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Table of Contents

September 2015

Bodies are often made of repeated units, or serial homologs, that develop using the same core gene regulatory network. Local inputs and modifications to this network allow serial homologs to evolve different morphologies, but currently we do not understand which modifications allow these repeated traits to evolve different levels of phenotypic plasticity. In this article, the authors describe variation in phenotypic plasticity across serial homologous eyespots of the butterfly Bicyclus anynana, hypothesized to be under selection for similar or different functions in the wet and dry seasonal forms. See Monteiro et al.

Image Credit: Monteiro et al.

Research Articles

Ty3 Retrotransposon Hijacks Mating Yeast RNA Processing Bodies to Infect New Genomes

Virginia Bilanchone, Kristina Clemens, Robyn Kaake, Anthony R. Dawson, Dina Matheos, Kunio Nagashima, Parth Sitlani, Kurt Patterson, Ivan Chang, Lan Huang, Suzanne Sandmeyer

Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles

Hao Chang, Hugh Cahill, Philip M. Smallwood, Yanshu Wang, Jeremy Nathans

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism

Anu Loukola, Jadwiga Buchwald, Richa Gupta, Teemu Palviainen, Jenni Hällfors, Emmi Tikkanen, Tellervo Korhonen, Miina Ollikainen, Antti-Pekka Sarin, Samuli Ripatti, Terho Lehtimäki, Olli Raitakari, Veikko Salomaa, Richard J. Rose, Rachel F. Tyndale, Jaakko Kaprio

Differential Expression of Ecdysone Receptor Leads to Variation in Phenotypic Plasticity across Serial Homologs

Antónia Monteiro, Xiaoling Tong, Ashley Bear, Seng Fatt Liew, Shivam Bhardwaj, Bethany R. Wasik, April Dinwiddie, Carole Bastianelli, Wei Fun Cheong, Markus R. Wenk, Hui Cao, Kathleen L. Prudic

Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception

Natacha Roudnitzky, Maik Behrens, Anika Engel, Susann Kohl, Sophie Thalmann, Sandra Hübner, Kristina Lossow, Stephen P. Wooding, Wolfgang Meyerhof

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci

Martijn van de Bunt, Adrian Cortes, IGAS Consortium, Matthew A. Brown, Andrew P. Morris, Mark I. McCarthy

Discovering Genetic Interactions in Large-Scale Association Studies by Stage-wise Likelihood Ratio Tests

Mattias Frånberg, Karl Gertow, Anders Hamsten, PROCARDIS consortium, Jens Lagergren, Bengt Sennblad

Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood

Ralph Burkhardt, Holger Kirsten, Frank Beutner, Lesca M. Holdt, Arnd Gross, Andrej Teren, Anke Tönjes, Susen Becker, Knut Krohn, Peter Kovacs, Michael Stumvoll, Daniel Teupser, Joachim Thiery, Uta Ceglarek, Markus Scholz

Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response

Kazue Kanehara, Chao-Yuan Yu, Yueh Cho, Wei-Fun Cheong, Federico Torta, Guanghou Shui, Markus R Wenk, Yuki Nakamura

Rescheduling Behavioral Subunits of a Fixed Action Pattern by Genetic Manipulation of Peptidergic Signaling

Do-Hyoung Kim, Mi-Ran Han, Gyunghee Lee, Sang Soo Lee, Young-Joon Kim, Michael E. Adams

Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians

Masahito Irie, Masanobu Yoshikawa, Ryuichi Ono, Hirotaka Iwafune, Tamio Furuse, Ikuko Yamada, Shigeharu Wakana, Yui Yamashita, Takaya Abe, Fumitoshi Ishino, Tomoko Kaneko-Ishino

Genome Sequence and Transcriptome Analyses of Chrysochromulina tobin: Metabolic Tools for Enhanced Algal Fitness in the Prominent Order Prymnesiales (Haptophyceae)

Blake T. Hovde, Chloe R. Deodato, Heather M. Hunsperger, Scott A. Ryken, Will Yost, Ramesh K. Jha, Johnathan Patterson, Raymond J. Monnat Jr., Steven B. Barlow, Shawn R. Starkenburg, Rose Ann Cattolico

The Arabidopsis RCC1 Family Protein TCF1 Regulates Freezing Tolerance and Cold Acclimation through Modulating Lignin Biosynthesis

