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Table of Contents: April 2014

Streptococcus pneumoniae cells display an ovoid shape due to the coordinated synthesis of septal (for division) and peripheral (for elongation) peptidoglycan. Upon deletion of the gpsB gene, we show that cells aberrantly elongate together with hampered cell division. We have used this mutant as a trick to further decipher how the pneumococcus manages cell elongation before constriction and separation. We notably observe that elongated cells display a FtsZ helical organization. Together with other observations, we propose that a single peptidoglycan synthesis machinery organized by FtsZ is finely tuned to allow successful division and elongation of pneumococcal cells. See Fleurie et al.

Image Credit: Aurore Fleurie, Bases Moléculaires et Structurales des Systèmes Infectieux, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon I, France.

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