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Table of Contents: May 2014

The image depicts a male Teleopsis dalmanni perched on a rootlet at night. Members of this species form aggregations which typically contain multiple females and a single large male. At some sites in peninsular Malaysia, 30% of males carry a driving X chromosome that exhibits segregation distortion during spermatogenesis such that functional sperm typically lack Y chromosomes. Hence, they produce predominantly female offspring. Comparison of gene expression in testes from drive and nondrive males reveals hundreds of genes, most of which are on the X, that differ in expression and show greater sequence divergence than other genes. See Reinhardt et al.

Image Credit: Gerald S. Wilkinson (University of Maryland)

Viewpoints

The Case for Junk DNA

Alexander F. Palazzo, T. Ryan Gregory

Research Articles

Copy Number Variation Is a Fundamental Aspect of the Placental Genome

Roberta L. Hannibal, Edward B. Chuong, Juan Carlos Rivera-Mulia, David M. Gilbert, Anton Valouev, Julie C. Baker

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Stefano Sechi, Gianni Colotti, Giorgio Belloni, Vincenzo Mattei, Anna Frappaolo, Grazia D. Raffa, Margaret T. Fuller, Maria Grazia Giansanti

Heterogeneity in the Frequency and Characteristics of Homologous Recombination in Pneumococcal Evolution

Rafal Mostowy, Nicholas J. Croucher, William P. Hanage, Simon R. Harris, Stephen Bentley, Christophe Fraser

R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome

Matthias Groh, Michele M. P. Lufino, Richard Wade-Martins, Natalia Gromak

Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction

Louise V. Wain, Ian Sayers, María Soler Artigas, Michael A. Portelli, Eleftheria Zeggini, Ma'en Obeidat, Don D. Sin, Yohan Bossé, David Nickle, Corry-Anke Brandsma, Anders Malarstig, Ciara Vangjeli, Scott A. Jelinsky, Sally John, Iain Kilty, Tricia McKeever, Nick R. G. Shrine, James P. Cook, Shrina Patel, Tim D. Spector, Edward J. Hollox, Ian P. Hall, Martin D. Tobin

Drosha Promotes Splicing of a Pre-microRNA-like Alternative Exon

Mallory A. Havens, Ashley A. Reich, Michelle L. Hastings

Allele-Specific Genome-wide Profiling in Human Primary Erythroblasts Reveal Replication Program Organization

Rituparna Mukhopadhyay, Julien Lajugie, Nicolas Fourel, Ari Selzer, Michael Schizas, Boris Bartholdy, Jessica Mar, Chii Mei Lin, Melvenia M. Martin, Michael Ryan, Mirit I. Aladjem, Eric E. Bouhassira

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A Novel C2H2 Transcription Factor that Regulates gliA Expression Interdependently with GliZ in Aspergillus fumigatus

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Genome Sequencing and Comparative Genomics of the Broad Host-Range Pathogen Rhizoctonia solani AG8

James K. Hane, Jonathan P. Anderson, Angela H. Williams, Jana Sperschneider, Karam B. Singh

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RPM-1 Uses Both Ubiquitin Ligase and Phosphatase-Based Mechanisms to Regulate DLK-1 during Neuronal Development

Scott T. Baker, Karla J. Opperman, Erik D. Tulgren, Shane M. Turgeon, Willy Bienvenut, Brock Grill

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Mlh2 Is an Accessory Factor for DNA Mismatch Repair in Saccharomyces cerevisiae

Christopher S. Campbell, Hans Hombauer, Anjana Srivatsan, Nikki Bowen, Kerstin Gries, Arshad Desai, Christopher D. Putnam, Richard D. Kolodner

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Daniel J. Coleman, Gloria Garcia, Stephen Hyter, Hyo Sang Jang, Sharmeen Chagani, Xiaobo Liang, Lionel Larue, Gitali Ganguli-Indra, Arup K. Indra

Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2

Marzia Scortegagna, Hyungsoo Kim, Jian-Liang Li, Hang Yao, Laurence M. Brill, Jaeseok Han, Eric Lau, David Bowtell, Gabriel Haddad, Randal J. Kaufman, Ze'ev A. Ronai

Population Genomic Analysis of Ancient and Modern Genomes Yields New Insights into the Genetic Ancestry of the Tyrolean Iceman and the Genetic Structure of Europe

Martin Sikora, Meredith L. Carpenter, Andres Moreno-Estrada, Brenna M. Henn, Peter A. Underhill, Federico Sánchez-Quinto, Ilenia Zara, Maristella Pitzalis, Carlo Sidore, Fabio Busonero, Andrea Maschio, Andrea Angius, Chris Jones, Javier Mendoza-Revilla, Georgi Nekhrizov, Diana Dimitrova, Nikola Theodossiev, Timothy T. Harkins, Andreas Keller, Frank Maixner, Albert Zink, Goncalo Abecasis, Serena Sanna, Francesco Cucca, Carlos D. Bustamante

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Jean-François Pombert, Nicolas Achille Blouin, Chris Lane, Drion Boucias, Patrick J. Keeling

Meiotic Drive Impacts Expression and Evolution of X-Linked Genes in Stalk-Eyed Flies

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Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression

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Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity

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Selectivity in Genetic Association with Sub-classified Migraine in Women

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Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder

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Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma

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