3D rendering of a live fruit fly larva launching an immune response to bacterial infection. Green is a fluorescent reporter of an antimicrobial peptide called Diptericin. Magenta marks the nuclei of fat body cells, which produce large quantities of antimicrobial peptides in response to infection. Here, the response is spatially heterogeneous, with a small subset of cells (left region, which is the anterior fat body) producing most of the response. Image was taken with light sheet fluorescent microscopy. Schlomann et al. 2026
Image Credit: Brandon Schlomann
Research Articles
The regenerative period of somatosensory nerves is closed by a DCC signaling axis
PLOS Genetics: published February 2, 2026 | https://doi.org/10.1371/journal.pgen.1012033
Using TraDIS as a complementary approach to long term evolution for mapping adaptive mutations in Escherichia coli
PLOS Genetics: published February 2, 2026 | https://doi.org/10.1371/journal.pgen.1011860
Rare heterozygous missense variants in VSX2 are associated with retinal detachment
PLOS Genetics: published February 3, 2026 | https://doi.org/10.1371/journal.pgen.1012027
Spatial microenvironments tune immune response dynamics in the Drosophila larval fat body
PLOS Genetics: published February 3, 2026 | https://doi.org/10.1371/journal.pgen.1012029
High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification
PLOS Genetics: published February 5, 2026 | https://doi.org/10.1371/journal.pgen.1012038
An essential gene screening identifies yeast Mot1 as a suppressor of R-loops and genome instability
PLOS Genetics: published February 9, 2026 | https://doi.org/10.1371/journal.pgen.1012040
Spatially distinct FRL and Ena dependent actin networks coordinate nuclear positioning in Drosophila nurse cells
PLOS Genetics: published February 9, 2026 | https://doi.org/10.1371/journal.pgen.1012042
A machine learning classifier to identify and prioritise genes associated with murine cardiac development
PLOS Genetics: published February 10, 2026 | https://doi.org/10.1371/journal.pgen.1011489
The rewiring of a terminal selector regulatory cascade generates convergent neuronal laterality
PLOS Genetics: published February 11, 2026 | https://doi.org/10.1371/journal.pgen.1011782
Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates Mycobacterium tuberculosis response to nitric oxide stress
PLOS Genetics: published February 12, 2026 | https://doi.org/10.1371/journal.pgen.1012043
Genetic dissection of signalling pathways that mediate iron-related tumor growth in a Drosophila model
PLOS Genetics: published February 13, 2026 | https://doi.org/10.1371/journal.pgen.1012017
PIKI-1, a class II PI 3-kinase, functions in endocytic trafficking
PLOS Genetics: published February 13, 2026 | https://doi.org/10.1371/journal.pgen.1011740
Hsp90 buffers behavioral variability by regulating Pdf transcription in clock neurons of Drosophila melanogaster
PLOS Genetics: published February 17, 2026 | https://doi.org/10.1371/journal.pgen.1012044
Octopamine signaling from clock neurons plays dual roles in Drosophila long-term memory
PLOS Genetics: published February 17, 2026 | https://doi.org/10.1371/journal.pgen.1012045
Cholinergic signaling modulates intestinal pathophysiology in a Drosophila model of cystic fibrosis
PLOS Genetics: published February 17, 2026 | https://doi.org/10.1371/journal.pgen.1012048
Regulatory rewiring drives intraspecies competition in Bacillus subtilis
PLOS Genetics: published February 17, 2026 | https://doi.org/10.1371/journal.pgen.1012050
Genetic underpinnings of chills from art and music
PLOS Genetics: published February 18, 2026 | https://doi.org/10.1371/journal.pgen.1012002
Loss of DNA mismatch repair genes leads to acquisition of antibiotic resistance independent of secondary mutations
PLOS Genetics: published February 20, 2026 | https://doi.org/10.1371/journal.pgen.1012057
Protein-interaction network analysis reveals the role of Prp19 splicing factor in transcription of both intron-containing and intron-lacking genes
PLOS Genetics: published February 20, 2026 | https://doi.org/10.1371/journal.pgen.1012051
The RPA-binding domain and the KKRK motif in Rad26ATRIP cooperate at the perturbed DNA replication fork for initiating checkpoint signalling
PLOS Genetics: published February 23, 2026 | https://doi.org/10.1371/journal.pgen.1012052
Combined mutations of hoxa13a, hoxa13b, and hoxd13a lead to structural shifts in zebrafish soft fin rays providing insight into spiny ray evolution
PLOS Genetics: published February 25, 2026 | https://doi.org/10.1371/journal.pgen.1012055
Expanding the fly eye gene regulatory network: From Drosophila to the hoverfly Episyrphus balteatus
PLOS Genetics: published February 26, 2026 | https://doi.org/10.1371/journal.pgen.1011864
Aneuploidy alleviates the cell proliferation defect caused by mutations affecting origin licensing in Saccharomyces cerevisiae
PLOS Genetics: published February 27, 2026 | https://doi.org/10.1371/journal.pgen.1012063
Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies
PLOS Genetics: published February 27, 2026 | https://doi.org/10.1371/journal.pgen.1012037
Corrections
Correction: Lack of ANKMY2 suppresses kidney cystogenesis in embryonic- and adult-onset polycystic kidney disease
PLOS Genetics: published February 17, 2026 | https://doi.org/10.1371/journal.pgen.1012049
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Correction: DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma
PLOS Genetics: published February 26, 2026 | https://doi.org/10.1371/journal.pgen.1012054