April 2017

WDR23 regulates NRF2 independently of KEAP1

Jacqueline Y. Lo, Brett N. Spatola, Sean P. Curran

PLOS Genetics: published April 28, 2017 | https://doi.org/10.1371/journal.pgen.1006762

Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos

Chani J. Hodonsky, Deepti Jain, Ursula M. Schick, Jean V. Morrison, Lisa Brown, Caitlin P. McHugh, Claudia Schurmann, Diane D. Chen, Yong Mei Liu, Paul L. Auer, Cecilia A. Laurie, Kent D. Taylor, Brian L. Browning, Yun Li, George Papanicolaou, Jerome I. Rotter, Ryo Kurita, Yukio Nakamura, Sharon R. Browning, Ruth J. F. Loos, Kari E. North, Cathy C. Laurie, Timothy A. Thornton, Nathan Pankratz, Daniel E. Bauer, Tamar Sofer, Alex P. Reiner

PLOS Genetics: published April 28, 2017 | https://doi.org/10.1371/journal.pgen.1006760

Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation

Ethiraj Ravindran, Hao Hu, Scott A. Yuzwa, Luis R. Hernandez-Miranda, Nadine Kraemer, Olaf Ninnemann, Luciana Musante, Eugen Boltshauser, Detlev Schindler, Angela Hübner, Hans-Christian Reinecker, Hans-Hilger Ropers, Carmen Birchmeier, Freda D. Miller, Thomas F. Wienker, Christoph Hübner, Angela M. Kaindl

PLOS Genetics: published April 28, 2017 | https://doi.org/10.1371/journal.pgen.1006746

Semaphorin-1a prevents Drosophila olfactory projection neuron dendrites from mis-targeting into select antennal lobe regions

Hung-Chang Shen, Sao-Yu Chu, Tsai-Chi Hsu, Chun-Han Wang, I-Ya Lin, Hung-Hsiang Yu

PLOS Genetics: published April 27, 2017 | https://doi.org/10.1371/journal.pgen.1006751

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer

Xiaofeng Jin, Jie Wang, Kun Gao, Pingzhao Zhang, Longfang Yao, Yan Tang, Lisha Tang, Jian Ma, Jiantao Xiao, Enceng Zhang, Jie Zhu, Bin Zhang, Shi-min Zhao, Yao Li, Shancheng Ren, Haojie Huang, Long Yu, Chenji Wang

PLOS Genetics: published April 27, 2017 | https://doi.org/10.1371/journal.pgen.1006748

Natural variation of piRNA expression affects immunity to transposable elements

Sergei Ryazansky, Elizaveta Radion, Anastasia Mironova, Natalia Akulenko, Yuri Abramov, Valeriya Morgunova, Maria Y. Kordyukova, Ivan Olovnikov, Alla Kalmykova

PLOS Genetics: published April 27, 2017 | https://doi.org/10.1371/journal.pgen.1006731

Evolutionary history of Tibetans inferred from whole-genome sequencing

Hao Hu, Nayia Petousi, Gustavo Glusman, Yao Yu, Ryan Bohlender, Tsewang Tashi, Jonathan M. Downie, Jared C. Roach, Amy M. Cole, Felipe R. Lorenzo, Alan R. Rogers, Mary E. Brunkow, Gianpiero Cavalleri, Leroy Hood, Sama M. Alpatty, Josef T. Prchal, Lynn B. Jorde, Peter A. Robbins, Tatum S. Simonson, Chad D. Huff

PLOS Genetics: published April 27, 2017 | https://doi.org/10.1371/journal.pgen.1006675

Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Mariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary F. Feitosa, Llilda Barata, Thomas W. Winkler, Audrey Y. Chu, Anubha Mahajan, David Hadley, Luting Xue, Tsegaselassie Workalemahu, Nancy L. Heard-Costa, Marcel den Hoed, Tarunveer S. Ahluwalia, Qibin Qi, Julius S. Ngwa, Frida Renström, Lydia Quaye, John D. Eicher, James E. Hayes, Marilyn Cornelis, Zoltan Kutalik, Elise Lim, Jian’an Luan, Jennifer E. Huffman, Weihua Zhang, Wei Zhao, Paula J. Griffin, Toomas Haller, Shafqat Ahmad, Pedro M. Marques-Vidal, Stephanie Bien, Loic Yengo, Alexander Teumer, Albert Vernon Smith, Meena Kumari, Marie Neergaard Harder, Johanne Marie Justesen, Marcus E. Kleber, Mette Hollensted, Kurt Lohman, Natalia V. Rivera, John B. Whitfield, Jing Hua Zhao, Heather M. Stringham, Leo-Pekka Lyytikäinen, Charlotte Huppertz, Gonneke Willemsen, Wouter J. Peyrot, Ying Wu, Kati Kristiansson, Ayse Demirkan, Myriam Fornage, Maija Hassinen, Lawrence F. Bielak, Gemma Cadby, Toshiko Tanaka, Reedik Mägi, Peter J. van der Most, Anne U. Jackson, Jennifer L. Bragg-Gresham, Veronique Vitart, Jonathan Marten, Pau Navarro, Claire Bellis, Dorota Pasko, Åsa Johansson, Søren Snitker, Yu-Ching Cheng, Joel Eriksson, Unhee Lim, Mette Aadahl, Linda S. Adair, Najaf Amin, Beverley Balkau, Juha Auvinen, John Beilby, Richard N. Bergman, Sven Bergmann, Alain G. Bertoni, John Blangero, Amélie Bonnefond, Lori L. Bonnycastle, Judith B. Borja, Søren Brage, Fabio Busonero, Steve Buyske, Harry Campbell, Peter S. Chines, Francis S. Collins, Tanguy Corre, George Davey Smith, Graciela E. Delgado, Nicole Dueker, Marcus Dörr, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Jessica D. Faul, Mao Fu, Kristine Færch, Christian Gieger, Sven Gläser, Jian Gong, Penny Gordon-Larsen, Harald Grallert, Tanja B. Grammer, Niels Grarup, Gerard van Grootheest, Kennet Harald, Nicholas D. Hastie, Aki S. Havulinna, Dena Hernandez, Lucia Hindorff, Lynne J. Hocking, Oddgeir L. Holmens, Christina Holzapfel, Jouke Jan Hottenga, Jie Huang, Tao Huang, Jennie Hui, Cornelia Huth, Nina Hutri-Kähönen, Alan L. James, John-Olov Jansson, Min A. Jhun, Markus Juonala, Leena Kinnunen, Heikki A. Koistinen, Ivana Kolcic, Pirjo Komulainen, Johanna Kuusisto, Kirsti Kvaløy, Mika Kähönen, Timo A. Lakka, Lenore J. Launer, Benjamin Lehne, Cecilia M. Lindgren, Mattias Lorentzon, Robert Luben, Michel Marre, Yuri Milaneschi, Keri L. Monda, Grant W. Montgomery, Marleen H. M. De Moor, Antonella Mulas, Martina Müller-Nurasyid, A. W. Musk, Reija Männikkö, Satu Männistö, Narisu Narisu, Matthias Nauck, Jennifer A. Nettleton, Ilja M. Nolte, Albertine J. Oldehinkel, Matthias Olden, Ken K. Ong, Sandosh Padmanabhan, Lavinia Paternoster, Jeremiah Perez, Markus Perola, Annette Peters, Ulrike Peters, Patricia A. Peyser, Inga Prokopenko, Hannu Puolijoki, Olli T. Raitakari, Tuomo Rankinen, Laura J. Rasmussen-Torvik, Rajesh Rawal, Paul M. Ridker, Lynda M. Rose, Igor Rudan, Cinzia Sarti, Mark A. Sarzynski, Kai Savonen, William R. Scott, Serena Sanna, Alan R. Shuldiner, Steve Sidney, Günther Silbernagel, Blair H. Smith, Jennifer A. Smith, Harold Snieder, Alena Stančáková, Barbara Sternfeld, Amy J. Swift, Tuija Tammelin, Sian-Tsung Tan, Barbara Thorand, Dorothée Thuillier, Liesbeth Vandenput, Henrik Vestergaard, Jana V. van Vliet-Ostaptchouk, Marie-Claude Vohl, Uwe Völker, Gérard Waeber, Mark Walker, Sarah Wild, Andrew Wong, Alan F. Wright, M. Carola Zillikens, Niha Zubair, Christopher A. Haiman, Loic Lemarchand, Ulf Gyllensten, Claes Ohlsson, Albert Hofman, Fernando Rivadeneira, André G. Uitterlinden, Louis Pérusse, James F. Wilson, Caroline Hayward, Ozren Polasek, Francesco Cucca, Kristian Hveem, Catharina A. Hartman, Anke Tönjes, Stefania Bandinelli, Lyle J. Palmer, Sharon L. R. Kardia, Rainer Rauramaa, Thorkild I. A. Sørensen, Jaakko Tuomilehto, Veikko Salomaa, Brenda W. J. H. Penninx, Eco J. C. de Geus, Dorret I. Boomsma, Terho Lehtimäki, Massimo Mangino, Markku Laakso, Claude Bouchard, Nicholas G. Martin, Diana Kuh, Yongmei Liu, Allan Linneberg, Winfried März, Konstantin Strauch, Mika Kivimäki, Tamara B. Harris, Vilmundur Gudnason, Henry Völzke, Lu Qi, Marjo-Riitta Järvelin, John C. Chambers, Jaspal S. Kooner, Philippe Froguel, Charles Kooperberg, Peter Vollenweider, Göran Hallmans, Torben Hansen, Oluf Pedersen, Andres Metspalu, Nicholas J. Wareham, Claudia Langenberg, David R. Weir, David J. Porteous, Eric Boerwinkle, Daniel I. Chasman, CHARGE Consortium, EPIC-InterAct Consortium, PAGE Consortium, Gonçalo R. Abecasis, Inês Barroso, Mark I. McCarthy, Timothy M. Frayling, Jeffrey R. O’Connell, Cornelia M. van Duijn, Michael Boehnke, Iris M. Heid, Karen L. Mohlke, David P. Strachan, Caroline S. Fox, Ching-Ti Liu, Joel N. Hirschhorn, Robert J. Klein, Andrew D. Johnson, Ingrid B. Borecki, Paul W. Franks, Kari E. North, L. Adrienne Cupples, Ruth J. F. Loos, Tuomas O. Kilpeläinen

