Table of Contents

October 2014

In this issue of PLOS Genetics, DiTommaso et al. describe the phenotype of mice carrying inactivating mutations in Keratin 76 (Krt76), highlighting the gene as indispensable for skin barrier function and cutaneous wound healing. They also describe a role for KRT76 in maintaining the function of intercellular tight junctions, where it is required for normal CLAUDIN1 localisation. This work supports an emerging body of evidence which challenges the classical view of the keratins as simple structural proteins. Image: Claudin 1 (green), Ecadherin (red) and keratin 14 (blue) in the tail skin of a mouse. See DiTommaso et al.

Image Credit: Tia DiTommaso


Keeping mtDNA in Shape between Generations

James B. Stewart, Nils-Göran Larsson

Research Articles

Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation

Andrew D. Hoffmann, Xinan Holly Yang, Ozanna Burnicka-Turek, Joshua D. Bosman, Xiaomeng Ren, Jeffrey D. Steimle, Steven A. Vokes, Andrew P. McMahon, Vladimir V. Kalinichenko, Ivan P. Moskowitz

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The Proteomic Landscape of the Suprachiasmatic Nucleus Clock Reveals Large-Scale Coordination of Key Biological Processes

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Systematic Dissection of Coding Exons at Single Nucleotide Resolution Supports an Additional Role in Cell-Specific Transcriptional Regulation

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Juvenile Hormone-Receptor Complex Acts on Mcm4 and Mcm7 to Promote Polyploidy and Vitellogenesis in the Migratory Locust

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A Complex Genetic Switch Involving Overlapping Divergent Promoters and DNA Looping Regulates Expression of Conjugation Genes of a Gram-positive Plasmid

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A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling

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Germline Mutations in MAP3K6 Are Associated with Familial Gastric Cancer

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Copy Number Variation in the Horse Genome

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The Not5 Subunit of the Ccr4-Not Complex Connects Transcription and Translation

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Abnormal Dosage of Ultraconserved Elements Is Highly Disfavored in Healthy Cells but Not Cancer Cells

Ruth B. McCole, Chamith Y. Fonseka, Amnon Koren, C.-ting Wu

FHIT Suppresses Epithelial-Mesenchymal Transition (EMT) and Metastasis in Lung Cancer through Modulation of MicroRNAs

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HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst

Eryn Wicklow, Stephanie Blij, Tristan Frum, Yoshikazu Hirate, Richard A. Lang, Hiroshi Sasaki, Amy Ralston

Protein Phosphatase 4 Promotes Chromosome Pairing and Synapsis, and Contributes to Maintaining Crossover Competence with Increasing Age

Aya Sato-Carlton, Xuan Li, Oliver Crawley, Sarah Testori, Enrique Martinez-Perez, Asako Sugimoto, Peter M. Carlton

A Splice Mutation in the PHKG1 Gene Causes High Glycogen Content and Low Meat Quality in Pig Skeletal Muscle

Junwu Ma, Jie Yang, Lisheng Zhou, Jun Ren, Xianxian Liu, Hui Zhang, Bin Yang, Zhiyan Zhang, Huanban Ma, Xianhua Xie, Yuyun Xing, Yuanmei Guo, Lusheng Huang

The Nuclear Immune Receptor RPS4 Is Required for RRS1SLH1-Dependent Constitutive Defense Activation in Arabidopsis thaliana

Kee Hoon Sohn, Cécile Segonzac, Ghanasyam Rallapalli, Panagiotis F. Sarris, Joo Yong Woo, Simon J. Williams, Toby E. Newman, Kyung Hee Paek, Bostjan Kobe, Jonathan D. G. Jones

A Conserved Role for p48 Homologs in Protecting Dopaminergic Neurons from Oxidative Stress

Peter Bou Dib, Bettina Gnägi, Fiona Daly, Virginie Sabado, Damla Tas, Dominique A. Glauser, Peter Meister, Emi Nagoshi

Keratin 76 Is Required for Tight Junction Function and Maintenance of the Skin Barrier

Tia DiTommaso, Denny L. Cottle, Helen B. Pearson, Holger Schlüter, Pritinder Kaur, Patrick O. Humbert, Ian M. Smyth

Dynamic Partnership between TFIIH, PGC-1α and SIRT1 Is Impaired in Trichothiodystrophy

Hussein Traboulsi, Serena Davoli, Philippe Catez, Jean-Marc Egly, Emmanuel Compe

Examination of Prokaryotic Multipartite Genome Evolution through Experimental Genome Reduction

George C. diCenzo, Allyson M. MacLean, Branislava Milunovic, G. Brian Golding, Turlough M. Finan

It's All in Your Mind: Determining Germ Cell Fate by Neuronal IRE-1 in C. elegans

Mor Levi-Ferber, Yehuda Salzberg, Modi Safra, Anat Haviv-Chesner, Hannes E. Bülow, Sivan Henis-Korenblit

The Master Activator of IncA/C Conjugative Plasmids Stimulates Genomic Islands and Multidrug Resistance Dissemination

Nicolas Carraro, Dominick Matteau, Peng Luo, Sébastien Rodrigue, Vincent Burrus

Ancient Expansion of the Hox Cluster in Lepidoptera Generated Four Homeobox Genes Implicated in Extra-Embryonic Tissue Formation

Laura Ferguson, Ferdinand Marlétaz, Jean-Michel Carter, William R. Taylor, Melanie Gibbs, Casper J. Breuker, Peter W. H. Holland

The Analysis of Mutant Alleles of Different Strength Reveals Multiple Functions of Topoisomerase 2 in Regulation of Drosophila Chromosome Structure

