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Table of Contents

August 2013

Unlike sigG mutants of B. subtilis, C. perfringens, and C. acetobutyilcum, C. difficile sigG- mutant cells produce forespores with ruffled membranes that appear to be surrounded by spore coat layers. See Fimlaid et al.

Image Credit: Kelly Fimlaid and Keyan Pishdadian (Department of Microbiology and Molecular Genetics, The University of Vermont, USA).

Viewpoints

Chromatin Sampling—An Emerging Perspective on Targeting Polycomb Repressor Proteins

Robert J. Klose, Sarah Cooper, Anca M. Farcas, Neil P. Blackledge, Neil Brockdorff

Reviews

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

Cristina Barbosa, Isabel Peixeiro, Luísa Romão

Transposon Domestication versus Mutualism in Ciliate Genome Rearrangements

Alexander Vogt, Aaron David Goldman, Kazufumi Mochizuki, Laura F. Landweber

Research Articles

Comparative Anatomy of Chromosomal Domains with Imprinted and Non-Imprinted Allele-Specific DNA Methylation

Anupam Paliwal, Alexis M. Temkin, Kristi Kerkel, Alexander Yale, Iveta Yotova, Natalia Drost, Simon Lax, Chia-Ling Nhan-Chang, Charles Powell, Alain Borczuk, Abraham Aviv, Ronald Wapner, Xiaowei Chen, Peter L. Nagy, Nicholas Schork, Catherine Do, Ali Torkamani, Benjamin Tycko

A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome

Bari J. Ballew, Vijai Joseph, Saurav De, Grzegorz Sarek, Jean-Baptiste Vannier, Travis Stracker, Kasmintan A. Schrader, Trudy N. Small, Richard O'Reilly, Chris Manschreck, Megan M. Harlan Fleischut, Liying Zhang, John Sullivan, Kelly Stratton, Meredith Yeager, Kevin Jacobs, Neelam Giri, Blanche P. Alter, Joseph Boland, Laurie Burdett, Kenneth Offit, Simon J. Boulton, Sharon A. Savage, John H. J. Petrini

Ras-Induced Changes in H3K27me3 Occur after Those in Transcriptional Activity

Masaki Hosogane, Ryo Funayama, Yuichiro Nishida, Takeshi Nagashima, Keiko Nakayama

Neuronal Reprograming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response

M. Catarina Silva, Margarida D. Amaral, Richard I. Morimoto

A Critical Function of Mad2l2 in Primordial Germ Cell Development of Mice

Mehdi Pirouz, Sven Pilarski, Michael Kessel

Species and Population Level Molecular Profiling Reveals Cryptic Recombination and Emergent Asymmetry in the Dimorphic Mating Locus of C. reinhardtii

Peter L. De Hoff, Patrick Ferris, Bradley J. S. C. Olson, Ayano Miyagi, Sa Geng, James G. Umen

Cross-Species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events in Zebrafish and Human Embryonal Rhabdomyosarcoma

Eleanor Y. Chen, Kimberly P. Dobrinski, Kim H. Brown, Ryan Clagg, Elena Edelman, Myron S. Ignatius, Jin Yun Helen Chen, Jillian Brockmann, G. Petur Nielsen, Sridhar Ramaswamy, Charles Keller, Charles Lee, David M. Langenau

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Dynamic Rewiring of the Drosophila Retinal Determination Network Switches Its Function from Selector to Differentiation

Mardelle Atkins, Yuwei Jiang, Leticia Sansores-Garcia, Barbara Jusiak, Georg Halder, Graeme Mardon

Meiotic Recombination Initiation in and around Retrotransposable Elements in Saccharomyces cerevisiae

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Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

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Recurrent Modification of a Conserved Cis-Regulatory Element Underlies Fruit Fly Pigmentation Diversity

William A. Rogers, Joseph R. Salomone, David J. Tacy, Eric M. Camino, Kristen A. Davis, Mark Rebeiz, Thomas M. Williams

Cauli: A Mouse Strain with an Ift140 Mutation That Results in a Skeletal Ciliopathy Modelling Jeune Syndrome

Kerry A. Miller, Casey J. Ah-Cann, Megan F. Welfare, Tiong Y. Tan, Kate Pope, Georgina Caruana, Mary-Louise Freckmann, Ravi Savarirayan, John F. Bertram, Michael S. Dobbie, John F. Bateman, Peter G. Farlie

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Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

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