November 2007

Chromosome segregation is one of the cornerstones of meiosis. Shown here is a Mongolian gerbil spermatocyte at anaphase I. The X (top) and Y (bottom) chromosomes (labeled in red) are segregating to opposite cell poles while they remain connected by a proteinaceous bridge (see de la Fuente et al., e198). Green, SYCP3 protein; red, ?-H2AX; blue, DNA staining with DAPI.

Image Credit: Photo by Roberto de la Fuente.

Review

Lessons from “Lower” Organisms: What Worms, Flies, and Zebrafish Can Teach Us about Human Energy Metabolism

Amnon Schlegel, Didier Y. R Stainier

PLOS Genetics: published November 30, 2007 | https://doi.org/10.1371/journal.pgen.0030199

Research Articles

Genetic Variation and Population Structure in Native Americans

Sijia Wang, Cecil M Lewis Jr., Mattias Jakobsson, Sohini Ramachandran, Nicolas Ray, Gabriel Bedoya, Winston Rojas, Maria V Parra, Julio A Molina, Carla Gallo, Guido Mazzotti, Giovanni Poletti, Kim Hill, Ana M Hurtado, Damian Labuda, William Klitz, Ramiro Barrantes, Maria Cátira Bortolini, Francisco M Salzano, Maria Luiza Petzl-Erler, Luiza T Tsuneto, Elena Llop, Francisco Rothhammer, Laurent Excoffier, Marcus W Feldman, Noah A Rosenberg, Andrés Ruiz-Linares

PLOS Genetics: published November 23, 2007 | https://doi.org/10.1371/journal.pgen.0030185

C. elegans Germ Cells Switch between Distinct Modes of Double-Strand Break Repair During Meiotic Prophase Progression

Michiko Hayashi, Gregory M Chin, Anne M Villeneuve

PLOS Genetics: published November 2, 2007 | https://doi.org/10.1371/journal.pgen.0030191

Identification of Two Independent Risk Factors for Lupus within the MHC in United Kingdom Families

Michelle M. A Fernando, Christine R Stevens, Pardis C Sabeti, Emily C Walsh, Alasdair J. M McWhinnie, Anila Shah, Todd Green, John D Rioux, Timothy J Vyse

PLOS Genetics: published November 9, 2007 | https://doi.org/10.1371/journal.pgen.0030192

The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts

Siguang Li, Serena Sanna, Andrea Maschio, Fabio Busonero, Gianluca Usala, Antonella Mulas, Sandra Lai, Mariano Dei, Marco Orrù, Giuseppe Albai, Stefania Bandinelli, David Schlessinger, Edward Lakatta, Angelo Scuteri, Samer S Najjar, Jack Guralnik, Silvia Naitza, Laura Crisponi, Antonio Cao, Gonçalo Abecasis, Luigi Ferrucci, Manuela Uda, Wei-Min Chen, Ramaiah Nagaraja

PLOS Genetics: published November 9, 2007 | https://doi.org/10.1371/journal.pgen.0030194

Allelic Heterogeneity at the Equine KIT Locus in Dominant White (W) Horses

Bianca Haase, Samantha A Brooks, Angela Schlumbaum, Pedro J Azor, Ernest Bailey, Ferial Alaeddine, Meike Mevissen, Dominik Burger, Pierre-André Poncet, Stefan Rieder, Tosso Leeb

PLOS Genetics: published November 9, 2007 | https://doi.org/10.1371/journal.pgen.0030195

A High-Density Admixture Scan in 1,670 African Americans with Hypertension

Rahul C Deo, Nick Patterson, Arti Tandon, Gavin J McDonald, Christopher A Haiman, Kristin Ardlie, Brian E Henderson, Sean O Henderson, David Reich

PLOS Genetics: published November 16, 2007 | https://doi.org/10.1371/journal.pgen.0030196

Gene Family Evolution across 12 Drosophila Genomes

Matthew W Hahn, Mira V Han, Sang-Gook Han

PLOS Genetics: published November 9, 2007 | https://doi.org/10.1371/journal.pgen.0030197

Meiotic Pairing and Segregation of Achiasmate Sex Chromosomes in Eutherian Mammals: The Role of SYCP3 Protein

Roberto de la Fuente, María Teresa Parra, Alberto Viera, Adela Calvente, Rocío Gómez, José Ángel Suja, Julio S Rufas, Jesús Page

PLOS Genetics: published November 2, 2007 | https://doi.org/10.1371/journal.pgen.0030198

Mutations in Drosophila Greatwall/Scant Reveal Its Roles in Mitosis and Meiosis and Interdependence with Polo Kinase

