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Table of Contents

March 2013

Cape Verde is an archipelago located off the West African coast that was found uninhabited by the Portuguese in the middle of the 15th century. Its unique settlement process gave rise to extensive genetic mixing between individuals of European and West African origin, reflected in the broad spectrum of morphologic variation observed today. In this issue, Beleza and colleagues use these unique properties of Cape Verde to study the genetic basis of skin and eye color variation in human populations.

Image Credit: Sandra Beleza and Sophie I. Candille

Interview

Review

Research Articles

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans

Carmen I. Nussbaum-Krammer, Kyung-Won Park, Liming Li, Ronald Melki, Richard I. Morimoto

Ataxin1L Is a Regulator of HSC Function Highlighting the Utility of Cross-Tissue Comparisons for Gene Discovery

Juliette J. Kahle, George P. Souroullas, Peng Yu, Fabian Zohren, Yoontae Lee, Chad A. Shaw, Huda Y. Zoghbi, Margaret A. Goodell

CRL2LRR-1 E3-Ligase Regulates Proliferation and Progression through Meiosis in the Caenorhabditis elegans Germline

Julien Burger, Jorge Merlet, Nicolas Tavernier, Bénédicte Richaudeau, Andreas Arnold, Rafal Ciosk, Bruce Bowerman, Lionel Pintard

A Gene Transfer Agent and a Dynamic Repertoire of Secretion Systems Hold the Keys to the Explosive Radiation of the Emerging Pathogen Bartonella

Lionel Guy, Björn Nystedt, Christina Toft, Katarzyna Zaremba-Niedzwiedzka, Eva C. Berglund, Fredrik Granberg, Kristina Näslund, Ann-Sofie Eriksson, Siv G. E. Andersson

Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

Jing Cui, Eli A. Stahl, Saedis Saevarsdottir, Corinne Miceli, Dorothee Diogo, Gosia Trynka, Towfique Raj, Maša Umiċeviċ Mirkov, Helena Canhao, Katsunori Ikari, Chikashi Terao, Yukinori Okada, Sara Wedrén, Johan Askling, Hisashi Yamanaka, Shigeki Momohara, Atsuo Taniguchi, Koichiro Ohmura, Fumihiko Matsuda, Tsuneyo Mimori, Namrata Gupta, Manik Kuchroo, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Marieke Herenius, Marieke E. Doorenspleet, Paul-Peter Tak, J. Bart A. Crusius, Irene E. van der Horst-Bruinsma, Gert Jan Wolbink, Piet L. C. M. van Riel, Mart van de Laar, Henk-Jan Guchelaar, Nancy A. Shadick, Cornelia F. Allaart, Tom W. J. Huizinga, Rene E. M. Toes, Robert P. Kimberly, S. Louis Bridges Jr, Lindsey A. Criswell, Larry W. Moreland, João Eurico Fonseca, Niek de Vries, Barbara E. Stranger, Philip L. De Jager, Soumya Raychaudhuri, Michael E. Weinblatt, Peter K. Gregersen, Xavier Mariette, Anne Barton, Leonid Padyukov, Marieke J. H. Coenen, Elizabeth W. Karlson, Robert M. Plenge

A Novel Function for the Hox Gene Abd-B in the Male Accessory Gland Regulates the Long-Term Female Post-Mating Response in Drosophila

Dragan Gligorov, Jessica L. Sitnik, Robert K. Maeda, Mariana F. Wolfner, François Karch

Dynamic Circadian Protein–Protein Interaction Networks Predict Temporal Organization of Cellular Functions

Thomas Wallach, Katja Schellenberg, Bert Maier, Ravi Kiran Reddy Kalathur, Pablo Porras, Erich E. Wanker, Matthias E. Futschik, Achim Kramer

The Tomato Yellow Leaf Curl Virus Resistance Genes Ty-1 and Ty-3 Are Allelic and Code for DFDGD-Class RNA–Dependent RNA Polymerases

Maarten G. Verlaan, Samuel F. Hutton, Ragy M. Ibrahem, Richard Kormelink, Richard G. F. Visser, John W. Scott, Jeremy D. Edwards, Yuling Bai

A Copy Number Variant at the KITLG Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit

Danielle M. Karyadi, Eric Karlins, Brennan Decker, Bridgett M. vonHoldt, Gretchen Carpintero-Ramirez, Heidi G. Parker, Robert K. Wayne, Elaine A. Ostrander

