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Table of Contents

September 2016

c-Fos overexpression (right image) in the ovary of the fruitfly (Drosophila melanogaster) results in enlarged tissue volume and germ cell developmental arrest. Pictured are an ovary from a wild-type (left) fruitfly and an ovary from a fruitfly that overexpresses the c-Fos transgene. Blue is DAPI stain. Green is immunofluorescence signal of Vasa, a germ cell marker. White bar is 100 um scale bar. Klein et al. uncovered that Piwi and non-coding Piwi-interacting RNAs repress c-Fos to regulate ovarian tissue morphogenesis, germ cell development, and animal fertility. Replacement of the 3’ untranslated region of the c-Fos mRNA, which originates Piwi-interacting RNAs, results in c-Fos overexpression, disorganized ovarian cells, arrest in germ cell maturation, and complete animal infertility. See Klein et al.

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Image Credit: Jonathon D. Klein and Victoria Frohlich, using a Zeiss LightSheet Z.1 system.

Review

Research Articles

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP

Bo Hu, Sezgi Arpag, Xuebao Zhang, Wiebke Möbius, Hauke Werner, Gina Sosinsky, Mark Ellisman, Yang Zhang, Audra Hamilton, Jonathan Chernoff, Jun Li

DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment

Teng Zhang, Jon Oatley, Vivian J. Bardwell, David Zarkower

dBRWD3 Regulates Tissue Overgrowth and Ectopic Gene Expression Caused by Polycomb Group Mutations

Hsueh-Tzu Shih, Wei-Yu Chen, Kwei-Yan Liu, Zong-Siou Shih, Yi-Jyun Chen, Paul-Chen Hsieh, Kuan-Lin Kuo, Kuo-How Huang, Pang-Hung Hsu, Ya-Wen Liu, Shih-Peng Chan, Hsiu-Hsiang Lee, Yu-Chen Tsai, June-Tai Wu

Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions

Lai H. Wong, Sunita Sinha, Julien R. Bergeron, Joseph C. Mellor, Guri Giaever, Patrick Flaherty, Corey Nislow

Evolution of New cis-Regulatory Motifs Required for Cell-Specific Gene Expression in Caenorhabditis

Michalis Barkoulas, Amhed M. Vargas Velazquez, Alexandre E. Peluffo, Marie-Anne Félix

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

Barbara Mair, Tomasz Konopka, Claudia Kerzendorfer, Katia Sleiman, Sejla Salic, Violeta Serra, Markus K. Muellner, Vasiliki Theodorou, Sebastian M. B. Nijman

Whole Exome Sequencing in Atrial Fibrillation

Steven A. Lubitz, Jennifer A. Brody, Nathan A. Bihlmeyer, Carolina Roselli, Lu-Chen Weng, Ingrid E. Christophersen, Alvaro Alonso, Eric Boerwinkle, Richard A. Gibbs, Joshua C. Bis, NHLBI GO Exome Sequencing Project, L. Adrienne Cupples, Peter J. Mohler, Deborah A. Nickerson, Donna Muzny, Marco V. Perez, Bruce M. Psaty, Elsayed Z. Soliman, Nona Sotoodehnia, Kathryn L. Lunetta, Emelia J. Benjamin, Susan R. Heckbert, Dan E. Arking, Patrick T. Ellinor, Honghuang Lin

DNA Replication Control Is Linked to Genomic Positioning of Control Regions in Escherichia coli

Jakob Frimodt-Møller, Godefroid Charbon, Karen A. Krogfelt, Anders Løbner-Olesen

Using Genetic Distance to Infer the Accuracy of Genomic Prediction

Marco Scutari, Ian Mackay, David Balding

Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice

François Redelsperger, Najat Raddi, Agathe Bacquin, Cécile Vernochet, Virginie Mariot, Vincent Gache, Nicolas Blanchard-Gutton, Stéphanie Charrin, Laurent Tiret, Julie Dumonceaux, Anne Dupressoir, Thierry Heidmann

Effects of Gene Dose, Chromatin, and Network Topology on Expression in Drosophila melanogaster

Hangnoh Lee, Dong-Yeon Cho, Cale Whitworth, Robert Eisman, Melissa Phelps, John Roote, Thomas Kaufman, Kevin Cook, Steven Russell, Teresa Przytycka, Brian Oliver

Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity

Karin R. McDonald, Amanda J. Guise, Parham Pourbozorgi-Langroudi, Ileana M. Cristea, Virginia A. Zakian, John A. Capra, Nasim Sabouri

mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium

Christina Bachmann, Huong Nguyen, Joachim Rosenbusch, Linh Pham, Tamara Rabe, Megha Patwa, Godwin Sokpor, Rho H. Seong, Ruth Ashery-Padan, Ahmed Mansouri, Anastassia Stoykova, Jochen F. Staiger, Tran Tuoc

