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November 2018

The drawing depicts the importance of admixture for fast and repeated evolution of two ecotypes of the saltmarsh beetle Pogonus chalceus. Long- and short-winged ecotypes of P. chalceus have diverged repeatedly along the Atlantic European coast in response to contrasting hydrological regimes. The repeated evolution is driven by an initial ancient and singular divergence of the short-winged ecotype, after which it admixed with the ancestral long-winged population. This admixture resulted in a polymorphic population that survived during the most recent glacial maxima and from which both ecotypes currently diverge rapidly and repeatedly by the reassembly of these ancient alleles when habitats become available. See Van Belleghem et al.

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Image Credit: Steven M. Van Belleghem and Frederik Hendrickx

Research Articles

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans

Qianyan Li, Takamune T. Saito, Marina Martinez-Garcia, Alison J. Deshong, Saravanapriah Nadarajan, Katherine S. Lawrence, Paula M. Checchi, Monica P. Colaiacovo, JoAnne Engebrecht

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Slower environmental change hinders adaptation from standing genetic variation

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How many individuals share a mitochondrial genome?

Mikkel M. Andersen, David J. Balding

Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

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An investigation of Y chromosome incorporations in 400 species of Drosophila and related genera

Eduardo G. Dupim, Gabriel Goldstein, Thyago Vanderlinde, Suzana C. Vaz, Flávia Krsticevic, Aline Bastos, Thadeo Pinhão, Marcos Torres, Jean R. David, Carlos R. Vilela, Antonio Bernardo Carvalho

Stereotypic generation of axial tenocytes from bipartite sclerotome domains in zebrafish

Roger C. Ma, Craig T. Jacobs, Priyanka Sharma, Katrinka M. Kocha, Peng Huang

A variably imprinted epiallele impacts seed development

Daniela Pignatta, Katherine Novitzky, P. R. V. Satyaki, Mary Gehring

Functional equivalence of germ plasm organizers

Pritesh Krishnakumar, Stephan Riemer, Roshan Perera, Thomas Lingner, Alexander Goloborodko, Hazem Khalifa, Franck Bontems, Felix Kaufholz, Mohamed A. El-Brolosy, Roland Dosch

Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness

Wen C. Aw, Samuel G. Towarnicki, Richard G. Melvin, Neil A. Youngson, Michael R. Garvin, Yifang Hu, Shaun Nielsen, Torsten Thomas, Russell Pickford, Sonia Bustamante, Antón Vila-Sanjurjo, Gordon K. Smyth, J. William O. Ballard

Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors

François Rousset, Lun Cui, Elise Siouve, Christophe Becavin, Florence Depardieu, David Bikard

Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis

Fernando H. Ramírez-Guadiana, Christopher D. A. Rodrigues, Kathleen A. Marquis, Nathalie Campo, Rocío del Carmen Barajas-Ornelas, Kelly Brock, Debora S. Marks, Andrew C. Kruse, David Z. Rudner

Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations

Rebecca C. Poulos, Yuen T. Wong, Regina Ryan, Herbert Pang, Jason W. H. Wong

Population genomics of grey wolves and wolf-like canids in North America

Mikkel-Holger S. Sinding, Shyam Gopalakrishan, Filipe G. Vieira, Jose A. Samaniego Castruita, Katrine Raundrup, Mads Peter Heide Jørgensen, Morten Meldgaard, Bent Petersen, Thomas Sicheritz-Ponten, Johan Brus Mikkelsen, Ulf Marquard-Petersen, Rune Dietz, Christian Sonne, Love Dalén, Lutz Bachmann, Øystein Wiig, Anders J. Hansen, M. Thomas P. Gilbert

A fast and agnostic method for bacterial genome-wide association studies: Bridging the gap between k-mers and genetic events

Magali Jaillard, Leandro Lima, Maud Tournoud, Pierre Mahé, Alex van Belkum, Vincent Lacroix, Laurent Jacob

The zinc finger protein DCM1 is required for male meiotic cytokinesis by preserving callose in rice

