Global variation in sequencing impedes SARS-CoV-2 surveillance

Dana C. Crawford, Scott M. Williams

PLOS Genetics: published July 15, 2021 | https://doi.org/10.1371/journal.pgen.1009620

Taste-testing tarsi: Gustatory receptors for glucosinolates in cabbage butterflies

Noah K. Whiteman, Julianne N. Peláez

PLOS Genetics: published July 15, 2021 | https://doi.org/10.1371/journal.pgen.1009616

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Tetrahymena meiosis: Simple yet ingenious

Josef Loidl

PLOS Genetics: published July 15, 2021 | https://doi.org/10.1371/journal.pgen.1009627

The H3.3K27M oncohistone antagonizes reprogramming in Drosophila

Kami Ahmad, Steven Henikoff

PLOS Genetics: published July 19, 2021 | https://doi.org/10.1371/journal.pgen.1009225

A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle

Young-Lim Lee, Haruko Takeda, Gabriel Costa Monteiro Moreira, Latifa Karim, Erik Mullaart, Wouter Coppieters, The GplusE consortium, Ruth Appeltant, Roel F. Veerkamp, Martien A. M. Groenen, Michel Georges, Mirte Bosse, Tom Druet, Aniek C. Bouwman, Carole Charlier

PLOS Genetics: published July 21, 2021 | https://doi.org/10.1371/journal.pgen.1009331

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation

Jinyue Liao, Hoi Ching Suen, Alfred Chun Shui Luk, Lele Yang, Annie Wing Tung Lee, Huayu Qi, Tin-Lap Lee

PLOS Genetics: published July 8, 2021 | https://doi.org/10.1371/journal.pgen.1009369

NuA4 and SAGA acetyltransferase complexes cooperate for repair of DNA breaks by homologous recombination

Xue Cheng, Valérie Côté, Jacques Côté

PLOS Genetics: published July 6, 2021 | https://doi.org/10.1371/journal.pgen.1009459

Homothorax controls a binary Rhodopsin switch in Drosophila ocelli

Abhishek Kumar Mishra, Cornelia Fritsch, Roumen Voutev, Richard S. Mann, Simon G. Sprecher

PLOS Genetics: published July 27, 2021 | https://doi.org/10.1371/journal.pgen.1009460

The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning

Leo T. H. Tang, Meera Trivedi, Jenna Freund, Christopher J. Salazar, Maisha Rahman, Nelson J. Ramirez-Suarez, Garrett Lee, Yu Wang, Barth D. Grant, Hannes E. Bülow

PLOS Genetics: published July 1, 2021 | https://doi.org/10.1371/journal.pgen.1009475

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

Ignacio Soriano, Enrique Vazquez, Nagore De Leon, Sibyl Bertrand, Ellen Heitzer, Sophia Toumazou, Zhihan Bo, Claire Palles, Chen-Chun Pai, Timothy C. Humphrey, Ian Tomlinson, Sue Cotterill, Stephen E. Kearsey

PLOS Genetics: published July 6, 2021 | https://doi.org/10.1371/journal.pgen.1009526

Identification of a gustatory receptor tuned to sinigrin in the cabbage butterfly Pieris rapae

Jun Yang, Hao Guo, Nan-Ji Jiang, Rui Tang, Guo-Cheng Li, Ling-Qiao Huang, Joop J. A. van Loon, Chen-Zhu Wang

PLOS Genetics: published July 15, 2021 | https://doi.org/10.1371/journal.pgen.1009527

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Mechanism underlying the DNA-binding preferences of the Vibrio cholerae and vibriophage VP882 VqmA quorum-sensing receptors

Olivia P. Duddy, Xiuliang Huang, Justin E. Silpe, Bonnie L. Bassler

PLOS Genetics: published July 6, 2021 | https://doi.org/10.1371/journal.pgen.1009550

CRISPR/Cas9 modified An. gambiae carrying kdr mutation L1014F functionally validate its contribution in insecticide resistance and combined effect with metabolic enzymes