Valentina Mengoli, Elisabetta Bucciarelli, Ramona Lattao, Roberto Piergentili, Maurizio Gatti, Silvia Bonaccorsi

Identification of Genes Important for Cutaneous Function Revealed by a Large Scale Reverse Genetic Screen in the Mouse

Tia DiTommaso, Lynelle K. Jones, Denny L. Cottle, The WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E. Vancollie, Fiona M. Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P. Steel, John P. Sundberg, Jacqueline K. White, Ian M. Smyth

A Gain-of-Function Mutation in Tnni2 Impeded Bone Development through Increasing Hif3a Expression in DA2B Mice

Xiaoquan Zhu, Fengchao Wang, Yanyang Zhao, Peng Yang, Jun Chen, Hanzi Sun, Lei Liu, Wenjun Li, Lin Pan, Yanru Guo, Zhaohui Kou, Yu Zhang, Cheng Zhou, Jiang He, Xue Zhang, Jianxin Li, Weitian Han, Jian Li, Guanghui Liu, Shaorong Gao, Ze Yang

Genetic Influences on Translation in Yeast

Frank W. Albert, Dale Muzzey, Jonathan S. Weissman, Leonid Kruglyak

Multifaceted Genome Control by Set1 Dependent and Independent of H3K4 Methylation and the Set1C/COMPASS Complex

Irina V. Mikheyeva, Patrick J. R. Grady, Fiona B. Tamburini, David R. Lorenz, Hugh P. Cam

Mmp1 Processing of the PDF Neuropeptide Regulates Circadian Structural Plasticity of Pacemaker Neurons

Ana Depetris-Chauvin, Ágata Fernández-Gamba, E. Axel Gorostiza, Anastasia Herrero, Eduardo M. Castaño, M. Fernanda Ceriani

Ribosomal Readthrough at a Short UGA Stop Codon Context Triggers Dual Localization of Metabolic Enzymes in Fungi and Animals

Alina C. Stiebler, Johannes Freitag, Kay O. Schink, Thorsten Stehlik, Britta A. M. Tillmann, Julia Ast, Michael Bölker

Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies

Gleb Kichaev, Wen-Yun Yang, Sara Lindstrom, Farhad Hormozdiari, Eleazar Eskin, Alkes L. Price, Peter Kraft, Bogdan Pasaniuc

Feeding State, Insulin and NPR-1 Modulate Chemoreceptor Gene Expression via Integration of Sensory and Circuit Inputs

Matthew Gruner, Dru Nelson, Ari Winbush, Rebecca Hintz, Leesun Ryu, Samuel H. Chung, Kyuhyung Kim, Chrisopher V. Gabel, Alexander M. van der Linden

COE Loss-of-Function Analysis Reveals a Genetic Program Underlying Maintenance and Regeneration of the Nervous System in Planarians

Martis W. Cowles, Kerilyn C. Omuro, Brianna N. Stanley, Carlo G. Quintanilla, Ricardo M. Zayas

A Role for Taiman in Insect Metamorphosis

Jesus Lozano, Takumi Kayukawa, Tetsuro Shinoda, Xavier Belles

Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation

John S. K. Kauwe, Matthew H. Bailey, Perry G. Ridge, Rachel Perry, Mark E. Wadsworth, Kaitlyn L. Hoyt, Lyndsay A. Staley, Celeste M. Karch, Oscar Harari, Carlos Cruchaga, Benjamin J. Ainscough, Kelly Bales, Eve H. Pickering, Sarah Bertelsen, the Alzheimer's Disease Neuroimaging Initiative, Anne M. Fagan, David M. Holtzman, John C. Morris, Alison M. Goate

Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss

Jing Chen, Neil Ingham, John Kelly, Shalini Jadeja, David Goulding, Johanna Pass, Vinit B. Mahajan, Stephen H. Tsang, Anastasia Nijnik, Ian J. Jackson, Jacqueline K. White, Andrew Forge, Daniel Jagger, Karen P. Steel

Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence

Meng C. Wang, Holly D. Oakley, Christopher E. Carr, Jessica N. Sowa, Gary Ruvkun

Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian Cancer

Jin-Gyoung Jung, Alexander Stoeck, Bin Guan, Ren-Chin Wu, Heng Zhu, Seth Blackshaw, Ie-Ming Shih, Tian-Li Wang

De Novo Mutations in Moderate or Severe Intellectual Disability

Fadi F. Hamdan, Myriam Srour, Jose-Mario Capo-Chichi, Hussein Daoud, Christina Nassif, Lysanne Patry, Christine Massicotte, Amirthagowri Ambalavanan, Dan Spiegelman, Ousmane Diallo, Edouard Henrion, Alexandre Dionne-Laporte, Anne Fougerat, Alexey V. Pshezhetsky, Sunita Venkateswaran, Guy A. Rouleau, Jacques L. Michaud

Telomeric ORFs (TLOs) in Candida spp. Encode Mediator Subunits That Regulate Distinct Virulence Traits

John Haran, Hannah Boyle, Karsten Hokamp, Tim Yeomans, Zhongle Liu, Michael Church, Alastair B. Fleming, Matthew Z. Anderson, Judith Berman, Lawrence C. Myers, Derek J. Sullivan, Gary P. Moran

The Listeria Small RNA Rli27 Regulates a Cell Wall Protein inside Eukaryotic Cells by Targeting a Long 5′-UTR Variant

Juan J. Quereda, Álvaro D. Ortega, M. Graciela Pucciarelli, Francisco García-del Portillo