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Table of Contents

March 2016

Facial motor neurons migrate in the plane of the hindbrain neuroepithelium, covering a distance of 100 microns in the course of about ten hours in the zebrafish shown here (red: cranial motor neuron nuclei, green: cranial motor neuron cytoplasm, blue: neuroepithelial nuclei; anterior is to the top, and the migrated facial motor neurons are the bilateral clusters at the bottom of the image). Facial motor neuron migration is tightly connected to the Planar Cell Polarity (PCP) pathway, and using genetic chimeras we show that signaling between the neurons and the planar polarized neuroepithelium controls filopodial dynamics and directional migration. Davey et al.

Image Credit: Cecilia Moens

Reviews

What Is Speciation?

B. Jesse Shapiro, Jean-Baptiste Leducq, James Mallet

Research Articles

Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics

Bartholomew P. Roland, Alison M. Zeccola, Samantha B. Larsen, Christopher G. Amrich, Aaron D. Talsma, Kimberly A. Stuchul, Annie Heroux, Edwin S. Levitan, Andrew P. VanDemark, Michael J. Palladino

Evolution of Social Insect Polyphenism Facilitated by the Sex Differentiation Cascade

Antonia Klein, Eva Schultner, Helena Lowak, Lukas Schrader, Jürgen Heinze, Luke Holman, Jan Oettler

The MKK7 p.Glu116Lys Rare Variant Serves as a Predictor for Lung Cancer Risk and Prognosis in Chinese

Fuman Qiu, Lei Yang, Xiaoxiao Lu, Jiansong Chen, Di Wu, Yongfang Wei, Qingqing Nong, Lisha Zhang, Wenxiang Fang, Xiaoliang Chen, Xiaoxuan Ling, Binyao Yang, Xin Zhang, Yifeng Zhou, Jiachun Lu

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

Heather A. Feaga, Michael D. Quickel, Pamela A. Hankey-Giblin, Kenneth C. Keiler

Bat Accelerated Regions Identify a Bat Forelimb Specific Enhancer in the HoxD Locus

Betty M. Booker, Tara Friedrich, Mandy K. Mason, Julia E. VanderMeer, Jingjing Zhao, Walter L. Eckalbar, Malcolm Logan, Nicola Illing, Katherine S. Pollard, Nadav Ahituv

Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila

Maitreyi Upadhyay, Yesenia Martino Cortez, SiuWah Wong-Deyrup, Leticia Tavares, Sean Schowalter, Pooja Flora, Corinne Hill, Mohamad Ali Nasrallah, Sridar Chittur, Prashanth Rangan

TGFβ and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions

Jennifer Zieba, Kimberly Nicole Forlenza, Jagteshwar Singh Khatra, Anna Sarukhanov, Ivan Duran, Diana Rigueur, Karen M. Lyons, Daniel H. Cohn, Amy E. Merrill, Deborah Krakow

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration

Marie Y. Davis, Kien Trinh, Ruth E. Thomas, Selina Yu, Alexandre A. Germanos, Brittany N. Whitley, Sergio Pablo Sardi, Thomas J. Montine, Leo J. Pallanck

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease

James E. Peters, Paul A. Lyons, James C. Lee, Arianne C. Richard, Mary D. Fortune, Paul J. Newcombe, Sylvia Richardson, Kenneth G. C. Smith

The Arabidopsis Receptor Kinase ZAR1 Is Required for Zygote Asymmetric Division and Its Daughter Cell Fate

Tian-Ying Yu, Dong-Qiao Shi, Peng-Fei Jia, Jun Tang, Hong-Ju Li, Jie Liu, Wei-Cai Yang

MicroProtein-Mediated Recruitment of CONSTANS into a TOPLESS Trimeric Complex Represses Flowering in Arabidopsis

Moritz Graeff, Daniel Straub, Tenai Eguen, Ulla Dolde, Vandasue Rodrigues, Ronny Brandt, Stephan Wenkel

Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response

Luisa Ojeda-Fernández, Lucía Recio-Poveda, Mikel Aristorena, Pedro Lastres, Francisco J. Blanco, Francisco Sanz-Rodríguez, Eunate Gallardo-Vara, Mateo de las Casas-Engel, Ángel Corbí, Helen M. Arthur, Carmelo Bernabeu, Luisa M. Botella

The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development

Josua Schinke, Miriam Kolog Gulko, Martin Christmann, Oliver Valerius, Sina Kristin Stumpf, Margarita Stirz, Gerhard H. Braus

ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size

Rotem Kadir, Tamar Harel, Barak Markus, Yonatan Perez, Anna Bakhrat, Idan Cohen, Michael Volodarsky, Miora Feintsein-Linial, Elana Chervinski, Joel Zlotogora, Sara Sivan, Ramon Y. Birnbaum, Uri Abdu, Stavit Shalev, Ohad S. Birk

Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status

Michele D. Binder, Andrew D. Fox, Daniel Merlo, Laura J. Johnson, Lauren Giuffrida, Sarah E. Calvert, Rainer Akkermann, Gerry Z. M. Ma, ANZgene, Ashwyn A. Perera, Melissa M. Gresle, Louise Laverick, Grace Foo, Marzena J. Fabis-Pedrini, Timothy Spelman, Margaret A. Jordan, Alan G. Baxter, Simon Foote, Helmut Butzkueven, Trevor J. Kilpatrick, Judith Field