Linda Grigoraki, Ruth Cowlishaw, Tony Nolan, Martin Donnelly, Gareth Lycett, Hilary Ranson

PLOS Genetics: published July 6, 2021 | https://doi.org/10.1371/journal.pgen.1009556

Pch2 orchestrates the meiotic recombination checkpoint from the cytoplasm

Esther Herruzo, Ana Lago-Maciel, Sara Baztán, Beatriz Santos, Jesús A. Carballo, Pedro A. San-Segundo

PLOS Genetics: published July 14, 2021 | https://doi.org/10.1371/journal.pgen.1009560

Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios

Debashree Ray, Sowmya Venkataraghavan, Wanying Zhang, Elizabeth J. Leslie, Jacqueline B. Hetmanski, Seth M. Weinberg, Jeffrey C. Murray, Mary L. Marazita, Ingo Ruczinski, Margaret A. Taub, Terri H. Beaty

PLOS Genetics: published July 9, 2021 | https://doi.org/10.1371/journal.pgen.1009584

Light affects behavioral despair involving the clock gene Period 1

Iwona Olejniczak, Jürgen A. Ripperger, Federica Sandrelli, Anna Schnell, Laureen Mansencal-Strittmatter, Katrin Wendrich, Ka Yi Hui, Andrea Brenna, Naila Ben Fredj, Urs Albrecht

PLOS Genetics: published July 8, 2021 | https://doi.org/10.1371/journal.pgen.1009625

Quantitative mapping of mRNA 3’ ends in Pseudomonas aeruginosa reveals a pervasive role for premature 3’ end formation in response to azithromycin

Salini Konikkat, Michelle R. Scribner, Rory Eutsey, N. Luisa Hiller, Vaughn S. Cooper, Joel McManus

PLOS Genetics: published July 12, 2021 | https://doi.org/10.1371/journal.pgen.1009634

Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans

Lidan Zeng, Xuesong Li, Christopher B. Preusch, Gary J. He, Ningyi Xu, Tom H. Cheung, Jianan Qu, Ho Yi Mak

PLOS Genetics: published July 8, 2021 | https://doi.org/10.1371/journal.pgen.1009635

A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings

Qifei Li, Michal Dibus, Alicia Casey, Christina S. K. Yee, Sara O. Vargas, Shiyu Luo, Samantha M. Rosen, Jill A. Madden, Casie A. Genetti, Jan Brabek, Catherine A. Brownstein, Shideh Kazerounian, Benjamin A. Raby, Klaus Schmitz-Abe, John C. Kennedy, Martha P. Fishman, Mary P. Mullen, Joan M. Taylor, Daniel Rosel, Pankaj B. Agrawal

PLOS Genetics: published July 7, 2021 | https://doi.org/10.1371/journal.pgen.1009639

Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1

Shuang Li, Yuanyuan Li, Blake R. Rushing, Sarah E. Harris, Susan L. McRitchie, Janice C. Jones, Daniel Dominguez, Susan J. Sumner, Henrik G. Dohlman

PLOS Genetics: published July 2, 2021 | https://doi.org/10.1371/journal.pgen.1009640

Repeated evolution of circadian clock dysregulation in cavefish populations

Katya L. Mack, James B. Jaggard, Jenna L. Persons, Emma Y. Roback, Courtney N. Passow, Bethany A. Stanhope, Estephany Ferrufino, Dai Tsuchiya, Sarah E. Smith, Brian D. Slaughter, Johanna Kowalko, Nicolas Rohner, Alex C. Keene, Suzanne E. McGaugh

PLOS Genetics: published July 12, 2021 | https://doi.org/10.1371/journal.pgen.1009642

Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons

Ines Hahn, Andre Voelzmann, Jill Parkin, Judith B. Fülle, Paula G. Slater, Laura Anne Lowery, Natalia Sanchez-Soriano, Andreas Prokop