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Function and regulation of the Caenorhabditis elegans Rab32 family member GLO-1 in lysosome-related organelle biogenesis

Caitlin Morris, Olivia K. Foster, Simran Handa, Kimberly Peloza, Laura Voss, Hannah Somhegyi, Youli Jian, My Van Vo, Marie Harp, Fiona M. Rambo, Chonglin Yang, Greg J. Hermann

Replicative and non-replicative mechanisms in the formation of clustered CNVs are indicated by whole genome characterization

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Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation

Vamsi K. Gali, David Dickerson, Yuki Katou, Katsunori Fujiki, Katsuhiko Shirahige, Tom Owen-Hughes, Takashi Kubota, Anne D. Donaldson

Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium

Nhung H. Vuong, David P. Cook, Laura A. Forrest, Lauren E. Carter, Pascale Robineau-Charette, Joshua M. Kofsky, Kendra M. Hodgkinson, Barbara C. Vanderhyden

Evolution at two time frames: Polymorphisms from an ancient singular divergence event fuel contemporary parallel evolution

Steven M. Van Belleghem, Carl Vangestel, Katrien De Wolf, Zoë De Corte, Markus Möst, Pasi Rastas, Luc De Meester, Frederik Hendrickx

Conditional mutagenesis by oligonucleotide-mediated integration of loxP sites in zebrafish

Leonard Burg, Nicholas Palmer, Khrievono Kikhi, Evgeniya S. Miroshnik, Helen Rueckert, Eleanor Gaddy, Carlee MacPherson Cunningham, Kenny Mattonet, Shih-Lei Lai, Rubén Marín-Juez, Richard B. Waring, Didier Y. R. Stainier, Darius Balciunas

Synthetic STARR-seq reveals how DNA shape and sequence modulate transcriptional output and noise

Stefanie Schöne, Melissa Bothe, Edda Einfeldt, Marina Borschiwer, Philipp Benner, Martin Vingron, Morgane Thomas-Chollier, Sebastiaan H. Meijsing

Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends

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A single class of ARF GTPase activated by several pathway-specific ARF-GEFs regulates essential membrane traffic in Arabidopsis

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Capitalizing on the heterogeneous effects of CFTR nonsense and frameshift variants to inform therapeutic strategy for cystic fibrosis

Neeraj Sharma, Taylor A. Evans, Matthew J. Pellicore, Emily Davis, Melis A. Aksit, Allison F. McCague, Anya T. Joynt, Zhongzhu Lu, Sangwoo T. Han, Arianna F. Anzmann, Anh-Thu N. Lam, Abigail Thaxton, Natalie West, Christian Merlo, Laura B. Gottschalk, Karen S. Raraigh, Patrick R. Sosnay, Calvin U. Cotton, Garry R. Cutting

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

Vivek Nanda, Ting Wang, Milos Pjanic, Boxiang Liu, Trieu Nguyen, Ljubica Perisic Matic, Ulf Hedin, Simon Koplev, Lijiang Ma, Oscar Franzén, Arno Ruusalepp, Eric E. Schadt, Johan L. M. Björkegren, Stephen B. Montgomery, Michael P. Snyder, Thomas Quertermous, Nicholas J. Leeper, Clint L. Miller

The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity

Isaac T. Sluder, Nitika, Laura E. Knighton, Andrew W. Truman

Spen limits intestinal stem cell self-renewal

Maheva Andriatsilavo, Marine Stefanutti, Katarzyna Siudeja, Carolina N. Perdigoto, Benjamin Boumard, Louis Gervais, Alexandre Gillet-Markowska, Lara Al Zouabi, François Schweisguth, Allison J. Bardin

Genetic variants influence on the placenta regulatory landscape

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FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation

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Genetic architecture and selective sweeps after polygenic adaptation to distant trait optima

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Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ

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Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish

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A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of the driver’s antidote

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Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine

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Correction

Topic Page

Selfish genetic elements

J. Arvid Ågren, Andrew G. Clark