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Table of Contents

December 2015

Tremendous cellular growth is required to construct a complex dendritic arbor, and it remains unclear how membrane and protein components are transported to support a rapidly growing, polarized dendrite. Shown here is the elaborate dendritic arbor of a PVD sensory neuron in Caenorhabditis elegans. In the PVD neuron, we demonstrate that the regulation of dendritic trafficking by the small GTPase RAB-10 is necessary to pattern a complex dendritic arbor. Taylor et al.

Image Credit: Caitlin Taylor, Shen Lab, Stanford University

Editorial

PLOS Genetics Data Sharing Policy: In Pursuit of Functional Utility

Gregory S. Barsh, Gregory M. Cooper, Gregory P. Copenhaver, Greg Gibson, Mark I. McCarthy, Hua Tang, Scott M. Williams

Reviews

New Perspectives on DNA and RNA Triplexes As Effectors of Biological Activity

Albino Bacolla, Guliang Wang, Karen M. Vasquez

DNA Methylation: Insights into Human Evolution

Irene Hernando-Herraez, Raquel Garcia-Perez, Andrew J. Sharp, Tomas Marques-Bonet

The Epitranscriptome and Innate Immunity

Mary A. O’Connell, Niamh M. Mannion, Liam P. Keegan

Research Articles

Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization

Yasuhiro Yamauchi, Jonathan M. Riel, Victor Ruthig, Monika A. Ward

RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification

Aneeshkumar G. Arimbasseri, Nathan H. Blewett, James R. Iben, Tek N. Lamichhane, Vera Cherkasova, Markus Hafner, Richard J. Maraia

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Origins of De Novo Genes in Human and Chimpanzee

Jorge Ruiz-Orera, Jessica Hernandez-Rodriguez, Cristina Chiva, Eduard Sabidó, Ivanela Kondova, Ronald Bontrop, Tomàs Marqués-Bonet, M.Mar Albà

The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling

Nadja Drusenheimer, Bernhard Migdal, Sandra Jäckel, Lena Tveriakhina, Kristina Scheider, Katharina Schulz, Jieny Gröper, Karl Köhrer, Thomas Klein

Viral Transmission Dynamics at Single-Cell Resolution Reveal Transiently Immune Subpopulations Caused by a Carrier State Association

William Cenens, Angela Makumi, Sander K. Govers, Rob Lavigne, Abram Aertsen

Auxin Response Factor SlARF2 Is an Essential Component of the Regulatory Mechanism Controlling Fruit Ripening in Tomato

Yanwei Hao, Guojian Hu, Dario Breitel, Mingchun Liu, Isabelle Mila, Pierre Frasse, Yongyao Fu, Asaph Aharoni, Mondher Bouzayen, Mohamed Zouine

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Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes

Jesse R. Raab, Samuel Resnick, Terry Magnuson

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Wesley K. Thompson, Yunpeng Wang, Andrew J. Schork, Aree Witoelar, Verena Zuber, Shujing Xu, Thomas Werge, Dominic Holland, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Ole A. Andreassen, Anders M. Dale

Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin Ligase Activity through Their Coiled-Coil Domains Association

Dongqing Xu, Fang Lin, Yan Jiang, Junjie Ling, Chamari Hettiarachchi, Christian Tellgren-Roth, Magnus Holm, Ning Wei, Xing Wang Deng

Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation

Santiago Naranjo, Justin D. Smith, Carlo G. Artieri, Mian Zhang, Yiqi Zhou, Michael E. Palmer, Hunter B. Fraser

Gene Regulatory Mechanisms Underlying the Spatial and Temporal Regulation of Target-Dependent Gene Expression in Drosophila Neurons

Anthony J. E. Berndt, Jonathan C. Y. Tang, Marc S. Ridyard, Tianshun Lian, Kathleen Keatings, Douglas W. Allan

Bacterial Proliferation: Keep Dividing and Don't Mind the Gap

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Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors

Ying Xu, Futing An, Jolanta A. Borycz, Janusz Borycz, Ian A. Meinertzhagen, Tao Wang

The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size

Elizabeth J. Rideout, Marcus S. Narsaiya, Savraj S. Grewal

Origin-Dependent Inverted-Repeat Amplification: Tests of a Model for Inverted DNA Amplification

Bonita J. Brewer, Celia Payen, Sara C. Di Rienzi, Megan M. Higgins, Giang Ong, Maitreya J. Dunham, M. K. Raghuraman

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains

Brian J. Bennett, Richard C. Davis, Mete Civelek, Luz Orozco, Judy Wu, Hannah Qi, Calvin Pan, René R. Sevag Packard, Eleazar Eskin, Mujing Yan, Todd Kirchgessner, Zeneng Wang, Xinmin Li, Jill C. Gregory, Stanley L. Hazen, Peter S. Gargalovic, Aldons J. Lusis

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Rebecca K. Holmes, Alex C. Tuck, Chenchen Zhu, Hywel R. Dunn-Davies, Grzegorz Kudla, Sandra Clauder-Munster, Sander Granneman, Lars M. Steinmetz, Christine Guthrie, David Tollervey

Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s

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EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes

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Deep Reads

"Women Who Don't Give a Crap"

Holly Tabor