Hongtao Ji, Youning Wang, Catherine Cloix, Kexue Li, Gareth I. Jenkins, Shuangfeng Wang, Zhonglin Shang, Yiting Shi, Shuhua Yang, Xia Li

Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis

Yannan Fan, Sylvie Richelme, Emilie Avazeri, Stéphane Audebert, Françoise Helmbacher, Rosanna Dono, Flavio Maina

Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes

Cornelius Schneider, Dmitry E. Agafonov, Jana Schmitzová, Klaus Hartmuth, Patrizia Fabrizio, Reinhard Lührmann

KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome

Laetitia Furio, Georgios Pampalakis, Iacovos P. Michael, Andras Nagy, Georgia Sotiropoulou, Alain Hovnanian

HANABA TARANU (HAN) Bridges Meristem and Organ Primordia Boundaries through PINHEAD, JAGGED, BLADE-ON-PETIOLE2 and CYTOKININ OXIDASE 3 during Flower Development in Arabidopsis

Lian Ding, Shuangshuang Yan, Li Jiang, Wensheng Zhao, Kang Ning, Jianyu Zhao, Xiaofeng Liu, Juan Zhang, Qian Wang, Xiaolan Zhang

An Interaction between RRP6 and SU(VAR)3-9 Targets RRP6 to Heterochromatin and Contributes to Heterochromatin Maintenance in Drosophila melanogaster

Andrea B. Eberle, Antonio Jordán-Pla, Antoni Gañez-Zapater, Viktoria Hessle, Gilad Silberberg, Anne von Euler, Rebecca A. Silverstein, Neus Visa

Recurrent Domestication by Lepidoptera of Genes from Their Parasites Mediated by Bracoviruses

Laila Gasmi, Helene Boulain, Jeremy Gauthier, Aurelie Hua-Van, Karine Musset, Agata K. Jakubowska, Jean-Marc Aury, Anne-Nathalie Volkoff, Elisabeth Huguet, Salvador Herrero, Jean-Michel Drezen

Autophosphorylation of the Bacterial Tyrosine-Kinase CpsD Connects Capsule Synthesis with the Cell Cycle in Streptococcus pneumoniae

Julien Nourikyan, Morten Kjos, Chryslène Mercy, Caroline Cluzel, Cécile Morlot, Marie-Francoise Noirot-Gros, Sébastien Guiral, Jean-Pierre Lavergne, Jan-Willem Veening, Christophe Grangeasse

A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary

Y. Q. Shirleen Soh, Jan Philipp Junker, Mark E. Gill, Jacob L. Mueller, Alexander van Oudenaarden, David C. Page

ARID1A Is Essential for Endometrial Function during Early Pregnancy

Tae Hoon Kim, Jung-Yoon Yoo, Zhong Wang, John P. Lydon, Shikha Khatri, Shannon M. Hawkins, Richard E. Leach, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Bon Jeong Ku, Jae-Wook Jeong

XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease

Trevor L. Cameron, Katrina M. Bell, Irma L. Gresshoff, Lisa Sampurno, Lorna Mullan, Joerg Ermann, Laurie H. Glimcher, Raymond P. Boot-Handford, John F. Bateman

Multicopy Single-Stranded DNA Directs Intestinal Colonization of Enteric Pathogens

Johanna R. Elfenbein, Leigh A. Knodler, Ernesto S. Nakayasu, Charles Ansong, Heather M. Brewer, Lydia Bogomolnaya, L. Garry Adams, Michael McClelland, Joshua N. Adkins, Helene L. Andrews-Polymenis

Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots

Christopher L. Baker, Pavlina Petkova, Michael Walker, Petr Flachs, Ondrej Mihola, Zdenek Trachtulec, Petko M. Petkov, Kenneth Paigen

Critical Function of γH2A in S-Phase

Eva Mejia-Ramirez, Oliver Limbo, Petra Langerak, Paul Russell

Synergistic and Dose-Controlled Regulation of Cellulase Gene Expression in Penicillium oxalicum

Zhonghai Li, Guangshan Yao, Ruimei Wu, Liwei Gao, Qinbiao Kan, Meng Liu, Piao Yang, Guodong Liu, Yuqi Qin, Xin Song, Yaohua Zhong, Xu Fang, Yinbo Qu

