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Table of Contents

June 2021

Increases in temperature in fields like this one may cause changes in genome stability due to activation of highly mutagenic transposable elements. See Guo et al.

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Image Credit: Damon Lisch

Research Articles

A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1

Joy H. Meserve, Jessica C. Nelson, Kurt C. Marsden, Jerry Hsu, Fabio A. Echeverry, Roshan A. Jain, Marc A. Wolman, Alberto E. Pereda, Michael Granato

Rad21l1 cohesin subunit is dispensable for spermatogenesis but not oogenesis in zebrafish

Yana P. Blokhina, Michelle A. Frees, An Nguyen, Masuda Sharifi, Daniel B. Chu, Kristi Bispo, Ivan Olaya, Bruce W. Draper, Sean M. Burgess

Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye

Jonathan M. Pojer, Abdul Jabbar Saiful Hilmi, Shu Kondo, Kieran F. Harvey

High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated with cytochrome P450-mediated detoxification in a generalist arthropod pest

Seyedeh Masoumeh Fotoukkiaii, Nicky Wybouw, Andre H. Kurlovs, Dimitra Tsakireli, Spiros A. Pergantis, Richard M. Clark, John Vontas, Thomas Van Leeuwen

Microtubule associated protein WAVE DAMPENED2-LIKE (WDL) controls microtubule bundling and the stability of the site of tip-growth in Marchantia polymorpha rhizoids

Clement Champion, Jasper Lamers, Victor Arnold Shivas Jones, Giulia Morieri, Suvi Honkanen, Liam Dolan

Novel EDGE encoding method enhances ability to identify genetic interactions

Molly A. Hall, John Wallace, Anastasia M. Lucas, Yuki Bradford, Shefali S. Verma, Bertram Müller-Myhsok, Kristin Passero, Jiayan Zhou, John McGuigan, Beibei Jiang, Sarah A. Pendergrass, Yanfei Zhang, Peggy Peissig, Murray Brilliant, Patrick Sleiman, Hakon Hakonarson, John B. Harley, Krzysztof Kiryluk, Kristel Van Steen, Jason H. Moore, Marylyn D. Ritchie

Patterns of recent natural selection on genetic loci associated with sexually differentiated human body size and shape phenotypes

Audrey M. Arner, Kathleen E. Grogan, Mark Grabowski, Hugo Reyes-Centeno, George H. Perry

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets

Matthew R. Hass, Daniel Brissette, Sreeja Parameswaran, Mario Pujato, Omer Donmez, Leah C. Kottyan, Matthew T. Weirauch, Raphael Kopan

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments

Jingshu Wang, Qingyuan Zhao, Jack Bowden, Gibran Hemani, George Davey Smith, Dylan S. Small, Nancy R. Zhang

A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor

Harry D. Green, Alistair Jones, Jonathan P. Evans, Andrew R. Wood, Robin N. Beaumont, Jessica Tyrrell, Timothy M. Frayling, Christopher Smith, Michael N. Weedon

Genetics of white color and iridophoroma in “Lemon Frost” leopard geckos

Longhua Guo, Joshua Bloom, Steve Sykes, Elaine Huang, Zain Kashif, Elise Pham, Katarina Ho, Ana Alcaraz, Xinshu Grace Xiao, Sandra Duarte-Vogel, Leonid Kruglyak

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

Emilie L. Cerezo, Thibault Houles, Oriane Lié, Marie-Kerguelen Sarthou, Charlotte Audoynaud, Geneviève Lavoie, Maral Halladjian, Sylvain Cantaloube, Carine Froment, Odile Burlet-Schiltz, Yves Henry, Philippe P. Roux, Anthony K. Henras, Yves Romeo

Towards the characterization of the hidden world of small proteins in Staphylococcus aureus, a proteogenomics approach

Stephan Fuchs, Martin Kucklick, Erik Lehmann, Alexander Beckmann, Maya Wilkens, Baban Kolte, Ayten Mustafayeva, Tobias Ludwig, Maurice Diwo, Josef Wissing, Lothar Jänsch, Christian H. Ahrens, Zoya Ignatova, Susanne Engelmann

Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma

Amanda J. Craig, Teresa Garcia-Lezana, Marina Ruiz de Galarreta, Carlos Villacorta-Martin, Edgar G. Kozlova, Sebastiao N. Martins-Filho, Johann von Felden, Mehmet Eren Ahsen, Erin Bresnahan, Gabriela Hernandez-Meza, Ismail Labgaa, Delia D’Avola, Myron Schwartz, Josep M. Llovet, Daniela Sia, Swan Thung, Bojan Losic, Amaia Lujambio, Augusto Villanueva

Genetic sensitivity analysis: Adjusting for genetic confounding in epidemiological associations

Jean-Baptiste Pingault, Frühling Rijsdijk, Tabea Schoeler, Shing Wan Choi, Saskia Selzam, Eva Krapohl, Paul F. O’Reilly, Frank Dudbridge

High-throughput framework for genetic analyses of adverse drug reactions using electronic health records

Neil S. Zheng, Cosby A. Stone, Lan Jiang, Christian M. Shaffer, V. Eric Kerchberger, Cecilia P. Chung, QiPing Feng, Nancy J. Cox, C. Michael Stein, Dan M. Roden, Joshua C. Denny, Elizabeth J. Phillips, Wei-Qi Wei

A cluster of Ankyrin and Ankyrin-TPR repeat genes is associated with panicle branching diversity in rice

