Table of Contents

January 2011

Different species of entomopathogenic fungi are being developed as environmentally friendly insect biocontrol agents. The genus Metarhizium includes the well-studied species M. anisopliae, which is capable of killing more than 200 insect species including cockroaches (left) and the locust-specific pathogen M. acridum that only infects locusts (right) or grasshoppers. In this issue of PLoS Genetics, Gao et al. report the comparative genomic studies of these two fungal species and find extensive gene expansions in M. anisopliae that may facilitate its ability to cope with a diverse range of insect hosts.

Image Credit: Chengshu Wang and Yuxian Xia.


Research Articles

Bub1-Mediated Adaptation of the Spindle Checkpoint

Greicy H. Goto, Ashutosh Mishra, Rashid Abdulle, Clive A. Slaughter, Katsumi Kitagawa

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

Eleonora A. M. Festen, Philippe Goyette, Todd Green, Gabrielle Boucher, Claudine Beauchamp, Gosia Trynka, Patrick C. Dubois, Caroline Lagacé, Pieter C. F. Stokkers, Daan W. Hommes, Donatella Barisani, Orazio Palmieri, Vito Annese, David A. van Heel, Rinse K. Weersma, Mark J. Daly, Cisca Wijmenga, John D. Rioux

Evolutionary Conserved Regulation of HIF-1β by NF-κB

Patrick van Uden, Niall S. Kenneth, Ryan Webster, H. Arno Müller, Sharon Mudie, Sonia Rocha

RNF12 Activates Xist and Is Essential for X Chromosome Inactivation

Tahsin Stefan Barakat, Nilhan Gunhanlar, Cristina Gontan Pardo, Eskeatnaf Mulugeta Achame, Mehrnaz Ghazvini, Ruben Boers, Annegien Kenter, Eveline Rentmeester, J. Anton Grootegoed, Joost Gribnau

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