PLOS Genetics: published July 6, 2021 | https://doi.org/10.1371/journal.pgen.1009647

Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila

Kun Wu, Yiming Tang, Qiaoqiao Zhang, Zhangpeng Zhuo, Xiao Sheng, Jingping Huang, Jie’er Ye, Xiaorong Li, Zhiming Liu, Haiyang Chen

PLOS Genetics: published July 6, 2021 | https://doi.org/10.1371/journal.pgen.1009649

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence

Amanda L. Fry, Amy K. Webster, Julia Burnett, Rojin Chitrakar, L. Ryan Baugh, E. Jane Albert Hubbard

PLOS Genetics: published July 21, 2021 | https://doi.org/10.1371/journal.pgen.1009650

Functional and structural analyses of novel Smith-Kingsmore Syndrome-Associated MTOR variants reveal potential new mechanisms and predictors of pathogenicity

Aaron D. Besterman, Thorsten Althoff, Peter Elfferich, Irma Gutierrez-Mejia, Joshua Sadik, Jonathan A. Bernstein, Yvette van Ierland, Anja A. Kattentidt-Mouravieva, Mark Nellist, Jeff Abramson, Julian A. Martinez-Agosto

PLOS Genetics: published July 1, 2021 | https://doi.org/10.1371/journal.pgen.1009651

Powerful detection of polygenic selection and evidence of environmental adaptation in US beef cattle

Troy N. Rowan, Harly J. Durbin, Christopher M. Seabury, Robert D. Schnabel, Jared E. Decker

PLOS Genetics: published July 22, 2021 | https://doi.org/10.1371/journal.pgen.1009652

Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development

Shengqian Xia, Nicholas W. VanKuren, Chunyan Chen, Li Zhang, Clause Kemkemer, Yi Shao, Hangxing Jia, UnJin Lee, Alexander S. Advani, Andrea Gschwend, Maria D. Vibranovski, Sidi Chen, Yong E. Zhang, Manyuan Long

PLOS Genetics: published July 9, 2021 | https://doi.org/10.1371/journal.pgen.1009654

Essential gene acquisition destabilizes plasmid inheritance

Tanita Wein, Yiqing Wang, Myriam Barz, Fenna T. Stücker, Katrin Hammerschmidt, Tal Dagan

PLOS Genetics: published July 12, 2021 | https://doi.org/10.1371/journal.pgen.1009656

The selfish yeast plasmid utilizes the condensin complex and condensed chromatin for faithful partitioning

Deepanshu Kumar, Hemant Kumar Prajapati, Anjali Mahilkar, Chien-Hui Ma, Priyanka Mittal, Makkuni Jayaram, Santanu K. Ghosh

PLOS Genetics: published July 16, 2021 | https://doi.org/10.1371/journal.pgen.1009660

Genetic variation of BnaA3.NIP5;1 expressing in the lateral root cap contributes to boron deficiency tolerance in Brassica napus

Mingliang He, Sheliang Wang, Cheng Zhang, Liu Liu, Jinyao Zhang, Shou Qiu, Hong Wang, Guangsheng Yang, Shaowu Xue, Lei Shi, Fangsen Xu

PLOS Genetics: published July 1, 2021 | https://doi.org/10.1371/journal.pgen.1009661

Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system

Marion Herbette, Xiaolu Wei, Ching-Ho Chang, Amanda M. Larracuente, Benjamin Loppin, Raphaëlle Dubruille

PLOS Genetics: published July 6, 2021 | https://doi.org/10.1371/journal.pgen.1009662

Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex

Maria Velkova, Nicola Silva, Maria Rosaria Dello Stritto, Alexander Schleiffer, Pierre Barraud, Markus Hartl, Verena Jantsch

PLOS Genetics: published July 12, 2021 | https://doi.org/10.1371/journal.pgen.1009663

Increased mitochondrial protein import and cardiolipin remodelling upon early mtUPR

