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Table of Contents

September 2026

Years-based measures compress distinct educational credentials into a single numerical scale. The schematic contrasts a single-liability model of attainment (left) with transition-specific liability models at successive milestones (right). Each later transition is studied only among people who reached the preceding milestone, highlighting how prior selection shapes the comparison groups used to estimate genetic associations. Kvalvik et al. 2026

Image Credit: Eirik H. Kvalvik

Research Articles

Abdominal-B regulates the male seminal fluid transferome and new fecundity factors required for sperm sex peptide binding

Kathrin Steck, Lina Verbakel, Peter Kerwin, Vladimir Trajanovikj, Katarzyna Kjøge, Jan J. Enghild, Anne C. von Philipsborn

Characterization of METTL3/14-mediated m6A modification in human transcriptome using Nanopore direct RNA sequencing

Emily Kurtyan, Andrew J. Stein, Kelly J. Abdalla, Zhangerjiao Yuan, Miten Jain, Fadia Ibrahim

Multi-organ single-cell transcriptomic atlas identifies QrIAA14 as a candidate negative regulator of adventitious root development in Quercus robur

Wenkai Hui, Jiayue Li, Hao Li, Hongyi Wu, Yi He, Shuangying Yang, Xiong Huang, Hanbo Yang, Gang Chen, Peng Zhu, Xiaohong Chen, Xingcui Xiao, Yu Zhong, Zhenfeng Xu, Fang He

The SigD regulon of Mycobacterium abscessus determines cell envelope composition and antibiotic susceptibility

Sean R. Jones, Kelly Maune, Kelley Hurst-Hess, Pallavi Ghosh

OsDUF1223 negatively regulates seedling drought tolerance and modulates nitrate-dependent root growth in rice

Xiulin Zhao, Ziyi Wang, Mingfei Chen, Lingxiang Lu, Hui Lin, Xiaofei Zan, Xiaomei Jia, Xiaoying Ye, Rongjun Chen, Jianqing Zhu, Jun Zhu, Lihua Li

ER-to-Golgi transport machinery promotes the excessive cargo-triggered unfolded protein response in C. elegans

Liying Guan, Tong Zhang, Zhigao Zhan, Yingchun Wang, Xun Huang, Mei Ding

FM-GPT: Bayesian fine mapping for phenome-wide transcriptome-wide association studies

Travis Canida, Zhenyao Ye, Shao-Hsuan Wang, Hsin-Hsiung Huang, Yezhi Pan, Menglu Liang, Shuo Chen, Tianzhou Ma

Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments

Marina M. Watowich, Rachel M. Petersen, Layla Brassington, Audrey M. Arner, Grace Rodenberg, Tan Bee Ting A/P Tan Boon Huat, Kar Lye Tam, Em Schellenberg, Izandis bin Mohd Sayed, Echwa John, John C. Kahumbu, Benjamin Muhoya, Michael Gurven, Benjamin C. Trumble, Sospeter Ngoci Njeru, Dino Martins, Julien F. Ayroles, Yvonne A. L. Lim, Vivek V. Venkataraman, Ian J. Wallace, Thomas S. Kraft, Amanda J. Lea

The highly heterozygous European amphioxus (Branchiostoma lanceolatum) at the edge of panmixia

Marina Brasó-Vives, Diego A. Hartasánchez, Angélica Pulido, Stéphanie Bertrand, Hector Escriva, Marc Robinson-Rechavi

Fission yeast RPA–TERT–Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination

Bettina A. Moser, Madeline Points, Sourav Agrawal, Adam C. Didier, Amanda K. Mennie, Ci Ji Lim, Yong-jie Xu, Toru M. Nakamura

Development of a low-coverage whole genome sequencing screen for apomixis using a diverse set of Malus germplasm

Charity Z. Goeckeritz, Václav Polcar, Benjamin Gutierrez, Tomáš Urfus, Alex Harkess

Life in sediments fosters ‘sexual’ speciation in the Shewanella baltica complex

Víctor Fernández-Juárez, Francisco Salvà-Serra, Guillem Seguí, Alberto J. Martín-Rodríguez

Assessing Hardy-Weinberg equilibrium in T2T-aligned 1000 genomes project

Elika Garg, Jaffa Romain, Lei Sun, Andrew D. Paterson

Beyond years of schooling: Genetic associations across educational milestones in two Norwegian cohorts

Eirik Haugland Kvalvik, Yunpeng Wang, Kristine Beate Walhovd, Torkild Hovde Lyngstad, Ole Røgeberg

Arginine Kinase 1 supports energy homeostasis in Drosophila flight muscle development

Maria Paula Zappia, Anton Westacott, Hannah Cooke, Rhianna Geary, Libby Travers, Lucia de Castro, Oliver Carty, Maxim V. Frolov

Identifying shared polygenic risk across cancers

Jiaqi Hu, Maiyier Muheyati, Leqi Xu, Andrew DeWan, Hongyu Zhao

Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition

Chaitali Khan, Nasser M. Rusan, Nicholas E. Baker

Prenatal consequences of GALT deficiency in a rat model of classic galactosemia

Shauna A. Rasmussen, Catherine M. Lemons, Madelyn M. Seemiller, Sabrina R. Dallas, Milan Cambon Ledesma, Yuhan Wu, Lauren E. Anshen, Ashlyn Farnham, Olivia S. Garrett, Judith L. Fridovich-Keil

METTL1-mediated m7G modification regulates hair follicle cycle via the HOXC13/FOXN1/DSG4 axis

Xinyan Gan, Qiwen Li, Qiuchan Xiong, Denghao Huang, Zizheng Liu, Qi Yin, Shuang Jiang, Takuma Matsubara, Shoichiro Kokabu, Wei Yan, Quan Yuan

Univariate-guided sparse regression for Biobank-scale high-dimensional omics data

Joshua Richland, Tuomo Kiiskinen, William Wang, Wenhui Sophia Lu, Balasubramanian Narasimhan, Trevor Hastie, Manuel Rivas, Robert Tibshirani

Role of the m6A methyltransferase Mettl16 in Drosophila development

Penghui Song, Lijuan Ma, Dong Yan

The SynMuvA lin-15A licenses natural transdifferentiation by antagonizing identity safeguarding mechanisms

Sarah Frieda Becker, Marie-Charlotte Morin, Julien Lambert, Shashi Kumar Suman, Francesco Nicola Carelli, Alex Appert, Stéphane Roth, Sarah Hoff-Yoessle, Jessica D. Medina-Sanchez, Manuela Portoso, Julie Ahringer, Sophie Jarriault

Genome wide transcriptional changes underlie gradual and recurrent adaptation to protein malnutrition in zebrafish

Siyao Wang, Laura Childers, Fernando Martinez III, Michel Bagnat, Jieun Park

Altered regulation of septal peptidoglycan synthesis modulates β-lactam susceptibility in Pseudomonas aeruginosa

Jake Colautti, Alexander C. Anderson, Wyatt P. K. Clark, Lindsey S. Marmont

The prevalence of protein misfolding as a mechanism for hereditary deafness

Rose A. Gogal, Genevieve M. Cox, Diana L. Kolbe, Amanda M. Odell, Chloe E. Ovel, Katherine I. McCormick, Brian Hong, Hela Azaiez, Thomas L. Casavant, Richard J. H. Smith, Terry A. Braun, Michael J. Schnieders

Immune markers mediate genetic relationships between immune diseases and psychiatric disorders

Sophie Breunig, Kristen M. Kelly, Lukas S. Schaffer, Jeremy M. Lawrence, Younga Heather Lee, Elizabeth W. Karlson, Andrew D. Grotzinger