Vincent Archambault, Xinbei Zhao, Helen White-Cooper, Adelaide T. C Carpenter, David M Glover

PLOS Genetics: published November 9, 2007 | https://doi.org/10.1371/journal.pgen.0030200

AGEMAP: A Gene Expression Database for Aging in Mice

Jacob M Zahn, Suresh Poosala, Art B Owen, Donald K Ingram, Ana Lustig, Arnell Carter, Ashani T Weeraratna, Dennis D Taub, Myriam Gorospe, Krystyna Mazan-Mamczarz, Edward G Lakatta, Kenneth R Boheler, Xiangru Xu, Mark P Mattson, Geppino Falco, Minoru S. H Ko, David Schlessinger, Jeffrey Firman, Sarah K Kummerfeld, William H Wood III, Alan B Zonderman, Stuart K Kim, Kevin G Becker

PLOS Genetics: published November 30, 2007 | https://doi.org/10.1371/journal.pgen.0030201

Developmental Role and Regulation of cortex, a Meiosis-Specific Anaphase-Promoting Complex/Cyclosome Activator

Jillian A Pesin, Terry L Orr-Weaver

PLOS Genetics: published November 16, 2007 | https://doi.org/10.1371/journal.pgen.0030202

The “Alternative” Choice of Constitutive Exons throughout Evolution

Galit Lev-Maor, Amir Goren, Noa Sela, Eddo Kim, Hadas Keren, Adi Doron-Faigenboim, Shelly Leibman-Barak, Tal Pupko, Gil Ast

PLOS Genetics: published November 16, 2007 | https://doi.org/10.1371/journal.pgen.0030203

Pre-mRNA Secondary Structures Influence Exon Recognition

Michael Hiller, Zhaiyi Zhang, Rolf Backofen, Stefan Stamm

PLOS Genetics: published November 16, 2007 | https://doi.org/10.1371/journal.pgen.0030204

Forty Years of Erratic Insecticide Resistance Evolution in the Mosquito Culex pipiens

Pierrick Labbé, Claire Berticat, Arnaud Berthomieu, Sandra Unal, Clothilde Bernard, Mylène Weill, Thomas Lenormand

PLOS Genetics: published November 16, 2007 | https://doi.org/10.1371/journal.pgen.0030205

Activation of Inflammation/NF-κB Signaling in Infants Born to Arsenic-Exposed Mothers

Rebecca C Fry, Panida Navasumrit, Chandni Valiathan, J. Peter Svensson, Bradley J Hogan, Manlin Luo, Sanchita Bhattacharya, Krittinee Kandjanapa, Sumitra Soontararuks, Sumontha Nookabkaew, Chulabhorn Mahidol, Mathuros Ruchirawat, Leona D Samson

PLOS Genetics: published November 23, 2007 | https://doi.org/10.1371/journal.pgen.0030207

The ets-Related Transcription Factor GABP Directs Bidirectional Transcription

Patrick J Collins, Yuya Kobayashi, Loan Nguyen, Nathan D Trinklein, Richard M Myers

PLOS Genetics: published November 16, 2007 | https://doi.org/10.1371/journal.pgen.0030208

POF and HP1 Bind Expressed Exons, Suggesting a Balancing Mechanism for Gene Regulation

Anna-Mia Johansson, Per Stenberg, Fredrik Pettersson, Jan Larsson

PLOS Genetics: published November 16, 2007 | https://doi.org/10.1371/journal.pgen.0030209

Genome Organization and Gene Expression Shape the Transposable Element Distribution in the Drosophila melanogaster Euchromatin

Pierre Fontanillas, Daniel L Hartl, Max Reuter

PLOS Genetics: published November 30, 2007 | https://doi.org/10.1371/journal.pgen.0030210

Genomic and Functional Studies of Drosophila Sex Hierarchy Regulated Gene Expression in Adult Head and Nervous System Tissues

Thomas D Goldman, Michelle N Arbeitman

PLOS Genetics: published November 23, 2007 | https://doi.org/10.1371/journal.pgen.0030216

Excess Single-Stranded DNA Inhibits Meiotic Double-Strand Break Repair

Rebecca Johnson, Valérie Borde, Matthew J Neale, Anna Bishop-Bailey, Matthew North, Sheila Harris, Alain Nicolas, Alastair S. H Goldman

PLOS Genetics: published November 30, 2007 | https://doi.org/10.1371/journal.pgen.0030223

Cover

A Mongolian gerbil spermatocyte at anaphase I