The clarifying role of time series data in the population genetics of HIV

Alison F. Feder, Pleuni S. Pennings, Dmitri A. Petrov

PLOS Genetics: published January 14, 2021 | https://doi.org/10.1371/journal.pgen.1009050

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The dose makes the poison—Novel insights into Dravet syndrome and SCN1A regulation through nonproductive splicing

Ingo Helbig, Ethan Goldberg

PLOS Genetics: published January 7, 2021 | https://doi.org/10.1371/journal.pgen.1009214

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Activation of a bacterial killing machine

Felicity Alcock, Tracy Palmer

PLOS Genetics: published January 7, 2021 | https://doi.org/10.1371/journal.pgen.1009261

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Harder, better, faster, stronger: Colistin resistance mechanisms in Escherichia coli

Axel B. Janssen, Willem van Schaik

PLOS Genetics: published January 7, 2021 | https://doi.org/10.1371/journal.pgen.1009262

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MED19 alters AR occupancy and gene expression in prostate cancer cells, driving MAOA expression and growth under low androgen

Hannah Weber, Rachel Ruoff, Michael J. Garabedian

PLOS Genetics: published January 29, 2021 | https://doi.org/10.1371/journal.pgen.1008540

Episodic evolution of coadapted sets of amino acid sites in mitochondrial proteins

Alexey D. Neverov, Anfisa V. Popova, Gennady G. Fedonin, Evgeny A. Cheremukhin, Galya V. Klink, Georgii A. Bazykin

PLOS Genetics: published January 25, 2021 | https://doi.org/10.1371/journal.pgen.1008711

Polygenic adaptation of rosette growth in Arabidopsis thaliana

Benedict Wieters, Kim A. Steige, Fei He, Evan M. Koch, Sebastián E. Ramos-Onsins, Hongya Gu, Ya-Long Guo, Shamil Sunyaev, Juliette de Meaux

PLOS Genetics: published January 25, 2021 | https://doi.org/10.1371/journal.pgen.1008748

Functional and transcriptional profiling of non-coding RNAs in yeast reveal context-dependent phenotypes and in trans effects on the protein regulatory network

Laura Natalia Balarezo-Cisneros, Steven Parker, Marcin G. Fraczek, Soukaina Timouma, Ping Wang, Raymond T. O’Keefe, Catherine B. Millar, Daniela Delneri

PLOS Genetics: published January 25, 2021 | https://doi.org/10.1371/journal.pgen.1008761

Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans

Shelby J. Priest, Marco A. Coelho, Verónica Mixão, Shelly Applen Clancey, Yitong Xu, Sheng Sun, Toni Gabaldón, Joseph Heitman

PLOS Genetics: published January 19, 2021 | https://doi.org/10.1371/journal.pgen.1008871

Predicting evolutionary change at the DNA level in a natural Mimulus population

Patrick J. Monnahan, Jack Colicchio, Lila Fishman, Stuart J. Macdonald, John K. Kelly

PLOS Genetics: published January 13, 2021 | https://doi.org/10.1371/journal.pgen.1008945

Differential role of cytosolic Hsp70s in longevity assurance and protein quality control

Rebecca Andersson, Anna Maria Eisele-Bürger, Sarah Hanzén, Katarina Vielfort, David Öling, Frederik Eisele, Gustav Johansson, Tobias Gustafsson, Kristian Kvint, Thomas Nyström

PLOS Genetics: published January 11, 2021 | https://doi.org/10.1371/journal.pgen.1008951

Essentiality of c-di-AMP in Bacillus subtilis: Bypassing mutations converge in potassium and glutamate homeostasis

Larissa Krüger, Christina Herzberg, Hermann Rath, Tiago Pedreira, Till Ischebeck, Anja Poehlein, Jan Gundlach, Rolf Daniel, Uwe Völker, Ulrike Mäder, Jörg Stülke

PLOS Genetics: published January 22, 2021 | https://doi.org/10.1371/journal.pgen.1009092

Impaired tumor immune response in metastatic tumors is a selective pressure for neutral evolution in CRC cases

