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Table of Contents

March 2019

Pigs are an excellent model to study harmful mutations causing embryonic lethality in homozygous affected individuals. In their study, Derks et al. identified five such recessive loci that impair the function of essential genes causing embryonic lethality in pigs. The lethal recessives affect up to 3% of the population litters, responsible for the death of 1 in 200 embryos. The study is intended to be used to lower the frequency of these harmful mutations to improve fertility in popular commercial pig breeds. See Derks et al.

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Image Credit: Anatolii Tsekhmister

Editorial

The Plight of Muntaser Ibrahim

Giorgio Sirugo, Scott M. Williams, Sarah A. Tishkoff, Heather J. Cordell, Jonathan Marchini, Gregory S. Barsh, Gregory P. Copenhaver

Viewpoints

Review

Errors in translational decoding: tRNA wobbling or misincorporation?

Xumin Ou, Jingyu Cao, Anchun Cheng, Maikel P. Peppelenbosch, Qiuwei Pan

Research Articles

Live cell monitoring of double strand breaks in S. cerevisiae

David P. Waterman, Felix Zhou, Kevin Li, Cheng-Sheng Lee, Michael Tsabar, Vinay V. Eapen, Allison Mazzella, James E. Haber

Evolution of an insect immune barrier through horizontal gene transfer mediated by a parasitic wasp

Ilaria Di Lelio, Anna Illiano, Federica Astarita, Luca Gianfranceschi, David Horner, Paola Varricchio, Angela Amoresano, Pietro Pucci, Francesco Pennacchio, Silvia Caccia

The complex geography of domestication of the African rice Oryza glaberrima

Jae Young Choi, Maricris Zaidem, Rafal Gutaker, Katherine Dorph, Rakesh Kumar Singh, Michael D. Purugganan

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

Yasmine J. Liu, Georges E. Janssens, Rebecca L. McIntyre, Marte Molenaars, Rashmi Kamble, Arwen W. Gao, Aldo Jongejan, Michel van Weeghel, Alyson W. MacInnes, Riekelt H. Houtkooper

Control of proliferation in the haploid meristem by CLE peptide signaling in Marchantia polymorpha

Yuki Hirakawa, Naoyuki Uchida, Yasuka L. Yamaguchi, Ryo Tabata, Sakiko Ishida, Kimitsune Ishizaki, Ryuichi Nishihama, Takayuki Kohchi, Shinichiro Sawa, John L. Bowman

Molecular and cellular modulators for multisensory integration in C. elegans

Gareth Harris, Taihong Wu, Gaia Linfield, Myung-Kyu Choi, He Liu, Yun Zhang

Genetic effects on the commensal microbiota in inflammatory bowel disease patients

Hugues Aschard, Vincent Laville, Eric Tchetgen Tchetgen, Dan Knights, Floris Imhann, Philippe Seksik, Noah Zaitlen, Mark S. Silverberg, Jacques Cosnes, Rinse K. Weersma, Ramnik Xavier, Laurent Beaugerie, David Skurnik, Harry Sokol

Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"

Mateus H. Gouveia, Andrew W. Bergen, Victor Borda, Kelly Nunes, Thiago P. Leal, Martin D. Ogwang, Edward D. Yeboah, James E. Mensah, Tobias Kinyera, Isaac Otim, Hadijah Nabalende, Ismail D. Legason, Sununguko Wata Mpoloka, Gaonyadiwe George Mokone, Patrick Kerchan, Kishor Bhatia, Steven J. Reynolds, Richard B. Birtwum, Andrew A. Adjei, Yao Tettey, Evelyn Tay, Robert Hoover, Ruth M. Pfeiffer, Robert J. Biggar, James J. Goedert, Ludmila Prokunina-Olsson, Michael Dean, Meredith Yeager, M. Fernanda Lima-Costa, Ann W. Hsing, Sarah A. Tishkoff, Stephen J. Chanock, Eduardo Tarazona-Santos, Sam M. Mbulaiteye

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy

Mark T. Handley, Kaalak Reddy, Jimi Wills, Elisabeth Rosser, Archith Kamath, Mihail Halachev, Gavin Falkous, Denise Williams, Phillip Cox, Alison Meynert, Eleanor S. Raymond, Harris Morrison, Stephen Brown, Emma Allan, Irene Aligianis, Andrew P. Jackson, Bernard H. Ramsahoye, Alex von Kriegsheim, Robert W. Taylor, Andrew J. Finch, David R. FitzPatrick

Rewired cellular signaling coordinates sugar and hypoxic responses for anaerobic xylose fermentation in yeast

Kevin S. Myers, Nicholas M. Riley, Matthew E. MacGilvray, Trey K. Sato, Mick McGee, Justin Heilberger, Joshua J. Coon, Audrey P. Gasch

The CPEB translational regulator, Orb, functions together with Par proteins to polarize the Drosophila oocyte

Justinn Barr, Sofia Charania, Rudolf Gilmutdinov, Konstantin Yakovlev, Yulii Shidlovskii, Paul Schedl

LINE-2 transposable elements are a source of functional human microRNAs and target sites