Multi-locus Genotypes Underlying Temperature Sensitivity in a Mutationally Induced Trait

Jonathan T. Lee, Matthew B. Taylor, Amy Shen, Ian M. Ehrenreich

The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA–Dependent Tel1 Activation

Daichi Iwasaki, Kayoko Hayashihara, Hiroki Shima, Mika Higashide, Masahiro Terasawa, Susan M. Gasser, Miki Shinohara

Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres

Mariana C. Gadaleta, Mukund M. Das, Hideki Tanizawa, Ya-Ting Chang, Ken-ichi Noma, Toru M. Nakamura, Eishi Noguchi

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development

Philip J. Byrd, Grant. S. Stewart, Anna Smith, Charlotte Eaton, Alexander J. Taylor, Chloe Guy, Ieva Eringyte, Peggy Fooks, James I. Last, Robert Horsley, Antony W. Oliver, Dragana Janic, Lidija Dokmanovic, Tatjana Stankovic, A. Malcolm R. Taylor

MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO

Nicole Kohrs, Stephan Kolodziej, Olga N. Kuvardina, Julia Herglotz, Jasmin Yillah, Stefanie Herkt, Alexander Piechatzek, Gabriela Salinas Riester, Thomas Lingner, Christian Wichmann, Halvard Bonig, Erhard Seifried, Uwe Platzbecker, Hind Medyouf, Manuel Grez, Jörn Lausen

A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis

Christina Spilker, Sven Nullmeier, Katarzyna M. Grochowska, Anne Schumacher, Ioana Butnaru, Tamar Macharadze, Guilherme M. Gomes, PingAn Yuanxiang, Gonca Bayraktar, Carolin Rodenstein, Carolin Geiseler, Angela Kolodziej, Jeffrey Lopez-Rojas, Dirk Montag, Frank Angenstein, Julia Bär, Wolfgang D’Hanis, Thomas Roskoden, Marina Mikhaylova, Eike Budinger, Frank W. Ohl, Oliver Stork, Ana C. Zenclussen, Anna Karpova, Herbert Schwegler, Michael R. Kreutz

Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis

Roberta Palorini, Giuseppina Votta, Yuri Pirola, Humberto De Vitto, Sara De Palma, Cristina Airoldi, Michele Vasso, Francesca Ricciardiello, Pietro Paolo Lombardi, Claudia Cirulli, Raffaella Rizzi, Francesco Nicotra, Karsten Hiller, Cecilia Gelfi, Lilia Alberghina, Ferdinando Chiaradonna

Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number

Manja Wachsmuth, Alexander Hübner, Mingkun Li, Burkhard Madea, Mark Stoneking

Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation

Valentina Grampa, Marion Delous, Mohamad Zaidan, Gweltas Odye, Sophie Thomas, Nadia Elkhartoufi, Emilie Filhol, Olivier Niel, Flora Silbermann, Corinne Lebreton, Sophie Collardeau-Frachon, Isabelle Rouvet, Jean-Luc Alessandri, Louise Devisme, Anne Dieux-Coeslier, Marie-Pierre Cordier, Yline Capri, Suonavy Khung-Savatovsky, Sabine Sigaudy, Rémi Salomon, Corinne Antignac, Marie-Claire Gubler, Alexandre Benmerah, Fabiola Terzi, Tania Attié-Bitach, Cécile Jeanpierre, Sophie Saunier

Meta-analysis Reveals Genome-Wide Significance at 15q13 for Nonsyndromic Clefting of Both the Lip and the Palate, and Functional Analyses Implicate GREM1 As a Plausible Causative Gene

Kerstin U. Ludwig, Syeda Tasnim Ahmed, Anne C. Böhmer, Nasim Bahram Sangani, Sheryil Varghese, Johanna Klamt, Hannah Schuenke, Pinar Gültepe, Andrea Hofmann, Michele Rubini, Khalid Ahmed Aldhorae, Regine P. Steegers-Theunissen, Augusto Rojas-Martinez, Rudolf Reiter, Guntram Borck, Michael Knapp, Mitsushiro Nakatomi, Daniel Graf, Elisabeth Mangold, Heiko Peters

High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast

Sabrina L. Andersen, Aimee Zhang, Margaret Dominska, María Moriel-Carretero, Emilia Herrera-Moyano, Andrés Aguilera, Thomas D. Petes

Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome

Matthew Van De Pette, Simon J. Tunster, Grainne I. McNamara, Tatyana Shelkovnikova, Steven Millership, Lindsay Benson, Stuart Peirson, Mark Christian, Antonio Vidal-Puig, Rosalind M. John

AUXIN RESPONSE FACTOR 2 Intersects Hormonal Signals in the Regulation of Tomato Fruit Ripening

Dario A. Breitel, Louise Chappell-Maor, Sagit Meir, Irina Panizel, Clara Pons Puig, Yanwei Hao, Tamar Yifhar, Hagai Yasuor, Mohamed Zouine, Mondher Bouzayen, Antonio Granell Richart, Ilana Rogachev, Asaph Aharoni

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