Table of Contents

October 2006

The modular architecture of type I polyketide synthases allows for truly natural biocombinatorics: creating new compounds very efficiently by recombination of gene segments. Shown here are the phylogenetic relationships of different domain types encoded in the genome of the actinobacterium Streptomyces avermitilis depicting an evolutionary history of extensive recombinational replacements (see Jenke-Kodama et al).

Image Credit: Illustration by Holger Jenke-Kodama


Biocurators: Contributors to the World of Science

Philip E Bourne, Johanna McEntyre


The Biocurator: Connecting and Enhancing Scientific Data

Nima Salimi, Randi Vita

Research Articles

Simulating Properties of In Vitro Epithelial Cell Morphogenesis

Mark R Grant, Keith E Mostov, Thea D Tlsty, C. Anthony Hunt

Large-Scale Turnover of Functional Transcription Factor Binding Sites in Drosophila

Alan M Moses, Daniel A Pollard, David A Nix, Venky N Iyer, Xiao-Yong Li, Mark D Biggin, Michael B Eisen

Natural Biocombinatorics in the Polyketide Synthase Genes of the Actinobacterium Streptomyces avermitilis

Holger Jenke-Kodama, Thomas Börner, Elke Dittmann

Viral and Latent Reservoir Persistence in HIV-1–Infected Patients on Therapy

Hwijin Kim, Alan S Perelson

Quantitative Analyses of Circadian Gene Expression in Mammalian Cell Cultures

Mariko Izumo, Takashi R Sato, Martin Straume, Carl Hirschie Johnson

The Transcriptional Regulator CBP Has Defined Spatial Associations within Interphase Nuclei

Kirk J McManus, David A Stephens, Niall M Adams, Suhail A Islam, Paul S Freemont, Michael J Hendzel

Cooperation Prevails When Individuals Adjust Their Social Ties

Francisco C Santos, Jorge M Pacheco, Tom Lenaerts

From Bad to Good: Fitness Reversals and the Ascent of Deleterious Mutations

Matthew C Cowperthwaite, J. J Bull, Lauren Ancel Meyers

Mapping Information Flow in Sensorimotor Networks

Max Lungarella, Olaf Sporns

Ab Initio Modeling of the Herpesvirus VP26 Core Domain Assessed by CryoEM Density

Matthew L Baker, Wen Jiang, William J Wedemeyer, Frazer J Rixon, David Baker, Wah Chiu