Rebecca Petri, Per Ludvik Brattås, Yogita Sharma, Marie E. Jönsson, Karolina Pircs, Johan Bengzon, Johan Jakobsson

Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal

Thomas W. Gould, Bertha Dominguez, Fred de Winter, Gene W. Yeo, Patrick Liu, Balaji Sundararaman, Thomas Stark, Anthony Vu, Jay L. Degen, Weichun Lin, Kuo-Fen Lee

Related Articles

Powerful gene set analysis in GWAS with the Generalized Berk-Jones statistic

Ryan Sun, Shirley Hui, Gary D. Bader, Xihong Lin, Peter Kraft

Regulation of anthocyanin accumulation via MYB75/HAT1/TPL-mediated transcriptional repression

Ting Zheng, Wenrong Tan, Huan Yang, Li’e Zhang, Taotao Li, Baohui Liu, Dawei Zhang, Honghui Lin

The molecular and cellular basis of olfactory response to tsetse fly attractants

J. Sebastian Chahda, Neeraj Soni, Jennifer S. Sun, Shimaa A. M. Ebrahim, Brian L. Weiss, John R. Carlson

Loss of function mutations in essential genes cause embryonic lethality in pigs

Martijn F. L. Derks, Arne B. Gjuvsland, Mirte Bosse, Marcos S. Lopes, Maren van Son, Barbara Harlizius, Beatrice F. Tan, Hanne Hamland, Eli Grindflek, Martien A. M. Groenen, Hendrik-Jan Megens

Cellular response to small molecules that selectively stall protein synthesis by the ribosome

Nadège Liaud, Max A. Horlbeck, Luke A. Gilbert, Ketrin Gjoni, Jonathan S. Weissman, Jamie H. D. Cate

Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans

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An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease

Suvi Mäkeläinen, Marta Gòdia, Minas Hellsand, Agnese Viluma, Daniela Hahn, Karim Makdoumi, Caroline J. Zeiss, Cathryn Mellersh, Sally L. Ricketts, Kristina Narfström, Finn Hallböök, Björn Ekesten, Göran Andersson, Tomas F. Bergström

Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing

Kathryn J. Grive, Yang Hu, Eileen Shu, Andrew Grimson, Olivier Elemento, Jennifer K. Grenier, Paula E. Cohen

A missense variant in FTCD is associated with arsenic metabolism and toxicity phenotypes in Bangladesh

Brandon L. Pierce, Lin Tong, Samantha Dean, Maria Argos, Farzana Jasmine, Muhammad Rakibuz-Zaman, Golam Sarwar, Md. Tariqul Islam, Hasan Shahriar, Tariqul Islam, Mahfuzar Rahman, Md. Yunus, Vincent J. Lynch, Devin Oglesbee, Joseph H. Graziano, Muhammad G. Kibriya, Mary V. Gamble, Habibul Ahsan

Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment

Lina Ding, Lauren B. Shunkwiler, Nicholas W. Harper, Yang Zhao, Kunihiko Hinohara, Sung Jin Huh, Muhammad B. Ekram, Jan Guz, Michael J. Kern, Alexander Awgulewitsch, James D. Shull, Bart M. G. Smits, Kornelia Polyak

Polygenic adaptation: From sweeps to subtle frequency shifts

Ilse Höllinger, Pleuni S. Pennings, Joachim Hermisson

Hypomorphic mutation of the mouse Huntington’s disease gene orthologue

Vidya Murthy, Toma Tebaldi, Toshimi Yoshida, Serkan Erdin, Teresa Calzonetti, Ravi Vijayvargia, Takshashila Tripathi, Emanuela Kerschbamer, Ihn Sik Seong, Alessandro Quattrone, Michael E. Talkowski, James F. Gusella, Katia Georgopoulos, Marcy E. MacDonald, Marta Biagioli

A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers

Deborah Biasoli, Lara Compston-Garnett, Sally L. Ricketts, Zeynep Birand, Celine Courtay-Cahen, Elena Fineberg, Maja Arendt, Kim Boerkamp, Malin Melin, Michele Koltookian, Sue Murphy, Gerard Rutteman, Kerstin Lindblad-Toh, Mike Starkey

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The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans

Adnane Sellam, Julien Chaillot, Jaideep Mallick, Faiza Tebbji, Julien Richard Albert, Michael A. Cook, Mike Tyers

Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity

Aleksandra I. Adamovich, Tapahsama Banerjee, Margaret Wingo, Kathryn Duncan, Jie Ning, Fernanda Martins Rodrigues, Kuan-lin Huang, Cindy Lee, Feng Chen, Li Ding, Jeffrey D. Parvin

Antero-posterior ectoderm patterning by canonical Wnt signaling during ascidian development

Stacy Feinberg, Agnès Roure, Julie Piron, Sébastien Darras

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

Dirk Schumacher, Geoffroy Andrieux, Karsten Boehnke, Marlen Keil, Alessandra Silvestri, Maxine Silvestrov, Ulrich Keilholz, Johannes Haybaeck, Gerrit Erdmann, Christoph Sachse, Markus Templin, Jens Hoffmann, Melanie Boerries, Reinhold Schäfer, Christian R. A. Regenbrecht