Shotaro Sakimura, Satoshi Nagayama, Mitsuko Fukunaga, Qingjiang Hu, Akihiro Kitagawa, Yuta Kobayashi, Takanori Hasegawa, Miwa Noda, Yuta Kouyama, Dai Shimizu, Tomoko Saito, Atsushi Niida, Yusuke Tsuruda, Hajime Otsu, Yoshihiro Matsumoto, Hiroki Uchida, Takaaki Masuda, Keishi Sugimachi, Shin Sasaki, Kazutaka Yamada, Kazuki Takahashi, Hideki Innan, Yutaka Suzuki, Hiromi Nakamura, Yasushi Totoki, Shinichi Mizuno, Masanobu Ohshima, Tatsuhiro Shibata, Koshi Mimori

PLOS Genetics: published January 21, 2021 | https://doi.org/10.1371/journal.pgen.1009113

Phase-related differences in egg production of the migratory locust regulated by differential oosorption through microRNA-34 targeting activinβ

Lianfeng Zhao, Wei Guo, Feng Jiang, Jing He, Hongran Liu, Juan Song, Dan Yu, Le Kang

PLOS Genetics: published January 6, 2021 | https://doi.org/10.1371/journal.pgen.1009174

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy

Yuliya Voskobiynyk, Gopal Battu, Stephanie A. Felker, J. Nicholas Cochran, Megan P. Newton, Laura J. Lambert, Robert A. Kesterson, Richard M. Myers, Gregory M. Cooper, Erik D. Roberson, Gregory S. Barsh

PLOS Genetics: published January 7, 2021 | https://doi.org/10.1371/journal.pgen.1009195

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Phage infection and sub-lethal antibiotic exposure mediate Enterococcus faecalis type VII secretion system dependent inhibition of bystander bacteria

Anushila Chatterjee, Julia L. E. Willett, Gary M. Dunny, Breck A. Duerkop

PLOS Genetics: published January 7, 2021 | https://doi.org/10.1371/journal.pgen.1009204

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Population structure of indigenous inhabitants of Arabia

Katsuhiko Mineta, Kosuke Goto, Takashi Gojobori, Fowzan S. Alkuraya

PLOS Genetics: published January 11, 2021 | https://doi.org/10.1371/journal.pgen.1009210

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome

Denis A. Baird, Jimmy Z. Liu, Jie Zheng, Solveig K. Sieberts, Thanneer Perumal, Benjamin Elsworth, Tom G. Richardson, Chia-Yen Chen, Minerva M. Carrasquillo, Mariet Allen, Joseph S. Reddy, Philip L. De Jager, Nilufer Ertekin-Taner, Lara M. Mangravite, Ben Logsdon, Karol Estrada, Philip C. Haycock, Gibran Hemani, Heiko Runz, George Davey Smith, Tom R. Gaunt, AMP-AD eQTL working group

PLOS Genetics: published January 8, 2021 | https://doi.org/10.1371/journal.pgen.1009224

A novel type of colistin resistance genes selected from random sequence space

Michael Knopp, Arianne M. Babina, Jónína S. Gudmundsdóttir, Martin V. Douglass, M. Stephen Trent, Dan I. Andersson

PLOS Genetics: published January 7, 2021 | https://doi.org/10.1371/journal.pgen.1009227

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Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways

Chen-Yi Tang, Mengrui Wu, Dongfeng Zhao, Diep Edwards, Abigail McVicar, Yuan Luo, Guochun Zhu, Yongjun Wang, Hou-De Zhou, Wei Chen, Yi-Ping Li

PLOS Genetics: published January 21, 2021 | https://doi.org/10.1371/journal.pgen.1009233

Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect

Julia Böck, Einar Krogsaeter, Marcel Passon, Yu-Kai Chao, Sapna Sharma, Harald Grallert, Annette Peters, Christian Grimm

PLOS Genetics: published January 19, 2021 | https://doi.org/10.1371/journal.pgen.1009236

Estimating F_ST and kinship for arbitrary population structures

Alejandro Ochoa, John D. Storey

PLOS Genetics: published January 19, 2021 | https://doi.org/10.1371/journal.pgen.1009241

Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus

Xavier Grau-Bové, Eric Lucas, Dimitra Pipini, Emily Rippon, Arjèn E. van ‘t Hof, Edi Constant, Samuel Dadzie, Alexander Egyir-Yawson, John Essandoh, Joseph Chabi, Luc Djogbénou, Nicholas J. Harding, Alistair Miles, Dominic Kwiatkowski, Martin J. Donnelly, David Weetman, The Anopheles gambiae 1000 Genomes Consortium

PLOS Genetics: published January 21, 2021 | https://doi.org/10.1371/journal.pgen.1009253

Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress

Bettina J. Lehman, Fernando J. Lopez-Diaz, Thom P. Santisakultarm, Linjing Fang, Maxim N. Shokhirev, Kenneth E. Diffenderfer, Uri Manor, Beverly M. Emerson

PLOS Genetics: published January 7, 2021 | https://doi.org/10.1371/journal.pgen.1009277

A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant

Pierre-Emmanuel Morange, Franck Peiretti, Lenaick Gourhant, Carole Proust, Omar Soukarieh, Anne-Sophie Pulcrano-Nicolas, Ganapathi-Varma Saripella, Luca Stefanucci, Romaric Lacroix, Manal Ibrahim-Kosta, Catherine A. Lemarié, Mattia Frontini, Marie-Christine Alessi, David-Alexandre Trégouët, Francis Couturaud

PLOS Genetics: published January 19, 2021 | https://doi.org/10.1371/journal.pgen.1009284

Genome-scale CRISPR screening for modifiers of cellular LDL uptake

Brian T. Emmer, Emily J. Sherman, Paul J. Lascuna, Sarah E. Graham, Cristen J. Willer, David Ginsburg

PLOS Genetics: published January 29, 2021 | https://doi.org/10.1371/journal.pgen.1009285

Htt is a repressor of Abl activity required for APP-induced axonal growth

Claire Marquilly, Germain U. Busto, Brittany S. Leger, Ana Boulanger, Edward Giniger, James A. Walker, Lee G. Fradkin, Jean-Maurice Dura

PLOS Genetics: published January 19, 2021 | https://doi.org/10.1371/journal.pgen.1009287

Natural variation in temperature-modulated immunity uncovers transcription factor bHLH059 as a thermoresponsive regulator in Arabidopsis thaliana

Friederike Bruessow, Jaqueline Bautor, Gesa Hoffmann, Ipek Yildiz, Jürgen Zeier, Jane E. Parker

PLOS Genetics: published January 25, 2021 | https://doi.org/10.1371/journal.pgen.1009290

Accurate genetic and environmental covariance estimation with composite likelihood in genome-wide association studies

Boran Gao, Can Yang, Jin Liu, Xiang Zhou

PLOS Genetics: published January 4, 2021 | https://doi.org/10.1371/journal.pgen.1009293

Temperature regulates synaptic subcellular specificity mediated by inhibitory glutamate signaling

Mengqing Wang, Daniel Witvliet, Mengting Wu, Lijun Kang, Zhiyong Shao

PLOS Genetics: published January 11, 2021 | https://doi.org/10.1371/journal.pgen.1009295

A regulatory sub-circuit downstream of Wnt signaling controls developmental transitions in neural crest formation

Ana Paula Azambuja, Marcos Simoes-Costa

PLOS Genetics: published January 19, 2021 | https://doi.org/10.1371/journal.pgen.1009296

Epithelial cell-turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants

Nanami Akai, Shizue Ohsawa, Yukari Sando, Tatsushi Igaki

PLOS Genetics: published January 28, 2021 | https://doi.org/10.1371/journal.pgen.1009300

Immune fingerprinting through repertoire similarity

Thomas Dupic, Meriem Bensouda Koraichi, Anastasia A. Minervina, Mikhail V. Pogorelyy, Thierry Mora, Aleksandra M. Walczak

PLOS Genetics: published January 4, 2021 | https://doi.org/10.1371/journal.pgen.1009301

UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin

Natalie Saini, Camille K. Giacobone, Leszek J. Klimczak, Brian N. Papas, Adam B. Burkholder, Jian-Liang Li, David C. Fargo, Re Bai, Kevin Gerrish, Cynthia L. Innes, Shepherd H. Schurman, Dmitry A. Gordenin

PLOS Genetics: published January 14, 2021 | https://doi.org/10.1371/journal.pgen.1009302

Kinetochore-independent mechanisms of sister chromosome separation

Hannah Vicars, Travis Karg, Brandt Warecki, Ian Bast, William Sullivan

PLOS Genetics: published January 29, 2021 | https://doi.org/10.1371/journal.pgen.1009304

Ciona Brachyury proximal and distal enhancers have different FGF dose-response relationships

Matthew J. Harder, Julie Hix, Wendy M. Reeves, Michael T. Veeman

PLOS Genetics: published January 19, 2021 | https://doi.org/10.1371/journal.pgen.1009305

Consequences of adaptation of TAL effectors on host susceptibility to Xanthomonas

Doron Teper, Nian Wang

PLOS Genetics: published January 19, 2021 | https://doi.org/10.1371/journal.pgen.1009310

Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

Cullen Roth, Debra Murray, Alexandria Scott, Ci Fu, Anna F. Averette, Sheng Sun, Joseph Heitman, Paul M. Magwene

PLOS Genetics: published January 25, 2021 | https://doi.org/10.1371/journal.pgen.1009313

Adaptation is influenced by the complexity of environmental change during evolution in a dynamic environment

Sébastien Boyer, Lucas Hérissant, Gavin Sherlock

PLOS Genetics: published January 25, 2021 | https://doi.org/10.1371/journal.pgen.1009314

RAFFI: Accurate and fast familial relationship inference in large scale biobank studies using RaPID

Ardalan Naseri, Junjie Shi, Xihong Lin, Shaojie Zhang, Degui Zhi

PLOS Genetics: published January 21, 2021 | https://doi.org/10.1371/journal.pgen.1009315

Natural variations of TFIIAγ gene and LOB1 promoter contribute to citrus canker disease resistance in Atalantia buxifolia

Xiaomei Tang, Xia Wang, Yue Huang, Ling Ma, Xiaolin Jiang, Muhammad Junaid Rao, Yuantao Xu, Ping Yin, Meng Yuan, Xiuxin Deng, Qiang Xu

PLOS Genetics: published January 25, 2021 | https://doi.org/10.1371/journal.pgen.1009316

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance

Andrew Hammond, Xenia Karlsson, Ioanna Morianou, Kyros Kyrou, Andrea Beaghton, Matthew Gribble, Nace Kranjc, Roberto Galizi, Austin Burt, Andrea Crisanti, Tony Nolan

PLOS Genetics: published January 29, 2021 | https://doi.org/10.1371/journal.pgen.1009321

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repair

Natasha C. Koussa, Duncan J. Smith

PLOS Genetics: published January 25, 2021 | https://doi.org/10.1371/journal.pgen.1009322

Ablation of DNA-methyltransferase 3A in skeletal muscle does not affect energy metabolism or exercise capacity

Lewin Small, Lars R. Ingerslev, Eleonora Manitta, Rhianna C. Laker, Ann N. Hansen, Brendan Deeney, Alain Carrié, Philippe Couvert, Romain Barrès

PLOS Genetics: published January 29, 2021 | https://doi.org/10.1371/journal.pgen.1009325

Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK Biobank

Ha My T. Vy, Daniel M. Jordan, Daniel J. Balick, Ron Do

PLOS Genetics: published January 25, 2021 | https://doi.org/10.1371/journal.pgen.1009337

Correction: Pathological mechanism and antisense oligonucleotide-mediated rescue of a non-coding variant suppressing factor 9 RNA biogenesis leading to hemophilia B

Simon Krooss, Sonja Werwitzke, Johannes Kopp, Alice Rovai, Dirk Varnholt, Amelie S. Wachs, Aurelie Goyenvalle, Annemieke Aartsma-Rus, Michael Ott, Andreas Tiede, Jörg Langemeier, Jens Bohne

PLOS Genetics: published January 28, 2021 | https://doi.org/10.1371/journal.pgen.1009345

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Correction: Unified inference of missense variant effects and gene constraints in the human genome

The PLOS Genetics Staff

PLOS Genetics: published January 28, 2021 | https://doi.org/10.1371/journal.pgen.1009348

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