PLOS Genetics: published April 27, 2017 | https://doi.org/10.1371/journal.pgen.1006528

GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states

Rachel Herndon Klein, Ziguang Lin, Amelia Soto Hopkin, William Gordon, Lam C. Tsoi, Yun Liang, Johann E. Gudjonsson, Bogi Andersen

PLOS Genetics: published April 26, 2017 | https://doi.org/10.1371/journal.pgen.1006745

Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice

Sayantani Sinha, Christina Mundy, Till Bechtold, Federica Sgariglia, Mazen M. Ibrahim, Paul C. Billings, Kristen Carroll, Eiki Koyama, Kevin B. Jones, Maurizio Pacifici

PLOS Genetics: published April 26, 2017 | https://doi.org/10.1371/journal.pgen.1006742

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium

Maggie C. Y. Ng, Mariaelisa Graff, Yingchang Lu, Anne E. Justice, Poorva Mudgal, Ching-Ti Liu, Kristin Young, Lisa R. Yanek, Mary F. Feitosa, Mary K. Wojczynski, Kristin Rand, Jennifer A. Brody, Brian E. Cade, Latchezar Dimitrov, Qing Duan, Xiuqing Guo, Leslie A. Lange, Michael A. Nalls, Hayrettin Okut, Salman M. Tajuddin, Bamidele O. Tayo, Sailaja Vedantam, Jonathan P. Bradfield, Guanjie Chen, Wei-Min Chen, Alessandra Chesi, Marguerite R. Irvin, Badri Padhukasahasram, Jennifer A. Smith, Wei Zheng, Matthew A. Allison, Christine B. Ambrosone, Elisa V. Bandera, Traci M. Bartz, Sonja I. Berndt, Leslie Bernstein, William J. Blot, Erwin P. Bottinger, John Carpten, Stephen J. Chanock, Yii-Der Ida Chen, David V. Conti, Richard S. Cooper, Myriam Fornage, Barry I. Freedman, Melissa Garcia, Phyllis J. Goodman, Yu-Han H. Hsu, Jennifer Hu, Chad D. Huff, Sue A. Ingles, Esther M. John, Rick Kittles, Eric Klein, Jin Li, Barbara McKnight, Uma Nayak, Barbara Nemesure, Adesola Ogunniyi, Andrew Olshan, Michael F. Press, Rebecca Rohde, Benjamin A. Rybicki, Babatunde Salako, Maureen Sanderson, Yaming Shao, David S. Siscovick, Janet L. Stanford, Victoria L. Stevens, Alex Stram, Sara S. Strom, Dhananjay Vaidya, John S. Witte, Jie Yao, Xiaofeng Zhu, Regina G. Ziegler, Alan B. Zonderman, Adebowale Adeyemo, Stefan Ambs, Mary Cushman, Jessica D. Faul, Hakon Hakonarson, Albert M. Levin, Katherine L. Nathanson, Erin B. Ware, David R. Weir, Wei Zhao, Degui Zhi, The Bone Mineral Density in Childhood Study (BMDCS) Group, Donna K. Arnett, Struan F. A. Grant, Sharon L. R. Kardia, Olufunmilayo I. Oloapde, D. C. Rao, Charles N. Rotimi, Michele M. Sale, L. Keoki Williams, Babette S. Zemel, Diane M. Becker, Ingrid B. Borecki, Michele K. Evans, Tamara B. Harris, Joel N. Hirschhorn, Yun Li, Sanjay R. Patel, Bruce M. Psaty, Jerome I. Rotter, James G. Wilson, Donald W. Bowden, L. Adrienne Cupples, Christopher A. Haiman, Ruth J. F. Loos, Kari E. North