The Role of the Arabidopsis Exosome in siRNA–Independent Silencing of Heterochromatic Loci

Jun-Hye Shin, Hsiao-Lin V. Wang, Jinwon Lee, Brandon L. Dinwiddie, Dmitry A. Belostotsky, Julia A. Chekanova

A Single Cohesin Complex Performs Mitotic and Meiotic Functions in the Protist Tetrahymena

Rachel A. Howard-Till, Agnieszka Lukaszewicz, Maria Novatchkova, Josef Loidl

Genome-Wide Testing of Putative Functional Exonic Variants in Relationship with Breast and Prostate Cancer Risk in a Multiethnic Population

Christopher A. Haiman, Ying Han, Ye Feng, Lucy Xia, Chris Hsu, Xin Sheng, Loreall C. Pooler, Yesha Patel, Laurence N. Kolonel, Erin Carter, Karen Park, Loic Le Marchand, David Van Den Berg, Brian E. Henderson, Daniel O. Stram

Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk

Mia M. Gaudet, Karoline B. Kuchenbaecker, Joseph Vijai, Robert J. Klein, Tomas Kirchhoff, Lesley McGuffog, Daniel Barrowdale, Alison M. Dunning, Andrew Lee, Joe Dennis, Sue Healey, Ed Dicks, Penny Soucy, Olga M. Sinilnikova, Vernon S. Pankratz, Xianshu Wang, Ronald C. Eldridge, Daniel C. Tessier, Daniel Vincent, Francois Bacot, Frans B. L. Hogervorst, Susan Peock, Dominique Stoppa-Lyonnet, KConFab Investigators, Paolo Peterlongo, Rita K. Schmutzler, Katherine L. Nathanson, Marion Piedmonte, Christian F. Singer, Mads Thomassen, Ontario Cancer Genetics Network, Thomas v. O. Hansen, Susan L. Neuhausen, Ignacio Blanco, Mark H. Greene, Judith Garber, Jeffrey N. Weitzel, Irene L. Andrulis, David E. Goldgar, Emma D'Andrea, Trinidad Caldes, Heli Nevanlinna, Ana Osorio, Elizabeth J. van Rensburg, Adalgeir Arason, Gad Rennert, Ans M. W. van den Ouweland, Annemarie H. van der Hout, Carolien M. Kets, Cora M. Aalfs, Juul T. Wijnen, Margreet G. E. M. Ausems, HEBON, EMBRACE, Debra Frost, Steve Ellis, Elena Fineberg, Radka Platte, D. Gareth Evans, Chris Jacobs, Julian Adlard, Marc Tischkowitz, Mary E. Porteous, Francesca Damiola, GEMO Study Collaborators, Lisa Golmard, Laure Barjhoux, Michel Longy, Muriel Belotti, Sandra Fert Ferrer, Sylvie Mazoyer, Amanda B. Spurdle, Siranoush Manoukian, Monica Barile, Maurizio Genuardi, Norbert Arnold, Alfons Meindl, Christian Sutter, Barbara Wappenschmidt, Susan M. Domchek, Georg Pfeiler, Eitan Friedman, Uffe Birk Jensen, Mark Robson, Sohela Shah, Conxi Lazaro, Phuong L. Mai, Javier Benitez, Melissa C. Southey, Marjanka K. Schmidt, Peter A. Fasching, Julian Peto, Manjeet K. Humphreys, Qin Wang, Kyriaki Michailidou, Elinor J. Sawyer, Barbara Burwinkel, Pascal Guénel, Stig E. Bojesen, Roger L. Milne, Hermann Brenner, Magdalena Lochmann, The GENICA Network, Kristiina Aittomäki, Thilo Dörk, Sara Margolin, Arto Mannermaa, Diether Lambrechts, Jenny Chang-Claude, Paolo Radice, Graham G. Giles, Christopher A. Haiman, Robert Winqvist, Peter Devillee, Montserrat García-Closas, Nils Schoof, Maartje J. Hooning, Angela Cox, Paul D. P. Pharoah, Anna Jakubowska, Nick Orr, Anna González-Neira, Guillermo Pita, M. Rosario Alonso, Per Hall, Fergus J. Couch, Jacques Simard, David Altshuler, Douglas F. Easton, Georgia Chenevix-Trench, Antonis C. Antoniou, Kenneth Offit

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Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Fergus J. Couch, Xianshu Wang, Lesley McGuffog, Andrew Lee, Curtis Olswold, Karoline B. Kuchenbaecker, Penny Soucy, Zachary Fredericksen, Daniel Barrowdale, Joe Dennis, Mia M. Gaudet, Ed Dicks, Matthew Kosel, Sue Healey, Olga M. Sinilnikova, Adam Lee, François Bacot, Daniel Vincent, Frans B. L. Hogervorst, Susan Peock, Dominique Stoppa-Lyonnet, Anna Jakubowska, kConFab Investigators, Paolo Radice, Rita Katharina Schmutzler, SWE-BRCA, Susan M. Domchek, Marion Piedmonte, Christian F. Singer, Eitan Friedman, Mads Thomassen, Ontario Cancer Genetics Network, Thomas V. O. Hansen, Susan L. Neuhausen, Csilla I. Szabo, Ignacio Blanco, Mark H. Greene, Beth Y. Karlan, Judy Garber, Catherine M. Phelan, Jeffrey N. Weitzel, Marco Montagna, Edith Olah, Irene L. Andrulis, Andrew K. Godwin, Drakoulis Yannoukakos, David E. Goldgar, Trinidad Caldes, Heli Nevanlinna, Ana Osorio, Mary Beth Terry, Mary B. Daly, Elizabeth J. van Rensburg, Ute Hamann, Susan J. Ramus, Amanda Ewart Toland, Maria A. Caligo, Olufunmilayo I. Olopade, Nadine Tung, Kathleen Claes, Mary S. Beattie, Melissa C. Southey, Evgeny N. Imyanitov, Marc Tischkowitz, Ramunas Janavicius, Esther M. John, Ava Kwong, Orland Diez, Judith Balmaña, Rosa B. Barkardottir, Banu K. Arun, Gad Rennert, Soo-Hwang Teo, Patricia A. Ganz, Ian Campbell, Annemarie H. van der Hout, Carolien H. M. van Deurzen, Caroline Seynaeve, Encarna B. Gómez Garcia, Flora E. van Leeuwen, Hanne E. J. Meijers-Heijboer, Johannes J. P. Gille, Margreet G. E. M. Ausems, Marinus J. Blok, Marjolijn J. L. Ligtenberg, Matti A. Rookus, Peter Devilee, Senno Verhoef, Theo A. M. van Os, Juul T. Wijnen, HEBON, EMBRACE, Debra Frost, Steve Ellis, Elena Fineberg, Radka Platte, D. Gareth Evans, Louise Izatt, Rosalind A. Eeles, Julian Adlard, Diana M. Eccles, Jackie Cook, Carole Brewer, Fiona Douglas, Shirley Hodgson, Patrick J. Morrison, Lucy E. Side, Alan Donaldson, Catherine Houghton, Mark T. Rogers, Huw Dorkins, Jacqueline Eason, Helen Gregory, Emma McCann, Alex Murray, Alain Calender, Agnès Hardouin, Pascaline Berthet, Capucine Delnatte, Catherine Nogues, Christine Lasset, Claude Houdayer, Dominique Leroux, Etienne Rouleau, Fabienne Prieur, Francesca Damiola, Hagay Sobol, Isabelle Coupier, Laurence Venat-Bouvet, Laurent Castera, Marion Gauthier-Villars, Mélanie Léoné, Pascal Pujol, Sylvie Mazoyer, Yves-Jean Bignon, GEMO Study Collaborators, Elżbieta Złowocka-Perłowska, Jacek Gronwald, Jan Lubinski, Katarzyna Durda, Katarzyna Jaworska, Tomasz Huzarski, Amanda B. Spurdle, Alessandra Viel, Bernard Peissel, Bernardo Bonanni, Giulia Melloni, Laura Ottini, Laura Papi, Liliana Varesco, Maria Grazia Tibiletti, Paolo Peterlongo, Sara Volorio, Siranoush Manoukian, Valeria Pensotti, Norbert Arnold, Christoph Engel, Helmut Deissler, Dorothea Gadzicki, Andrea Gehrig, Karin Kast, Kerstin Rhiem, Alfons Meindl, Dieter Niederacher, Nina Ditsch, Hansjoerg Plendl, Sabine Preisler-Adams, Stefanie Engert, Christian Sutter, Raymonda Varon-Mateeva, Barbara Wappenschmidt, Bernhard H. F. Weber, Brita Arver, Marie Stenmark-Askmalm, Niklas Loman, Richard Rosenquist, Zakaria Einbeigi, Katherine L. Nathanson, Timothy R. Rebbeck, Stephanie V. Blank, David E. Cohn, Gustavo C. Rodriguez, Laurie Small, Michael Friedlander, Victoria L. Bae-Jump, Anneliese Fink-Retter, Christine Rappaport, Daphne Gschwantler-Kaulich, Georg Pfeiler, Muy-Kheng Tea, Noralane M. Lindor, Bella Kaufman, Shani Shimon Paluch, Yael Laitman, Anne-Bine Skytte, Anne-Marie Gerdes, Inge Sokilde Pedersen, Sanne Traasdahl Moeller, Torben A. Kruse, Uffe Birk Jensen, Joseph Vijai, Kara Sarrel, Mark Robson, Noah Kauff, Anna Marie Mulligan, Gord Glendon, Hilmi Ozcelik, Bent Ejlertsen, Finn C. Nielsen, Lars Jønson, Mette K. Andersen, Yuan Chun Ding, Linda Steele, Lenka Foretova, Alex Teulé, Conxi Lazaro, Joan Brunet, Miquel Angel Pujana, Phuong L. Mai, Jennifer T. Loud, Christine Walsh, Jenny Lester, Sandra Orsulic, Steven A. Narod, Josef Herzog, Sharon R. Sand, Silvia Tognazzo, Simona Agata, Tibor Vaszko, Joellen Weaver, Alexandra V. Stavropoulou, Saundra S. Buys, Atocha Romero, Miguel de la Hoya, Kristiina Aittomäki, Taru A. Muranen, Mercedes Duran, Wendy K. Chung, Adriana Lasa, Cecilia M. Dorfling, Alexander Miron, BCFR, Javier Benitez, Leigha Senter, Dezheng Huo, Salina B. Chan, Anna P. Sokolenko, Jocelyne Chiquette, Laima Tihomirova, Tara M. Friebel, Bjarni A. Agnarsson, Karen H. Lu, Flavio Lejbkowicz, Paul A. James, Per Hall, Alison M. Dunning, Daniel Tessier, Julie Cunningham, Susan L. Slager, Chen Wang, Steven Hart, Kristen Stevens, Jacques Simard, Tomi Pastinen, Vernon S. Pankratz, Kenneth Offit, Douglas F. Easton, Georgia Chenevix-Trench, Antonis C. Antoniou, on behalf of CIMBA