The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway

Yuzuru Imai, Yoshito Kobayashi, Tsuyoshi Inoshita, Hongrui Meng, Taku Arano, Kengo Uemura, Takeshi Asano, Kenji Yoshimi, Chang-Liang Zhang, Gen Matsumoto, Toshiyuki Ohtsuka, Ryoichiro Kageyama, Hiroshi Kiyonari, Go Shioi, Nobuyuki Nukina, Nobutaka Hattori, Ryosuke Takahashi

Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality

Johannes Raffler, Nele Friedrich, Matthias Arnold, Tim Kacprowski, Rico Rueedi, Elisabeth Altmaier, Sven Bergmann, Kathrin Budde, Christian Gieger, Georg Homuth, Maik Pietzner, Werner Römisch-Margl, Konstantin Strauch, Henry Völzke, Melanie Waldenberger, Henri Wallaschofski, Matthias Nauck, Uwe Völker, Gabi Kastenmüller, Karsten Suhre

Point Mutations in Centromeric Histone Induce Post-zygotic Incompatibility and Uniparental Inheritance

Sundaram Kuppu, Ek Han Tan, Hanh Nguyen, Andrea Rodgers, Luca Comai, Simon W. L. Chan, Anne B. Britt

Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins

Tetsuji Yamashita, Pierre Hakizimana, Siva Wu, Ahmed Hassan, Stefan Jacob, Jamshid Temirov, Jie Fang, Marcia Mellado-Lagarde, Richard Gursky, Linda Horner, Barbara Leibiger, Sara Leijon, Victoria E. Centonze, Per-Olof Berggren, Sharon Frase, Manfred Auer, William E. Brownell, Anders Fridberger, Jian Zuo

A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis

Michelle K. Scotland, Justin M. H. Heltzel, James E. Kath, Jung-Suk Choi, Anthony J. Berdis, Joseph J. Loparo, Mark D. Sutton

The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis

Sébastien Andreuzza, Bindu Nishal, Aparna Singh, Imran Siddiqi

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation

Oliver Kluth, Daniela Matzke, Anne Kamitz, Markus Jähnert, Heike Vogel, Stephan Scherneck, Matthias Schulze, Harald Staiger, Fausto Machicao, Hans-Ulrich Häring, Hans-Georg Joost, Annette Schürmann

A NIMA-Related Kinase Suppresses the Flagellar Instability Associated with the Loss of Multiple Axonemal Structures

Huawen Lin, Zhengyan Zhang, Suyang Guo, Fan Chen, Jonathan M. Kessler, Yan Mei Wang, Susan K. Dutcher

FUS Interacts with HSP60 to Promote Mitochondrial Damage

Jianwen Deng, Mengxue Yang, Yanbo Chen, Xiaoping Chen, Jianghong Liu, Shufeng Sun, Haipeng Cheng, Yang Li, Eileen H. Bigio, Marsel Mesulam, Qi Xu, Sidan Du, Kazuo Fushimi, Li Zhu, Jane Y. Wu

Three Different Pathways Prevent Chromosome Segregation in the Presence of DNA Damage or Replication Stress in Budding Yeast

Gloria Palou, Roger Palou, Fanli Zeng, Ajay A. Vashisht, James A. Wohlschlegel, David G. Quintana

The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity

Slavé Petrovski, Ayal B. Gussow, Quanli Wang, Matt Halvorsen, Yujun Han, William H. Weir, Andrew S. Allen, David B. Goldstein

A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease

Solveig Gretarsdottir, Hannes Helgason, Anna Helgadottir, Asgeir Sigurdsson, Gudmar Thorleifsson, Audur Magnusdottir, Asmundur Oddsson, Valgerdur Steinthorsdottir, Thorunn Rafnar, Jacqueline de Graaf, Maryam S. Daneshpour, Mehdi Hedayati, Fereidoun Azizi, Niels Grarup, Torben Jørgensen, Henrik Vestergaard, Torben Hansen, Gudmundur Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Lambertus A. Kiemeney, Oluf Pedersen, Patrick Sulem, Gudmundur Thorgeirsson, Daniel F. Gudbjartsson, Hilma Holm, Unnur Thorsteinsdottir, Kari Stefansson

Retraction

Retraction: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells

Constance Ciaudo, Florence Jay, Ikuhiro Okamoto, Chong-Jian Chen, Alexis Sarazin, Nicolas Servant, Emmanuel Barillot, Edith Heard, Olivier Voinnet

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