PLOS Genetics: published April 21, 2017 | https://doi.org/10.1371/journal.pgen.1006719

Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy

Penelope J. Boyd, Wen-Yo Tu, Hannah K. Shorrock, Ewout J. N. Groen, Roderick N. Carter, Rachael A. Powis, Sophie R. Thomson, Derek Thomson, Laura C. Graham, Anna A. L. Motyl, Thomas M. Wishart, J. Robin Highley, Nicholas M. Morton, Thomas Becker, Catherina G. Becker, Paul R. Heath, Thomas H. Gillingwater

PLOS Genetics: published April 20, 2017 | https://doi.org/10.1371/journal.pgen.1006744

Three distinct mechanisms of long-distance modulation of gene expression in yeast

Manyu Du, Qian Zhang, Lu Bai

PLOS Genetics: published April 20, 2017 | https://doi.org/10.1371/journal.pgen.1006736

Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene

Haruhiko Fujihira, Yuki Masahara-Negishi, Masaru Tamura, Chengcheng Huang, Yoichiro Harada, Shigeharu Wakana, Daisuke Takakura, Nana Kawasaki, Naoyuki Taniguchi, Gen Kondoh, Tadashi Yamashita, Yoko Funakoshi, Tadashi Suzuki

PLOS Genetics: published April 20, 2017 | https://doi.org/10.1371/journal.pgen.1006696

Joint genetic analysis using variant sets reveals polygenic gene-context interactions

Francesco Paolo Casale, Danilo Horta, Barbara Rakitsch, Oliver Stegle

PLOS Genetics: published April 20, 2017 | https://doi.org/10.1371/journal.pgen.1006693

Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

Sofie V. Nielsen, Amelie Stein, Alexander B. Dinitzen, Elena Papaleo, Michael H. Tatham, Esben G. Poulsen, Maher M. Kassem, Lene J. Rasmussen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

PLOS Genetics: published April 19, 2017 | https://doi.org/10.1371/journal.pgen.1006739

The ESCRT regulator Did2 maintains the balance between long-distance endosomal transport and endocytic trafficking

Carl Haag, Thomas Pohlmann, Michael Feldbrügge

PLOS Genetics: published April 19, 2017 | https://doi.org/10.1371/journal.pgen.1006734

The SnRK2 kinases modulate miRNA accumulation in Arabidopsis

Jun Yan, Pengcheng Wang, Bangshing Wang, Chuan-Chih Hsu, Kai Tang, Hairong Zhang, Yueh-Ju Hou, Yang Zhao, Qiming Wang, Chunzhao Zhao, Xiaohong Zhu, W. Andy Tao, Jianming Li, Jian-Kang Zhu

PLOS Genetics: published April 18, 2017 | https://doi.org/10.1371/journal.pgen.1006753

The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness

Eros Di Giorgio, Elisa Franforte, Sebastiano Cefalù, Sabrina Rossi, Angelo Paolo Dei Tos, Monica Brenca, Maurizio Polano, Roberta Maestro, Harikrishnareddy Paluvai, Raffaella Picco, Claudio Brancolini

