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In silico irradiation of Hi-C genome conformation

The in silico proton irradiation of 3D genome structure derived from Hi-C geometry. The track-structure of the primary protons (red) traversing through the IMR90 cell nucleus, producing secondary electrons (green) as they travel, the energy depositions of these particles damage the DNA. This damage to the DNA is then scored as single- or double-stranded breaks and the distribution of these are analysed. Ingram et al.

Image Credit: Samuel P Ingram Nicholas T Henthorn