Table of Contents: April 2009

The lateral line is a superficial sensory organ that allows fish to sense water movements. It is made up of neuromasts that are distributed in lines on the head and side of the fish. Neuromasts are small neuroepithelial patches made of two cell types: hair cells (red) and supporting cells (green). Hair cells are mechanoreceptors, which send cilia into the water. Their deflection triggers signaling that is transmitted to the central nervous system. Supporting cells surround and isolate each hair cell and provide cohesion to the structure. They also account for the regenerative power of the organ when hair cells are destroyed (see Behra et al., doi:10.1371/journal.pgen.1000455).

Image Credit: Image Credit: Stack of images taken on an upright Zeiss confocal microscope by Martine Behra in Dr. Ben Feldman's laboratory (National Human Genome Research Institute, National Institutes of Health).


The Genetic Signatures of Noncoding RNAs

John S. Mattick

Research Articles

Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size

Nicole Soranzo, Fernando Rivadeneira, Usha Chinappen-Horsley, Ida Malkina, J. Brent Richards, Naomi Hammond, Lisette Stolk, Alexandra Nica, Michael Inouye, Albert Hofman, Jonathan Stephens, Eleanor Wheeler, Pascal Arp, Rhian Gwilliam, P. Mila Jhamai, Simon Potter, Amy Chaney, Mohammed J. R. Ghori, Radhi Ravindrarajah, Sergey Ermakov, Karol Estrada, Huibert A. P. Pols, Frances M. Williams, Wendy L. McArdle, Joyce B. van Meurs, Ruth J. F. Loos, Emmanouil T. Dermitzakis, Kourosh R. Ahmadi, Deborah J. Hart, Willem H. Ouwehand, Nicholas J. Wareham, Inês Barroso, Manjinder S. Sandhu, David P. Strachan, Gregory Livshits, Timothy D. Spector, André G. Uitterlinden, Panos Deloukas

Microarray Profiling of Phage-Display Selections for Rapid Mapping of Transcription Factor–DNA Interactions

Gordon Freckleton, Soyeon I. Lippman, James R. Broach, Saeed Tavazoie

Harmonics of Circadian Gene Transcription in Mammals

Michael E. Hughes, Luciano DiTacchio, Kevin R. Hayes, Christopher Vollmers, S. Pulivarthy, Julie E. Baggs, Satchidananda Panda, John B. Hogenesch

Control of Metabolic Homeostasis by Stress Signaling Is Mediated by the Lipocalin NLaz

Julie Hull-Thompson, Julien Muffat, Diego Sanchez, David W. Walker, Seymour Benzer, Maria D. Ganfornina, Heinrich Jasper

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

David Cristina, Michael Cary, Adam Lunceford, Catherine Clarke, Cynthia Kenyon

Phoenix Is Required for Mechanosensory Hair Cell Regeneration in the Zebrafish Lateral Line

Martine Behra, John Bradsher, Rachid Sougrat, Viviana Gallardo, Miguel L. Allende, Shawn M. Burgess

Conserved Alternative Splicing and Expression Patterns of Arthropod N-Cadherin

Shu-Ning Hsu, Shinichi Yonekura, Chun-Yuan Ting, Hugh M. Robertson, Youichi Iwai, Tadashi Uemura, Chi-Hon Lee, Akira Chiba

Genetic Evidence That the Non-Homologous End-Joining Repair Pathway Is Involved in LINE Retrotransposition

Jun Suzuki, Katsumi Yamaguchi, Masaki Kajikawa, Kenji Ichiyanagi, Noritaka Adachi, Hideki Koyama, Shunichi Takeda, Norihiro Okada

The RNA Polymerase Dictates ORF1 Requirement and Timing of LINE and SINE Retrotransposition

Emily N. Kroutter, Victoria P. Belancio, Bradley J. Wagstaff, Astrid M. Roy-Engel

Inferring the Demographic History of African Farmers and Pygmy Hunter–Gatherers Using a Multilocus Resequencing Data Set

Etienne Patin, Guillaume Laval, Luis B. Barreiro, Antonio Salas, Ornella Semino, Silvana Santachiara-Benerecetti, Kenneth K. Kidd, Judith R. Kidd, Lolke Van der Veen, Jean-Marie Hombert, Antoine Gessain, Alain Froment, Serge Bahuchet, Evelyne Heyer, Lluís Quintana-Murci

Positive Feedback between Transcriptional and Kinase Suppression in Nematodes with Extraordinary Longevity and Stress Resistance

Çagdaþ Tazearslan, Srinivas Ayyadevara, Puneet Bharill, Robert J. Shmookler Reis

The Bantam microRNA Is Associated with Drosophila Fragile X Mental Retardation Protein and Regulates the Fate of Germline Stem Cells

Yingyue Yang, Shunliang Xu, Laixin Xia, Jun Wang, Shengmei Wen, Peng Jin, Dahua Chen

Combined In Silico and In Vivo Analyses Reveal Role of Hes1 in Taste Cell Differentiation

Masato S. Ota, Yoshiyuki Kaneko, Kaori Kondo, Soichi Ogishima, Hiroshi Tanaka, Kazuhiro Eto, Takashi Kondo

Loss of the Transcriptional Repressor PAG-3/Gfi-1 Results in Enhanced Neurosecretion that is Dependent on the Dense-Core Vesicle Membrane Protein IDA-1/IA-2

Tao Cai, Hiroki Hirai, Tetsunari Fukushige, Ping Yu, Guofeng Zhang, Abner L. Notkins, Michael Krause

Transcription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells

Joana Sequeira-Mendes, Ramón Díaz-Uriarte, Anwyn Apedaile, Derek Huntley, Neil Brockdorff, María Gómez

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