PLOS Genetics: published April 18, 2017 | https://doi.org/10.1371/journal.pgen.1006752

Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions

Supriya Sinha, Fuyang Li, Diana Villarreal, Jae Hoon Shim, Suhyeon Yoon, Kyungjae Myung, Eun Yong Shim, Sang Eun Lee

PLOS Genetics: published April 18, 2017 | https://doi.org/10.1371/journal.pgen.1006714

Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo

Shuai Li, Marleny Garcia, Rachel L. Gewiss, Wipawee Winuthayanon

PLOS Genetics: published April 17, 2017 | https://doi.org/10.1371/journal.pgen.1006743

Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene

Johannes Stratmann, Stefan Thor

PLOS Genetics: published April 17, 2017 | https://doi.org/10.1371/journal.pgen.1006729

Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration

Jillian N. Pearring, Jovenal T. San Agustin, Ekaterina S. Lobanova, Christopher J. Gabriel, Eric C. Lieu, William J. Monis, Michael W. Stuck, Lara Strittmatter, Samer M. Jaber, Vadim Y. Arshavsky, Gregory J. Pazour

PLOS Genetics: published April 14, 2017 | https://doi.org/10.1371/journal.pgen.1006740

DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation

Patrick Narbonne, Paul S. Maddox, Jean-Claude Labbé

PLOS Genetics: published April 14, 2017 | https://doi.org/10.1371/journal.pgen.1006738

Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments

Alex N. Nguyen Ba, Bob Strome, Selma Osman, Elizabeth-Ann Legere, Taraneh Zarin, Alan M. Moses

PLOS Genetics: published April 14, 2017 | https://doi.org/10.1371/journal.pgen.1006735

A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion

Omaya Dudin, Laura Merlini, Felipe O. Bendezú, Raphaël Groux, Vincent Vincenzetti, Sophie G. Martin

PLOS Genetics: published April 14, 2017 | https://doi.org/10.1371/journal.pgen.1006721

Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila

Chiara Gamberi, David R. Hipfner, Marie Trudel, William D. Lubell

PLOS Genetics: published April 13, 2017 | https://doi.org/10.1371/journal.pgen.1006694

Gene co-expression network connectivity is an important determinant of selective constraint

Niklas Mähler, Jing Wang, Barbara K. Terebieniec, Pär K. Ingvarsson, Nathaniel R. Street, Torgeir R. Hvidsten

PLOS Genetics: published April 13, 2017 | https://doi.org/10.1371/journal.pgen.1006402

Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function

Kexin Gai, Xuemei Cao, Qing Dong, Zhaolan Ding, Yashang Wei, Yingchun Liu, Xiao Liu, Qun He

PLOS Genetics: published April 12, 2017 | https://doi.org/10.1371/journal.pgen.1006732

VAMP3/Syb and YKT6 are required for the fusion of constitutive secretory carriers with the plasma membrane

David E. Gordon, Joanne Chia, Kamburpola Jayawardena, Robin Antrobus, Frederic Bard, Andrew A. Peden

PLOS Genetics: published April 12, 2017 | https://doi.org/10.1371/journal.pgen.1006698

Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila

Tom V. Lee, Ashutosh Pandey, Hamed Jafar-Nejad

PLOS Genetics: published April 10, 2017 | https://doi.org/10.1371/journal.pgen.1006723

Tissue-specific enhancer repression through molecular integration of cell signaling inputs

Luis Humberto Mojica-Vázquez, Mikhail H. Benetah, Aissette Baanannou, Sandra Bernat-Fabre, Bart Deplancke, David L. Cribbs, Henri-Marc Bourbon, Muriel Boube

PLOS Genetics: published April 10, 2017 | https://doi.org/10.1371/journal.pgen.1006718

Larval crowding accelerates C. elegans development and reduces lifespan

Andreas H. Ludewig, Clotilde Gimond, Joshua C. Judkins, Staci Thornton, Dania C. Pulido, Robert J. Micikas, Frank Döring, Adam Antebi, Christian Braendle, Frank C. Schroeder

PLOS Genetics: published April 10, 2017 | https://doi.org/10.1371/journal.pgen.1006717

Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci

Joana Rolo, Peder Worning, Jesper Boye Nielsen, Rita Sobral, Rory Bowden, Ons Bouchami, Peter Damborg, Luca Guardabassi, Vincent Perreten, Henrik Westh, Alexander Tomasz, Hermínia de Lencastre, Maria Miragaia

