS Genetics: published February 24, 2017 | https://doi.org/10.1371/journal.pgen.1006638
A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B
PLOS Genetics: published February 24, 2017 | https://doi.org/10.1371/journal.pgen.1006633
Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo
PLOS Genetics: published February 23, 2017 | https://doi.org/10.1371/journal.pgen.1006640
Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae
PLOS Genetics: published February 23, 2017 | https://doi.org/10.1371/journal.pgen.1006626
The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin
PLOS Genetics: published February 23, 2017 | https://doi.org/10.1371/journal.pgen.1006606
Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas
PLOS Genetics: published February 23, 2017 | https://doi.org/10.1371/journal.pgen.1006546
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A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy
PLOS Genetics: published February 21, 2017 | https://doi.org/10.1371/journal.pgen.1006637
ANLN truncation causes a familial fatal acute respiratory distress syndrome in Dalmatian dogs
PLOS Genetics: published February 21, 2017 | https://doi.org/10.1371/journal.pgen.1006625
Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase
PLOS Genetics: published February 21, 2017 | https://doi.org/10.1371/journal.pgen.1006621
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The genetic basis of resistance and matching-allele interactions of a host-parasite system: The Daphnia magna-Pasteuria ramosa model
PLOS Genetics: published February 21, 2017 | https://doi.org/10.1371/journal.pgen.1006596
Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation
PLOS Genetics: published February 21, 2017 | https://doi.org/10.1371/journal.pgen.1006564
Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors
PLOS Genetics: published February 17, 2017 | https://doi.org/10.1371/journal.pgen.1006634
Sequencing the extrachromosomal circular mobilome reveals retrotransposon activity in plants
PLOS Genetics: published February 17, 2017 | https://doi.org/10.1371/journal.pgen.1006630
The Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system
PLOS Genetics: published February 17, 2017 | https://doi.org/10.1371/journal.pgen.1006629
JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity
PLOS Genetics: published February 16, 2017 | https://doi.org/10.1371/journal.pgen.1006632
Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA
PLOS Genetics: published February 16, 2017 | https://doi.org/10.1371/journal.pgen.1006628
Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis
PLOS Genetics: published February 16, 2017 | https://doi.org/10.1371/journal.pgen.1006627
Discovery of a new family of relaxases in Firmicutes bacteria
PLOS Genetics: published February 16, 2017 | https://doi.org/10.1371/journal.pgen.1006586
Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis
PLOS Genetics: published February 16, 2017 | https://doi.org/10.1371/journal.pgen.1006508
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An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways
PLOS Genetics: published February 16, 2017 | https://doi.org/10.1371/journal.pgen.1006438
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Genetic prediction of male pattern baldness
PLOS Genetics: published February 14, 2017 | https://doi.org/10.1371/journal.pgen.1006594
Differential paralog divergence modulates genome evolution across yeast species
PLOS Genetics: published February 14, 2017 | https://doi.org/10.1371/journal.pgen.1006585
Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7
PLOS Genetics: published February 14, 2017 | https://doi.org/10.1371/journal.pgen.1006577
Enhancer of polycomb coordinates multiple signaling pathways to promote both cyst and germline stem cell differentiation in the Drosophila adult testis
PLOS Genetics: published February 14, 2017 | https://doi.org/10.1371/journal.pgen.1006571
Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder
PLOS Genetics: published February 10, 2017 | https://doi.org/10.1371/journal.pgen.1006618
GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway
PLOS Genetics: published February 10, 2017 | https://doi.org/10.1371/journal.pgen.1006609
Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease
PLOS Genetics: published February 10, 2017 | https://doi.org/10.1371/journal.pgen.1006587
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RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides
PLOS Genetics: published February 9, 2017 | https://doi.org/10.1371/journal.pgen.1006613
ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans
PLOS Genetics: published February 9, 2017 | https://doi.org/10.1371/journal.pgen.1006611
Protecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress
PLOS Genetics: published February 9, 2017 | https://doi.org/10.1371/journal.pgen.1006603
TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo
PLOS Genetics: published February 8, 2017 | https://doi.org/10.1371/journal.pgen.1006600
A high throughput mutagenic analysis of yeast sumo structure and function
PLOS Genetics: published February 6, 2017 | https://doi.org/10.1371/journal.pgen.1006612
Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes
PLOS Genetics: published February 6, 2017 | https://doi.org/10.1371/journal.pgen.1006610
Evolutionary analysis reveals regulatory and functional landscape of coding and non-coding RNA editing
PLOS Genetics: published February 6, 2017 | https://doi.org/10.1371/journal.pgen.1006563
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Rapid turnover of DnaA at replication origin regions contributes to initiation control of DNA replication
PLOS Genetics: published February 6, 2017 | https://doi.org/10.1371/journal.pgen.1006561
The Arabidopsis bZIP11 transcription factor links low-energy signalling to auxin-mediated control of primary root growth
PLOS Genetics: published February 3, 2017 | https://doi.org/10.1371/journal.pgen.1006607
Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci
PLOS Genetics: published February 3, 2017 | https://doi.org/10.1371/journal.pgen.1006604
ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13
PLOS Genetics: published February 3, 2017 | https://doi.org/10.1371/journal.pgen.1006481
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A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3")-II, is horizontally transferred among Acinetobacter spp. by homologous recombination
PLOS Genetics: published February 2, 2017 | https://doi.org/10.1371/journal.pgen.1006602
Genomic Footprints of Selective Sweeps from Metabolic Resistance to Pyrethroids in African Malaria Vectors Are Driven by Scale up of Insecticide-Based Vector Control
PLOS Genetics: published February 2, 2017 | https://doi.org/10.1371/journal.pgen.1006539
Genome-wide exonic small interference RNA-mediated gene silencing regulates sexual reproduction in the homothallic fungus Fusarium graminearum
PLOS Genetics: published February 1, 2017 | https://doi.org/10.1371/journal.pgen.1006595
Differences in the rare variant spectrum among human populations
PLOS Genetics: published February 1, 2017 | https://doi.org/10.1371/journal.pgen.1006581