Y chromosome labelling in mitotic chromosomes from Anopheles gambiae testis. In this image, two Anopheles gambiae Y-linked satellite elements, AgY53B (Green) and AgY53A (Red), have been stained using DNA FISH on male gonial cell metaphase chromosomes. The CRISPR/Cas9 system was used to specifically target the satellite AgY53B during male meiosis, causing extensive damage to the Y chromosome. This damage results in Y-bearing sperm being unable to fertilize eggs while X-bearing sperm remain intact and viable. As a result, a strong bias toward female offspring is observed in the progeny of transgenic males. See Vitale et al. Download June’s cover page.
Image Credit: Matteo Vitale
Research Articles
The conserved σD envelope stress response monitors multiple aspects of envelope integrity in corynebacteria
PLOS Genetics: published June 3, 2024 | https://doi.org/10.1371/journal.pgen.1011127
Myeloid Targeted Human MLL-ENL and MLL-AF9 Induces cdk9 and bcl2 Expression in Zebrafish Embryos
PLOS Genetics: published June 3, 2024 | https://doi.org/10.1371/journal.pgen.1011308
Conserved signalling functions for Mps1, Mad1 and Mad2 in the Cryptococcus neoformans spindle checkpoint
PLOS Genetics: published June 3, 2024 | https://doi.org/10.1371/journal.pgen.1011302
A systematic screen identifies Saf5 as a link between splicing and transcription in fission yeast
PLOS Genetics: published June 4, 2024 | https://doi.org/10.1371/journal.pgen.1011316
Long-term evolution of Streptococcus mitis and Streptococcus pneumoniae leads to higher genetic diversity within rather than between human populations
PLOS Genetics: published June 6, 2024 | https://doi.org/10.1371/journal.pgen.1011317
Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter
PLOS Genetics: published June 7, 2024 | https://doi.org/10.1371/journal.pgen.1011303
An eQTL-based approach reveals candidate regulators of LINE-1 RNA levels in lymphoblastoid cells
PLOS Genetics: published June 7, 2024 | https://doi.org/10.1371/journal.pgen.1011311
CRISPRi screen of long non-coding RNAs identifies LINC03045 regulating glioblastoma invasion
PLOS Genetics: published June 10, 2024 | https://doi.org/10.1371/journal.pgen.1011314
Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement
PLOS Genetics: published June 10, 2024 | https://doi.org/10.1371/journal.pgen.1011326
Growth deficiency in a mouse model of Kabuki syndrome 2 bears mechanistic similarities to Kabuki syndrome 1
PLOS Genetics: published June 10, 2024 | https://doi.org/10.1371/journal.pgen.1011310
Cross-regulation and cross-talk of conserved and accessory two-component regulatory systems orchestrate Pseudomonas copper resistance
PLOS Genetics: published June 11, 2024 | https://doi.org/10.1371/journal.pgen.1011325
Co-transcriptional splicing facilitates transcription of gigantic genes
PLOS Genetics: published June 13, 2024 | https://doi.org/10.1371/journal.pgen.1011241
Single-step generation of homozygous knockout/knock-in individuals in an extremotolerant parthenogenetic tardigrade using DIPA-CRISPR
PLOS Genetics: published June 13, 2024 | https://doi.org/10.1371/journal.pgen.1011298
History of tuberculosis disease is associated with genetic regulatory variation in Peruvians
PLOS Genetics: published June 13, 2024 | https://doi.org/10.1371/journal.pgen.1011313
TGF-β ligand cross-subfamily interactions in the response of Caenorhabditis elegans to a bacterial pathogen
PLOS Genetics: published June 14, 2024 | https://doi.org/10.1371/journal.pgen.1011324
Interplay between Pitx2 and Pax7 temporally governs specification of extraocular muscle stem cells
PLOS Genetics: published June 14, 2024 | https://doi.org/10.1371/journal.pgen.1010935
Escherichia coli adaptation under prolonged resource exhaustion is characterized by extreme parallelism and frequent historical contingency
PLOS Genetics: published June 17, 2024 | https://doi.org/10.1371/journal.pgen.1011333
Single-cell analysis identifies PLK1 as a driver of immunosuppressive tumor microenvironment in LUAD
PLOS Genetics: published June 17, 2024 | https://doi.org/10.1371/journal.pgen.1011309
An endothelial regulatory module links blood pressure regulation with elite athletic performance
PLOS Genetics: published June 17, 2024 | https://doi.org/10.1371/journal.pgen.1011285
Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum
PLOS Genetics: published June 17, 2024 | https://doi.org/10.1371/journal.pgen.1011162
Wild Patagonian yeast improve the evolutionary potential of novel interspecific hybrid strains for lager brewing
PLOS Genetics: published June 20, 2024 | https://doi.org/10.1371/journal.pgen.1011154
Filamin protects myofibrils from contractile damage through changes in its mechanosensory region
PLOS Genetics: published June 21, 2024 | https://doi.org/10.1371/journal.pgen.1011101
Genetic evidence for functional diversification of gram-negative intermembrane phospholipid transporters
PLOS Genetics: published June 24, 2024 | https://doi.org/10.1371/journal.pgen.1011335
Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species
PLOS Genetics: published June 24, 2024 | https://doi.org/10.1371/journal.pgen.1011329