PLOS Genetics: published April 10, 2017 | https://doi.org/10.1371/journal.pgen.1006674

The bHLH transcription factor SPATULA enables cytokinin signaling, and both activate auxin biosynthesis and transport genes at the medial domain of the gynoecium

J. Irepan Reyes-Olalde, Víctor M. Zúñiga-Mayo, Joanna Serwatowska, Ricardo A. Chavez Montes, Paulina Lozano-Sotomayor, Humberto Herrera-Ubaldo, Karla L. Gonzalez-Aguilera, Patricia Ballester, Juan José Ripoll, Ignacio Ezquer, Dario Paolo, Alexander Heyl, Lucia Colombo, Martin F. Yanofsky, Cristina Ferrandiz, Nayelli Marsch-Martínez, Stefan de Folter

PLOS Genetics: published April 7, 2017 | https://doi.org/10.1371/journal.pgen.1006726

Phenome-wide heritability analysis of the UK Biobank

Tian Ge, Chia-Yen Chen, Benjamin M. Neale, Mert R. Sabuncu, Jordan W. Smoller

PLOS Genetics: published April 7, 2017 | https://doi.org/10.1371/journal.pgen.1006711

Triplin, a small molecule, reveals copper ion transport in ethylene signaling from ATX1 to RAN1

Wenbo Li, Randy F. Lacey, Yajin Ye, Juan Lu, Kuo-Chen Yeh, Youli Xiao, Laigeng Li, Chi-Kuang Wen, Brad M. Binder, Yang Zhao

PLOS Genetics: published April 7, 2017 | https://doi.org/10.1371/journal.pgen.1006703

Fetal de novo mutations and preterm birth

Jingjing Li, John Oehlert, Michael Snyder, David K. Stevenson, Gary M. Shaw

PLOS Genetics: published April 7, 2017 | https://doi.org/10.1371/journal.pgen.1006689

The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A

Doreen Schwochow Thalmann, Henrik Ring, Elisabeth Sundström, Xiaofang Cao, Mårten Larsson, Susanne Kerje, Andrey Höglund, Jesper Fogelholm, Dominic Wright, Per Jemth, Finn Hallböök, Bertrand Bed’Hom, Ben Dorshorst, Michèle Tixier-Boichard, Leif Andersson

PLOS Genetics: published April 7, 2017 | https://doi.org/10.1371/journal.pgen.1006665

A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling

Chun-Hao Chen, Chun-Wei He, Chien-Po Liao, Chun-Liang Pan

PLOS Genetics: published April 6, 2017 | https://doi.org/10.1371/journal.pgen.1006720

Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice

Ya-Yun Wang, Ying-Hung Lin, Yi-No Wu, Yen-Lin Chen, Yung-Chih Lin, Chiao-Yin Cheng, Han-Sun Chiang

PLOS Genetics: published April 6, 2017 | https://doi.org/10.1371/journal.pgen.1006715

Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior

Navonil Banerjee, Raja Bhattacharya, Michael Gorczyca, Kevin M. Collins, Michael M. Francis

PLOS Genetics: published April 6, 2017 | https://doi.org/10.1371/journal.pgen.1006697

Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip

Madapura M. Pradeepa, Fionnuala McKenna, Gillian C. A. Taylor, Hemant Bengani, Graeme R. Grimes, Andrew J. Wood, Shipra Bhatia, Wendy A. Bickmore

PLOS Genetics: published April 6, 2017 | https://doi.org/10.1371/journal.pgen.1006677

Structured mating: Patterns and implications

Ronnie Sebro, Gina M. Peloso, Josée Dupuis, Neil J. Risch

PLOS Genetics: published April 6, 2017 | https://doi.org/10.1371/journal.pgen.1006655

TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone

Cody J. Smith, Michael A. Wheeler, Lindsay Marjoram, Michel Bagnat, Christopher D. Deppmann, Sarah Kucenas

PLOS Genetics: published April 5, 2017 | https://doi.org/10.1371/journal.pgen.1006712

Meioc maintains an extended meiotic prophase I in mice

Y. Q. Shirleen Soh, Maria M. Mikedis, Mina Kojima, Alexander K. Godfrey, Dirk G. de Rooij, David C. Page

PLOS Genetics: published April 5, 2017 | https://doi.org/10.1371/journal.pgen.1006704