Giang Ngan Khong, Nhu Thi Le, Mai Thi Pham, Helene Adam, Carole Gauron, Hoa Quang Le, Dung Tien Pham, Kelly Colonges, Xuan Hoi Pham, Vinh Nang Do, Michel Lebrun, Stefan Jouannic

Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences

Xing Zhang, Benjamin W. Harding, Dina Aggad, Damien Courtine, Jia-Xuan Chen, Nathalie Pujol, Jonathan J. Ewbank

Crosstalk between H2A variant-specific modifications impacts vital cell functions

Anna Schmücker, Bingkun Lei, Zdravko J. Lorković, Matías Capella, Sigurd Braun, Pierre Bourguet, Olivier Mathieu, Karl Mechtler, Frédéric Berger

Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans

Jose Verdezoto Mosquera, Meghan C. Bacher, James R. Priess

Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures

Lore Pottie, Wouter Van Gool, Michiel Vanhooydonck, Franz-Georg Hanisch, Geert Goeminne, Andreja Rajkovic, Paul Coucke, Patrick Sips, Bert Callewaert

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation

Sahar Keshvari, Melanie Caruso, Ngari Teakle, Lena Batoon, Anuj Sehgal, Omkar L. Patkar, Michelle Ferrari-Cestari, Cameron E. Snell, Chen Chen, Alex Stevenson, Felicity M. Davis, Stephen J. Bush, Clare Pridans, Kim M. Summers, Allison R. Pettit, Katharine M. Irvine, David A. Hume

Permethrin resistance in Aedes aegypti: Genomic variants that confer knockdown resistance, recovery, and death

Karla Saavedra-Rodriguez, Corey L. Campbell, Saul Lozano, Patricia Penilla-Navarro, Alma Lopez-Solis, Francisco Solis-Santoyo, Americo D. Rodriguez, Rushika Perera, William C. Black IV

SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking

Yangli Tian, Qiaoju Kang, Xuemeng Shi, Yuan Wang, Nali Zhang, Huan Ye, Qifeng Xu, Tao Xu, Rongying Zhang

X-linked neonatal-onset epileptic encephalopathy associated with a gain-of-function variant p.R660T in GRIA3

Jia-Hui Sun, Jiang Chen, Fernando Eduardo Ayala Valenzuela, Carolyn Brown, Diane Masser-Frye, Marilyn Jones, Leslie Patron Romero, Berardo Rinaldi, Wenhui Laura Li, Qing-Qing Li, Dan Wu, Benedicte Gerard, Erin Thorpe, Allan Bayat, Yun Stone Shi

Predicting population genetic change in an autocorrelated random environment: Insights from a large automated experiment

Marie Rescan, Daphné Grulois, Enrique Ortega Aboud, Pierre de Villemereuil, Luis-Miguel Chevin

Forward genetics in Wolbachia: Regulation of Wolbachia proliferation by the amplification and deletion of an addictive genomic island

Elves H. Duarte, Ana Carvalho, Sergio López-Madrigal, João Costa, Luís Teixeira

A combinatorial cis-regulatory logic restricts color-sensing Rhodopsins to specific photoreceptor subsets in Drosophila

Clara Poupault, Diane Choi, Khanh Lam-Kamath, Deepshe Dewett, Ansa Razzaq, Joseph Bunker, Alexis Perry, Irene Cho, Jens Rister

Disrupting hierarchical control of nitrogen fixation enables carbon-dependent regulation of ammonia excretion in soil diazotrophs

Marcelo Bueno Batista, Paul Brett, Corinne Appia-Ayme, Yi-Ping Wang, Ray Dixon

DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans

Hui Hong, Huicheng Chen, Yuxia Zhang, Zhimao Wu, Yingying Zhang, Yingyi Zhang, Zeng Hu, Jian V. Zhang, Kun Ling, Jinghua Hu, Qing Wei

LAMP3 deficiency affects surfactant homeostasis in mice

Lars P. Lunding, Daniel Krause, Guido Stichtenoth, Cordula Stamme, Niklas Lauterbach, Jan Hegermann, Matthias Ochs, Björn Schuster, Radislav Sedlacek, Paul Saftig, Dominik Schwudke, Michael Wegmann, Markus Damme

VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms

Jim P. Fouracre, Jia He, Victoria J. Chen, Simone Sidoli, R. Scott Poethig

A MYB4-MAN3-Mannose-MNB1 signaling cascade regulates cadmium tolerance in Arabidopsis

Xingxing Yan, Ying Huang, Hui Song, Feng Chen, Qingliu Geng, Min Hu, Cheng Zhang, Xi Wu, Tingting Fan, Shuqing Cao

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity

Aurélie Quillien, Guerric Gilbert, Manon Boulet, Séverine Ethuin, Lucas Waltzer, Laurence Vandel

An enhancer screen identifies new suppressors of small-RNA-mediated epigenetic gene silencing

Yukiko Shimada, Sarah H. Carl, Merle Skribbe, Valentin Flury, Tahsin Kuzdere, Georg Kempf, Marc Bühler

Neofunctionalization of a second insulin receptor gene in the wing-dimorphic planthopper, Nilaparvata lugens

Wen-Hua Xue, Nan Xu, Sun-Jie Chen, Xin-Yang Liu, Jin-Li Zhang, Hai-Jun Xu

Methods

Rare variants regulate expression of nearby individual genes in multiple tissues

Jiajin Li, Nahyun Kong, Buhm Han, Jae Hoon Sul