Daniel Poveda-Huertes, Asli Aras Taskin, Ines Dhaouadi, Lisa Myketin, Adinarayana Marada, Lukas Habernig, Sabrina Büttner, F.-Nora Vögtle

PLOS Genetics: published July 2, 2021 | https://doi.org/10.1371/journal.pgen.1009664

A spectral theory for Wright’s inbreeding coefficients and related quantities

Olivier François, Clément Gain

PLOS Genetics: published July 19, 2021 | https://doi.org/10.1371/journal.pgen.1009665

The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish

Yin Ho Vong, Lavanya Sivashanmugam, Rebecca Leech, Andreas Zaucker, Alex Jones, Karuna Sampath

PLOS Genetics: published July 2, 2021 | https://doi.org/10.1371/journal.pgen.1009667

Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination

Jie Su, Ran Xu, Piyusha Mongia, Naoko Toyofuku, Takuro Nakagawa

PLOS Genetics: published July 22, 2021 | https://doi.org/10.1371/journal.pgen.1009671

The 3’tsRNAs are aminoacylated: Implications for their biogenesis

Ziwei Liu, Hak Kyun Kim, Jianpeng Xu, Yuqing Jing, Mark A. Kay

PLOS Genetics: published July 29, 2021 | https://doi.org/10.1371/journal.pgen.1009675

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome

Jesse A. Garcia, Kirk E. Lohmueller

PLOS Genetics: published July 28, 2021 | https://doi.org/10.1371/journal.pgen.1009676

Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster

Qiang Wang, Peng Xu, Felipe Andreazza, Yahui Liu, Yoshiko Nomura, Phil Duran, Lan Jiang, Mengli Chen, Genki Takamatsu, Makoto Ihara, Kazuhiko Matsuda, Rufus Isaacs, Eugenio E. Oliveira, Yuzhe Du, Ke Dong

PLOS Genetics: published July 8, 2021 | https://doi.org/10.1371/journal.pgen.1009677

CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression

JiSoo Park, Hyekyoung Oh, Do-Young Kim, YongJin Cheon, Yeon-Ji Park, Hyeonjeong Hwang, Scott J. Neal, Abdul Rouf Dar, Rebecca A. Butcher, Piali Sengupta, Dae-Won Kim, Kyuhyung Kim

PLOS Genetics: published July 14, 2021 | https://doi.org/10.1371/journal.pgen.1009678

Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease

Enrique Audain, Anna Wilsdon, Jeroen Breckpot, Jose M. G. Izarzugaza, Tomas W. Fitzgerald, Anne-Karin Kahlert, Alejandro Sifrim, Florian Wünnemann, Yasset Perez-Riverol, Hashim Abdul-Khaliq, Mads Bak, Anne S. Bassett, Woodrow D. Benson, Felix Berger, Ingo Daehnert, Koenraad Devriendt, Sven Dittrich, Piers EF Daubeney, Vidu Garg, Karl Hackmann, Kirstin Hoff, Philipp Hofmann, Gregor Dombrowsky, Thomas Pickardt, Ulrike Bauer, Bernard D. Keavney, Sabine Klaassen, Hans-Heiner Kramer, Christian R. Marshall, Dianna M. Milewicz, Scott Lemaire, Joseph S. Coselli, Michael E. Mitchell, Aoy Tomita-Mitchell, Siddharth K. Prakash, Karl Stamm, Alexandre F. R. Stewart, Candice K. Silversides, Reiner Siebert, Brigitte Stiller, Jill A. Rosenfeld, Inga Vater, Alex V. Postma, Almuth Caliebe, J. David Brook, Gregor Andelfinger, Matthew E. Hurles, Bernard Thienpont, Lars Allan Larsen, Marc-Phillip Hitz

PLOS Genetics: published July 29, 2021 | https://doi.org/10.1371/journal.pgen.1009679

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Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in the beet armyworm

