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Table of Contents

April 2022

Dorsal view of a Drosophila larval brain stained for mitotic chromatin (magenta) and the neuronal marker Prospero (orange). Asymmetrically dividing stem cells expressing the Deadpan protein (cyan) are located within Prospero-positive regions in the central part of the brain and in the ventral ganglion. See Gallaud et al.

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Image Credit: Emmanuel Gallaud (image analysis) and Régis Giet (data acquisition).

Research Articles

Heteroplasmic mitochondrial DNA variants in cardiovascular diseases

Claudia Calabrese, Angela Pyle, Helen Griffin, Jonathan Coxhead, Rafiqul Hussain, Peter S Braund, Linxin Li, Annette Burgess, Patricia B Munroe, Louis Little, Helen R Warren, Claudia Cabrera, Alistair Hall, Mark J Caulfield, Peter M Rothwell, Nilesh J Samani, Gavin Hudson, Patrick F. Chinnery

Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose

Anna N. Senko, Rupert W. Overall, Jan Silhavy, Petr Mlejnek, Hana Malínská, Martina Hüttl, Irena Marková, Klaus S. Fabel, Lu Lu, Ales Stuchlik, Robert W. Williams, Michal Pravenec, Gerd Kempermann

Reassembling a cannon in the DNA defense arsenal: Genetics of StySA, a BREX phage exclusion system in Salmonella lab strains

Julie Zaworski, Oyut Dagva, Julius Brandt, Chloé Baum, Laurence Ettwiller, Alexey Fomenkov, Elisabeth A. Raleigh

The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number

Jyoti Iyer, Lindsey K. Gentry, Mary Bergwell, Amy Smith, Sarah Guagliardo, Peter A. Kropp, Prabhu Sankaralingam, Yan Liu, Eric Spooner, Bruce Bowerman, Kevin F. O’Connell

The spindle assembly checkpoint and the spatial activation of Polo kinase determine the duration of cell division and prevent tumor formation

Emmanuel Gallaud, Laurent Richard-Parpaillon, Laetitia Bataillé, Aude Pascal, Mathieu Métivier, Vincent Archambault, Régis Giet

Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index

Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V. Khera, John Danesh, Philippe Frossard, Danish Saleheen

Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study

Yurong Cheng, Yong Li, Nora Scherer, Franziska Grundner-Culemann, Terho Lehtimäki, Binisha H. Mishra, Olli T. Raitakari, Matthias Nauck, Kai-Uwe Eckardt, Peggy Sekula, Ulla T. Schultheiss, on behalf of the GCKD investigators

Aneuploidy influences the gene expression profiles in Saccharomyces pastorianus group I and II strains during fermentation

Roberto de la Cerda Garcia-Caro, Karsten Hokamp, Fiona Roche, Georgia Thompson, Soukaina Timouma, Daniela Delneri, Ursula Bond

Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration

Yanying Huo, Akshada Sawant, Yongmei Tan, Amar H Mahdi, Tao Li, Hui Ma, Vrushank Bhatt, Run Yan, Jake Coleman, Cheryl F Dreyfus, Jessie Yanxiang Guo, M. Maral Mouradian, Eileen White, Bing Xia

TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice

Hui-Yuan Wu, Yongqi Rong, Parmil K. Bansal, Peng Wei, Hong Guo, James I. Morgan

Filling gaps in bacterial catabolic pathways with computation and high-throughput genetics

Morgan N. Price, Adam M. Deutschbauer, Adam P. Arkin

The C-terminal domain of Hsp70 is responsible for paralog-specific regulation of ribonucleotide reductase

Laura E. Knighton, Nitika, Siddhi Omkar, Andrew W. Truman

Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross

Kristin Scoggin, Rachel Lynch, Jyotsana Gupta, Aravindh Nagarajan, Maxwell Sheffield, Ahmed Elsaadi, Christopher Bowden, Manuchehr Aminian, Amy Peterson, L. Garry Adams, Michael Kirby, David W. Threadgill, Helene L. Andrews-Polymenis

Abnormal global alternative RNA splicing in COVID-19 patients

Changli Wang, Lijun Chen, Yaobin Chen, Wenwen Jia, Xunhui Cai, Yufeng Liu, Fenghu Ji, Peng Xiong, Anyi Liang, Ren Liu, Yuanlin Guan, Zhongyi Cheng, Yejing Weng, Weixin Wang, Yaqi Duan, Dong Kuang, Sanpeng Xu, Hanghang Cai, Qin Xia, Dehua Yang, Ming-Wei Wang, Xiangping Yang, Jianjun Zhang, Chao Cheng, Liang Liu, Zhongmin Liu, Ren Liang, Guopin Wang, Zhendong Li, Han Xia, Tian Xia

Ubiquitin ligase activity inhibits Cdk5 to control axon termination

Muriel Desbois, Karla J. Opperman, Jonathan Amezquita, Gabriel Gaglio, Oliver Crawley, Brock Grill

A locus conferring tolerance to Theileria infection in African cattle

David Wragg, Elizabeth A. J. Cook, Perle Latré de Laté, Tatjana Sitt, Johanneke D. Hemmink, Maurine C. Chepkwony, Regina Njeru, E. Jane Poole, Jessica Powell, Edith A. Paxton, Rebecca Callaby, Andrea Talenti, Antoinette A. Miyunga, Gideon Ndambuki, Stephen Mwaura, Harriet Auty, Oswald Matika, Musa Hassan, Karen Marshall, Timothy Connelley, Liam J. Morrison, B. Mark deC. Bronsvoort, W. Ivan Morrison, Philip G. Toye, James G. D. Prendergast

Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer

Nejla Ozirmak Lermi, Stanton B. Gray, Charles M. Bowen, Laura Reyes-Uribe, Beth K. Dray, Nan Deng, R. Alan Harris, Muthuswamy Raveendran, Fernando Benavides, Carolyn L. Hodo, Melissa W. Taggart, Karen Colbert Maresso, Krishna M. Sinha, Jeffrey Rogers, Eduardo Vilar

Regulation of Mus81-Eme1 structure-specific endonuclease by Eme1 SUMO-binding and Rad3ATR kinase is essential in the absence of Rqh1BLM helicase

Cédric Giaccherini, Sarah Scaglione, Stéphane Coulon, Pierre-Marie Dehé, Pierre-Henri L. Gaillard

MiR172-APETALA2-like genes integrate vernalization and plant age to control flowering time in wheat

Juan M. Debernardi, Daniel P. Woods, Kun Li, Chengxia Li, Jorge Dubcovsky

Patagonian sheepdog: Genomic analyses trace the footprints of extinct UK herding dogs to South America

Natasha Barrios, César González-Lagos, Dayna L. Dreger, Heidi G. Parker, Guillermo Nourdin-Galindo, Andrew N. Hogan, Marcelo A. Gómez, Elaine A. Ostrander

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

Anurag Verma, Noah L. Tsao, Lauren O. Thomann, Yuk-Lam Ho, Sudha K. Iyengar, Shiuh-Wen Luoh, Rotonya Carr, Dana C. Crawford, Jimmy T. Efird, Jennifer E. Huffman, Adriana Hung, Kerry L. Ivey, Michael G. Levin, Julie Lynch, Pradeep Natarajan, Saiju Pyarajan, Alexander G. Bick, Lauren Costa, Giulio Genovese, Richard Hauger, Ravi Madduri, Gita A. Pathak, Renato Polimanti, Benjamin Voight, Marijana Vujkovic, Seyedeh Maryam Zekavat, Hongyu Zhao, Marylyn D. Ritchie, VA Million Veteran Program COVID-19 Science Initiative, Kyong-Mi Chang, Kelly Cho, Juan P. Casas, Philip S. Tsao, J. Michael Gaziano, Christopher O’Donnell, Scott M. Damrauer, Katherine P. Liao

Differential modulation of C. elegans motor behavior by NALCN and two-pore domain potassium channels

Chuanman Zhou, Qian Zhou, Xiaohui He, Yunxia He, Xiaoqin Wang, Xiaowei Zhu, Yujia Zhang, Long Ma

Subnuclear localisation is associated with gene expression more than parental origin at the imprinted Dlk1-Dio3 locus

Rahia Mashoodh, Lisa C. Hülsmann, Frances L. Dearden, Nozomi Takahashi, Carol Edwards, Anne C. Ferguson-Smith

ENPP1 variants in patients with GACI and PXE expand the clinical and genetic heterogeneity of heritable disorders of ectopic calcification

Douglas Ralph, Yvonne Nitschke, Michael A. Levine, Matthew Caffet, Tamara Wurst, Amir Hossein Saeidian, Leila Youssefian, Hassan Vahidnezhad, Sharon F. Terry, Frank Rutsch, Jouni Uitto, Qiaoli Li

Activation of class 1 integron integrase is promoted in the intestinal environment

Murielle Baltazar, Nadège Bourgeois-Nicolaos, Macarena Larroudé, William Couet, Solange Uwajeneza, Florence Doucet-Populaire, Marie-Cécile Ploy, Sandra Da Re

The differential expression of PilY1 proteins by the HsfBA phosphorelay allows twitching motility in the absence of exopolysaccharides

Shuanghong Xue, Romain Mercier, Annick Guiseppi, Artemis Kosta, Rossella De Cegli, Severine Gagnot, Tâm Mignot, Emilia M. F. Mauriello

Classification of non-coding variants with high pathogenic impact

Lambert Moyon, Camille Berthelot, Alexandra Louis, Nga Thi Thuy Nguyen, Hugues Roest Crollius

Transcription of ncRNAs promotes repair of UV induced DNA lesions in Saccharomyces cerevisiae subtelomeres

Laetitia Guintini, Audrey Paillé, Marco Graf, Brian Luke, Raymund J. Wellinger, Antonio Conconi

α-Phenylalanyl tRNA synthetase competes with Notch signaling through its N-terminal domain

Manh Tin Ho, Jiongming Lu, Paula Vazquez-Pianzola, Beat Suter

Correction

Correction: Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

Kelly Jin, Kenneth A. Wilson, Jennifer N. Beck, Christopher S. Nelson, George W. Brownridge III, Benjamin R. Harrison, Danijel Djukovic, Daniel Raftery, Rachel B. Brem, Shiqing Yu, Mathias Drton, Ali Shojaie, Pankaj Kapahi, Daniel Promislow

Related Articles

Methods

A modified TurboID approach identifies tissue-specific centriolar components in C. elegans

Elisabeth Holzer, Cornelia Rumpf-Kienzl, Sebastian Falk, Alexander Dammermann