Table of Contents

July 2017

Archaeological remains of individual MC337 excavated from the site of Hipogeu de Monte Canelas I, Portugal, and analysed by archaeologist Rui Parreira and anthropologist Ana Maria Silva. This was one of the 14 Neolithic and Bronze Age samples sequenced by Martiniano et al. The authors show that in contrast with other parts of Europe where evidence for mass migration was observed after the Neolithic era, only subtle genetic changes can be observed between the Portuguese Neolithic and Bronze Age samples, possibly resulting from small-scale migration. See Martiniano et al.

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Image Credit: Rui Parreira, UNIARQ, University of Lisbon, Portugal.


Genetic compensation: A phenomenon in search of mechanisms

Mohamed A. El-Brolosy, Didier Y. R. Stainier

Research Articles

Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport

Daniel J. Barbosa, Joana Duro, Bram Prevo, Dhanya K. Cheerambathur, Ana X. Carvalho, Reto Gassmann

The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling

Sumbul Jawed Khan, Syeda Nayab Fatima Abidi, Andrea Skinner, Yuan Tian, Rachel K. Smith-Bolton

Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein

Charles Anthony Scott, Autumn N. Marsden, Michael R. Rebagliati, Qihong Zhang, Xitiz Chamling, Charles C. Searby, Lisa M. Baye, Val C. Sheffield, Diane C. Slusarski

The RhoJ-BAD signaling network: An Achilles’ heel for BRAF mutant melanomas

Rolando Ruiz, Sohail Jahid, Melissa Harris, Diego M. Marzese, Francisco Espitia, Priya Vasudeva, Chi-Fen Chen, Sebastien de Feraudy, Jie Wu, Daniel L. Gillen, Tatiana B. Krasieva, Bruce J. Tromberg, William J. Pavan, Dave S. Hoon, Anand K. Ganesan

Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements

Elodie Thierion, Johan Le Men, Samuel Collombet, Céline Hernandez, Fanny Coulpier, Patrick Torbey, Morgane Thomas-Chollier, Daan Noordermeer, Patrick Charnay, Pascale Gilardi-Hebenstreit

Replication stress affects the fidelity of nucleosome-mediated epigenetic inheritance

Wenzhu Li, Jia Yi, Pamela Agbu, Zheng Zhou, Richard L. Kelley, Scott Kallgren, Songtao Jia, Xiangwei He

MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth

Mengfan Pu, Chenggang Li, Xinming Qi, Jing Chen, Yizheng Wang, Lulu Gao, Lingling Miao, Jin Ren

The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods

Rui Martiniano, Lara M. Cassidy, Ros Ó'Maoldúin, Russell McLaughlin, Nuno M. Silva, Licinio Manco, Daniel Fidalgo, Tania Pereira, Maria J. Coelho, Miguel Serra, Joachim Burger, Rui Parreira, Elena Moran, Antonio C. Valera, Eduardo Porfirio, Rui Boaventura, Ana M. Silva, Daniel G. Bradley

Dynamic hyper-editing underlies temperature adaptation in Drosophila

Ilana Buchumenski, Osnat Bartok, Reut Ashwal-Fluss, Varun Pandey, Hagit T. Porath, Erez Y. Levanon, Sebastian Kadener

Reduced dosage of the chromosome axis factor Red1 selectively disrupts the meiotic recombination checkpoint in Saccharomyces cerevisiae

Tovah E. Markowitz, Daniel Suarez, Hannah G. Blitzblau, Neem J. Patel, Andrew L. Markhard, Amy J. MacQueen, Andreas Hochwagen

Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis

Marion Miller, Aichun Chen, Vanessa Gobert, Benoit Augé, Mathilde Beau, Odile Burlet-Schiltz, Marc Haenlin, Lucas Waltzer

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease

Qiongshi Lu, Ryan L. Powles, Sarah Abdallah, Derek Ou, Qian Wang, Yiming Hu, Yisi Lu, Wei Liu, Boyang Li, Shubhabrata Mukherjee, Paul K. Crane, Hongyu Zhao

Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially

Xi Luo, Jill A. Rosenfeld, Shinya Yamamoto, Tamar Harel, Zhongyuan Zuo, Melissa Hall, Klaas J. Wierenga, Matthew T. Pastore, Dennis Bartholomew, Mauricio R. Delgado, Joshua Rotenberg, Richard Alan Lewis, Lisa Emrick, Carlos A. Bacino, Mohammad K. Eldomery, Zeynep Coban Akdemir, Fan Xia, Yaping Yang, Seema R. Lalani, Timothy Lotze, James R. Lupski, Brendan Lee, Hugo J. Bellen, Michael F. Wangler, Members of the UDN

T-DNA-genome junctions form early after infection and are influenced by the chromatin state of the host genome

Shay Shilo, Pooja Tripathi, Cathy Melamed-Bessudo, Oren Tzfadia, Theodore R. Muth, Avraham A. Levy

Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function

Joshua W. Vincentz, Kevin P. Toolan, Wenjun Zhang, Anthony B. Firulli

Mutations in the Caenorhabditis elegans orthologs of human genes required for mitochondrial tRNA modification cause similar electron transport chain defects but different nuclear responses

Carmen Navarro-González, Ismaïl Moukadiri, Magda Villarroya, Ernesto López-Pascual, Simon Tuck, M.-Eugenia Armengod

A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure

Shanshan Zhou, Sarah E. Luoma, Genevieve E. St. Armour, Esha Thakkar, Trudy F. C. Mackay, Robert R. H. Anholt

Filamin actin-binding and titin-binding fulfill distinct functions in Z-disc cohesion

Nicanor González-Morales, Tristan K. Holenka, Frieder Schöck

Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli

Jessica M. Moore, Raul Correa, Susan M. Rosenberg, P. J. Hastings

Termination factor Rho: From the control of pervasive transcription to cell fate determination in Bacillus subtilis

Vladimir Bidnenko, Pierre Nicolas, Aleksandra Grylak-Mielnicka, Olivier Delumeau, Sandrine Auger, Anne Aucouturier, Cyprien Guerin, Francis Repoila, Jacek Bardowski, Stéphane Aymerich, Elena Bidnenko

The nucleoid occlusion factor Noc controls DNA replication initiation in Staphylococcus aureus

Ting Pang, Xindan Wang, Hoong Chuin Lim, Thomas G. Bernhardt, David Z. Rudner

Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis

Adrian Santos-Ledo, Marina Garcia-Macia, Philip D. Campbell, Marta Gronska, Florence L. Marlow

Related Articles

Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid

Maha El Shahawy, Claes-Göran Reibring, Cynthia L. Neben, Kristina Hallberg, Pauline Marangoni, Brian D. Harfe, Ophir D. Klein, Anders Linde, Amel Gritli-Linde

A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription

Chelsea Herdman, Jean-Clement Mars, Victor Y. Stefanovsky, Michel G. Tremblay, Marianne Sabourin-Felix, Helen Lindsay, Mark D. Robinson, Tom Moss

The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast

Stephanie Patchett, Sharmishtha Musalgaonkar, Andrey G. Malyutin, Arlen W. Johnson

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway

Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, Franziska Kranz, James L. Platt, James Smythies, Hani Choudhry, Margarete Goppelt-Struebe, Peter J. Ratcliffe, David R. Mole, Johannes Schödel

African genetic ancestry interacts with body mass index to modify risk for uterine fibroids

Ayush Giri, Todd L. Edwards, Katherine E. Hartmann, Eric S. Torstenson, Melissa Wellons, Pamela J. Schreiner, Digna R. Velez Edwards

OsCNGC13 promotes seed-setting rate by facilitating pollen tube growth in stylar tissues

Yang Xu, Jie Yang, Yihua Wang, Jiachang Wang, Yang Yu, Yu Long, Yunlong Wang, Huan Zhang, Yulong Ren, Jun Chen, Ying Wang, Xin Zhang, Xiuping Guo, Fuqing Wu, Shanshan Zhu, Qibing Lin, Ling Jiang, Chuanyin Wu, Haiyang Wang, Jianmin Wan

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Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes

