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May 2016

African trypanosome parasites are densely coated in a single Variant Surface Glycoprotein (VSG - visualized here by immunofluorescence microscopy, DAPI staining are shown). While growing in the bloodstream of humans and other mammals, Trypanosoma brucei species evade the host immune response by switching from the expression of one VSG coat to another. This requires selection and activation of a single new VSG gene from a huge number of possible VSG variants encoded throughout the genome. In this study, we showed that selection of VSG donors from the genomic archive requires a specific repetitive DNA element and defined its critical features. See Hovel-Miner et al.

Image Credit: Mark Field, University of Cambridge

Review

Exploiting Genetic Interference for Antiviral Therapy

Elizabeth J. Tanner, Karla A. Kirkegaard, Leor S. Weinberger

Research Articles

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Soheil Baharian, Maxime Barakatt, Christopher R. Gignoux, Suyash Shringarpure, Jacob Errington, William J. Blot, Carlos D. Bustamante, Eimear E. Kenny, Scott M. Williams, Melinda C. Aldrich, Simon Gravel

Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila

Wenhua Li, Aiyu Yao, Hui Zhi, Kuldeep Kaur, Yong-chuan Zhu, Mingyue Jia, Hui Zhao, Qifu Wang, Shan Jin, Guoli Zhao, Zhi-Qi Xiong, Yong Q. Zhang

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein

Nirmalya Chatterjee, Min Tian, Kerstin Spirohn, Michael Boutros, Dirk Bohmann

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Sveta Chakrabarti, Jan Paul Dudzic, Xiaoxue Li, Esther Jeanne Collas, Jean-Phillipe Boquete, Bruno Lemaitre

Predicting Ancestral Segmentation Phenotypes from Drosophila to Anopheles Using In Silico Evolution

Jeremy B. Rothschild, Panagiotis Tsimiklis, Eric D. Siggia, Paul François

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The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer

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Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling

Joo Yeun Lee, Jessica Y. Chen, Jillian L. Shaw, Karen T. Chang

The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles

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Marjo K. Hytönen, Meharji Arumilli, Anu K. Lappalainen, Marta Owczarek-Lipska, Vidhya Jagannathan, Sruthi Hundi, Elina Salmela, Patrick Venta, Eva Sarkiala, Tarja Jokinen, Daniela Gorgas, Juha Kere, Pekka Nieminen, Cord Drögemüller, Hannes Lohi

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Anne-Lyse Denizot, Vanessa Besson, Rosa Maria Correra, Alessia Mazzola, Izolina Lopes, Jean-Remy Courbard, Giovanna Marazzi, David A. Sassoon

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Ana Bratic, Paula Clemente, Javier Calvo-Garrido, Camilla Maffezzini, Andrea Felser, Rolf Wibom, Anna Wedell, Christoph Freyer, Anna Wredenberg

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Gaël Chambonnier, Lorène Roux, David Redelberger, Firas Fadel, Alain Filloux, Melissa Sivaneson, Sophie de Bentzmann, Christophe Bordi

Characterization of Expression Quantitative Trait Loci in Pedigrees from Colombia and Costa Rica Ascertained for Bipolar Disorder

Christine B. Peterson, Susan K. Service, Anna J. Jasinska, Fuying Gao, Ivette Zelaya, Terri M. Teshiba, Carrie E. Bearden, Rita M. Cantor, Victor I. Reus, Gabriel Macaya, Carlos López-Jaramillo, Marina Bogomolov, Yoav Benjamini, Eleazar Eskin, Giovanni Coppola, Nelson B. Freimer, Chiara Sabatti

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A Genetic Screen Identifies a Requirement for Cysteine-Rich–Receptor-Like Kinases in Rice NH1 (OsNPR1)-Mediated Immunity

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