A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions

Kazuhiro Katsumata, Ami Hirayasu, Junpei Miyoshi, Eriko Nishi, Kento Ichikawa, Kazuki Tateho, Airi Wakuda, Hirotada Matsuhara, Ayumu Yamamoto

The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia

Chao Shen, Ming-Tai Chen, Xin-Hua Zhang, Xiao-Lin Yin, Hong-Mei Ning, Rui Su, Hai-Shuang Lin, Li Song, Fang Wang, Yan-Ni Ma, Hua-Lu Zhao, Jia Yu, Jun-Wu Zhang

Related Articles

Combined Analysis of Variation in Core, Accessory and Regulatory Genome Regions Provides a Super-Resolution View into the Evolution of Bacterial Populations

Alan McNally, Yaara Oren, Darren Kelly, Ben Pascoe, Steven Dunn, Tristan Sreecharan, Minna Vehkala, Niko Välimäki, Michael B. Prentice, Amgad Ashour, Oren Avram, Tal Pupko, Ulrich Dobrindt, Ivan Literak, Sebastian Guenther, Katharina Schaufler, Lothar H. Wieler, Zong Zhiyong, Samuel K. Sheppard, James O. McInerney, Jukka Corander

Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly

Hanqian Mao, John J. McMahon, Yi-Hsuan Tsai, Zefeng Wang, Debra L. Silver

Oligomerization of SCFTIR1 Is Essential for Aux/IAA Degradation and Auxin Signaling in Arabidopsis

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The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice

Xiaobo Zhu, Junjie Yin, Sihui Liang, Ruihong Liang, Xiaogang Zhou, Zhixiong Chen, Wen Zhao, Jing Wang, Weitao Li, Min He, Can Yuan, Koji Miyamoto, Bingtian Ma, Jichun Wang, Peng Qin, Weilan Chen, Yuping Wang, Wenming Wang, Xianjun Wu, Hisakazu Yamane, Lihuang Zhu, Shigui Li, Xuewei Chen

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium

Shefali Setia Verma, Jessica N. Cooke Bailey, Anastasia Lucas, Yuki Bradford, James G. Linneman, Michael A. Hauser, Louis R. Pasquale, Peggy L. Peissig, Murray H. Brilliant, Catherine A. McCarty, Jonathan L. Haines, Janey L. Wiggs, Tamara R. Vrabec, Gerard Tromp, Marylyn D. Ritchie, eMERGE Network, NEIGHBOR Consortium

c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis

Jonathon D. Klein, Chunxu Qu, Xiaoyang Yang, Yiping Fan, Chunlao Tang, Jamy C. Peng

Nuclear Localised MORE SULPHUR ACCUMULATION1 Epigenetically Regulates Sulphur Homeostasis in Arabidopsis thaliana

Xin-Yuan Huang, Dai-Yin Chao, Anna Koprivova, John Danku, Markus Wirtz, Steffen Müller, Francisco J. Sandoval, Hermann Bauwe, Sanja Roje, Brian Dilkes, Rüdiger Hell, Stanislav Kopriva, David E Salt

The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1

Gang Li, Pierre Cunin, Di Wu, Dorothée Diogo, Yu Yang, Yukinori Okada, Robert M. Plenge, Peter A. Nigrovic

The Contribution of Mosaic Variants to Autism Spectrum Disorder

Donald Freed, Jonathan Pevsner

The Genetic Basis of Host Preference and Resting Behavior in the Major African Malaria Vector, Anopheles arabiensis

Bradley J Main, Yoosook Lee, Heather M. Ferguson, Katharina S. Kreppel, Anicet Kihonda, Nicodem J. Govella, Travis C. Collier, Anthony J. Cornel, Eleazar Eskin, Eun Yong Kang, Catelyn C. Nieman, Allison M. Weakley, Gregory C. Lanzaro

Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

M. Kasim Diril, Xavier Bisteau, Mayumi Kitagawa, Matias J. Caldez, Sheena Wee, Jayantha Gunaratne, Sang Hyun Lee, Philipp Kaldis

A Recombination Directionality Factor Controls the Cell Type-Specific Activation of σK and the Fidelity of Spore Development in Clostridium difficile

Mónica Serrano, Nicolas Kint, Fátima C. Pereira, Laure Saujet, Pierre Boudry, Bruno Dupuy, Adriano O. Henriques, Isabelle Martin-Verstraete

XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans

Takashi S. Miki, Sarah H. Carl, Michael B. Stadler, Helge Großhans

Bmp15 Is an Oocyte-Produced Signal Required for Maintenance of the Adult Female Sexual Phenotype in Zebrafish

Daniel B. Dranow, Kevin Hu, April M. Bird, S. Terese Lawry, Melissa T. Adams, Angelica Sanchez, James F. Amatruda, Bruce W. Draper

The Impact of Endurance Training on Human Skeletal Muscle Memory, Global Isoform Expression and Novel Transcripts

Maléne E Lindholm, Stefania Giacomello, Beata Werne Solnestam, Helene Fischer, Mikael Huss, Sanela Kjellqvist, Carl Johan Sundberg

Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome

Laura S. Burrack, Hannah F. Hutton, Kathleen J. Matter, Shelly Applen Clancey, Ivan Liachko, Alexandra E. Plemmons, Amrita Saha, Erica A. Power, Breanna Turman, Mathuravani Aaditiyaa Thevandavakkam, Ferhat Ay, Maitreya J. Dunham, Judith Berman

A Broad Set of Chromatin Factors Influences Splicing

Eric Allemand, Michael P. Myers, Jose Garcia-Bernardo, Annick Harel-Bellan, Adrian R. Krainer, Christian Muchardt

Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements

Amanda Swain, Ziva Misulovin, Michelle Pherson, Maria Gause, Kathie Mihindukulasuriya, Ryan A Rickels, Ali Shilatifard, Dale Dorsett

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PARAQUAT TOLERANCE3 Is an E3 Ligase That Switches off Activated Oxidative Response by Targeting Histone-Modifying PROTEIN METHYLTRANSFERASE4b

Chao Luo, Xiao-Teng Cai, Jin Du, Tao-Lan Zhao, Peng-Fei Wang, Ping-Xia Zhao, Rui Liu, Qi Xie, Xiao-Feng Cao, Cheng-Bin Xiang

Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy

Stacey D. Wagner, Adam J. Struck, Riti Gupta, Dylan R. Farnsworth, Amy E. Mahady, Katy Eichinger, Charles A. Thornton, Eric T. Wang, J. Andrew Berglund

Arabidopsis CaM1 and CaM4 Promote Nitric Oxide Production and Salt Resistance by Inhibiting S-Nitrosoglutathione Reductase via Direct Binding

Shuo Zhou, Lixiu Jia, Hongye Chu, Dan Wu, Xuan Peng, Xu Liu, Jiaojiao Zhang, Junfeng Zhao, Kunming Chen, Liqun Zhao

Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution

Vitor G. Faria, Nelson E. Martins, Sara Magalhães, Tânia F. Paulo, Viola Nolte, Christian Schlötterer, Élio Sucena, Luis Teixeira

NUCLEAR FACTOR Y, Subunit C (NF-YC) Transcription Factors Are Positive Regulators of Photomorphogenesis in Arabidopsis thaliana

Zachary A. Myers, Roderick W. Kumimoto, Chamindika L. Siriwardana, Krystal K. Gayler, Jan R. Risinger, Daniela Pezzetta, Ben F. Holt III

Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans

Douglas J. Cattie, Claire E. Richardson, Kirthi C. Reddy, Elan M. Ness-Cohn, Rita Droste, Mary K. Thompson, Wendy V. Gilbert, Dennis H. Kim

Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

Staci L. Haney, G. Michael Upchurch, Jana Opavska, David Klinkebiel, Ryan A. Hlady, Sohini Roy, Samikshan Dutta, Kaustubh Datta, Rene Opavsky

Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection

Athma A. Pai, Golshid Baharian, Ariane Pagé Sabourin, Jessica F. Brinkworth, Yohann Nédélec, Joseph W. Foley, Jean-Christophe Grenier, Katherine J. Siddle, Anne Dumaine, Vania Yotova, Zachary P. Johnson, Robert E. Lanford, Christopher B. Burge, Luis B. Barreiro

Anchoring of Heterochromatin to the Nuclear Lamina Reinforces Dosage Compensation-Mediated Gene Repression

Martha J. Snyder, Alyssa C. Lau, Elizabeth A. Brouhard, Michael B. Davis, Jianhao Jiang, Margarita H. Sifuentes, Györgyi Csankovszki

STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function

Anukana Bhattacharjee, Jason Stewart, Mary Chaiken, Carolyn M. Price

Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF

Jiangtian Chen, Wencke Reiher, Christiane Hermann-Luibl, Azza Sellami, Paola Cognigni, Shu Kondo, Charlotte Helfrich-Förster, Jan A. Veenstra, Christian Wegener

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Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa