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Table of Contents

April 2013

This confocal image shows a wild type Drosophila melanogaster ring gland. This gland is responsible for the synthesis of the steroid hormone ecdysone, which controls animal growth and development. In this issue, Talamillo and coworkers report that the capture of lipids by the ring gland, which are necessary for the synthesis of the hormone, depends on the ubiquitin-like SUMO protein, the nuclear hormone receptor Ftz-f1, and the Scavenger Receptor Snmp1. The nuclei of the gland are marked with DAPI (blue) and the cell contours are marked by phalloidin (red). The image has been mirror-duplicated.

Image Credit: Ana Talamillo and Rosa Barrio, CIC bioGUNE

Review

The G4 Genome

Nancy Maizels, Lucas T. Gray

Research Articles

Six Homeoproteins Directly Activate Myod Expression in the Gene Regulatory Networks That Control Early Myogenesis

Frédéric Relaix, Josiane Demignon, Christine Laclef, Julien Pujol, Marc Santolini, Claire Niro, Mounia Lagha, Didier Rocancourt, Margaret Buckingham, Pascal Maire

All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs

Andrew J. Schork, Wesley K. Thompson, Phillip Pham, Ali Torkamani, J. Cooper Roddey, Patrick F. Sullivan, John R. Kelsoe, Michael C. O'Donovan, Helena Furberg, The Tobacco and Genetics Consortium, The Bipolar Disorder Psychiatric Genomics Consortium, The Schizophrenia Psychiatric Genomics Consortium, Nicholas J. Schork, Ole A. Andreassen, Anders M. Dale

Signatures of Diversifying Selection in European Pig Breeds

Samantha Wilkinson, Zen H. Lu, Hendrik-Jan Megens, Alan L. Archibald, Chris Haley, Ian J. Jackson, Martien A. M. Groenen, Richard P. M. A. Crooijmans, Rob Ogden, Pamela Wiener

Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

Ole A. Andreassen, Wesley K. Thompson, Andrew J. Schork, Stephan Ripke, Morten Mattingsdal, John R. Kelsoe, Kenneth S. Kendler, Michael C. O'Donovan, Dan Rujescu, Thomas Werge, Pamela Sklar, The Psychiatric Genomics Consortium (PGC), Bipolar Disorder and Schizophrenia Working Groups, J. Cooper Roddey, Chi-Hua Chen, Linda McEvoy, Rahul S. Desikan, Srdjan Djurovic, Anders M. Dale

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Breakpoint Analysis of Transcriptional and Genomic Profiles Uncovers Novel Gene Fusions Spanning Multiple Human Cancer Types

Craig P. Giacomini, Steven Sun, Sushama Varma, A. Hunter Shain, Marilyn M. Giacomini, Jay Balagtas, Robert T. Sweeney, Everett Lai, Catherine A. Del Vecchio, Andrew D. Forster, Nicole Clarke, Kelli D. Montgomery, Shirley Zhu, Albert J. Wong, Matt van de Rijn, Robert B. West, Jonathan R. Pollack

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Melinda Roberts, Saijun Tang, Anna Stallmann, Jeffery L. Dangl, Vera Bonardi

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Genome-Wide Association Studies Identify Two Novel BMP15 Mutations Responsible for an Atypical Hyperprolificacy Phenotype in Sheep

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The Genome Organization of Thermotoga maritima Reflects Its Lifestyle

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TIP48/Reptin and H2A.Z Requirement for Initiating Chromatin Remodeling in Estrogen-Activated Transcription

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Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality

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Rod Monochromacy and the Coevolution of Cetacean Retinal Opsins

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Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies

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Mouse Oocyte Methylomes at Base Resolution Reveal Genome-Wide Accumulation of Non-CpG Methylation and Role of DNA Methyltransferases

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Smaug/SAMD4A Restores Translational Activity of CUGBP1 and Suppresses CUG-Induced Myopathy

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Comprehensive Assignment of Roles for Salmonella Typhimurium Genes in Intestinal Colonization of Food-Producing Animals

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Identification of a Tissue-Selective Heat Shock Response Regulatory Network

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Scavenger Receptors Mediate the Role of SUMO and Ftz-f1 in Drosophila Steroidogenesis

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A Nonsynonymous Polymorphism in Semaphorin 3A as a Risk Factor for Human Unexplained Cardiac Arrest with Documented Ventricular Fibrillation

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