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Table of Contents

February 2017

Kinase activity is frequently regulated by phosphorylation. Enhanced sampling molecular dynamics (MD) methods are used to find structural changes of a specific kinase on phosphorylation of its activation loop. Experimental methods do not currently probe completely the conformational space accessible to the activation loop. MD simulation can then complement and extend hypothesis of the mechanisms of kinase activation based on crystallographic and other methods. The results of this study identify a novel role for specific residues in accelerating phosphotransfer. Karp et al.

Image Credit: Jerome M. Karp


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Ten Simple Rules for Developing a Successful Research Proposal in Brazil

Dyoni M. de Oliveira, Marcos S. Buckeridge, Wanderley D. dos Santos

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graph-GPA: A graphical model for prioritizing GWAS results and investigating pleiotropic architecture

Dongjun Chung, Hang J. Kim, Hongyu Zhao

Testing the limits of gradient sensing

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Quantifying the Value of Perfect Information in Emergency Vaccination Campaigns

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A mathematical model of calcium dynamics in HSY cells

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Depth-dependent flow and pressure characteristics in cortical microvascular networks

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Conformational diversity analysis reveals three functional mechanisms in proteins

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James M. Osborne, Alexander G. Fletcher, Joe M. Pitt-Francis, Philip K. Maini, David J. Gavaghan

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