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April 2016

Vision is highly dependent on the number and types of retinal photoreceptors and their arrangement. This image shows the asymmetric distribution of rod photoreceptors (yellow) in the cone-dominated larval zebrafish retina. The density of rods is highest in the ventral retina but rapidly declines in the central and dorsal retina. Exploiting photoreceptor patterning in zebrafish, Sotolongo-Lopez and colleagues reveal two independent functions of six7 in photoreceptor development. Their study shows that the asymmetric distribution of rods is regulated in a dosage dependent manner by the transcription factor six7, and that six7 is essential for survival of green-wavelength sensitive cone precursors. See Sotolongo-Lopez et al.

Image Credit: James M. Fadool and Karen Alvarez-Delfin

Reviews

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The Increasing Importance of Gene-Based Analyses

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