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Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

Stefan Nickels, Thérèse Truong, Rebecca Hein, Kristen Stevens, Katharina Buck, Sabine Behrens, Ursula Eilber, Martina Schmidt, Lothar Häberle, Alina Vrieling, Mia Gaudet, Jonine Figueroa, Nils Schoof, Amanda B. Spurdle, Anja Rudolph, Peter A. Fasching, John L. Hopper, Enes Makalic, Daniel F. Schmidt, Melissa C. Southey, Matthias W. Beckmann, Arif B. Ekici, Olivia Fletcher, Lorna Gibson, Isabel dos Santos Silva, Julian Peto, Manjeet K. Humphreys, Jean Wang, Emilie Cordina-Duverger, Florence Menegaux, Børge G. Nordestgaard, Stig E. Bojesen, Charlotte Lanng, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina A. Clarke, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Hiltrud Brauch, Thomas Brüning, Volker Harth, The GENICA Network, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, kConFab, AOCS Management Group, Diether Lambrechts, Dominiek Smeets, Patrick Neven, Robert Paridaens, Dieter Flesch-Janys, Nadia Obi, Shan Wang-Gohrke, Fergus J. Couch, Janet E. Olson, Celine M. Vachon, Graham G. Giles, Gianluca Severi, Laura Baglietto, Kenneth Offit, Esther M. John, Alexander Miron, Irene L. Andrulis, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Stephen J. Chanock, Jolanta Lissowska, Jianjun Liu, Angela Cox, Helen Cramp, Dan Connley, Sabapathy Balasubramanian, Alison M. Dunning, Mitul Shah, Amy Trentham-Dietz, Polly Newcomb, Linda Titus, Kathleen Egan, Elizabeth K. Cahoon, Preetha Rajaraman, Alice J. Sigurdson, Michele M. Doody, Pascal Guénel, Paul D. P. Pharoah, Marjanka K. Schmidt, Per Hall, Doug F. Easton, Montserrat Garcia-Closas, Roger L. Milne, Jenny Chang-Claude