The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples

Signe Penner-Goeke, Zelda Lichtensztejn, Megan Neufeld, Jennifer L. Ali, Alon D. Altman, Mark W. Nachtigal, Kirk J. McManus

PLOS Genetics: published April 4, 2017 | https://doi.org/10.1371/journal.pgen.1006707

Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans

Eve W. L. Chow, Shelly A. Clancey, R. Blake Billmyre, Anna Floyd Averette, Joshua A. Granek, Piotr Mieczkowski, Maria E. Cardenas, Joseph Heitman

PLOS Genetics: published April 4, 2017 | https://doi.org/10.1371/journal.pgen.1006667

Novel insights into SLC25A46-related pathologies in a genetic mouse model

Maria Eirini Terzenidou, Aikaterini Segklia, Toshimi Kano, Florentia Papastefanaki, Alexandros Karakostas, Maria Charalambous, Fotis Ioakeimidis, Maria Papadaki, Ismini Kloukina, Margarita Chrysanthou-Piterou, Martina Samiotaki, George Panayotou, Rebecca Matsas, Eleni Douni

PLOS Genetics: published April 4, 2017 | https://doi.org/10.1371/journal.pgen.1006656

The time and place of European admixture in Ashkenazi Jewish history

James Xue, Todd Lencz, Ariel Darvasi, Itsik Pe’er, Shai Carmi

PLOS Genetics: published April 4, 2017 | https://doi.org/10.1371/journal.pgen.1006644

Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health

Amandine Duchesne, Anne Vaiman, Johan Castille, Christian Beauvallet, Pauline Gaignard, Sandrine Floriot, Sabrina Rodriguez, Marthe Vilotte, Laurent Boulanger, Bruno Passet, Olivier Albaric, François Guillaume, Abdelhak Boukadiri, Laurence Richard, Maud Bertaud, Edouard Timsit, Raphaël Guatteo, Florence Jaffrézic, Pierre Calvel, Louise Helary, Rachid Mahla, Diane Esquerré, Christine Péchoux, Sophie Liuu, Jean-Michel Vallat, Didier Boichard, Abdelhamid Slama, Jean-Luc Vilotte

PLOS Genetics: published April 4, 2017 | https://doi.org/10.1371/journal.pgen.1006597

Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [PSI⁺] prion formation

Shaun H. Speldewinde, Victoria A. Doronina, Mick F. Tuite, Chris M. Grant

PLOS Genetics: published April 3, 2017 | https://doi.org/10.1371/journal.pgen.1006708

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Lasse Folkersen, Eric Fauman, Maria Sabater-Lleal, Rona J. Strawbridge, Mattias Frånberg, Bengt Sennblad, Damiano Baldassarre, Fabrizio Veglia, Steve E. Humphries, Rainer Rauramaa, Ulf de Faire, Andries J. Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Stefan Enroth, Åsa Johansson, Sofia Bosdotter Enroth, Stefan Gustafsson, Lars Lind, Cecilia Lindgren, Andrew P. Morris, Vilmantas Giedraitis, Angela Silveira, Anders Franco-Cereceda, Elena Tremoli, IMPROVE study group, Ulf Gyllensten, Erik Ingelsson, Søren Brunak, Per Eriksson, Daniel Ziemek, Anders Hamsten, Anders Mälarstig

PLOS Genetics: published April 3, 2017 | https://doi.org/10.1371/journal.pgen.1006706

Probing the canonicity of the Wnt/Wingless signaling pathway

Alexandra Franz, Daria Shlyueva, Erich Brunner, Alexander Stark, Konrad Basler

PLOS Genetics: published April 3, 2017 | https://doi.org/10.1371/journal.pgen.1006700

The Zic family homologue Odd-paired regulates Alk expression in Drosophila

Patricia Mendoza-García, Fredrik Hugosson, Mahsa Fallah, Michael L. Higgins, Yasuno Iwasaki, Kathrin Pfeifer, Georg Wolfstetter, Gaurav Varshney, Dmitry Popichenko, J. Peter Gergen, Korneel Hens, Bart Deplancke, Ruth H. Palmer

PLOS Genetics: published April 3, 2017 | https://doi.org/10.1371/journal.pgen.1006617

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Challenging the Wnt signaling dogma.

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