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Table of Contents

August 2019

Craig et al. introduce the concept of "Cooperative adaptation to therapy" (CAT), in which cancer cells work together immediately upon 'seeing' a drug to build resistance even in the absence of new, acquired mutations. This novel paradigm may help explain why aggressive cancers, such as non-small cell lung cancer, are able to rapidly overcome the pressures of anticancer therapy even when 'druggable' mutations exist.

The image depicts clones of cancer cells converging in a unified, cooperative fashion on an iron throne of 'medicine'. The use of game theory mathematical modeling is represented by the 'foundation', which supports the overtaking of the 'throne'!

Image Credit: Artist: Illustration by Jesse Morris, 2019 Jesse Morris Art, www.jessemorrisart, provided under CC BY 4.0.

Education

Twelve quick tips for designing sound dynamical models for bioprocesses

Francis Mairet, Olivier Bernard

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Reappraising the utility of Google Flu Trends

Sasikiran Kandula, Jeffrey Shaman

Bayesian hypothesis testing and experimental design for two-photon imaging data

Luke E. Rogerson, Zhijian Zhao, Katrin Franke, Thomas Euler, Philipp Berens

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