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Human Spermatogenic Failure Purges Deleterious Mutation Load from the Autosomes and Both Sex Chromosomes, including the Gene DMRT1

Alexandra M. Lopes, Kenneth I. Aston, Emma Thompson, Filipa Carvalho, João Gonçalves, Ni Huang, Rune Matthiesen, Michiel J. Noordam, Inés Quintela, Avinash Ramu, Catarina Seabra, Amy B. Wilfert, Juncheng Dai, Jonathan M. Downie, Susana Fernandes, Xuejiang Guo, Jiahao Sha, António Amorim, Alberto Barros, Angel Carracedo, Zhibin Hu, Matthew E. Hurles, Sergey Moskovtsev, Carole Ober, Darius A. Paduch, Joshua D. Schiffman, Peter N. Schlegel, Mário Sousa, Douglas T. Carrell, Donald F. Conrad

A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype

Gianluca Occhi, Daniela Regazzo, Giampaolo Trivellin, Francesca Boaretto, Denis Ciato, Sara Bobisse, Sergio Ferasin, Filomena Cetani, Elena Pardi, Márta Korbonits, Natalia S. Pellegata, Viktoryia Sidarovich, Alessandro Quattrone, Giuseppe Opocher, Franco Mantero, Carla Scaroni

The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans

Trisha A. Staab, Trevor C. Griffen, Connor Corcoran, Oleg Evgrafov, James A. Knowles, Derek Sieburth

Astakine 2—the Dark Knight Linking Melatonin to Circadian Regulation in Crustaceans

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Fine Characterisation of a Recombination Hotspot at the DPY19L2 Locus and Resolution of the Paradoxical Excess of Duplications over Deletions in the General Population

Charles Coutton, Farid Abada, Thomas Karaouzene, Damien Sanlaville, Véronique Satre, Joël Lunardi, Pierre-Simon Jouk, Christophe Arnoult, Nicolas Thierry-Mieg, Pierre F. Ray

Recurrent Rearrangement during Adaptive Evolution in an Interspecific Yeast Hybrid Suggests a Model for Rapid Introgression

Barbara Dunn, Terry Paulish, Alison Stanbery, Jeff Piotrowski, Gregory Koniges, Evgueny Kroll, Edward J. Louis, Gianni Liti, Gavin Sherlock, Frank Rosenzweig

A Novel Role for the RNA–Binding Protein FXR1P in Myoblasts Cell-Cycle Progression by Modulating p21/Cdkn1a/Cip1/Waf1 mRNA Stability

Laetitia Davidovic, Nelly Durand, Olfa Khalfallah, Ricardo Tabet, Pascal Barbry, Bernard Mari, Sabrina Sacconi, Hervé Moine, Barbara Bardoni

Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB

Vidisha Tripathi, Zhen Shen, Arindam Chakraborty, Sumanprava Giri, Susan M. Freier, Xiaolin Wu, Yongqing Zhang, Myriam Gorospe, Supriya G. Prasanth, Ashish Lal, Kannanganattu V. Prasanth

MTL–Independent Phenotypic Switching in Candida tropicalis and a Dual Role for Wor1 in Regulating Switching and Filamentation

Allison M. Porman, Matthew P. Hirakawa, Stephen K. Jones, Na Wang, Richard J. Bennett

Genetic Architecture of Skin and Eye Color in an African-European Admixed Population

Sandra Beleza, Nicholas A. Johnson, Sophie I. Candille, Devin M. Absher, Marc A. Coram, Jailson Lopes, Joana Campos, Isabel Inês Araújo, Tovi M. Anderson, Bjarni J. Vilhjálmsson, Magnus Nordborg, António Correia e Silva, Mark D. Shriver, Jorge Rocha, Gregory S. Barsh, Hua Tang

Association Mapping and the Genomic Consequences of Selection in Sunflower

Jennifer R. Mandel, Savithri Nambeesan, John E. Bowers, Laura F. Marek, Daniel Ebert, Loren H. Rieseberg, Steven J. Knapp, John M. Burke

