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Table of Contents

November 2019

LPS structural difference between European and East-Asian H. pylori strains. LPS in European H. pylori strains (blue) usually harbors an intermediate heptan and glucan, whereas East-Asian strains (red) synthesize heptan-deficient LPS. It is worth pondering whether the heptan is acquired in European strains or lost in East-Asian strains during human migration out of Africa. See Li et al.

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Image Credit: Hong Li

Reviews

The joy of balancers

Danny E. Miller, Kevin R. Cook, R. Scott Hawley

Mouse protein coding diversity: What’s left to discover?

Jingtao Lilue, Anu Shivalikanjli, David J. Adams, Thomas M. Keane

Research Articles

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes

Anaïs Darracq, Helen Pak, Vincent Bourgoin, Farah Zmiri, Graham Dellaire, El Bachir Affar, Eric Milot

UMAP reveals cryptic population structure and phenotype heterogeneity in large genomic cohorts

Alex Diaz-Papkovich, Luke Anderson-Trocmé, Chief Ben-Eghan, Simon Gravel

Genomic dissection of an extended phenotype: Oak galling by a cynipid gall wasp

Jack Hearn, Mark Blaxter, Karsten Schönrogge, José-Luis Nieves-Aldrey, Juli Pujade-Villar, Elisabeth Huguet, Jean-Michel Drezen, Joseph D. Shorthouse, Graham N. Stone

Systems genomics approaches provide new insights into Arabidopsis thaliana root growth regulation under combinatorial mineral nutrient limitation

Nadia Bouain, Arthur Korte, Santosh B. Satbhai, Hye-In Nam, Seung Y. Rhee, Wolfgang Busch, Hatem Rouached

Chromatin dynamics enable transcriptional rhythms in the cnidarian Nematostella vectensis

Eviatar N. Weizman, Miriam Tannenbaum, Ann M. Tarrant, Ofir Hakim, Oren Levy

A circadian output center controlling feeding:fasting rhythms in Drosophila

Austin P. Dreyer, Madison M. Martin, Carson V. Fulgham, Daniel A. Jabr, Lei Bai, Jennifer Beshel, Daniel J. Cavanaugh

Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice

Rena M. Schweizer, Jonathan P. Velotta, Catherine M. Ivy, Matthew R. Jones, Sarah M. Muir, Gideon S. Bradburd, Jay F. Storz, Graham R. Scott, Zachary A. Cheviron

The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries)

Alexandra M. Sparks, Kathryn Watt, Rona Sinclair, Jill G. Pilkington, Josephine M. Pemberton, Tom N. McNeilly, Daniel H. Nussey, Susan E. Johnston

Role of α-Catenin and its mechanosensing properties in regulating Hippo/YAP-dependent tissue growth

Ritu Sarpal, Victoria Yan, Lidia Kazakova, Luka Sheppard, Jessica C. Yu, Rodrigo Fernandez-Gonzalez, Ulrich Tepass

Linking high GC content to the repair of double strand breaks in prokaryotic genomes

Jake L. Weissman, William F. Fagan, Philip L. F. Johnson

Microbial phenotypic heterogeneity in response to a metabolic toxin: Continuous, dynamically shifting distribution of formaldehyde tolerance in Methylobacterium extorquens populations

Jessica A. Lee, Siavash Riazi, Shahla Nemati, Jannell V. Bazurto, Andreas E. Vasdekis, Benjamin J. Ridenhour, Christopher H. Remien, Christopher J. Marx

Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania

Megan A. Sloan, Karen Brooks, Thomas D. Otto, Mandy J. Sanders, James A. Cotton, Petros Ligoxygakis

Genome-wide identification of short 2′,3′-cyclic phosphate-containing RNAs and their regulation in aging

Megumi Shigematsu, Keisuke Morichika, Takuya Kawamura, Shozo Honda, Yohei Kirino

Cardiac Snail family of transcription factors directs systemic lipid metabolism in Drosophila

Ying Liu, Hong Bao, Weidong Wang, Hui-Ying Lim

Inference of recombination maps from a single pair of genomes and its application to ancient samples

Gustavo V. Barroso, Nataša Puzović, Julien Y. Dutheil

Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants

John Snedeker, William J. Gibbons Jr., David F. Paulding, Zakia Abdelhamed, Daniel R. Prows, Rolf W. Stottmann

Contribution of Common Genetic Variants to Familial Aggregation of Disease and Implications for Sequencing Studies

Andrew Schlafly, Ruth M. Pfeiffer, Eduardo Nagore, Susana Puig, Donato Calista, Paola Ghiorzo, Chiara Menin, Maria Concetta Fargnoli, Ketty Peris, Lei Song, Tongwu Zhang, Jianxin Shi, Maria Teresa Landi, Joshua Neil Sampson

A meta-analysis of genome-wide association studies of epigenetic age acceleration

Jude Gibson, Tom C. Russ, Toni-Kim Clarke, David M. Howard, Robert F. Hillary, Kathryn L. Evans, Rosie M. Walker, Mairead L. Bermingham, Stewart W. Morris, Archie Campbell, Caroline Hayward, Alison D. Murray, David J. Porteous, Steve Horvath, Ake T. Lu, Andrew M. McIntosh, Heather C. Whalley, Riccardo E. Marioni

CRL4 regulates recombination and synaptonemal complex aggregation in the Caenorhabditis elegans germline

Benjamin Alleva, Sean Clausen, Emily Koury, Adam Hefel, Sarit Smolikove

Photodamage repair pathways contribute to the accurate maintenance of the DNA methylome landscape upon UV exposure

Stéfanie Graindorge, Valérie Cognat, Philippe Johann to Berens, Jérôme Mutterer, Jean Molinier

East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide

Hong Li, Michael Marceau, Tiandi Yang, Tingting Liao, Xiaoqiong Tang, Renwei Hu, Yan Xie, Hong Tang, Alfred Tay, Ying Shi, Yalin Shen, Tiankuo Yang, Xuenan Pi, Binit Lamichhane, Yong Luo, Aleksandra W. Debowski, Hans-Olof Nilsson, Stuart M. Haslam, Barbara Mulloy, Anne Dell, Keith A. Stubbs, Barry J. Marshall, Mohammed Benghezal

Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation

Raymond T. Suhandynata, Yun Quan, Yusheng Yang, Wei-Tsung Yuan, Claudio P. Albuquerque, Huilin Zhou

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

Mihail Halachev, Alison Meynert, Martin S. Taylor, Veronique Vitart, Shona M. Kerr, Lucija Klaric, S. G. P. Consortium, Timothy J. Aitman, Chris S. Haley, James G. Prendergast, Carys Pugh, David A. Hume, Sarah E. Harris, David C. Liewald, Ian J. Deary, Colin A. Semple, James F. Wilson

The impact of genetic adaptation on chimpanzee subspecies differentiation

Joshua M. Schmidt, Marc de Manuel, Tomas Marques-Bonet, Sergi Castellano, Aida M. Andrés

STK-12 acts as a transcriptional brake to control the expression of cellulase-encoding genes in Neurospora crassa

Liangcai Lin, Shanshan Wang, Xiaolin Li, Qun He, J. Philipp Benz, Chaoguang Tian

Availability of splicing factors in the nucleoplasm can regulate the release of mRNA from the gene after transcription

Hodaya Hochberg-Laufer, Noa Neufeld, Yehuda Brody, Shani Nadav-Eliyahu, Rakefet Ben-Yishay, Yaron Shav-Tal

Correction

Correction: Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans

Yang Zhou, Yan Qin, Yingying Qin, Binyang Xu, Ting Guo, Hanni Ke, Min Chen, Lianjun Zhang, Feng Han, Yaqiong Li, Min Chen, Axel Behrens, Yaqing Wang, Zhiheng Xu, Zi-Jiang Chen, Fei Gao

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