James H. Crichton, Christopher J. Playfoot, Marie MacLennan, David Read, Howard J. Cooke, Ian R. Adams

NlpD links cell wall remodeling and outer membrane invagination during cytokinesis in Escherichia coli

Mary-Jane Tsang, Anastasiya A. Yakhnina, Thomas G. Bernhardt

Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing

Ai Tian, Hassina Benchabane, Zhenghan Wang, Chloe Zimmerman, Nan Xin, Jessica Perochon, Gabriela Kalna, Owen J. Sansom, Chao Cheng, Julia B. Cordero, Yashi Ahmed

The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis

Jeffrey L. Kurkewich, Justin Hansen, Nathan Klopfenstein, Helen Zhang, Christian Wood, Austin Boucher, Joseph Hickman, David E. Muench, H. Leighton Grimes, Richard Dahl

Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition

Thomas Arbogast, Giovanni Iacono, Claire Chevalier, Nurudeen O. Afinowi, Xander Houbaert, Matthijs C. van Eede, Christine Laliberte, Marie-Christine Birling, Katrin Linda, Hamid Meziane, Mohammed Selloum, Tania Sorg, Nael Nadif Kasri, David A. Koolen, Henk G. Stunnenberg, R. Mark Henkelman, Maksym Kopanitsa, Yann Humeau, Bert B. A. De Vries, Yann Herault

The ancestral levels of transcription and the evolution of sexual phenotypes in filamentous fungi

Frances Trail, Zheng Wang, Kayla Stefanko, Caitlyn Cubba, Jeffrey P. Townsend

Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks

Syed Abbas Bukhari, Michael C. Saul, Christopher H. Seward, Huimin Zhang, Miles Bensky, Noelle James, Sihai Dave Zhao, Sriram Chandrasekaran, Lisa Stubbs, Alison M. Bell

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

Stefan Zdraljevic, Christine Strand, Hannah S. Seidel, Daniel E. Cook, John G. Doench, Erik C. Andersen

Systematic identification and characterization of regulatory elements derived from human endogenous retroviruses

Jumpei Ito, Ryota Sugimoto, Hirofumi Nakaoka, Shiro Yamada, Tetsuaki Kimura, Takahide Hayano, Ituro Inoue

Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis

Zhidan Xia, Jiayu Wei, Yingniang Li, Jia Wang, Wenwen Li, Kai Wang, Xiaoli Hong, Lu Zhao, Caiyong Chen, Junxia Min, Fudi Wang

Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage

Joakim Klar, Jörg Piontek, Susanne Milatz, Muhammad Tariq, Muhammad Jameel, Tilman Breiderhoff, Jens Schuster, Ambrin Fatima, Maria Asif, Muhammad Sher, Katrin Mäbert, Anja Fromm, Shahid M. Baig, Dorothee Günzel, Niklas Dahl

Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression

Minghui Yue, Akiyo Ogawa, Norishige Yamada, John Lalith Charles Richard, Artem Barski, Yuya Ogawa

Genetic control of the root system in rice under normal and drought stress conditions by genome-wide association study

Xiaokai Li, Zilong Guo, Yan Lv, Xiang Cen, Xipeng Ding, Hua Wu, Xianghua Li, Jianping Huang, Lizhong Xiong

Processing closely spaced lesions during Nucleotide Excision Repair triggers mutagenesis in E. coli

Régine Janel-Bintz, Rita L. Napolitano, Asako Isogawa, Shingo Fujii, Robert P. Fuchs

Yorkie is required to restrict the injury responses in planarians

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Stochasticity in the enterococcal sex pheromone response revealed by quantitative analysis of transcription in single cells

Rebecca J. Breuer, Arpan Bandyopadhyay, Sofie A. O’Brien, Aaron M. T. Barnes, Ryan C. Hunter, Wei-Shou Hu, Gary M. Dunny

Evolution and multiple roles of the Pancrustacea specific transcription factor zelda in insects

Lupis Ribeiro, Vitória Tobias-Santos, Daniele Santos, Felipe Antunes, Geórgia Feltran, Jackson de Souza Menezes, L. Aravind, Thiago M. Venancio, Rodrigo Nunes da Fonseca