Yayun Zuo, Yu Shi, Feng Zhang, Fang Guan, Jianpeng Zhang, René Feyereisen, Jeffrey A. Fabrick, Yihua Yang, Yidong Wu

PLOS Genetics: published July 12, 2021 | https://doi.org/10.1371/journal.pgen.1009680

Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage

Neta Degani, Yoav Lubelsky, Rotem Ben-Tov Perry, Elena Ainbinder, Igor Ulitsky

PLOS Genetics: published July 19, 2021 | https://doi.org/10.1371/journal.pgen.1009681

Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms

Kazuo Kobayashi

PLOS Genetics: published July 19, 2021 | https://doi.org/10.1371/journal.pgen.1009682

Sense-overlapping lncRNA as a decoy of translational repressor protein for dimorphic gene expression

Christelle Alexa Garcia Perez, Shungo Adachi, Quang Dang Nong, Nikko Adhitama, Tomoaki Matsuura, Toru Natsume, Tadashi Wada, Yasuhiko Kato, Hajime Watanabe

PLOS Genetics: published July 28, 2021 | https://doi.org/10.1371/journal.pgen.1009683

An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?

Margot Brandt, Sarah Kim-Hellmuth, Marcello Ziosi, Alper Gokden, Aaron Wolman, Nora Lam, Yocelyn Recinos, Zharko Daniloski, John A. Morris, Veit Hornung, Johannes Schumacher, Tuuli Lappalainen

PLOS Genetics: published July 27, 2021 | https://doi.org/10.1371/journal.pgen.1009684

The blood flow-klf6a-tagln2 axis drives vessel pruning in zebrafish by regulating endothelial cell rearrangement and actin cytoskeleton dynamics

Lin Wen, Tao Zhang, Jinxuan Wang, Xuepu Jin, Muhammad Abdul Rouf, Desha Luo, Yuan Zhu, Daoxi Lei, Hans Gregersen, Yeqi Wang, Guixue Wang

PLOS Genetics: published July 28, 2021 | https://doi.org/10.1371/journal.pgen.1009690

Induction of a chromatin boundary in vivo upon insertion of a TAD border

Andréa Willemin, Lucille Lopez-Delisle, Christopher Chase Bolt, Marie-Laure Gadolini, Denis Duboule, Eddie Rodriguez-Carballo

PLOS Genetics: published July 22, 2021 | https://doi.org/10.1371/journal.pgen.1009691

Oligopaint DNA FISH reveals telomere-based meiotic pairing dynamics in the silkworm, Bombyx mori

Leah F. Rosin, Jose Gil Jr., Ines A. Drinnenberg, Elissa P. Lei

PLOS Genetics: published July 28, 2021 | https://doi.org/10.1371/journal.pgen.1009700

Ras/ERK and PI3K/AKT signaling differentially regulate oncogenic ERG mediated transcription in prostate cells

Brady G. Strittmatter, Travis J. Jerde, Peter C. Hollenhorst

PLOS Genetics: published July 27, 2021 | https://doi.org/10.1371/journal.pgen.1009708

Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage

Xiaojuan Zhang, Sisi Tian, Sara E. Beese-Sims, Jingjie Chen, Nara Shin, Monica P. Colaiácovo, Hyun-Min Kim

PLOS Genetics: published July 30, 2021 | https://doi.org/10.1371/journal.pgen.1009715

Meiosis in Quarantine discussions lead to an action plan to increase diversity and inclusion within the genetics community

Katherine K. Billmyre, María Angélica Bravo Núñez, Douglas K. Bishop, Francesca Cole

PLOS Genetics: published July 15, 2021 | https://doi.org/10.1371/journal.pgen.1009648

What connectomics can learn from genomics

Patrick B. Chen, Jonathan Flint

PLOS Genetics: published July 16, 2021 | https://doi.org/10.1371/journal.pgen.1009692

A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics

Geyu Zhou, Hongyu Zhao

PLOS Genetics: published July 26, 2021 | https://doi.org/10.1371/journal.pgen.1009697