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Ying Wu, Lindsay L. Waite, Anne U. Jackson, Wayne H-H. Sheu, Steven Buyske, Devin Absher, Donna K. Arnett, Eric Boerwinkle, Lori L. Bonnycastle, Cara L. Carty, Iona Cheng, Barbara Cochran, Damien C. Croteau-Chonka, Logan Dumitrescu, Charles B. Eaton, Nora Franceschini, Xiuqing Guo, Brian E. Henderson, Lucia A. Hindorff, Eric Kim, Leena Kinnunen, Pirjo Komulainen, Wen-Jane Lee, Loic Le Marchand, Yi Lin, Jaana Lindström, Oddgeir Lingaas-Holmen, Sabrina L. Mitchell, Narisu Narisu, Jennifer G. Robinson, Fred Schumacher, Alena Stančáková, Jouko Sundvall, Yun-Ju Sung, Amy J. Swift, Wen-Chang Wang, Lynne Wilkens, Tom Wilsgaard, Alicia M. Young, Linda S. Adair, Christie M. Ballantyne, Petra Bůžková, Aravinda Chakravarti, Francis S. Collins, David Duggan, Alan B. Feranil, Low-Tone Ho, Yi-Jen Hung, Steven C. Hunt, Kristian Hveem, Jyh-Ming J. Juang, Antero Y. Kesäniemi, Johanna Kuusisto, Markku Laakso, Timo A. Lakka, I-Te Lee, Mark F. Leppert, Tara C. Matise, Leena Moilanen, Inger Njølstad, Ulrike Peters, Thomas Quertermous, Rainer Rauramaa, Jerome I. Rotter, Jouko Saramies, Jaakko Tuomilehto, Matti Uusitupa, Tzung-Dau Wang, Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North, Karen L. Mohlke

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

Antoine Reginensi, Rizaldy P. Scott, Alex Gregorieff, Mazdak Bagherie-Lachidan, Chaeuk Chung, Dae-Sik Lim, Tony Pawson, Jeff Wrana, Helen McNeill

Genome-Wide Control of RNA Polymerase II Activity by Cohesin

Cheri A. Schaaf, Hojoong Kwak, Amanda Koenig, Ziva Misulovin, David W. Gohara, Audrey Watson, Yanjiao Zhou, John T. Lis, Dale Dorsett

Mouse HFM1/Mer3 Is Required for Crossover Formation and Complete Synapsis of Homologous Chromosomes during Meiosis

Michel F. Guiraldelli, Craig Eyster, Joseph L. Wilkerson, Michael E. Dresser, Roberto J. Pezza

Ancient Evolutionary Trade-Offs between Yeast Ploidy States

Enikö Zörgö, Karolina Chwialkowska, Arne B. Gjuvsland, Elena Garré, Per Sunnerhagen, Gianni Liti, Anders Blomberg, Stig W. Omholt, Jonas Warringer

Molecular Networks of Human Muscle Adaptation to Exercise and Age

Bethan E. Phillips, John P. Williams, Thomas Gustafsson, Claude Bouchard, Tuomo Rankinen, Steen Knudsen, Kenneth Smith, James A. Timmons, Philip J. Atherton

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Nuclear Myosin 1c Facilitates the Chromatin Modifications Required to Activate rRNA Gene Transcription and Cell Cycle Progression

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Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest

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Complex Patterns of Genomic Admixture within Southern Africa

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The Population and Evolutionary Dynamics of Phage and Bacteria with CRISPR–Mediated Immunity

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Microhomology-Mediated Mechanisms Underlie Non-Recurrent Disease-Causing Microdeletions of the FOXL2 Gene or Its Regulatory Domain

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Tom Stiff, Meryem Alagoz, Diana Alcantara, Emily Outwin, Han G. Brunner, Ernie M. H. F. Bongers, Mark O'Driscoll, Penny A. Jeggo

Blood-Informative Transcripts Define Nine Common Axes of Peripheral Blood Gene Expression

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Rare Copy Number Variants Are a Common Cause of Short Stature

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Alternative Splicing and Subfunctionalization Generates Functional Diversity in Fungal Proteomes

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A Conserved Upstream Motif Orchestrates Autonomous, Germline-Enriched Expression of Caenorhabditis elegans piRNAs

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