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Table of Contents: November 2017

Artist impression of localised lactation failure restricted to a mammary ductal branch while the remaining breast continues to lactate. Here, Oakes et al. show that mutation of Oas2 activated viral sensing within murine mammary glands and resulted in decreased milk protein synthesis, loss of proliferation, increased apoptosis and a robust interferon response. Activation of the Oas2 pathway could provide an evolutionary conserved mechanism to prevent viral transmission via milk. See Oakes et al.

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Image Credit: Dr. Samantha R. Oakes. Pencil on paper.

Review

The evolution and adaptation of A-to-I RNA editing

Arielle L. Yablonovitch, Patricia Deng, Dionna Jacobson, Jin Billy Li

Research Articles

A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations

Xiaolin Zhu, Raghavendra Padmanabhan, Brett Copeland, Joshua Bridgers, Zhong Ren, Sitharthan Kamalakaran, Ailbhe O'Driscoll-Collins, Samuel F. Berkovic, Ingrid E. Scheffer, Annapurna Poduri, Davide Mei, Renzo Guerrini, Daniel H. Lowenstein, Andrew S. Allen, Erin L. Heinzen, David B. Goldstein

Rv0004 is a new essential member of the mycobacterial DNA replication machinery

Katherine M. Mann, Deborah L. Huang, Anna J. Hooppaw, Michelle M. Logsdon, Kirill Richardson, Hark Joon Lee, Jacqueline M. Kimmey, Bree B. Aldridge, Christina L. Stallings

Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases

Zarko Manojlovic, Austin Christofferson, Winnie S. Liang, Jessica Aldrich, Megan Washington, Shukmei Wong, Daniel Rohrer, Scott Jewell, Rick A. Kittles, Mary Derome, Daniel Auclair, David Wesley Craig, Jonathan Keats, John D. Carpten

How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects

Christopher H. Chandler, Sudarshan Chari, Alycia Kowalski, Lin Choi, David Tack, Michael DeNieu, William Pitchers, Anne Sonnenschein, Leslie Marvin, Kristen Hummel, Christian Marier, Andrew Victory, Cody Porter, Anna Mammel, Julie Holms, Gayatri Sivaratnam, Ian Dworkin

mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay

Jennifer L. Anderson, Timothy S. Mulligan, Meng-Chieh Shen, Hui Wang, Catherine M. Scahill, Frederick J. Tan, Shao J. Du, Elisabeth M. Busch-Nentwich, Steven A. Farber

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A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation

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